Stroke as a clinical problem in hypertension.

abstract：:Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underly...

journal_title：Journal of cardiovascular pharmacology

authors： Zhu Y,Wang DH

更新日期：2008-05-01 00:00:00

abstract：:Insulin resistance is associated with endothelial dysfunction and increased production of the pro-inflammatory vasoconstrictor peptide endothelin-1 (ET-1). The aim of this study was to test the hypothesis that blockade of ET receptors results in enhanced endothelium-dependent vasodilatation (EDV) in individuals with i...

journal_title：Journal of cardiovascular pharmacology

authors： Shemyakin A,Böhm F,Wagner H,Efendic S,Båvenholm P,Pernow J

更新日期：2006-03-01 00:00:00

abstract：:The present study was designed to investigate the lipid-lowering properties and mechanisms of action of a new HMG-CoA reductase inhibitor, rosuvastatin, in female ApoE*3-Leiden transgenic mice. Mice received a high fat/cholesterol (HFC) diet containing either rosuvastatin (0 [control], 0.00125%, 0.0025%, or 0.005% [w/...

journal_title：Journal of cardiovascular pharmacology

authors： Delsing DJ,Post SM,Groenendijk M,Solaas K,van der Boom H,van Duyvenvoorde W,de Wit EC,Bloks VW,Kuipers F,Havekes LM,Princen HM

更新日期：2005-01-01 00:00:00

abstract：:Clopidogrel (CLO) is a clinical antiplatelet agent, about which there are major concerns because its antiplatelet efficiency decreases with insufficient metabolic activation, leading to "clopidogrel resistance." We aimed to determine the antiplatelet effects of W1, a novel molecule composed of 2-O-clopidogrel and aspi...

journal_title：Journal of cardiovascular pharmacology

authors： Ge P,Du L,Han C,Li H,Feng Y,Han J,Wang Z,Xiong L,Yuan M,Liu Y

更新日期：2017-02-01 00:00:00

abstract：:In a prospective randomized study, we assessed the electrophysiologic effects and the efficacy of ajmaline versus propafenone in patients with accessory pathways (APs). During initiated atrioventricular (AV) reentrant tachycardia or atrial fibrillation (AF), ajmaline (1 mg/kg as bolus followed by infusion of 15 microg...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Borggrefe M,Martinez-Rubio A,Hief C,Haverkamp W,Hindricks G,Breithardt G

更新日期：1994-10-01 00:00:00

abstract：:The cardiopulmonary profile of three different rat strains was compared after exposure to hypoxia (9% O2) for 0, 7, or 14 days. In Sprague-Dawley (SD), Wistar (W), and high altitude-sensitive (HAS) rats, pulmonary arterial pressure (PAP) rose 30, 58, and 85% respectively, after 7 days of hypoxia, and by 108, 116, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Underwood DC,Bochnowicz S,Osborn RR,Louden CS,Hart TK,Ohlstein EH,Hay DW

更新日期：1998-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) has been proven to activate two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC) in rabbit internal carotid artery vascular smooth muscle cells (ICA VSMCs). Ca2+ influx through these channels plays an essential role for ET-...

journal_title：Journal of cardiovascular pharmacology

authors： Kawanabe Y,Hashimoto N,Masaki T

更新日期：2002-08-01 00:00:00

abstract：:Heart failure (HF) is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including an increase in betaAR kinase 1 (betaARK1) levels and activity. Gene therapy using a peptide inhibitor of betaARK1 (betaARKct) in infarcted rabbit hearts has improved compromised cardiac function. To determine...

journal_title：Journal of cardiovascular pharmacology

authors： Suzuki Y,Nakano K,Sugiyama M,Imagawa J

更新日期：2004-09-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-residue peptide isolated from the conditioned medium of cultured porcine endothelial cells and is widely distributed throughout the body, with relatively high levels in the kidney and lung. In this study we examined the influence of thyroid hormone status on immunoreactive endothelin (ir-ET...

journal_title：Journal of cardiovascular pharmacology

authors： Lam HC,Wang JP,Lee JK,Ho LT,Han TM,Lu CC,Chiang HT,Cheng DL

更新日期：1993-01-01 00:00:00

abstract：:The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE) were compared. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5, 0.034, and 78 microM, respectiv...

