Influence of alpha 1- and alpha 2-adrenoceptor antagonist therapy on the development of hypertension in spontaneously hypertensive rats.

abstract：:The relationship between adrenergic nerve activity and neuronal uptake was investigated. Helically cut strips of rat tail artery were mounted in organ chambers and isometric contractions were recorded. Spontaneous contractions were occasionally observed and these contractions were blocked by phentolamine. Cumulative a...

journal_title：Journal of cardiovascular pharmacology

authors： Webb RC,Vanhoutte PM,Bohr DF

更新日期：1980-01-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in the modulation of renal O2 consumption in dogs with pacing-induced congestive heart failure (CHF). O2 consumption in the renal cortex (C) and medulla (M) of normal dogs and dogs with CHF was measured under control conditions and in the presence of increasing concentrati...

journal_title：Journal of cardiovascular pharmacology

authors： Adler S,Huang H,Loke K,Xu X,Laumas A,Hintze TH

更新日期：2001-03-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in blood pressure control and in water and salt homeostasis. It is involved in the pathophysiology of hypertension and structural alterations of the vasculature, kidney, and heart, including neointima formation, nephrosclerosis, postinfarction remodeling, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Stroth U,Unger T

更新日期：1999-01-01 00:00:00

abstract：:This report summarizes the most important results of 11 studies regarding efficacy and safety of bisoprolol in patients with stable angina pectoris due to coronary heart disease. Assessments carried out 2-3 h after the administration of the beta 1-selective adrenoceptor blocking agent bisoprolol revealed that the dose...

journal_title：Journal of cardiovascular pharmacology

authors： Wagner G

更新日期：1986-01-01 00:00:00

abstract：:The effects of purified baicalin and baicalein from the traditional Chinese herb, Huangqin, on contractions induced by phenylephrine, U46619, and high extracellular K+ were investigated in isolated rat mesenteric arteries. Both baicalin (1-100 microM) and baicalein (1-50 microM) potentiated the contractile response to...

journal_title：Journal of cardiovascular pharmacology

authors： Tsang SY,Chen ZY,Yao XQ,Huang Y

更新日期：2000-08-01 00:00:00

abstract：:Prazosin, in daily doses of 6--16 mg, was used along with furosemide and polythiazide in 11 hypertensive heart failure patients. Average supine and standing blood pressures were reduced from 180/108 and 171/106 to 130/84 and 135/86, respectively. Average heart rate decreased from 83 to 73 supine and from 84 to 75 stan...

journal_title：Journal of cardiovascular pharmacology

authors： Antani JA

更新日期：1979-11-01 00:00:00

abstract：:21-Aminosteroids are a group of new synthetic compounds developed as antiperoxidants. Although several studies have demonstrated their cardioprotective properties in acute ischemic models, none has assessed their long-term benefits after chronic myocardial infarction. In this investigation, we examined the cardioprote...

journal_title：Journal of cardiovascular pharmacology

authors： Ngo PL,Chen H,Qi S,Paquette F,Dumont L

更新日期：1999-12-01 00:00:00

abstract：:Labedipinedilol-A is a novel 1, 4-dihydropyridine type calcium antagonist with alpha-receptor blocking activity. This study investigates the effects of labedipinedilol-A on mitogen-induced proliferation of rat vascular smooth muscle cells (VSMCs). Labedipinedilol-A's inhibition on cell proliferation was measured by th...

journal_title：Journal of cardiovascular pharmacology

authors： Liou SF,Yeh JL,Liang JC,Chiu CC,Lin YT,Chen IJ

更新日期：2004-11-01 00:00:00

abstract：:We examined the electromechanical effects of two class III antiarrhythmic agents, dofetilide (UK-68,798) and D-sotalol, in acidic myocardium. Right ventricular papillary muscle preparations isolated from guinea pigs were divided into three groups (n = 6 per group): (a) drug-free, (b) dofetilide (10 nM), and (c) D-sota...

journal_title：Journal of cardiovascular pharmacology

authors： Yang T,Tande PM,Refsum H

更新日期：1992-12-01 00:00:00

abstract：:Stroke is a major clinical problem in hypertension. Cerebral hemorrhage has become considerably less frequent since treatment of hypertension has become more widely used. Antihypertensive treatment has also reduced the incidence of lacunar stroke, which is a result of hypertensive vascular disease of small arteries. C...

journal_title：Journal of cardiovascular pharmacology

authors： Doyle AE,Donnan GA

更新日期：1990-01-01 00:00:00

abstract：:The long QT-related arrhythmia torsades de pointes (TdP) can arise with mutations in HERG and during treatment with drugs that block cardiac I Kr, the current encoded by HERG. Multiple test systems have been used to assess drug block of I Kr. This study evaluated the I Kr blocking potency of a series of antiarrhythmic...

