Nifedipine corrects the blunted renal response to saline loading in hypertension-prone SBH rats.

abstract：:Oxidative stress might exert deleterious cardiovascular effects. The aim of the present study was to compare the antioxidative effects of carvedilol and atenolol. Levels of oxidized low-density lipoprotein cholesterol (ox-LDL), vitamin E, and thiobarbituric acid reactive substances (TBARS) were measured. In a prospect...

journal_title：Journal of cardiovascular pharmacology

authors： Jonsson G,Abdelnoor M,Seljeflot I,Arnesen H,Hostmark AT,Kjeldsen SE,Os I,Westheim AS

更新日期：2007-01-01 00:00:00

abstract：:In this study the contribution of alternating architecture and Ca2+ handling of mitochondria to cytosolic Ca2+ homeostasis was elucidated under normoglycemic and hyperglycemic (HGC) conditions in the human endothelial cell line EA.hy926. Exposure of endothelial cells to hyperglycemic medium elevated basal cytosolic fr...

journal_title：Journal of cardiovascular pharmacology

authors： Paltauf-Doburzynska J,Malli R,Graier WF

更新日期：2004-10-01 00:00:00

abstract：:The amplifier properties associated with the structural changes in the heart and resistance vessels in chronic hypertension together play a major role in maintaining the elevated blood pressure (BP) in chronic hypertension, which is greater than that of the initiating cause. In patients with primary hypertension, long...

journal_title：Journal of cardiovascular pharmacology

authors： Korner PI,Bobik A,Jennings GL,Angus JA,Anderson WP

更新日期：1991-01-01 00:00:00

abstract：:beta-Adrenoceptor antagonists such as propranolol and atenolol ameliorate the symptoms of human hyperthyroidism. We wished to define whether the cardiac changes of hyperthyroidism are attenuated by treatment with the beta-adrenoceptor antagonist atenolol. Rats were treated with triiodothyronine (T3) [1 mg/kg/day subcu...

journal_title：Journal of cardiovascular pharmacology

authors： Amos G,Kerr D,Sernia C,Brown L

更新日期：1994-08-01 00:00:00

abstract：:Plasma-membrane receptors for angiotensin II (AII) have been identified in many AII-responsive tissues involved in the control of blood pressure via direct or indirect actions on vascular contractility. The specific, high-affinity receptors for AII in adrenal zona glomerulosa, vascular smooth muscle, kidney, brain, an...

journal_title：Journal of cardiovascular pharmacology

authors： Catt KJ,Mendelsohn FA,Millan MA,Aguilera G

更新日期：1984-01-01 00:00:00

abstract：BACKGROUND:The sympathetic nervous system (SNS) of the whole body, including cardiac sympathetic nerves, is activated in patients with severe congestive systolic heart failure (CHF). Carvedilol can improve clinical status in such patients. This study aimed to determine how carvedilol acts on the SNS to improve CHF. ME...

journal_title：Journal of cardiovascular pharmacology

authors： Machida M,Takechi S,Fujimoto T,Kakinoki S,Nomura A

更新日期：2012-02-01 00:00:00

abstract：:With increasing age, cardiac beta-adrenoceptor function decreases. To study possible mechanisms underlying this process, we assessed in right atrial appendages from 52 patients of different ages (group A, < 20 years, mean age 3.7 +/- 1.0 years, n = 20; group B, 20-50 years, mean age, 37.9 +/- 2.3 years, n = 9; group C...

journal_title：Journal of cardiovascular pharmacology

authors： Brodde OE,Zerkowski HR,Schranz D,Broede-Sitz A,Michel-Reher M,Schäfer-Beisenbusch E,Piotrowski JA,Oelert H

更新日期：1995-07-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:The relationship between sodium sensitivity and borderline hypertension was explored in 63 subjects. Thirty percent of those with borderline hypertension and 15% of normal subjects increased mean arterial pressure by more than 5% when daily sodium intake was increased from 10 to 200 mEq. While most displayed an increa...

journal_title：Journal of cardiovascular pharmacology

authors： Sullivan JM

更新日期：1986-01-01 00:00:00

abstract：:Desethylamiodarone (DA) is a major metabolite of amiodarone (AM), a Class III antiarrhythmic drug. The plasma pharmacokinetics and tissue distribution of AM and DA (10 mg/kg i.v.) were compared in anesthetized dogs. Plasma, white blood cell (WBC), red blood cell (RBC), liver, and skeletal muscle samples were obtained ...

