Combination therapy of hypertension with beta-adrenoceptor blockers and the calcium channel antagonist nitrendipine.

abstract：:Perturbations of the trans-sarcolemmal and sarcoplasmic Ca2+ transport contribute to the abnormal myocardial activity provoked by anoxia and reoxygenation. Whether Ca2+ pools of the extracellular compartment and sarcoplasmic reticulum (SR) are involved to the same extent in the dysfunction of the anoxic-reoxygenated i...

journal_title：Journal of cardiovascular pharmacology

authors： Tenthorey D,de Ribaupierre Y,Kucera P,Raddatz E

更新日期：1998-02-01 00:00:00

abstract：:One of the earliest structural changes in the heart adapting to hypertension is left ventricular hypertrophy, which can now be exactly measured by echocardiography. Left ventricular hypertrophy increases the incidence of coronary artery disease, heart failure, and sudden death severalfold, independent of the blood pre...

journal_title：Journal of cardiovascular pharmacology

authors： Schmieder RE

更新日期：1992-01-01 00:00:00

abstract：:Prostaglandins (PG) E2, E2, E2 alpha, and I2 [prostacyclin (PGI2)] were tested in vitro on collateral arteries that enlarge following chronic occlusion of the femoral artery in the dog. After contraction with an ED50 dose of KCl, serial doses of a PG were added. Collateral arteries relaxed significantly to PGI2 (10(-7...

journal_title：Journal of cardiovascular pharmacology

authors： Williams PB,Joyner JH

更新日期：1982-09-01 00:00:00

abstract：:We examined the influence of the new angiotensin-converting enzyme inhibitor (ACEI) fosinopril on function and perfusion of the diabetic rat heart. Streptozotocin-diabetic rats (60 mg/kg body weight) were treated with fosinopril (10 mg/kg body weight/day) for 4 months. Cardiac performance was analyzed in the isolated ...

journal_title：Journal of cardiovascular pharmacology

authors： Rösen P,Rump AF,Rösen R

更新日期：1996-01-01 00:00:00

abstract：:Plasma-membrane receptors for angiotensin II (AII) have been identified in many AII-responsive tissues involved in the control of blood pressure via direct or indirect actions on vascular contractility. The specific, high-affinity receptors for AII in adrenal zona glomerulosa, vascular smooth muscle, kidney, brain, an...

journal_title：Journal of cardiovascular pharmacology

authors： Catt KJ,Mendelsohn FA,Millan MA,Aguilera G

更新日期：1984-01-01 00:00:00

abstract：:The maximal increases in heart rate produced by intravenous xamoterol in anaesthetized cats and rats are less than that of (-)-isoprenaline. In cats, blood pressure was slightly raised, while in rats, supramaximal cardiac-stimulant doses produced reductions in blood pressure. In anaesthetized guinea pigs, cardiac-stim...

journal_title：Journal of cardiovascular pharmacology

authors： Mian MA,Malta E,Raper C

更新日期：1986-03-01 00:00:00

abstract：:The renin-angiotensin-aldosterone system is mainly involved in the regulation of arterial blood pressure and fluid balance. One of the main stimuli for the secretion of renin present in the renal juxtamedullary cells, but also in some other tissues, is provided by the sympathetic nervous system via the action of norep...

journal_title：Journal of cardiovascular pharmacology

authors： Saxena PR

更新日期：1992-01-01 00:00:00

abstract：:We have previously demonstrated that cocaine induces apoptosis in primary cultures of fetal rat cardiomyocytes. The current study was designed to determine whether cocaine administered to the mother during pregnancy induced apoptosis in fetal rat heart. Pregnant rats were treated with cocaine subcutaneously (30 and 60...

journal_title：Journal of cardiovascular pharmacology

authors： Xiao Y,Xiao D,He J,Zhang L

更新日期：2001-06-01 00:00:00

abstract：:Binge drinking of alcohol causes cardiac dysfunction in some people. The mechanism remains unclear. This study was designed to investigate high doses of alcohol-induced oxidative stress and apoptosis in cardiomyocytes and protective effects of antioxidants. Cardiomyocytes isolated from 1- to 2-day-old Sprague-Dawley r...

journal_title：Journal of cardiovascular pharmacology

authors： Guan Z,Lui CY,Morkin E,Bahl JJ

更新日期：2004-12-01 00:00:00

abstract：:In fetal human left ventricular endocardial endothelial cells (EECLs), both plasma membrane (PM) ET(A)R and ET(B)R were reported to mediate ET-1-induced increase of intracellular calcium [Ca](i); however, this effect was mediated by ET(A)R in right EECs (EECRs). In this study, we verified whether, as for the PM, nucle...