journal_title：Journal of cardiovascular pharmacology

authors： Yang T,Snyders D,Roden DM

更新日期：2001-11-01 00:00:00

abstract：:An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

journal_title：Journal of cardiovascular pharmacology

authors： Haïat R,Piot O,Gallois H,Hanania G

更新日期：1999-06-01 00:00:00

abstract：:We compared the effect of verapamil slow-release (VSR) and the combination of nifedipine plus propranolol on transient myocardial ischemia in a double-blind study comprising 20 patients with proven coronary artery disease and chronic stable angina. According to the results of 24-h Holter-monitoring recording, patients...

journal_title：Journal of cardiovascular pharmacology

authors： Molinero E,Salcedo A,Sagastagoitia JD,Arzubiaga J,Iriarte MM,Gómez Pajuelo C,Fernández Vidal P

更新日期：1992-04-01 00:00:00

abstract：:Endothelium-derived relaxing factor (EDRF) and donors of nitric oxide (NO) (glyceryl trinitrate, SIN-1--a metabolite of molsidomine--S-nitroso-N-acetyl-penicillamine, and sodium nitroprusside) but not prostacyclin and its analog, iloprost, relax strips of rabbit aorta. Strips of human coronary artery also relax when e...

journal_title：Journal of cardiovascular pharmacology

authors： Gryglewski RJ,Korbut R,Trabka-Janik E,Zembowicz A,Trybulec M

更新日期：1989-01-01 00:00:00

abstract：:Depression of myocardial contractility by muscarinic agonists is dependent on underlying beta-adrenergic tone. The negative inotropic effect of muscarinic agonists is enhanced by previous beta-adrenergic stimulation, an action that has been termed accentuated antagonism. We wished to determine whether accentuated anta...

journal_title：Journal of cardiovascular pharmacology

authors： Thurston TA,Mathew BP

更新日期：1995-12-01 00:00:00

abstract：:Endothelium-dependent relaxations can be evoked by a variety of stimuli, among them substance P (SP), which is found in sensory nerve fibers supplying the adventitia-media junction of most muscular arteries. This study determined the role of endothelium-derived nitric oxide as a mediator of endothelium-dependent relax...

journal_title：Journal of cardiovascular pharmacology

authors： Fiscus RR,Gross DR,Hao H,Wang X,Arden WA,Maley RH,Salley RK

更新日期：1992-01-01 00:00:00

abstract：:The hypotensive effects of ketanserin, a selective blocker of 5-hydroxytryptamine2, are well defined, but its electrophysiologic effects in humans are not. Intravenous ketanserin (0.15 mg/kg) was therefore given to 10 patients undergoing electrophysiologic evaluation, and data were obtained before and after drug admin...

journal_title：Journal of cardiovascular pharmacology

authors： Nademanee K,Lockhart E,Pruitt C,Singh BN

更新日期：1987-01-01 00:00:00

abstract：:Death during and following myocardial infarction can arise from a number of different causes. Some of them, such as early ventricular fibrillation and cardiac rupture, seem unrelated to infarct size. However, deaths occurring later during the course of infarction do seem to be related to the extent of myocardial damag...

journal_title：Journal of cardiovascular pharmacology

authors： Julian DG

更新日期：1991-01-01 00:00:00

abstract：:In this study the contribution of alternating architecture and Ca2+ handling of mitochondria to cytosolic Ca2+ homeostasis was elucidated under normoglycemic and hyperglycemic (HGC) conditions in the human endothelial cell line EA.hy926. Exposure of endothelial cells to hyperglycemic medium elevated basal cytosolic fr...

journal_title：Journal of cardiovascular pharmacology

authors： Paltauf-Doburzynska J,Malli R,Graier WF

更新日期：2004-10-01 00:00:00

abstract：:Some calcium antagonists, including nitrendipine, were noted to cause a dose-dependent and reversible inhibition of insulin release in certain animal models. Therefore, it is important to know the effects of clinical treatment with calcium antagonists in nondiabetic or diabetic man. A review of the literature allows t...

journal_title：Journal of cardiovascular pharmacology

authors： Trost BN,Weidmann P

更新日期：1984-01-01 00:00:00

abstract：:Acute discontinuation of statins induces vascular dysfunction and increases cardiovascular events. The mechanisms underlying these events are under investigation. We showed an increase in angiotensin II (AngII) signaling after acute statin withdrawal. We investigated whether AngII-AT1-receptor expression (AT1-R mRNA) ...

