Intracellular resistance in rat papillary muscle: interaction between cyclic AMP and calcium.

abstract：:The effects of noradrenaline (NA, 10(-5) M) and [arginine8]vasopressin (AVP, 10(-7) M) on tension in Ca2+-free medium and on membrane potential, and the inhibition of NA- and AVP-induced contractions by isradipine, have been compared in mesenteric resistance vessels (MRVs) from Wistar-Kyoto (WKY) rats. The release of ...

journal_title：Journal of cardiovascular pharmacology

authors： Cauvin C,Weir SW,Wallnöfer A,Rüegg U

更新日期：1988-01-01 00:00:00

abstract：:Activity in central sympathetic pathways can be modified by stimulating central alpha 2-adrenoceptors, e.g., with clonidine, or, more recently, by stimulating central 5-hydroxytryptamine (5-HT1A) receptors. Stimulation of 5-HT1A receptors causes central sympathoinhibition and an increase in cardiac vagal drive, which ...

journal_title：Journal of cardiovascular pharmacology

authors： Ramage AG

更新日期：1990-01-01 00:00:00

abstract：:Atrial Fibrillation (AF) is accompanied by an increased risk for thromboembolic events in most affected patients. Current guidelines therefore recommend antithrombotic therapy with vitamin K antagonist (VKA) or non VKA oral anticoagulant (NOAC) in the majority of AF patients. Current AF treatment guidelines recommend ...

journal_title：Journal of cardiovascular pharmacology

authors： Hammwöhner M,Goette A

更新日期：2015-12-01 00:00:00

abstract：:Cardiac remodeling is regulated by an extensive intracellular signal transduction network. Each of the many signaling pathways in this network contributes uniquely to the control of cellular adaptation. In the last few years, it has become apparent that multimolecular signaling complexes or "signalosomes" are importan...

journal_title：Journal of cardiovascular pharmacology

authors： Passariello CL,Li J,Dodge-Kafka K,Kapiloff MS

更新日期：2015-03-01 00:00:00

abstract：:Mesenteric resistance arteries (internal diameter 174-337 microns) from rats, rabbits, pigs, and humans were isolated and mounted in a myograph. In all preparations, phenylephrine (alpha 1-adrenoceptor agonist) evoked concentration-dependent contractions that were antagonized by prazosin (alpha 1-adrenoceptor antagoni...

journal_title：Journal of cardiovascular pharmacology

authors： Nielsen H,Pilegaard HK,Hasenkam JM,Mortensen FV,Mulvany MJ

更新日期：1991-07-01 00:00:00

abstract：:Primary pulmonary hypertension continues to be a fatal disease. We have recently demonstrated that long-term inhibition of Rho-kinase, an effector of the small GTPase Rho, is effective for the treatment of pulmonary hypertension (PH) in rats and humans. Prostacyclin has been clinically used for the treatment of PH wit...

journal_title：Journal of cardiovascular pharmacology

authors： Abe K,Morikawa K,Hizume T,Uwatoku T,Oi K,Seto M,Ikegaki I,Asano T,Kaibuchi K,Shimokawa H

更新日期：2005-02-01 00:00:00

abstract：:Labedipinedilol-A is a novel 1, 4-dihydropyridine type calcium antagonist with alpha-receptor blocking activity. This study investigates the effects of labedipinedilol-A on mitogen-induced proliferation of rat vascular smooth muscle cells (VSMCs). Labedipinedilol-A's inhibition on cell proliferation was measured by th...

journal_title：Journal of cardiovascular pharmacology

authors： Liou SF,Yeh JL,Liang JC,Chiu CC,Lin YT,Chen IJ

更新日期：2004-11-01 00:00:00

abstract：:The antihypertensive efficacy and tolerability of amlodipine in combination with enalapril were assessed in this two-center study. Patients with moderate to severe hypertension and with diastolic blood pressure > 95 mm Hg after 4 weeks of treatment with open-label enalapril 5-10 mg daily were randomized to receive aml...

journal_title：Journal of cardiovascular pharmacology

authors： Davies J,Jensen H,Garsdal P

更新日期：1991-01-01 00:00:00

abstract：:Inhibition of plasma angiotensin II generation does not fully explain the chronic hypotensive effects of angiotensin-converting enzyme (ACE) inhibitors. Therefore, the pattern of tissue ACE inhibition in rats was studied after oral administration of perindopril, a new ACE inhibitor. Tissue ACE was measured by quantita...

journal_title：Journal of cardiovascular pharmacology

authors： Sakaguchi K,Jackson B,Chai SY,Mendelsohn FA,Johnson CI

更新日期：1988-12-01 00:00:00

abstract：:In a prospective randomized study, we assessed the electrophysiologic effects and the efficacy of ajmaline versus propafenone in patients with accessory pathways (APs). During initiated atrioventricular (AV) reentrant tachycardia or atrial fibrillation (AF), ajmaline (1 mg/kg as bolus followed by infusion of 15 microg...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Borggrefe M,Martinez-Rubio A,Hief C,Haverkamp W,Hindricks G,Breithardt G

