Efficacy of ajmaline and propafenone in patients with accessory pathways: a prospective randomized study.

abstract：:We undertook a systematic comparison of the effects of diltiazem and nifedipine and a nonspecific vasodilator, sodium nitroprusside, on renal perfusion, function, and activation of potentially relevant neurohormonal systems in the anesthetized dog. These agents were employed to reduce blood pressure to two levels, a m...

journal_title：Journal of cardiovascular pharmacology

authors： Blackshear JL,Orlandi C,Williams GH,Hollenberg NK

更新日期：1986-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) in the central nervous system has been suggested to produce suppressive effects on pain transmission. We investigated the manner by which ET-1 exerts this action. ET-1 administered intracerebroventricularly produced a dose-dependent antinociceptive effect in a thermal pain test that utilized a spin...

journal_title：Journal of cardiovascular pharmacology

authors： Hasue F,Kuwaki T,Yamada H,Fukuda Y,Shimoyama M

更新日期：2004-11-01 00:00:00

abstract：:[3H]lacidipine binding to its receptor was characterized to explain its slow onset and long duration of antihypertensive activity. Binding parameters were studied in guinea pig myocardial and cerebral membrane preparations and compared with another dihydropyridine (DHP) calcium antagonist, isradipine. Lacidipine binds...

journal_title：Journal of cardiovascular pharmacology

authors： Graziani F,Ratti E,van Amsterdam FT

更新日期：1996-02-01 00:00:00

abstract：:Cilazapril (CLZ) is a new, long-acting nonsulfhydril converting enzyme inhibitor (ACE-I). Its effect on peak and trough sitting diastolic blood pressure (SDBP) was studied in a total of 85 patients with uncomplicated, essential hypertension at three centers. After 4 weeks of a single-blind placebo (PLA) run-in period,...

journal_title：Journal of cardiovascular pharmacology

authors： Güntzel P,Kobrin I,Pasquier C,Zimlichman R,Viskoper JR

更新日期：1991-01-01 00:00:00

abstract：:Relationships between lipoprotein fractions, lipoprotein lipase activities, thyroid hormones, and coronary lesion growth were studied among 35 male patients with severe coronary atherosclerosis, who had participated in the Leiden Intervention Trial, a lipid-lowering dietary intervention program. Coronary arteriography...

journal_title：Journal of cardiovascular pharmacology

authors： Barth JD,Jansen H,Kromhout D,Reiber JH,Birkenhäger JC,Arntzenius AC

更新日期：1987-01-01 00:00:00

abstract：:Ethanol can affect the regulation of liver hemodynamics through the release of vasoactive mediators such as nitric oxide and endothelins (ETs). The purpose of this study was to investigate the effects of ethanol on the changes in arterial and portal perfusion pressure induced by ET receptor activation. Ethanol signifi...

journal_title：Journal of cardiovascular pharmacology

authors： Faro F,Ferraz JG,Stella HJ,Faro R,Antunes E,Opgennorth TJ,Withrington PG,de Nucci G

更新日期：1998-01-01 00:00:00

abstract：:We investigated the effect of oral ibopamine (SB 7505) on myocardial and renal function in eight patients suffering from congestive heart failure. Ibopamine was administered orally 50 mg twice a day for 7 days. Systolic time intervals PEP (preejection period) and EMS (electromechanical systole) decreased significantly...

journal_title：Journal of cardiovascular pharmacology

authors： Dei Cas L,Manca C,Bernardini B,Vasini G,Visioli O

更新日期：1982-05-01 00:00:00

abstract：:Roughly 40% of all diabetics, whether insulin dependent or not, develop persistent albuminuria, a decline in their glomerular filtration rate, and elevated blood pressure, i.e., diabetic nephropathy. Diabetic nephropathy is the single most important cause of end-stage renal disease in the Western world, accounting for...

journal_title：Journal of cardiovascular pharmacology

authors： Parving HH

更新日期：1992-01-01 00:00:00

abstract：:The equilibrating process of catecholamines (CAs) between plasma and red blood cells (RBC) was studied by measuring their erythrocyte/plasma concentration gradient (E/P ratio); ratio of E/P > 1 for a given amine was considered the consequence of its accumulation in or on RBC. We studied in vitro human blood obtained f...

journal_title：Journal of cardiovascular pharmacology

authors： Azoui R,Vignon D,Safar M,Cuche JL

更新日期：1994-04-01 00:00:00

abstract：:This study investigated the effects of adrenomedullin on left ventricular myocardial contraction and relaxation, coronary blood flow, and myocardial oxygen consumption in comparison with those of atrial natriuretic peptide (ANP). Fourteen patients who had had myocardial infarctions were randomly assigned to receive IV...