journal_title：Journal of cardiovascular pharmacology

authors： Castejon AM,Zollner E,Tristano AG,Cubeddu LX

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:We investigate the impact of different regimens of parenteral hydrogen sulfide (H2S) administration on myocardium during ischemia-reperfusion (IR) and the molecular pathways involved in its cytoprotective effects. METHODS:Eighteen male Yorkshire pigs underwent 60 minutes of mid-left anterior descending coron...

journal_title：Journal of cardiovascular pharmacology

authors： Osipov RM,Robich MP,Feng J,Liu Y,Clements RT,Glazer HP,Sodha NR,Szabo C,Bianchi C,Sellke FW

更新日期：2009-10-01 00:00:00

abstract：:The antiarrhythmic agent propafenone and its primary electropharmacologically active metabolite, 5-hydroxypropafenone, are known inhibitors of cardiac myocyte repolarizing currents. We recently documented potent propafenone inhibition of the transient outward potassium current (Ito) in human atrial myocytes from patie...

journal_title：Journal of cardiovascular pharmacology

authors： Cahill SA,Kirshenbaum LA,Gross GJ

更新日期：2001-09-01 00:00:00

abstract：:Electrophysiologic properties of surviving Purkinje cardiomyocytes in the late postmyocardial-infarction phase are not well established. By using standard microelectrode techniques, we evaluated the effects of the class III agent d-sotalol on action potential parameters of single Purkinje cardiomyocytes isolated from ...

journal_title：Journal of cardiovascular pharmacology

authors： Marschang H,Schöls W,Karolyi L,Beyer T,Kübler W,Brachmann J

更新日期：1998-08-01 00:00:00

abstract：:The objective of this study was to investigate the cardioactive properties of oxybutynin, a drug that is widely prescribed for management of voiding dysfunction. Membrane currents were recorded from whole-cell-configured guinea pig ventricular myocytes, and action potentials were recorded from guinea pig and rabbit pa...

journal_title：Journal of cardiovascular pharmacology

authors： Jones SE,Kasamaki Y,Shuba LM,Ogura T,McCullough JR,McDonald TF

更新日期：2000-02-01 00:00:00

abstract：:To evaluate the possible role of endothelin in the development and/or maintenance of hypertension in Dahl rats, we examined the responsiveness of isolated vascular smooth muscle and glomerular mesangial cells, as well as deendothelialized vascular ring preparations to endothelin-1 (ET-1). Production of immunoreactive ...

journal_title：Journal of cardiovascular pharmacology

authors： Goligorsky MS,Iijima K,Morgan M,Yanagisawa M,Masaki T,Lin L,Nasjletti A,Kaskel F,Frazer M,Badr KF

更新日期：1991-01-01 00:00:00

abstract：:To evaluate the role of intracellular calcium and particularly Ca2+-uptake in the initiation of lymphocyte mitogenesis, the effect of mibefradil, which blocks both L- and T-type calcium channels with a more selective blockade of T-type channels, on the proliferation of human peripheral blood mononuclear cells (PBMCs) ...

journal_title：Journal of cardiovascular pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-04-01 00:00:00

abstract：:To assess the interaction of endothelin (ET) with nitric oxide (NO) and the effects on venous circulation and handling of renal water and electrolytes, ET (1.0 ng/kg/min) or saline was administered with or without three doses (0.27, 2.7 and 27 ng/kg/min for 40 min) of N omega-nitro-L-arginine methyl ester (L-NAME), an...

journal_title：Journal of cardiovascular pharmacology

authors： Ota K,Kimura T,Shoji M,Ota M,Funyu T,Mori T,Sahata T

更新日期：1998-01-01 00:00:00

abstract：:To evaluate whether the combination of nifedipine with chlorthalidone exerts an additive antihypertensive effect when compared to single-drug treatment, 66 uncomplicated essential hypertensives, whose diastolic blood pressure was greater than 100 and less than 115 mm Hg at the end of a 1-month washout placebo period, ...

journal_title：Journal of cardiovascular pharmacology

authors： Salvetti A,Magagna A,Innocenti P,Ponzanelli F,Cagianelli A,Cipriani M,Gandolfi E,Del Prato C,Ballestra AM,Saba P

更新日期：1991-02-01 00:00:00

abstract：:The effects of bilateral sinoaortic denervation were examined in rabbits in vivo and in vitro. In the in vivo studies the effects of intravenous administration of the alpha-adrenoceptor agonists phenylephrine and guanabenz and the antagonists prazosin and phentolamine on mean arterial pressure, heart rate, and plasma ...

journal_title：Journal of cardiovascular pharmacology

authors： Berthelot A,Hamilton CA,Petty MA,Reid JL

更新日期：1982-07-01 00:00:00