当前位置： SCI文献检索 > JOURNAL OF CARDIOVASCULAR PHARMACOLOGY期刊下所有文献 > Role of adenosine in vasodilation of epimyocardial coronary microvessels during reduction in perfusion pressure.

Role of adenosine in vasodilation of epimyocardial coronary microvessels during reduction in perfusion pressure.

Abstract：

:Previous studies in which an isolated heart or in situ constant pressure preparation was used suggested a minimal role for adenosine in autoregulatory control of coronary circulation. These results, however, are controversial, and the role of adenosine in autoregulation of flow in heart is uncertain. To test the hypothesis that adenosine mediates microvascular dilation in response to reduction in perfusion pressure (PP), we performed experiments in 41 open-chest chloralose-anesthetized dogs. Internal diameters (ID) of epicardial small arterioles < 100 mumol were measured with an intravital microscope and stroboscopic epiillumination synchronized to cardiac cycle. PP was reduced by graded stenoses of the left anterior descending coronary artery (LAD, mild stenosis PP = 60 mm Hg; critical stenosis PP = 40 mm Hg) and complete occlusion. 8-Phenyltheophylline (8-PT 10 microM) or adenosine deaminase (ADA 10 U/min) was topically superfused onto the heart. Arteriolar dilation induced by topically applied adenosine < or = 10 microM was completely blocked by 8-PT. Without 8-PT (vehicle group), mild critical stenosis and complete occlusion caused arteriolar dilation (percentage of change in diameter 8.6 +/- 2.6, 16.0 +/- 2.7, and 13.6 +/- 4.8%). 8-PT did not inhibit this dilation (8.5 +/- 2.8, 16.1 +/- 4.6, 15.1 +/- 5.7%, NS vs. vehicle group). Topically applied ADA significantly inhibited intravenously (i.v.) administered adenosine-induced arteriolar dilation. Without ADA, arteriolar dilation occurred (16.6 +/- 3.0, 28.2 +/- 4.3, 15.4 +/- 6.2%, at each PP). However, ADA did not inhibit dilation induced by gradual stenoses (10.6 +/- 1.4, 24.2 +/- 4.3, 17.5 +/- 6.9%, at each PP, NS vs. vehicle group).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Cardiovasc Pharmacol

journal_title

Journal of cardiovascular pharmacology

authors

Komaru T,Lamping KG,Dellsperger KC

doi

10.1097/00005344-199409000-00012

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

434-42

issue

3

eissn

0160-2446

issn

1533-4023

journal_volume

24

pub_type

杂志文章

相关文献

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY文献大全
  • Oral naftidrofuryl prevents platelet hyperreactivity ex vivo and inhibits functional desensitization to prostacyclin in hypercholesterolemic rabbits.

    abstract：:Among other mediators, platelet-derived serotonin (5-HT) may contribute to thromboembolic complications of atherosclerosis. We determined whether long-term oral treatment with the 5-HT2 antagonist naftidrofuryl (NAF, 50 mg/kg daily for 12 weeks) alters platelet function in cholesterol-fed (1%) rabbits. Hypercholestero...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199302000-00021

    authors： Weber AA,Hohlfeld T,Strobach H,Schrör K

    更新日期：1993-02-01 00:00:00

  • Effect of congestive heart failure treatment on incidence and prognosis of ventricular tachyarrhythmias.

    abstract：:The prognosis for patients with congestive heart failure (CHF) is poor, with a mortality exceeding 50% within 5 years from diagnosis. This poor prognosis remains despite improved pharmacological therapy. Because the prevalence of sudden death among these patients is high, reported to exceed 40%, the prognostic importa...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Birgersdotter-Green U,Rosenqvist M,Rydén L

    更新日期：1991-01-01 00:00:00

  • Hemodynamic and cardiac anti-hypertrophic actions of clonidine in Goldblatt one-kidney, one-clip rats.

