Hypertensive heart disease--significance of left ventricular hypertrophy.

abstract：:The effects of the thromboxane A2 (TXA2)/prostaglandin endoperoxide (TP) receptor antagonist ifetroban (BMS-180291) on infarct size (IS) resulting from coronary occlusion/reperfusion was determined in anesthetized dogs and ferrets. In dogs, ifetroban (1 + 1 mg/kg/h, intravenously, i.v.) or vehicle administration was i...

journal_title：Journal of cardiovascular pharmacology

authors： Gomoll AW,Grover GJ,Ogletree ML

更新日期：1994-12-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in the modulation of renal O2 consumption in dogs with pacing-induced congestive heart failure (CHF). O2 consumption in the renal cortex (C) and medulla (M) of normal dogs and dogs with CHF was measured under control conditions and in the presence of increasing concentrati...

journal_title：Journal of cardiovascular pharmacology

authors： Adler S,Huang H,Loke K,Xu X,Laumas A,Hintze TH

更新日期：2001-03-01 00:00:00

abstract：:Prostaglandins (PG) E2, E2, E2 alpha, and I2 [prostacyclin (PGI2)] were tested in vitro on collateral arteries that enlarge following chronic occlusion of the femoral artery in the dog. After contraction with an ED50 dose of KCl, serial doses of a PG were added. Collateral arteries relaxed significantly to PGI2 (10(-7...

journal_title：Journal of cardiovascular pharmacology

authors： Williams PB,Joyner JH

更新日期：1982-09-01 00:00:00

abstract：:Spirapril is a new angiotensin-converting enzyme (ACE) inhibitor. It is a prodrug with a resorption of about 50%. The active metabolite spiraprilat reaches maximal plasma concentration within 2-3 h after oral administration. Spirapril can be administered once daily because of its long duration of action caused by an e...

journal_title：Journal of cardiovascular pharmacology

authors： Hayduk K,Kraul H

更新日期：1999-08-01 00:00:00

abstract：:Antiarrhythmic concentrations of disopyramide in canine plasma and myocardium were determined by gas chromatography. Ventricular tachycardia was incuded in anesthetized dogs by the intravenous administration of ouabain. Disopyramide phosphate was then administered by a two-stage continuous infusion method. A rapid inf...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Stetson P,Lucchesi BR

更新日期：1979-09-01 00:00:00

abstract：:We established a real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) system for the analysis of rat endothelin-1 (ET-1) and vasoactive intestinal contractor (VIC)/ET-2 gene expression. We used this technique to examine the expression levels in rat in 16 different organs. ET-1 gene expressio...

journal_title：Journal of cardiovascular pharmacology

authors： Uchide T,Adur J,Fukamachi T,Saida K

更新日期：2000-11-01 00:00:00

abstract：:To assess efficacy and side effects during chronic oral therapy, we studied the effect of ketanserin (Kn) in 17 hypertensive patients for a period up to 1 year. Ketanserin controlled blood pressure satisfactorily in 25%, in part in 50% and had little or no effect in 25%. Reduction in diastolic pressure equalled that i...

journal_title：Journal of cardiovascular pharmacology

authors： Waal-Manning HJ,Brown SA,Spears GF,Simpson FO

更新日期：1985-01-01 00:00:00

abstract：:Cardiac electrophysiologic effects of PK 10139 (PK), a new quinoleic antiarrhythmic agent, were compared with those of quinidine sulphate (Q) after three cumulative intravenous doses of 0.75, 1.5, and 3 mg/kg of PK and 5, 10, and 20 mg/kg of Q in anesthetized dogs. A control group of animals received saline solution o...

journal_title：Journal of cardiovascular pharmacology

authors： Heckle J,Jaillon P,Jozefczak C,Cheymol G

更新日期：1985-01-01 00:00:00

abstract：:Peripheral vascular resistance, arterial blood pressure, and left ventricular hypertrophy (LVH) are closely related. In systemic hypertension, hemodynamic changes in systolic and diastolic function accompany LVH. Both of these cardiac functions are detected with echocardiography and were measured during this study in ...

journal_title：Journal of cardiovascular pharmacology

authors： Moisejev VS,Ivleva AY,Gurochkin AB,Kobalava ZD

更新日期：1994-01-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is increasingly used in the clinical evaluation of hypertension. However, a number of limitations restrict its routine use. One of the limitations is a lack of definite conclusions about ambulatory blood pressure normality, because of the shortcomings of previous studies on ...