journal_title：Journal of cardiovascular pharmacology

authors： Kukkola PJ,Savage P,Sakane Y,Berry JC,Bilci NA,Ghai RD,Jeng AY

更新日期：1995-01-01 00:00:00

abstract：:We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2 diabetes with increased body...

journal_title：Journal of cardiovascular pharmacology

authors： Huang JP,Hsu SC,Li DE,Chen KH,Kuo CY,Hung LM

更新日期：2018-11-01 00:00:00

abstract：:Fifteen patients with stable angina participated in a 12-week crossover study to evaluate the efficacy of nifedipine and nitroglycerin patches. There was an initial 2-week drug washout period followed by a 2-week control period when patients received no other antianginal treatment other than sublingual nitroglycerin f...

journal_title：Journal of cardiovascular pharmacology

authors： Eldridge JE,Burdick DC,Jones RH,Hossack KF

更新日期：1987-09-01 00:00:00

abstract：:The elimination of an acute oral saline load is markedly blunted in adult Sabra hypertension-prone (SBH) rats compared with hypertension-resistant Sabra normotensive (SBN) rats. Within 2 h, urinary output and the excretion of sodium and potassium are significantly reduced, while urine osmolality is markedly elevated i...

journal_title：Journal of cardiovascular pharmacology

authors： Mekler J,Ben-Ishay D,Garthoff B,Kazda S

更新日期：1987-01-01 00:00:00

abstract：:Recently, we provided in vitro and in vivo evidence that several vastatins with different potencies decrease arterial smooth-muscle cell (SMC) proliferation independently of their hypocholesterolemic properties. In this study, the in vivo dose-dependent antiproliferative activity of fluvastatin on neointimal formation...

journal_title：Journal of cardiovascular pharmacology

authors： Soma MR,Parolini C,Donetti E,Fumagalli R,Paoletti R

更新日期：1995-01-01 00:00:00

abstract：:Enhanced renin-angiotensin activity causes hypertension and cardiac hypertrophy. The angiotensin (Ang)-converting enzyme (ACE)2/Ang(1-7)/Mas axis pathway functions against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (Olm), an AT1R blocker, inhibits cardiac hypertrophy independently of b...

journal_title：Journal of cardiovascular pharmacology

authors： Tanno T,Tomita H,Narita I,Kinjo T,Nishizaki K,Ichikawa H,Kimura Y,Tanaka M,Osanai T,Okumura K

更新日期：2016-06-01 00:00:00

abstract：:The mechanisms by which tolerance to organic nitrates develops are still poorly understood. Enhanced oxidative stress, i.e., increased free radical production following organic nitrate administration, has been recently suggested as a possible mechanism. A randomized, double-blind, crossover study assessed in 18 health...

journal_title：Journal of cardiovascular pharmacology

authors： Keimer R,Stutzer FK,Tsikas D,Troost R,Gutzki FM,Frölich JC

更新日期：2003-02-01 00:00:00

abstract：:Erythrocyte lithium-sodium countertransport, a mode of ouabain-insensitive monovalent cation metabolism, is increased in human essential hypertension, but no pathophysiological link to hypertension has yet been established. Similarities between red cell lithium-sodium countertransport and renal proximal tubular sodium...

journal_title：Journal of cardiovascular pharmacology

authors： Weder AB,Fitzpatrick MA

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the effect of a combination of bone marrow mononuclear cell (BM-MNC) implantation and sarpogrelate, a selective 5-HT(2A) antagonist, on endothelial function in patients with critical limb ischemia (CLI). METHODS:We evaluated the leg blood flow (LBF) responses to ac...

journal_title：Journal of cardiovascular pharmacology

authors： Higashi Y,Miyazaki M,Goto C,Sanada H,Sueda T,Chayama K

更新日期：2010-01-01 00:00:00

abstract：:In an 8-week, double-blind, randomized, active-controlled, multicenter study with three parallel treatment groups, we compared the efficacy and safety of once-daily 20 mg quinapril plus 12.5 mg hydrochlorothiazide (HCTZ) with each drug as monotherapy in patients with moderate to severe hypertension. Hypertensive out-p...

journal_title：Journal of cardiovascular pharmacology

authors： Romero R,Castellote E,Ocón J,Wagner B

更新日期：1995-07-01 00:00:00

abstract：:A subset of essential hypertensives sensitive to salt and having normal or high renin levels are termed nonmodulators. These subjects fail to modulate their renal blood flow and aldosterone responsiveness when dietary sodium is changed. We have found that a positive family history of hypertension in a first degree rel...