journal_title：Journal of cardiovascular pharmacology

authors： Bandyopadhyay S,Somani P

更新日期：1987-10-01 00:00:00

abstract：:Bay k 8644, a new dihydropyridine calcium channel activator has been shown to have positive inotropic and vasoconstrictor properties following intravenous (i.v.) administration. In the present study, intracoronary administration of Bay k 8644 was used to isolate drug effects on regional myocardial blood flow and contr...

journal_title：Journal of cardiovascular pharmacology

authors： Pelc LR,Gross GJ,Brooks HL,Warltier DC

更新日期：1986-11-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-amino-acid local and circulating factor whose plasma concentrations are increased in advanced atherosclerosis. ET-1 is cleaved from a prohormone (big ET-1) by endothelin-converting enzymes (ECEs) into the biologically active mature form which mediates vasoconstriction and cell proliferation...

journal_title：Journal of cardiovascular pharmacology

authors： Grantham JA,Schirger JA,Williamson EE,Heublein DM,Wennberg PW,Kirchengast M,Muenter K,Subkowski T,Burnett JC Jr

更新日期：1998-01-01 00:00:00

abstract：:The actions of SK&F 94120, a selective phosphodiesterase (PDE III) inhibitor, have been characterised on human ventricular myocardium obtained from heart failure patients. Some actions have been compared directly with those of the drug on guinea pig and cat ventricular myocardium. SK&F 94120 caused positive inotropic ...

journal_title：Journal of cardiovascular pharmacology

authors： Gristwood RW,English TA,Wallwork J,Sampford KA,Owen DA

更新日期：1987-06-01 00:00:00

abstract：:Biological aging is an independent risk factor for many cardiovascular diseases; some are treated with beta-blockers that may protect dysfunctional endothelium during aging by increasing NO, decreasing ONOO, and restoring NO/ONOO balance. A nanotechnological approach was used to simultaneously monitor NO and ONOO prod...

journal_title：Journal of cardiovascular pharmacology

authors： Funovic P,Korda M,Kubant R,Barlag RE,Jacob RF,Mason RP,Malinski T

更新日期：2008-02-01 00:00:00

abstract：:The safety of concomitant use of angiotensin-converting enzyme (ACE) inhibitors and potassium-sparing diuretics (PSD) in severe heart failure remains a controversial issue. The database of the recently reported double-blind international trial, "Xamoterol in Severe Heart Failure," was investigated to elucidate this qu...

journal_title：Journal of cardiovascular pharmacology

authors： Bergler-Klein J,Sochor H,Pouleur H,Pacher R,Porenta G,Glogar D

更新日期：1994-08-01 00:00:00

abstract：:The adrenal medulla and pheochromocytomas are known to secrete various neuropeptides and vasoactive peptides. On the other hand, the production and secretion of peptides by adrenocortical tumors have not been studied in detail. The study reported here therefore set out to examine these two functions for two vasoactive...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Yoshinoya A,Murakami O,Totsune K,Shibahara S

更新日期：2000-11-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of long-term monotherapy with four beta-blockers provided with different pharmacological properties on plasma lipids in both normocholesterolemic and hypercholesterolemic hypertensive patients. After a 1-month run-in period on placebo, 70 hypertensive patients with bas...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Zoppi A,Tettamanti F,Poletti L,Lazzari P,Pasotti C,Corradi L

更新日期：1990-01-01 00:00:00

abstract：:Since minoxidil was previously shown to raise plasma renin activity (PRA) but not the plasma aldosterone concentration (PAC), the effect of minoxidil on the rate of aldosterone metabolic clearance was studied. After the addition of minoxidil to the antihypertensive regimen of 7 hypertensive patients, the aldosterone m...

journal_title：Journal of cardiovascular pharmacology

authors： Pratt JH,Yager CJ,Grim CE,Parkinson CA

更新日期：1980-01-01 00:00:00

abstract：:In urban Australia, the risk of retiring with hypertension is greater than 40%, and the basic abnormality--a rise in blood pressure (BP) with age--is almost universal. A hypothesis linking this with salt, therefore, concerns everyone. The diet of early humans was unsalted, and the Na content of breast milk (6 mmol/kg)...

journal_title：Journal of cardiovascular pharmacology

authors： Beard TC

更新日期：1990-01-01 00:00:00

abstract：:Development of tolerance to nicorandil (NCR), N-(2-hydroxyethyl)nicotinamide nitrate (ester), was compared with that to nitroglycerin (NTG) or isosorbide dinitrate (ISDN) in dogs. An intracoronary arterial (i.a.) injection of NCR (20 micrograms), ISDN (30 micrograms), or NTG (1 microgram) caused coronary vasodilation....

