Replacement of L-Lys by D-Lys(NH2) in peptide Ala-Arg-Pro-Ala-Lys (peptide 6A) increases its coronary blood flow-promoting properties.

abstract：:Vasoconstrictor actions of endothelin-1 (ET) were compared between endothelium-removed strips of cerebral (basilar, posterior cerebral, and middle cerebral) and peripheral (coronary and mesenteric) arteries of the dog. ET produced a concentration-dependent contraction in these arteries. A threshold concentration and E...

journal_title：Journal of cardiovascular pharmacology

authors： Tanoi C,Suzuki Y,Shibuya M,Sugita K,Masuzawa-Ito K,Asano M

更新日期：1992-04-01 00:00:00

abstract：:To assess the cardiac functional reserve of elderly hypertensive patients with left ventricular hypertrophy (LVH) we studied cardiac function after isometric exercise and beta-adrenergic stimulation. Forty-five elderly hypertensive and 16 normotensive patients (NC group) were recruited for the study. The hypertensive ...

journal_title：Journal of cardiovascular pharmacology

authors： Suzuki Y,Kuwajima I,Hoshino S,Kanemaru A,Shimozawa T,Matsushita S,Kuramoto K

更新日期：1991-01-01 00:00:00

abstract：:Milrinone is a new inotropic agent for the treatment of refractory congestive heart failure. Our understanding of the mechanisms(s) of action of this synthetic cardiotonic drug is incomplete. We examined the effects of milrinone and the parent compound amrinone on sarcoplasmic reticulum function (45Ca-uptake and Ca-AT...

journal_title：Journal of cardiovascular pharmacology

authors： Earl CQ,Linden J,Weglicki WB

更新日期：1986-07-01 00:00:00

abstract：:Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

journal_title：Journal of cardiovascular pharmacology

authors： Meschig R,Breuer J,Arnold G

更新日期：1985-01-01 00:00:00

abstract：:The effects of bufuralol and its carbinol metabolite have been compared with those of propranolol in the anaesthetised and conscious cat and dog. Bufuralol and its carbinol metabolite are nonselective beta-adrenoceptor antagonists; the former has equivalent potency to propranolol, whereas the latter is six times more ...

journal_title：Journal of cardiovascular pharmacology

authors： Blaber LC,Burden DT,Eigenmann R,Gerold M

更新日期：1984-01-01 00:00:00

abstract：:We assessed the contribution of angiotensin-(1-7) [Ang-(1-7)] to captopril-induced cardiovascular protection in spontaneously hypertensive rats (SHRs) chronically treated with the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (SHR-l). NG-nitro-L-arginine methyl ester (80 mg/L) administration for 3 ...

journal_title：Journal of cardiovascular pharmacology

authors： Benter IF,Yousif MH,Al-Saleh FM,Raghupathy R,Chappell MC,Diz DI

更新日期：2011-05-01 00:00:00

abstract：:Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of ca...

journal_title：Journal of cardiovascular pharmacology

authors： de Leiris J,de Lorgeril M,Boucher F

更新日期：2009-11-01 00:00:00

abstract：:The cardiovascular profile of SC-36602, a new class 1A/1B antiarrhythmic agent, was compared to those of disopyramide, lidocaine, mexiletine, flecainide, encainide, lorcainide, and quinidine. These drugs were compared at their respective canine antiarrhythmic doses in a hemodynamic evaluation using anesthetized dogs. ...

journal_title：Journal of cardiovascular pharmacology

authors： Frederick LG,Hatley FR,McDonald SJ,Stamm MH,Garthwaite SM

更新日期：1988-06-01 00:00:00

abstract：:There are several first choices for mild and moderate hypertension. The selection of a drug may of course be influenced by concomitant pathology, with positive indications for particular drugs: for coexistent angina, a beta-receptor blocking drug or a calcium antagonist; for fluid retention, a diuretic; or for contrai...

journal_title：Journal of cardiovascular pharmacology

authors： Prichard BN

更新日期：1987-01-01 00:00:00

abstract：:The mechanism of lithium action, an effective treatment for bipolar disease, is still unknown. The present study examined the role of nitric oxide (NO) and prostaglandin systems in lithium modulation of acetylcholine in mesenteric vascular bed of rats by cannulating superior mesenteric artery. Acetylcholine (ACh) or s...

journal_title：Journal of cardiovascular pharmacology

authors： Rahimzadeh-Rofouyi B,Afsharimani B,Moezi L,Ebrahimi F,Mehr SE,Mombeini T,Ghahremani MH,Dehpour AR