journal_title：Journal of cardiovascular pharmacology

authors： Sega G,Bravi C,Cesana G,Valagussa F,Mancia G,Zanchetti A

更新日期：1994-01-01 00:00:00

abstract：:Qiliqiangxin (QL), a traditional Chinese medicine, has been used in the treatment of chronic heart failure. However, whether QL can benefit cardiac remodeling in the hypertensive state is unknown. We here examined the effects of QL on the development of cardiac hypertrophy through comparing those of losartan in C57BL/...

journal_title：Journal of cardiovascular pharmacology

authors： Zou Y,Lin L,Ye Y,Wei J,Zhou N,Liang Y,Gong H,Li L,Wu J,Li Y,Jia Z,Wu Y,Zhou J,Ge J

更新日期：2012-03-01 00:00:00

abstract：:CGS 26303 has previously been shown to inhibit human endothelin converting enzyme-1 (ECE-1) with an IC50 of 410 nM and to be efficacious in several animal disease models. However, it is a more potent inhibitor of neutral endopeptidase 24.11 (NEP) with an IC50 of 1 nM. The aim of this study was to optimize CGS 26303 fo...

journal_title：Journal of cardiovascular pharmacology

authors： Jeng AY,De Lombaert S,Beil ME,Bruseo CW,Savage P,Chou M,Trapani AJ

更新日期：2000-11-01 00:00:00

abstract：:Toll-like receptors (TLRs) are important in innate immune responses, which are crucial in collateral artery formation (arteriogenesis). TLR4⁻/⁻ mice undergoing hind limb ischemia show decreased perfusion recovery accompanied by an impaired infiltration of inflammatory cells. TLR antagonists are currently developed and...

journal_title：Journal of cardiovascular pharmacology

authors： van den Borne P,Bastiaansen AJ,de Vries MR,Quax PH,Hoefer IE,Pasterkamp G

更新日期：2014-01-01 00:00:00

abstract：:Statins are known to have cholesterol-independent pleiotropic effects, such as upregulation of the enzyme ecto-5'-nucleotidase. These effects may contribute to the protective effect of statins against ischemia and reperfusion (IR). Interestingly, pleiotropic effects have been shown to differ between hydrophilic and li...

journal_title：Journal of cardiovascular pharmacology

authors： Wouters CW,Wever KE,Bronckers I,Hopman MT,Smits P,Thijssen DH,Rongen GA

更新日期：2012-01-01 00:00:00

abstract：:Currently used antiplatelet drugs including aspirin, ticlopidine, and others are effective against certain but not all of the many endogenous platelet activators. Because of their limited efficacy, a significant number of serious thromboembolic complications still occur, highlighting the need for a more effective ther...

journal_title：Journal of cardiovascular pharmacology

authors： Mousa SA,Forsythe M,Wityak J,Bozarth J,Mu DX

更新日期：1998-03-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF), a potent mitogen and chemoattractant for smooth muscle cells and fibroblasts in culture, is believed to play an important role in the formation of proliferative lesions of arterio-sclerosis. PDGF appears as three different dimeric isoforms: AA, AB, and BB. These were recently fou...

journal_title：Journal of cardiovascular pharmacology

authors： Hosang M,Rouge M

更新日期：1989-01-01 00:00:00

abstract：:The heavy impact of obesity on the development and progression of cardiovascular disease has sparked sustained efforts to uncover the mechanisms linking excess adiposity to vascular dysfunction. In addition to its well-established role in maintaining vascular homeostasis, the endothelium has been increasingly recogniz...

journal_title：Journal of cardiovascular pharmacology

authors： Schinzari F,Tesauro M,Cardillo C

更新日期：2017-06-01 00:00:00

abstract：:The relationships between the effects on blood pressure and vascular responsiveness, and the whole blood concentration of the antihypertensive drug trimazosin and its major metabolite were investigated in six normotensive male volunteers following 100 mg i.v. and 200 mg p.o. administration. Pressor responses to intrav...

journal_title：Journal of cardiovascular pharmacology

authors： Vincent J,Elliott HL,Meredith PA,Reid JL

更新日期：1985-09-01 00:00:00

abstract：:The angiotensin II receptor-1 blockers have generally been shown to have antiatherogenic effects, and dendritic cells (DCs) are the most efficient antigen presenting cells that play an active role in the development of atherosclerosis through inflammatory-immune responses. Here, we tested the hypothesis that the antia...

journal_title：Journal of cardiovascular pharmacology

authors： Huang D,Lu H,Liu H,Yao K,Sun A,Zou Y,Ge J

更新日期：2012-08-01 00:00:00

abstract：:The role of endothelin-B (ETB) receptor in partial ablation-induced chronic renal failure was evaluated using the spotting-lethal (sl) rat, which carries a naturally occurring deletion in the ETB receptor gene. After 5/6 nephrectomy in ETB-deficient homozygous and wild-type (+/+) rats, we measured the systolic blood p...

