Salusins protect neonatal rat cardiomyocytes from serum deprivation-induced cell death through upregulation of GRP78.

abstract：:The haemodynamic effects of three different methods of nitrate administration [intravenous (i.v.) isosorbide dinitrate (ISDN) and buccal and transdermal nitroglycerin (NTG)] were evaluated in 36 patients with acute left ventricular failure due to a recent myocardial infarction. Similar reductions in pulmonary artery o...

journal_title：Journal of cardiovascular pharmacology

authors： Verma SP,Silke B,Reynolds GW,Richmond A,Taylor SH

更新日期：1989-11-01 00:00:00

abstract：:Erythrocyte lithium-sodium countertransport, a mode of ouabain-insensitive monovalent cation metabolism, is increased in human essential hypertension, but no pathophysiological link to hypertension has yet been established. Similarities between red cell lithium-sodium countertransport and renal proximal tubular sodium...

journal_title：Journal of cardiovascular pharmacology

authors： Weder AB,Fitzpatrick MA

更新日期：1986-01-01 00:00:00

abstract：:According to the standard model of G protein-coupled receptor (GPCR) signaling, GPCRs are localized to the cell membrane where they respond to extracellular signals. Stimulation of GPCRs leads to the activation of heterotrimeric G proteins and their intracellular signaling pathways. However, this model fails to accomm...

journal_title：Journal of cardiovascular pharmacology

authors： Campden R,Audet N,Hébert TE

更新日期：2015-02-01 00:00:00

abstract：:We studied 12 patients receiving either chronic oral (p.o.) maintenance bretylium and/or acute intravenous (i.v.) bretylium to evaluate drug efficacy and pharmacokinetics. All patients were survivors of ventricular tachycardia or fibrillation. A new assay for bretylium was applied, and it proved sensitive and reliable...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson JL,Patterson E,Wagner JG,Johnson TA,Lucchesi BR,Pitt B

更新日期：1981-05-01 00:00:00

abstract：:Since the end of 1976 ten orally active converting enzyme inhibitors [SQ 14,225 (captopril), MK 421 (enalapril), MK 422, MK 521 (lysinopril), RHC 3659, CGS 13945, CGS 13928C, CGS 14824A, Hoe 498, S 9490-3, and Ro 31-2848] have been evaluated by our group in normal volunteers. Their ability to blunt the pressor respons...

journal_title：Journal of cardiovascular pharmacology

authors： Brunner HR,Nussberger J,Waeber B

更新日期：1985-01-01 00:00:00

abstract：:In anesthetized and ventilated guinea pigs, intravenous injection of ET-1, ET-2, or ET-3 induced similar rapid and dose-related increases in pulmonary inflation pressure (PIP) and mean arterial blood pressure (MABP). Indomethacin inhibited the increase in PIP evoked by ET-1, ET-2, or ET-3, whereas the changes in MABP ...

journal_title：Journal of cardiovascular pharmacology

authors： Pons F,Touvay C,Lagente V,Mencia-Huerta JM,Braquet P

更新日期：1991-01-01 00:00:00

abstract：:Because the role of sodium channels in the initiation and maintenance of VF is not fully elucidated, we studied the significance of sodium channel activity in VF using sodium channel blockers. In nonischemic isolated feline hearts, the following electrophysiologic parameters were measured before and after application ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Schoels W,Visokovsky A,Lev-Ran V,Novikov I,Mueller M,Kraft P,Kaplinsky E,Eldar M

更新日期：2000-12-01 00:00:00

abstract：:Experience with angiotensin converting enzyme (ACE) inhibitor drugs as with other antihypertensive agents, is limited in the elderly. Nevertheless, they appear effective and well tolerated but without evidence to suggest that they have any special role in the elderly compared to a younger age group. Most are excreted ...

journal_title：Journal of cardiovascular pharmacology

authors： Ball SG

更新日期：1988-01-01 00:00:00

abstract：:Nebivolol, a chemically novel beta 1-adrenoceptor antagonist, acutely lowers blood pressure in spontaneously hypertensive rats, anaesthetised normotensive dogs, and hypertensive patients. We have investigated the actions of dl-nebivolol in five conscious normotensive rabbits (sham, mean blood pressure (BP) of 82.2 +/-...

journal_title：Journal of cardiovascular pharmacology

authors： Ward JE,Coles P,Cox H,Eisenhofer G,Angus JA

更新日期：1992-07-01 00:00:00

abstract：:Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of ca...