更新日期：2007-12-01 00:00:00

abstract：:Thirty-two hypertensive subjects with diastolic blood pressure greater than 95 mm Hg were treated with ramipril over a period of 3 months. To determine the effective decrease of blood pressure and for reliable and reproducible demonstration of regression of myocardial hypertrophy during ramipril treatment, we performe...

journal_title：Journal of cardiovascular pharmacology

authors： Eichstaedt H,Danne O,Langer M,Cordes M,Schubert C,Felix R,Schmutzler H

更新日期：1989-01-01 00:00:00

abstract：:Hyperinsulinemia, lipid abnormalities, and impaired fibrinolytic capacity may accompany hypertension, and comprise the metabolic cardiovascular syndrome. They are all independent risk factors for coronary artery disease. Lifestyle modifications can reduce the coronary artery risk. Physical activity has been shown to i...

journal_title：Journal of cardiovascular pharmacology

authors： Westheim A,Os I

更新日期：1992-01-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF), a potent mitogen and chemoattractant for smooth muscle cells and fibroblasts in culture, is believed to play an important role in the formation of proliferative lesions of arterio-sclerosis. PDGF appears as three different dimeric isoforms: AA, AB, and BB. These were recently fou...

journal_title：Journal of cardiovascular pharmacology

authors： Hosang M,Rouge M

更新日期：1989-01-01 00:00:00

abstract：:We investigated the vasoactive actions of the wound-healing agent tetrachlorodecaoxygen (TCDO). TCDO (20 microM) had no direct effect on tone in isolated calf pulmonary arteries precontracted with potassium with or without 1 microM reduced hemoglobin under O2 or N2 atmosphere. However, TCDO, in a reduced hemoglobin-de...

journal_title：Journal of cardiovascular pharmacology

authors： Wolin MS,Kleber E,Mohazzab KM,Elstner EF

更新日期：1994-04-01 00:00:00

abstract：:The understanding of blood pressure (BP) and heart rate (HR) variation, circadian changes, and the responses to nonclinical situations has been improved by automated ambulatory recordings. The antihypertensive efficacy of a once-daily regimen (10/20 mg) of nitrendipine was evaluated in detail using the lightest availa...

journal_title：Journal of cardiovascular pharmacology

authors： Meyer-Sabellek W,Schulte KL,Streitberg B,Gotzen R,Distler A

更新日期：1988-01-01 00:00:00

abstract：:The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations....

journal_title：Journal of cardiovascular pharmacology

authors： Van Taunay JS,Albelda MT,Frias JC,Lipinski MJ

更新日期：2018-08-01 00:00:00

abstract：:At present, endothelin (ET) receptor classification remains controversial. We investigated the presence of atypical ETA receptors in human saphenous veins (SV). Human SV was obtained from 24 patients undergoing coronary artery bypass grafting. Vessels were set up in organ baths, stretched to a tension of 6 g, and left...

journal_title：Journal of cardiovascular pharmacology

authors： Pate MA,Chester AH,Brown TJ,Roach AG,Yacoub MH

更新日期：1998-01-01 00:00:00

abstract：:We studied the acute intravenous (i.v.) effects of the antiarrhythmic agents ibutilide, sematilide, lidocaine, and encainide in a canine Y-shaped right atrial incision model of atrial flutter. After baseline determination of atrial effective refractory period (AERP), sustained atrial flutter (AFL) was initiated by atr...

journal_title：Journal of cardiovascular pharmacology

authors： Buchanan LV,Kabell G,Gibson JK

更新日期：1995-04-01 00:00:00

abstract：:The potential therapeutic value of a new prostacyclin analogue, (4z, 16s)-4,5,18,18,19,19-hexadehydro-16,20-dimethyl-delta 6(9a)- 9-(O)-methano-PGI1 (KP-10614), was studied in acute myocardial infarction in rats. Myocardial infarction was induced by ligation of the left coronary artery and ischemic injury was followed...

journal_title：Journal of cardiovascular pharmacology

authors： Kanayama T,Kimura Y,Tamao Y,Mizogami S

更新日期：1992-10-01 00:00:00

abstract：:We observed that heterozygous knockout (+/-, KO) of either endothelin-A- (ET(A)) or -B- (ET(B)) receptors significantly reduced the pressor responses to systemically administered endothelin-1 (ET-1) in ET(A) or ET(B) (+/-) KO mice when compared to wild-type (WT) mice (data not shown). Also, we observed that basal mean...