journal_title：Journal of cardiovascular pharmacology

authors： Jules F,Avedanian L,Al-Khoury J,Keita R,Normand A,Bkaily G,Jacques D

更新日期：2015-07-01 00:00:00

abstract：:From the membrane fraction of cultured human renal adenocarcinoma (ACHN) cells, two endothelin-2-converting enzymes (ECE-2A and ECE-2B) were solubilized with detergent Lubrol PX and separated by hydrophobic butyl fast-performance liquid chromatography. The pH range of the converting activity of ECE-2B for big endothel...

journal_title：Journal of cardiovascular pharmacology

authors： Shinmi O,Yorimitsu K,Moroi K,Nishiyama M,Sugita Y,Saito T,Inagaki Y,Masaki T,Kimura S

更新日期：1993-01-01 00:00:00

abstract：:Acute myocardial infarction (AMI) is known to alter the pharmacokinetics of several antiarrhythmic agents. To study the effects of AMI on the kinetics of mexiletine (MEX), a single intravenous dose of 200 mg MEX HCl was infused over 30 min in 11 patients with AMI. The study was performed within 24 h of the onset of pa...

journal_title：Journal of cardiovascular pharmacology

authors： Pentikäinen PJ,Halinen MO,Helin MJ

更新日期：1984-01-01 00:00:00

abstract：:In this study, we compared the effects of nitrendipine (20-40 mg daily) and enalapril (20-40 mg daily) in 44 patients with mild to moderate essential hypertension. After a 4-week placebo period, the patients entered a double-blind, crossover study of 16 weeks, divided by a second 4-week placebo period. Sitting and sta...

journal_title：Journal of cardiovascular pharmacology

authors： Verkaaik R,Hogewind BL,Woittiez AJ

更新日期：1991-01-01 00:00:00

abstract：:The effects of the adrenergic antihypertensive drugs propranolol, clonidine, alpha-methyldopa, urapidil, indoramin, and prazosin on the relative rate of sterol synthesis were studied in freshly isolated human mononuclear leukocytes. Incubation of cells for 6 h in a medium containing lipid-depleted serum led to a three...

journal_title：Journal of cardiovascular pharmacology

authors： Krone W,Müller-Wieland D,Greten H

更新日期：1985-11-01 00:00:00

abstract：:Antecubital venous plasma neuropeptide Y-like immunoreactivity (NPY-LI) and catecholamines were analyzed in six healthy volunteers performing a graded bicycle exercise without medication and after acute administration of clonidine, phentolamine, and nifedipine. During the control exercise, plasma noradrenaline (NA), a...

journal_title：Journal of cardiovascular pharmacology

authors： Pernow J,Lundberg JM,Kaijser L

更新日期：1988-01-01 00:00:00

abstract：:Acute occlusion of a coronary artery can result in myocardial infarction-a leading cause of premature death. Prompt restoration of blood flow to the myocardium can prevent excessive death of cardiomyocytes and improve clinical outcome. Although the major mechanism of cell death after reperfusion is necrosis, it is now...

journal_title：Journal of cardiovascular pharmacology

authors： Rauf A,Shah M,Yellon DM,Davidson SM

更新日期：2019-09-01 00:00:00

abstract：:Intracerebroventricular injections of endothelin-1 (ET-1) are reported to cause dose-related increases in sympathetic nerve activity and blood pressure in anesthetized normotensive rats. These studies were performed to determine the following: which endothelin receptor, A or B, is involved in mediating sympathetic and...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura K,Sasaki S,Moriguchi J,Morimoto S,Miki S,Kawa T,Itoh H,Nakata T,Takeda K,Nakagawa M

更新日期：1999-06-01 00:00:00

abstract：:Twenty-three patients [mean age 49.7 +/- 5.6 years (WHO II-III)] with severe hypertension and not responding to previous drug treatment were included in the study to evaluate the effect of nitrendipine (NTP) as monotherapy and also in combination with propranolol (PRO). After a control period of 10 days, NTP was start...

journal_title：Journal of cardiovascular pharmacology

authors： Faulhaber HD,Gruner R,Homuth V,Naumann E,Menz M,Hartrodt W,Schmidt J,Mohnike W

更新日期：1988-01-01 00:00:00

abstract：:To elucidate the pathophysiologic significance of endothelin-1 (ET-1) in adrenal and the mechanism for reduced responsiveness to exogenous ET-1 in aldosterone-producing adenoma (APA), we have investigated ET-1 receptors by radioligand binding assay (RBA) in human normal adrenal (NA), APA, idiopathic hyperaldosteronism...

journal_title：Journal of cardiovascular pharmacology

authors： Zeng Z,Tang X,Yang D,Li H,Zhang R,Zeng Q,Li M,Chen J,Lu Z,Demura H,Naruse M,Shi Y

更新日期：1998-01-01 00:00:00

abstract：:This review deals with cellular factors that contribute to individualities of vascular smooth-muscle function in different organ systems and at different levels of the vascular tree. Particular attention has been given to: membrane receptors responsive to catecholamines, serotonin, angiotensin II, dopamine, and acetyl...