journal_title：Journal of cardiovascular pharmacology

authors： Nagaya N,Goto Y,Satoh T,Sumida H,Kojima S,Miyatake K,Kangawa K

更新日期：2002-05-01 00:00:00

abstract：:The cardioprotective effects of bisoprolol were studied in a rat model of severe heart failure induced by autoimmune myocarditis. Twenty-eight days after immunization, Lewis rats were divided into four groups: 0.1 mg/kg/day bisoprolol (Group 0.1), 1.0 mg/kg/day bisoprolol (Group 1) and 10 mg/kg/day bisoprolol (Group 1...

journal_title：Journal of cardiovascular pharmacology

authors： Watanabe K,Ohta Y,Inoue M,Ma M,Wahed MI,Nakazawa M,Hasegawa G,Naito M,Fuse K,Ito M,Kato K,Hanawa H,Kodama M,Aizawa Y

更新日期：2001-10-01 00:00:00

abstract：:Conflicting evidence has been reported on the hypothesis that vascular nitric oxide (NO) release is modulated by autonomic influences. Another controversial question is whether an insufficient degree of NO-dependent vasodilation may play a contributory role in the genesis of arterial hypertension. To address these que...

journal_title：Journal of cardiovascular pharmacology

authors： Ferrari AU,Radaelli A,Mori T,Mircoli L,Perlini S,Meregalli P,Fedele L,Mancia G

更新日期：2001-11-01 00:00:00

abstract：:Endothelium-dependent relaxations can be evoked by a variety of stimuli, among them substance P (SP), which is found in sensory nerve fibers supplying the adventitia-media junction of most muscular arteries. This study determined the role of endothelium-derived nitric oxide as a mediator of endothelium-dependent relax...

journal_title：Journal of cardiovascular pharmacology

authors： Fiscus RR,Gross DR,Hao H,Wang X,Arden WA,Maley RH,Salley RK

更新日期：1992-01-01 00:00:00

abstract：:Coronary arteries from animals on normal diets (ND) exhibit well-maintained responses to dilators under ischemic conditions. The reported altered metabolic requirements and K+-currents in blood vessels from hypercholesterolemic animals fed high-fat diets (HF) led us to hypothesize that under metabolically depressed co...

journal_title：Journal of cardiovascular pharmacology

authors： Franke R,Yang Y,Rubin LJ,Magliola L,Jones AW

更新日期：2004-04-01 00:00:00

abstract：:Ranolazine was previously shown to stimulate cardiac glucose oxidation. Dichloroacetate (DCA) also does and was shown to improve exercise capacity in animals, but it has long-term toxicity problems. To test the hypothesis that ranolazine would increase exercise performance in the chronic heart failure (CHF) condition,...

journal_title：Journal of cardiovascular pharmacology

authors： Aaker A,McCormack JG,Hirai T,Musch TI

更新日期：1996-09-01 00:00:00

abstract：:Cromakalim relaxes vascular smooth muscle by increasing potassium channel conductance, thus hyperpolarizing cell membranes. Its interactions in humans with the cardiovascular effects of norepinephrine, angiotensin II, and isoproterenol were investigated. Eight young normotensive male volunteers received on three diffe...

journal_title：Journal of cardiovascular pharmacology

authors： von Nguyen P,Holliwell DL,Davis A,Tasker TC,Leenen FH

更新日期：1991-12-01 00:00:00

abstract：:As a receptor for transforming growth factor-β, nodal and activin, activin receptor-like kinase 7 (ALK7) previously acts as a suppressor of tumorigenesis and metastasis, which has emerged to play a key role in cardiovascular diseases. However, the potential effect and molecular mechanism of ALK7 on vascular smooth mus...

journal_title：Journal of cardiovascular pharmacology

authors： Gong FH,Cheng WL,Zhang Q,Chen XL,Cao JL,Yang T,Song WH,Zhao F

更新日期：2020-08-01 00:00:00

abstract：:Acute effects of piretanide, a loop diuretic, on blood pressure (BP) and urinary output as well as long-term effects on serum electrolytes were compared in conscious spontaneously hypertensive rats (SHR) to that of hydrochlorothiazide (HCT) both given alone and in combination with the converting enzyme (CE) inhibitor ...