journal_title：Journal of cardiovascular pharmacology

authors： de Leiris J,de Lorgeril M,Boucher F

更新日期：2009-11-01 00:00:00

abstract：:The comparative contributions of arachidonic acid (AA) metabolites and 5-hydroxytryptamine (5-HT) to the delay of reperfusion and rate of reocclusion after coronary thrombolysis with streptokinase were assessed in dogs using (a) single TXA2 synthase inhibition; (b) single 5-HT2-receptor blockade; (c) dual TXA2 synthas...

journal_title：Journal of cardiovascular pharmacology

authors： Vandeplassche G,Hermans C,Van Dael L,Wouters L,De Clerck F

更新日期：1993-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha) is an inflammatory cytokine involved in atherogenesis. Adipose tissue is an important source of endogenous TNFalpha production. The aim of this study was to evaluate the effect of atorvastatin on TNFalpha serum concentration and mRNA expressions of subcutaneous adipose in hyperch...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao SP,Wu ZH,Wu J,Hong SC,Deng P

更新日期：2005-08-01 00:00:00

abstract：:Conscious dogs were given diltiazem hydrochloride (DTZ) orally for 5 successive days at doses of 1, 3, and 10 mg/kg/day. During the 5th day, cardiovascular responses were monitored at various timed intervals after dosing. Arterial blood was sampled concomitantly for drug analysis. DTZ produced a dose-related decrease ...

journal_title：Journal of cardiovascular pharmacology

authors： Browne RK,Dimmitt DC,Miller LD,Korol B

更新日期：1983-05-01 00:00:00

abstract：:High blood pressure (BP) is associated with increased risk of vascular disease, including myocardial infarction and stroke. Since drugs that lower BP will reduce the risk of those complications of hypertension that are due to high pressure (strokes due to small-vessel disease, including lacunar infarction and intracer...

journal_title：Journal of cardiovascular pharmacology

authors： Spence JD

更新日期：1987-01-01 00:00:00

abstract：:Recent studies have suggested that central nervous mechanisms are involved in the enhanced sympathetic drive observed in heart failure (HF). Nitric oxide (NO) in the brainstem has been shown to reduce sympathetic nerve activity. The aim of this study was to determine whether the expression of neuronal nitric oxide syn...

journal_title：Journal of cardiovascular pharmacology

authors： Hirooka Y,Shigematsu H,Kishi T,Kimura Y,Ueta Y,Takeshita A

更新日期：2003-12-01 00:00:00

abstract：:Cilnidipine has a blocking action against N-type calcium channels as well as L-type calcium channels. We studied the effect of morning and bedtime dosing on circadian variation of blood pressure (BP), heart rate (HR), and activity of the autonomic nervous system, using an open randomized crossover study in 13 essentia...

journal_title：Journal of cardiovascular pharmacology

authors： Kitahara Y,Saito F,Akao M,Fujita H,Takahashi A,Taguchi H,Hino T,Otsuka Y,Kushiro T,Kanmatsuse K

更新日期：2004-01-01 00:00:00

abstract：:Cardiovascular function is regulated by short-term and long-term neurohormonal and autocrine-paracrine mechanisms that act synergistically or sequentially. Structural adaptive changes that occur progressively over time also contribute to the long-term outcome. The renin-angiotensin system (RAS) can operate as both an ...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1989-01-01 00:00:00

abstract：:Myocardial alpha 1-adrenoceptor number has been reported to increase during ischaemia in myocytes consequent to an increase in acyl carnitine levels. We investigated whether this phenomenon occurs in vivo and whether the novel antiischaemic agent ranolazine will protect against it. Thirty-minute occlusion of the left ...

journal_title：Journal of cardiovascular pharmacology

authors： Allely MC,Brown CM,Kenny BA,Kilpatrick AT,Martin A,Spedding M

更新日期：1993-06-01 00:00:00

abstract：:Alpha 2-adrenoceptor agonists are effective antihypertensive drugs that may provide particular advantages in the treatment of many types of patients. Of those now available, guanabenz has been shown to lower serum cholesterol concentration and not to cause sodium and water retention, offering additional protection aga...

journal_title：Journal of cardiovascular pharmacology

authors： Kaplan NM

更新日期：1985-01-01 00:00:00

abstract：:The effects of streptozotocin (STZ)-induced diabetes (DM) and insulin on cardiac performance were investigated during reperfusion after low-flow ischemia in rats. Hearts were isolated 4 weeks after intravenous injection of STZ (65 mg/kg) or vehicle and retrogradely perfused in the presence (throughout the perfusion pe...