journal_title：Journal of cardiovascular pharmacology

authors： Tazawa N,Okada Y,Nakata M,Izumoto H,Takasu M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

更新日期：2004-11-01 00:00:00

abstract：:According to the standard model of G protein-coupled receptor (GPCR) signaling, GPCRs are localized to the cell membrane where they respond to extracellular signals. Stimulation of GPCRs leads to the activation of heterotrimeric G proteins and their intracellular signaling pathways. However, this model fails to accomm...

journal_title：Journal of cardiovascular pharmacology

authors： Campden R,Audet N,Hébert TE

更新日期：2015-02-01 00:00:00

abstract：:The influence of isoniazid (ISO) preincubation on the relaxant effects of a group of nitrovasodilators was examined in norepinephrine-contracted rat aortic rings with and without endothelium. ISO displaced to the left the dose-response curves to all nitrovasodilators and increased the negative logarithm of their media...

journal_title：Journal of cardiovascular pharmacology

authors： Vidrio H,Fernández G

更新日期：1998-09-01 00:00:00

abstract：:An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

journal_title：Journal of cardiovascular pharmacology

authors： Haïat R,Piot O,Gallois H,Hanania G

更新日期：1999-06-01 00:00:00

abstract：:The clinical activity of metformin (N,N-dimethyl biguanide), a widely used antidiabetic agent, on arterial blood flow was evaluated in 15 patients with peripheral atherosclerosis. Flow was determined by quantitative strain-gauge plethysmography; plasma lipid, lipoprotein, and apoprotein levels were repeatedly tested d...

journal_title：Journal of cardiovascular pharmacology

authors： Sirtori CR,Franceschini G,Gianfranceschi G,Sirtori M,Montanari G,Bosisio E,Mantero E,Bondioli A

更新日期：1984-09-01 00:00:00

abstract：:On the basis of animal studies, it has been proposed that calcium antagonists selectively interfere with the pressor response to alpha 2-adrenoceptor antagonists and have less direct action on alpha 1-adrenoceptor mechanisms. In placebo-controlled randomized studies in healthy normotensives, we have found that verapam...

journal_title：Journal of cardiovascular pharmacology

authors： Reid JL,Pasanisi F,Meredith PA,Elliott HL

更新日期：1985-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) stimulated cAMP formation in Chinese hamster ovary cells stably expressing human wild-type ET(A) (CHO/hET(A) cells) and inhibited the formation in cells expressing human wild-type ETB (CHO/hETB cells), suggesting a selective coupling of hET(A) and hETB with G alpha s and G alpha i, respectively. To...

journal_title：Journal of cardiovascular pharmacology

authors： Ninomiya H,Takagi Y,Miwa S,Masaki T

更新日期：1995-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a 21-residue peptide isolated from the conditioned medium of cultured porcine endothelial cells and is widely distributed throughout the body, with relatively high levels in the kidney and lung. In this study we examined the influence of thyroid hormone status on immunoreactive endothelin (ir-ET...

journal_title：Journal of cardiovascular pharmacology

authors： Lam HC,Wang JP,Lee JK,Ho LT,Han TM,Lu CC,Chiang HT,Cheng DL

更新日期：1993-01-01 00:00:00

abstract：:Endothelin-1 reduces the chronotropic and inotropic effects of the beta-adrenoceptor agonist isoproterenol in rabbit isolated atria. Vascular interactions between endothelin-1 and isoproterenol have not been reported. Rings of the rabbit aorta without endothelium were mounted on myographs to measure isometric tension....

journal_title：Journal of cardiovascular pharmacology

authors： Gilbert P,Thorin E

更新日期：2003-10-01 00:00:00

abstract：:In primarily cultured pig coronary smooth muscle cells, extracellular adenosine triphosphate (ATP; 10(-9) to 10(-3) M) dose-dependently increases intracellular calcium ([Ca2+]i). The [Ca2+]i transients measured by fura-2 fluorescence consist of peak and plateau phases with [Ca2+]i values of 191.84 +/- 5.67 nM (n = 10)...

journal_title：Journal of cardiovascular pharmacology

authors： Seiler L,Matyas S,Fleckenstein-Grün G

更新日期：1999-05-01 00:00:00

abstract：:Gamma-hydroxybutyrate (GHB) is generally thought to be a central nervous system depressant; however, GHB also has sympathomimetic cardiovascular actions. Radio telemetry was used to record the cardiovascular responses elicited by GHB (180-1000 mg/kg IV) in conscious rats. GHB elicited increases in mean arterial pressu...

journal_title：Journal of cardiovascular pharmacology

authors： Hicks AR,Kapusta DR,Varner KJ

更新日期：2004-12-01 00:00:00