journal_title：Journal of cardiovascular pharmacology

authors： Bell DR,Webb RC,Bohr DF

更新日期：1985-01-01 00:00:00

abstract：:The antihypertensive efficacy of the calcium entry blocker nitrendipine administered as monotherapy (20-80 mg; mean, 36/day) on the average for 144 days to 46 patients with essential hypertension (WHO I and II) was investigated in relation to age, pretreatment blood pressure, and plasma renin activity. In addition, we...

journal_title：Journal of cardiovascular pharmacology

authors： Müller FB,Bolli P,Erne P,Block LH,Kiowski W,Bühler FR

更新日期：1984-01-01 00:00:00

abstract：:The effects of bilateral sinoaortic denervation were examined in rabbits in vivo and in vitro. In the in vivo studies the effects of intravenous administration of the alpha-adrenoceptor agonists phenylephrine and guanabenz and the antagonists prazosin and phentolamine on mean arterial pressure, heart rate, and plasma ...

journal_title：Journal of cardiovascular pharmacology

authors： Berthelot A,Hamilton CA,Petty MA,Reid JL

更新日期：1982-07-01 00:00:00

abstract：:We examined the effects of NIP-121, a potassium channel opener, on KCl- and norepinephrine (NE)-induced contraction, the phasic-contraction under the Ca(2+)-free condition and cytosolic free-Ca2+ mobilization using isolated rat aorta. NIP-121 as well as cromakalim inhibited, in the KCl- and NE-contractions concentrati...

journal_title：Journal of cardiovascular pharmacology

authors： Yamashita T,Masuda Y,Tanaka S

更新日期：1994-12-01 00:00:00

abstract：:Vascular repair plays important roles in postischemic remodeling and rehabilitation in cardiovascular and cerebrovascular disease, such as stroke and myocardial infarction. Nicotinamide adenine dinucleotide (NAD), a well-known coenzyme involved in electron transport chain for generation of adenosine triphosphate, has ...

journal_title：Journal of cardiovascular pharmacology

authors： Wang P,Li WL,Liu JM,Miao CY

更新日期：2016-06-01 00:00:00

abstract：:Acute effects of piretanide, a loop diuretic, on blood pressure (BP) and urinary output as well as long-term effects on serum electrolytes were compared in conscious spontaneously hypertensive rats (SHR) to that of hydrochlorothiazide (HCT) both given alone and in combination with the converting enzyme (CE) inhibitor ...

journal_title：Journal of cardiovascular pharmacology

authors： Becker RH,Baldes L,Treudler M

更新日期：1987-01-01 00:00:00

abstract：:The positive inotropic action of phenylephrine in cardiac muscle is mediated by alpha- and beta-adrenoceptors. Data suggest the responsiveness of myocardium to inotropic agents is altered in cardiac disease. We evaluated the actions of phenylephrine on isometric contraction and K+-induced contracture in isolated cat r...

journal_title：Journal of cardiovascular pharmacology

authors： Gaide MS,Wiggins JR,Fitterman WS,Cameron JS,Myerburg RJ,Bassett AL

更新日期：1984-03-01 00:00:00

abstract：:Conscious dogs were given diltiazem hydrochloride (DTZ) orally for 5 successive days at doses of 1, 3, and 10 mg/kg/day. During the 5th day, cardiovascular responses were monitored at various timed intervals after dosing. Arterial blood was sampled concomitantly for drug analysis. DTZ produced a dose-related decrease ...

journal_title：Journal of cardiovascular pharmacology

authors： Browne RK,Dimmitt DC,Miller LD,Korol B

更新日期：1983-05-01 00:00:00

abstract：:Patients with untreated hypertension have been shown to be resistant to insulin-stimulated glucose uptake. They are also hyperinsulinemic and hypertriglyceridemic when compared with matched control groups with normal blood pressure. In addition, insulin resistance, hyperinsulinemia, and hypertriglyceridemia have been ...

journal_title：Journal of cardiovascular pharmacology

authors： Reaven GM

更新日期：1990-01-01 00:00:00

abstract：:We wished to determine whether pharmacologic inhibition of the exaggerated sympathetic nerve activity in congestive heart failure (CHF) could restore the renal response to exogenous atrial natriuretic peptide (ANP) administration. Left ventricular (LV) myocardial infarction was induced in Sprague-Dawley rats (n = 16) ...

journal_title：Journal of cardiovascular pharmacology

authors： Feng QP,Hedner T,Hedner J,Pettersson A

更新日期：1990-11-01 00:00:00

abstract：:Cardiovascular function is regulated by short-term and long-term neurohormonal and autocrine-paracrine mechanisms that act synergistically or sequentially. Structural adaptive changes that occur progressively over time also contribute to the long-term outcome. The renin-angiotensin system (RAS) can operate as both an ...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1989-01-01 00:00:00