journal_title：Journal of cardiovascular pharmacology

authors： Nawata T,Takahashi N,Ooie T,Kaneda K,Saikawa T,Sakata T

更新日期：2002-10-01 00:00:00

abstract：:The hypothesis that local release of prostanoids may contribute to the pharmacologic effect of nitroglycerin (NTG) has long been debated. Results of prostanoid blockade by indomethacin on NTG-induced effects, to date, have been inconclusive. To quantitate the effects of intravenous indomethacin on NTG-induced myocardi...

journal_title：Journal of cardiovascular pharmacology

authors： Bednarcyzk EM,Furniss SM,Green JA,Munger MA

更新日期：1997-12-01 00:00:00

abstract：:Protein kinase C (PKC) isoforms improve endothelial nitric oxide synthase activity and contractile Ca sensitivity in blood vessels. These actions may have opposite effects on propofol-induced vasodilation. This study examines the hypothesis that propofol induces relaxation by enhancing the PKC-mediated nitric oxide sy...

journal_title：Journal of cardiovascular pharmacology

authors： Wang Y,Zhou H,Wu B,Zhou Q,Cui D,Wang L

更新日期：2015-09-01 00:00:00

abstract：:The cardiovascular profile of SC-36602, a new class 1A/1B antiarrhythmic agent, was compared to those of disopyramide, lidocaine, mexiletine, flecainide, encainide, lorcainide, and quinidine. These drugs were compared at their respective canine antiarrhythmic doses in a hemodynamic evaluation using anesthetized dogs. ...

journal_title：Journal of cardiovascular pharmacology

authors： Frederick LG,Hatley FR,McDonald SJ,Stamm MH,Garthwaite SM

更新日期：1988-06-01 00:00:00

abstract：:A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell a...

journal_title：Journal of cardiovascular pharmacology

authors： Anavekar SN,Christophidis N,Louis WJ,Doyle AE

更新日期：1981-03-01 00:00:00

abstract：:Beta-adrenergic-blocking drugs (BABs) have a firm place in the therapy of cardiovascular conditions including angina and hypertension. Although all BABs are competitive inhibitors of beta-receptors, they may differ in their additional pharmacodynamics, i.e., beta1-(cardio)selectivity, partial agonistic activity (PAA),...

journal_title：Journal of cardiovascular pharmacology

authors： Tamargo J,Delpón E

更新日期：1990-01-01 00:00:00

abstract：:Both population (mass) strategies and targeted strategies for the management of high blood pressure are necessary. However, it has yet to be proven that reducing blood pressure by lifestyle changes in the population will confer the same cardiovascular benefit that results from lowering blood pressure by drugs. It is i...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston CI

更新日期：1996-01-01 00:00:00

abstract：:The primary purpose of the arterial baroreflex is to keep blood pressure close to a particular set point over a relatively short period of time. The rapid resetting of arterial baroreceptor afferents toward any sustained new level of blood pressure ensures that the reflex acts as an effective buffer of short-term bloo...

journal_title：Journal of cardiovascular pharmacology

authors： Head GA

更新日期：1995-01-01 00:00:00

abstract：:The dependency of arteriolar tone on calcium influx was studied in 11 patients with essential hypertension (EHT) and compared to 11 age-matched normotensive (NT) subjects by measuring the forearm blood flow (FAF) response to intraarterial infusion of the calcium channel blocker verapamil (Verap) and the nonspecific va...

journal_title：Journal of cardiovascular pharmacology

authors： Hulthén UL,Bolli P,Amann FW,Kiowski W,Bühler FR

更新日期：1982-01-01 00:00:00

abstract：:The mechanism by which enoximone, a reported phosphodiesterase inhibitor, inhibits the oxidation of long-chain fatty acids was studied in isolated rat heart mitochondria using a series of 14C-labeled substrates. Enoximone decreased palmitate oxidation in a time- and concentration-dependent manner. Fifty percent inhibi...

journal_title：Journal of cardiovascular pharmacology

authors： Abdel-aleem S,Youssef J,Badr M,Morgan P,Frangakis C

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:To investigate whether upregulation of OX40-OX40 ligand (OX40L) system is related to stability of coronary atherosclerotic plaque in patients with coronary heart diseases. METHODS:Thirty normal controls and 250 patients, including 80 with stable angina (SA), 110 with unstable angina (UA), and 60 with acute m...

journal_title：Journal of cardiovascular pharmacology

authors： Yan J,Chen G,Gong J,Wang C,Du R

更新日期：2009-11-01 00:00:00