journal_title：Journal of cardiovascular pharmacology

authors： Becker RH,Baldes L,Treudler M

更新日期：1987-01-01 00:00:00

abstract：:Experiments were designed to characterize cardiac alpha-adrenoceptors and the alpha-adrenoceptor-mediated positive inotropic effects in human myocardial tissue from patients with moderate New York Heart Association (NYHA) class II-III and severe (NYHA class IV) heart failure. The number of cardiac alpha-adrenoceptors ...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Feiler G,Kemkes B,Erdmann E

更新日期：1988-09-01 00:00:00

abstract：:Vascular smooth muscle cells (SMCs) play a key role in the development of atherosclerotic lesions. Vascular smooth muscle, however, does not represent a homogeneous tissue. Using myosin as a marker of the differentiation processes in development and in vascular disease, we have been able to demonstrate the existence o...

journal_title：Journal of cardiovascular pharmacology

authors： Pauletto P,Sartore S,Giuriato L,Scatena M,Tonello M,Scannapieco G,Pessina AC,Dal Palù C

更新日期：1992-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha) is an inflammatory cytokine involved in atherogenesis. Adipose tissue is an important source of endogenous TNFalpha production. The aim of this study was to evaluate the effect of atorvastatin on TNFalpha serum concentration and mRNA expressions of subcutaneous adipose in hyperch...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao SP,Wu ZH,Wu J,Hong SC,Deng P

更新日期：2005-08-01 00:00:00

abstract：:To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg),...

journal_title：Journal of cardiovascular pharmacology

authors： Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

更新日期：1993-01-01 00:00:00

abstract：:The object of this study was to differentiate losartan, an AT1-selective angiotensin II (ANG II) receptor antagonist, from enalapril, an angiotensin-converting enzyme (ACE) inhibitor, by measuring forearm vascular responses to AI, AII, and bradykinin. Eight healthy men were studied in a randomised, 4-period crossover ...

journal_title：Journal of cardiovascular pharmacology

authors： Cockcroft JR,Sciberras DG,Goldberg MR,Ritter JM

更新日期：1993-10-01 00:00:00

abstract：:The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Erdmann E

更新日期：1988-04-01 00:00:00

abstract：:As cyclic 3',5'-guanosine monophosphate (cGMP) is still discussed as a possible mediator of the negative inotropic effects of cholinergic agents, the influence of acetylcholine (ACh) on force of contraction and cGMP tissue levels was studied in isolated, electrically driven guinea pig auricles in the presence of methy...

journal_title：Journal of cardiovascular pharmacology

authors： Groschner K,Holzmann S,Kukovetz WR

更新日期：1986-11-01 00:00:00

abstract：:Desethylamiodarone (DA) is a major metabolite of amiodarone (AM), a Class III antiarrhythmic drug. The plasma pharmacokinetics and tissue distribution of AM and DA (10 mg/kg i.v.) were compared in anesthetized dogs. Plasma, white blood cell (WBC), red blood cell (RBC), liver, and skeletal muscle samples were obtained ...

journal_title：Journal of cardiovascular pharmacology

authors： Bandyopadhyay S,Somani P

更新日期：1987-10-01 00:00:00

abstract：:Thirty-two hypertensive subjects with diastolic blood pressure greater than 95 mm Hg were treated with ramipril over a period of 3 months. To determine the effective decrease of blood pressure and for reliable and reproducible demonstration of regression of myocardial hypertrophy during ramipril treatment, we performe...

journal_title：Journal of cardiovascular pharmacology

authors： Eichstaedt H,Danne O,Langer M,Cordes M,Schubert C,Felix R,Schmutzler H

更新日期：1989-01-01 00:00:00

abstract：:The cardioprotective effect of angiotensin-converting enzyme (ACE) inhibitors in cardiac ischemia/reperfusion damage is assumed to result largely from inhibition of the enzymatic breakdown of endogenous bradykinin (BK). We assessed the role of nitric oxide (NO) in mediating the beneficial actions of BK and the possibl...

journal_title：Journal of cardiovascular pharmacology

authors： Massoudy P,Becker BF,Gerlach E

更新日期：1995-03-01 00:00:00

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:We investigated the effect of gallopamil on cardiac sarcoplasmic reticulum (SR) function. Heavy SR was prepared from bovine ventricular muscle. Oxalate-supported calcium uptake was stimulated by gallopamil at concentrations ranging from 10 to 300 nM, whereas higher concentrations were ineffective. Peak stimulation ave...

journal_title：Journal of cardiovascular pharmacology

authors： Zucchi R,Ronca-Testoni S,Limbruno U,Yu G,Galbani P,Ronca G,Mariani M

更新日期：1992-01-01 00:00:00