journal_title：Journal of cardiovascular pharmacology

authors： Dluhy RG,Hopkins P,Hollenberg NK,Williams GH,Williams RR

更新日期：1988-01-01 00:00:00

abstract：:Celiprolol is reported to be a new cardioselective beta blocker with novel ancillary properties including vasodilator effects. The purpose of this study was to investigate whether celiprolol possesses a direct vasodilatory effect on human vasculature in vivo and in vitro. We studied the in vivo effects of intra-arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Hughes A,Martin G,Goldberg P,Thom S,Sever P

更新日期：1987-11-01 00:00:00

abstract：:Angiopeptin (AP: BIM23014C), a cyclic analogue of the peptide hormone somatostatin, inhibits intimal hyperplasia after balloon angioplasty. This inhibition has been attributed to a direct inhibitory effect on smooth muscle cell (SMC) proliferation. However, the SMC that proliferate in the intima and contribute to inti...

journal_title：Journal of cardiovascular pharmacology

authors： Mooradian DL,Fernandes B,Diglio CA,Lester BR

更新日期：1995-04-01 00:00:00

abstract：:Endothelin-1 (ET-1) is an endothelium-derived peptide with powerful vasoconstrictor and mitogenic properties. A pathophysiologic role for ET-1 has been suggested, because increased plasma and tissue levels of this peptide have been described in a number of disease states, including atherosclerosis. Immunocytochemistry...

journal_title：Journal of cardiovascular pharmacology

authors： Timm M,Kaski JC,Dashwood MR

更新日期：1995-01-01 00:00:00

abstract：:Chronic stimulation of beta-adrenoceptors with isoproterenol induces alteration of vascular reactivity and increases local pro-inflammatory cytokines. We investigated whether fenofibrate and pioglitazone, PPAR-alpha and -gamma agonists, respectively, improve the changes in vascular reactivity induced by isoproterenol....

journal_title：Journal of cardiovascular pharmacology

authors： Fukuda LE,Davel AP,Verissimo-Filho S,Lopes LR,Cachofeiro V,Lahera V,Rossoni LV

更新日期：2008-11-01 00:00:00

abstract：:Relative DA1-dopamine-receptor agonist and alpha-adrenoceptor antagonist activities of fenoldopam were determined in pentobarbital anesthetized dogs. The renal vasodilating effect of intravenous infusions of fenoldopam was used as an index of its DA1-agonist activity. Inhibition by fenoldopam of femoral vasoconstricti...

journal_title：Journal of cardiovascular pharmacology

authors： Kohli JD,Glock D,Goldberg LI

更新日期：1988-01-01 00:00:00

abstract：:In an initial double-blind randomized study with three parallel groups, 48 patients, mean age 49.6 years (32-65 years), with hypertension WHO I-II, were given bisoprolol in doses of 5, 10, and 20 mg. Bisoprolol is a new beta 1-selective beta-blocking agent with a plasma half-life of 10-12 h and without intrinsic sympa...

journal_title：Journal of cardiovascular pharmacology

authors： Weiner L,Frithz G

更新日期：1986-01-01 00:00:00

abstract：:Although case reports of a possible association between statin therapy and tendon rupture have been published, no analytical studies exploring this relationship have been reported. We conducted a case-control study using the electronic medical records at Michigan State University from 2002 to 2007 to assess whether st...

journal_title：Journal of cardiovascular pharmacology

authors： Beri A,Dwamena FC,Dwamena BA

更新日期：2009-05-01 00:00:00

abstract：:Atherosclerosis is a complex vascular disease initiated by abnormal accumulation of plasma lipoproteins in the subendothelial space. Elevated levels of plasma triglycerides (TG) and low-density lipoprotein (LDL)-cholesterol as well as low concentrations of high-density lipoprotein (HDL) play a causal role in the devel...

journal_title：Journal of cardiovascular pharmacology

authors： Declercq V,Yeganeh B,Moshtaghi-Kashanian GR,Khademi H,Bahadori B,Moghadasian MH

更新日期：2005-07-01 00:00:00

abstract：:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >...

journal_title：Journal of cardiovascular pharmacology

authors： Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck E

更新日期：1992-01-01 00:00:00