更新日期：1994-10-01 00:00:00

abstract：:The force generators in myocardial cells of rats and rabbits can exist in three different states: relaxed and calcium unresponsive; relaxed and calcium responsive; and contracted. The transition between the two calcium responsive states is produced by the abrupt rise in the concentration of calcium ions during activat...

journal_title：Journal of cardiovascular pharmacology

authors： Winegrad S,McClellan G,Weisberg A,Lin LE,Weindling S

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:S-equol is known as an estrogenic substance, but its ability to restore vascular endothelial function is unknown. The aim of this study was to investigate the impact of S-equol on endothelial function and intimal thickening under isoflavone- and estrogen-deficient circumstances. METHODS:Twelve-week-old fema...

journal_title：Journal of cardiovascular pharmacology

authors： Ohkura Y,Obayashi S,Yamada K,Yamada M,Kubota T

更新日期：2015-05-01 00:00:00

abstract：:Coronary artery disease is the most important cause of morbidity and mortality in Western countries. Its pathogenesis is unknown but involves an enhanced vasoconstriction and increased interaction of platelets and monocytes with the vessel wall, as well as proliferation, migration, and extracellular matrix formation o...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Noll G

更新日期：1994-01-01 00:00:00

abstract：:We investigated the effects of endothelin (ET) and thrombin on the production of interleukin 6 (IL-6) in human umbilical vein endothelial cells (HUVECs). ET-1 increased IL-6 production twofold in HUVECs incubated for 18 h with 10(-10) M ET-1. Thrombin also significantly increased IL-6 production. However, stimulation ...

journal_title：Journal of cardiovascular pharmacology

authors： Stanková J,Rola-Pleszczynski M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:The mechanism of lithium action, an effective treatment for bipolar disease, is still unknown. The present study examined the role of nitric oxide (NO) and prostaglandin systems in lithium modulation of acetylcholine in mesenteric vascular bed of rats by cannulating superior mesenteric artery. Acetylcholine (ACh) or s...

journal_title：Journal of cardiovascular pharmacology

authors： Rahimzadeh-Rofouyi B,Afsharimani B,Moezi L,Ebrahimi F,Mehr SE,Mombeini T,Ghahremani MH,Dehpour AR

更新日期：2007-12-01 00:00:00

abstract：:Lidocaine and tocainide had no effect on ventricular conduction of extrasystoles with coupling intervals longer than 500 msec in isolated blood-perfused dog hearts, but caused interval-related increases in conduction time of extrasystoles in the range of 250--400 msec, here called mid-range extrasystoles (MRE). Quinid...

journal_title：Journal of cardiovascular pharmacology

authors： Man RY,Dresel PE

更新日期：1979-05-01 00:00:00

abstract：:The effects of reactive oxygen species (ROS) on different cellular types are variable. In some conditions they can be harmful metabolites, but they can also act as intracellular messengers that are able to activate different transcription factors. Based on previous reports in which ROS were shown to stimulate the prol...

journal_title：Journal of cardiovascular pharmacology

authors： Ruiz-Ginés JA,López-Ongil S,González-Rubio M,González-Santiago L,Rodríguez-Puyol M,Rodríguez-Puyol D

更新日期：2000-01-01 00:00:00

abstract：:This study assessed the possible local nociceptive and hyperalgesic properties of endothelin-1 (ET-1) in the rat knee-joint incapacitation test, in which animals are placed for 1 min/h on a revolving (3 rpm) metal cylinder and nociception is measured as the time the hindpaw of the injected limb was off the cylinder (i...

journal_title：Journal of cardiovascular pharmacology

authors： De-Melo JD,Tonussi CR,D'Orléans-Juste P,Rae GA

更新日期：1998-01-01 00:00:00

abstract：:Some calcium antagonists, including nitrendipine, were noted to cause a dose-dependent and reversible inhibition of insulin release in certain animal models. Therefore, it is important to know the effects of clinical treatment with calcium antagonists in nondiabetic or diabetic man. A review of the literature allows t...

journal_title：Journal of cardiovascular pharmacology

authors： Trost BN,Weidmann P

更新日期：1984-01-01 00:00:00

abstract：:The hypothesis that local release of prostanoids may contribute to the pharmacologic effect of nitroglycerin (NTG) has long been debated. Results of prostanoid blockade by indomethacin on NTG-induced effects, to date, have been inconclusive. To quantitate the effects of intravenous indomethacin on NTG-induced myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Bednarcyzk EM,Furniss SM,Green JA,Munger MA