journal_title：Journal of cardiovascular pharmacology

authors： Berthiaume N,Yanagisawa M,D'Orléans-Juste P

更新日期：2000-11-01 00:00:00

abstract：:Sarcosyl1, cysteinyl-S-methyl8-angiotensin II [(Sar1, Cys-Me8) Ang II] was examined for antagonism of angiotensin (Ang) responses in isolated rabbit atrial and aortic tissues. (Sar1, Cys-Me8) Ang II competitively antagonized Ang II responses in aorta at a concentration of 5 nM. Concentrations of the antagonist greater...

journal_title：Journal of cardiovascular pharmacology

authors： Trachte GJ,Peach MJ

更新日期：1983-11-01 00:00:00

abstract：:Death during and following myocardial infarction can arise from a number of different causes. Some of them, such as early ventricular fibrillation and cardiac rupture, seem unrelated to infarct size. However, deaths occurring later during the course of infarction do seem to be related to the extent of myocardial damag...

journal_title：Journal of cardiovascular pharmacology

authors： Julian DG

更新日期：1991-01-01 00:00:00

abstract：:We have studied the effect of ramipril (10 mg/kg daily by gastric gavage) on the development of neointima 2 and 14 days after injury to rat aorta with a balloon catheter. In treated animals, there was no significant inhibition of the early mitotic reaction after injury (synthesis of DNA, as reflected by aortic thymidi...

journal_title：Journal of cardiovascular pharmacology

authors： Capron L,Heudes D,Chajara A,Bruneval P

更新日期：1991-08-01 00:00:00

abstract：:Previous studies in which an isolated heart or in situ constant pressure preparation was used suggested a minimal role for adenosine in autoregulatory control of coronary circulation. These results, however, are controversial, and the role of adenosine in autoregulation of flow in heart is uncertain. To test the hypot...

journal_title：Journal of cardiovascular pharmacology

authors： Komaru T,Lamping KG,Dellsperger KC

更新日期：1994-09-01 00:00:00

abstract：:The combination of a beta-adrenoceptor-blocking drug with the dihydropyridine calcium channel antagonist, nitrendipine, has particular therapeutic advantages in the management of hypertension. The beta-blocker reduces any reflex increases in sympathetic nervous system and renin-angiotensin system activity that result ...

journal_title：Journal of cardiovascular pharmacology

authors： Mac Carthy EP

更新日期：1988-01-01 00:00:00

abstract：:Coronary artery disease (CAD) is the major cause of death in hypertensive patients in Western populations and further efforts are required to determine how best to reduce its incidence. Large-scale placebo-controlled trials of blood pressure reduction could resolve the uncertainty about the effects of antihypertensive...

journal_title：Journal of cardiovascular pharmacology

authors： MacMahon S,Sharpe N

更新日期：1990-01-01 00:00:00

abstract：:The evolutionary relationships among 17 protein and nucleic acid sequences from the sarafotoxin/endothelin/endothelin-like superfamily of peptides were studied. The endothelin/endothelin-like gene family has diverged from an ancestral gene that has experienced an exon duplication event followed by two complete gene du...

journal_title：Journal of cardiovascular pharmacology

authors： Landan G,Bdolah A,Wollberg Z,Kochva E,Graur D

更新日期：1991-01-01 00:00:00

abstract：:Cardiac endothelial nitric oxide synthase (ecNOS) was suppressed and inducible NOS (iNOS) enhanced at the decompensated heart failure stage in 18-week-old Dahl salt-sensitive (DS) hypertensive rats to which a high-salt diet had been administered from the age of 6 weeks. Nicorandil (NIC) enhanced ecNOS by activating Ad...

journal_title：Journal of cardiovascular pharmacology

authors： Horinaka S,Kobayashi N,Yagi H,Mori Y,Matsuoka H

更新日期：2006-05-01 00:00:00

abstract：:The peptide vasoconstrictors angiotensin II (Ang II) and endothelin-1 (ET-1), originally thought to derive exclusively from the plasma renin-angiotensin system and vascular endothelium, respectively, have been demonstrated to be produced independently of such sources. Local tissue angiotensin-generating systems are we...

journal_title：Journal of cardiovascular pharmacology

authors： Hahn AW,Resink TJ,Kern F,Bühler FR

更新日期：1993-01-01 00:00:00

abstract：:In urban Australia, the risk of retiring with hypertension is greater than 40%, and the basic abnormality--a rise in blood pressure (BP) with age--is almost universal. A hypothesis linking this with salt, therefore, concerns everyone. The diet of early humans was unsalted, and the Na content of breast milk (6 mmol/kg)...

journal_title：Journal of cardiovascular pharmacology

authors： Beard TC

更新日期：1990-01-01 00:00:00