journal_title：Journal of cardiovascular pharmacology

authors： Sakai K,Kuromaru O

更新日期：1987-01-01 00:00:00

abstract：:The complex formed between endothelin (ET) and its binding protein was adequately stable to be separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) at low temperature. Cross-linking was not necessary. This simple method was applied for both qualitative (determination of molecular weight ...

journal_title：Journal of cardiovascular pharmacology

authors： Takasuka T,Satoh N,Horii I,Furuichi Y,Watanabe T

更新日期：1991-01-01 00:00:00

abstract：:Since beta-adrenoceptor blocking drugs were originally discovered and shown to be important therapeutic agents in the management of both angina pectoris and hypertension, many other similar drugs have become available. These share the common property of beta-adrenoceptor antagonism, though they may vary in terms of po...

journal_title：Journal of cardiovascular pharmacology

authors： McDevitt DG

更新日期：1986-01-01 00:00:00

abstract：:Intracellular calcium ([Ca]i) overload on reperfusion may be one of the mechanisms responsible for ischemia-induced regional myocardial dysfunction. Because inhibiting the Na-H exchanger (NHE) limits intracellular sodium ([Na]i) and subsequent [Ca]i accumulation, we hypothesized that NHE inhibition would attenuate reg...

journal_title：Journal of cardiovascular pharmacology

authors： Symons JD,Correa SD,Schaefer S

更新日期：1998-12-01 00:00:00

abstract：:Neonatal exposure to a selective serotonin reuptake inhibitor (SSRI) leads to decreased left ventricular volumes and sympathetic activation in adult mice. We hypothesized this neonatal SSRI exposure-induced small left heart syndrome would increase post-myocardial infarction (MI) morbidity and mortality. C57BL/6 mice r...

journal_title：Journal of cardiovascular pharmacology

authors： Haskell SE,Peotta VA,Reinking BE,Hermann GM,Roghair RD

更新日期：2013-11-01 00:00:00

abstract：:The present study was undertaken to investigate the interaction between endothelin-1 (ET-1) and norepinephrine (NE) on contractile regulation in dog ventricular myocardium. ET-1 alone did not elicit any inotropic response in isolated dog ventricular trabeculae (37 degrees C, 0.5 Hz). In the presence of NE at a high co...

journal_title：Journal of cardiovascular pharmacology

authors： Chu L,Endoh M

更新日期：2000-01-01 00:00:00

abstract：:The ongoing COVID-19 pandemic has produced serious turmoil world-wide. Lung injury causing acute respiratory distress syndrome seems to be a most dreaded complication occurring in ∼30%. Older patients with cardiovascular comorbidities and acute respiratory distress syndrome have an increased mortality. Although the pr...

journal_title：Journal of cardiovascular pharmacology

authors： Manolis AS,Manolis TA,Manolis AA,Melita H

更新日期：2020-10-01 00:00:00

abstract：:[3H]lacidipine binding to its receptor was characterized to explain its slow onset and long duration of antihypertensive activity. Binding parameters were studied in guinea pig myocardial and cerebral membrane preparations and compared with another dihydropyridine (DHP) calcium antagonist, isradipine. Lacidipine binds...

journal_title：Journal of cardiovascular pharmacology

authors： Graziani F,Ratti E,van Amsterdam FT

更新日期：1996-02-01 00:00:00

abstract：:Heart failure after myocardial infarction (MI) is associated with endothelial dysfunction. There is conflicting evidence on the exact nature of this endothelial dysfunction and how endothelium-dependent vasodilation is affected by angiotensin-converting enzyme inhibitor (ACE-I) therapy. Furthermore, consequences of ac...

journal_title：Journal of cardiovascular pharmacology

authors： Westendorp B,Schoemaker RG,van Gilst WH,Buikema H

更新日期：2005-12-01 00:00:00

abstract：:We examined the effects of prolonged oral administration of oxprenolol (twice daily for 6 weeks) to male Sprague-Dawley rats. At two times (1 or 16-18 h) after the last oral dose, the rats were anaesthetised and subjected to acute coronary artery ligation, and the severity of the resulting arrhythmias was assessed. Is...

journal_title：Journal of cardiovascular pharmacology

authors： Campbell CA,Parratt JR,Kane KA,Bullock G

更新日期：1984-05-01 00:00:00

abstract：:Heart failure is associated with attenuation of parasympathetic nervous function and enhanced renin-angiotensin activity. We tested whether there was a dysfunction in the efferent cholinergic neurotransmission in the heart of rats with chronic myocardial infarction (MI) and the potential role of angiotensin II (Ang II...

journal_title：Journal of cardiovascular pharmacology

authors： Du XJ,Cox HS,Dart AM,Esler MD

更新日期：1998-06-01 00:00:00