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Some patients with atrial fibrillation (AF) received underdoses of non-vitamin K antagonist oral anticoagulants (NOACs) in the real world. Underdosing is defined as administration of a dose lower than the manufacturer recommended dose. OBJECTIVES:To identify the efficacy and safety of underdosing NOACs as p...

journal_title：Journal of cardiovascular pharmacology

authors： Yamaji H,Murakami T,Hina K,Higashiya S,Kawamura H,Murakami M,Kamikawa S,Komatsubara I,Kusachi S

更新日期：2017-02-01 00:00:00

abstract：:Evidence for the hypothesis that the rise in peripheral resistance that occurs in inherited hypertension is due largely to the observed rise in the circulating level of a sodium transport inhibitor is reviewed. A sequence of events is proposed linking a postulated genetic defect in the kidney's ability to excrete sodi...

journal_title：Journal of cardiovascular pharmacology

authors： MacGregor GA,de Wardener HE

更新日期：1984-01-01 00:00:00

abstract：:Calcium-antagonist drugs are therapeutic agents of first choice in patients with coronary artery disease. We have reviewed a number of clinical trials in which the safety and efficacy of calcium blockers have been tested and discuss the established clinical effects of these compounds, which range from relief of angina...

journal_title：Journal of cardiovascular pharmacology

authors： Ghio S,Specchia G

更新日期：1992-01-01 00:00:00

abstract：:We have studied the effects of bremazocine on the peripheral sympathetic nervous system and the arterial blood pressure of pithed rabbits with electrically (2 Hz) stimulated sympathetic outflow, and compared them with the effects of Leu-enkephalin and fentanyl. The 3H-noradrenaline plasma clearance and the plasma conc...

journal_title：Journal of cardiovascular pharmacology

authors： Ensinger H,Hedler L,Szabo B,Starke K

更新日期：1986-05-01 00:00:00

abstract：:In humans, three endothelin (ET) isoforms are predicted to exist by analysis of genomic DNA. However, evidence for the presence of all three mature ET peptides and their precursors remains unclear. Our aim was to identify the ET isoforms present in human heart, using radioimmunoassay (RIA) and reverse-phase high-perfo...

journal_title：Journal of cardiovascular pharmacology

authors： Plumpton C,Champeney R,Ashby MJ,Kuc RE,Davenport AP

更新日期：1993-01-01 00:00:00

abstract：:The cholinergic anti-inflammatory pathway has been found to exert a protective role in myocardial ischemia-reperfusion injury (MIRI). Alpha7 nicotinic acetylcholine receptor (α7nAChR) is a regulator of cholinergic anti-inflammatory pathway; however, little information is available on the effect of α7nAChR on MIRI. In ...

journal_title：Journal of cardiovascular pharmacology

authors： Li H,Zhang ZZ,Zhan J,He XH,Song XM,Wang YL

更新日期：2012-06-01 00:00:00

abstract：:Dobutamine is frequently used for acute therapy in heart failure. In the present study, the hemodynamic effects of long-term intermittent dobutamine therapy were investigated in conscious rats with heart failure. Rats with healed myocardial infarctions received two i.p. injections of dobutamine per day for 2 weeks. He...

journal_title：Journal of cardiovascular pharmacology

authors： Schoemaker RG,Debets JJ,Struyker-Boudier HA,Smits JF

更新日期：1991-06-01 00:00:00

abstract：:Coronary heart disease secondary to atherosclerosis is the leading cause of death for men in the United States. Using a new, nontransgenic, non-fat-fed mouse model of hyperlipidemia and atherosclerosis developed in our laboratory, we investigated the effect of sex on lipid profiles and subsequent aortic atheroscleroti...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Coker JW,Paigen BJ,Tawfik O

更新日期：2002-03-01 00:00:00

abstract：:The effects of the selective neutral endopeptidase (EC 3.4.24.11, NEP) inhibitor SQ 28,603 on endogenous plasma endothelin (ET) concentration and on the clearance from the circulation of exogenously administered synthetic human ET-1 were examined in Sprague-Dawley rats. Inhibition of NEP by SQ 28,603 (100 mumol/kg int...

journal_title：Journal of cardiovascular pharmacology

authors： Asaad MM,Dorso CR,Moreland SM

更新日期：1993-04-01 00:00:00

abstract：:The long-term effects (9 weeks) on renal hemodynamics of the new calcium entry blocker isradipine (PN 200-110) were assessed in 20 middle-aged male patients with essential hypertension. The study was double-blind placebo-controlled with a crossover design. Isradipine or placebo tablets were titrated from 2.5, 5, and 7...

journal_title：Journal of cardiovascular pharmacology

authors： Persson B,Wysocki M,Andersson OK

更新日期：1989-07-01 00:00:00