    abstract：:In congestive heart failure, the chronic sympathetic hyperactivity contributes to a poor prognosis. In this respect, clonidine, a centrally acting sympathoinhibitory drug, has previously been tested in clinical trials. The aim of the current study was to evaluate the effects of clonidine on morbidity and mortality in ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200302000-00008

    authors： Thomas L,Gasser B,Bousquet P,Monassier L

    更新日期：2003-02-01 00:00:00

  • The pharmacologic profile of 606A, a novel angiotensin II receptor antagonist.

    abstract：:The pharmacologic profile of a novel angiotensin I (AT1) receptor antagonist 606A was studied in various in vitro and in vivo preparations. The 606A showed a high affinity at AT1 receptors [inhibition constant (Ki), 12.8 +/- 0.4 nM] in rabbit adrenal cortical membrane and a low affinity to AT2 receptors (Ki, > 1 mM) i...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199702000-00019

    authors： Hashimoto Y,Harada Y,Narita H,Naito K,Murata S

    更新日期：1997-02-01 00:00:00

  • Chronic inhibition of nitric oxide production augments skin vasoconstriction in the rabbit ear.

    abstract：:The effect of chronic inhibition of nitric oxide (NO) synthesis by NG-nitro-L-arginine methyl ester (L-NAME) on cutaneous ear blood flow (EBF) in the rabbit was examined in vivo with use of laser Doppler flowmetry. Additionally, the efficacy of inhibition of NO by L-NAME was studied ex vivo in isolated preparations of...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199308000-00017

    authors： Khan F,Palacino JJ,Coffman JD,Cohen RA

    更新日期：1993-08-01 00:00:00

  • Rate-dependent class III antiarrhythmic action, negative chronotropy, and positive inotropy of a novel Ik blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium.

    abstract：:The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) and atria in vitro using conventional microelectrode technique. UK (10(-8)-10(-6) M) prolonged the action potential duration (APD) by 21-58% and effective refractory period...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199009000-00008

    authors： Tande PM,Bjørnstad H,Yang T,Refsum H

    更新日期：1990-09-01 00:00:00

  • Differential effects of alpha 1- and alpha 2-adrenoceptor agonists on peripheral vasoconstriction in pithed diabetic rats.

    abstract：:The pressor responses to selective alpha 1-adrenoceptor agonists (cirazoline and methoxamine) and to alpha 2-adrenoceptor agonists (UK-14,304 and B-HT 933) were investigated in pithed, streptozotocin-induced diabetic rats and age-matched control animals. Three months after induction of diabetes, the basal values of di...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199210000-00007

    authors： Heijnis JB,Mathy MJ,Pfaffendorf M,van Zwieten PA

    更新日期：1992-10-01 00:00:00

  • Salicylate reduces ventricular dysfunction and arrhythmias during reperfusion in isolated rat hearts.

    abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199202000-00009

    authors： Liu XK,Tosaki A,Engleman RM,Das DK

    更新日期：1992-02-01 00:00:00

  • Felodipine compared to prazosin as additional therapy to a beta-blocking drug.

    abstract：:Felodipine was compared with prazosin in patients with essential hypertension whose blood pressure was not controlled by a beta-blocking drug. One hundred patients with a supine diastolic blood pressure greater than or equal to mm Hg after 4 weeks or more on a beta-blocking drug and placebo were randomly assigned to f...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Chalmers J,Wing L,West M,Bune A,Johnston C,Jackson B,McGrath B,Mashford ML,Heath W,Westwood B

    更新日期：1987-01-01 00:00:00

  • Nitrate tolerance: comparison of nicorandil, isosorbide dinitrate, and nitroglycerin in anesthetized dogs.

    abstract：:Development of tolerance to nicorandil (NCR), N-(2-hydroxyethyl)nicotinamide nitrate (ester), was compared with that to nitroglycerin (NTG) or isosorbide dinitrate (ISDN) in dogs. An intracoronary arterial (i.a.) injection of NCR (20 micrograms), ISDN (30 micrograms), or NTG (1 microgram) caused coronary vasodilation....

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：

    authors： Sakai K,Kuromaru O

    更新日期：1987-01-01 00:00:00

  • Selective adenosine-2 agonist produces both direct and reflex tachycardia in normotensive rats.

    abstract：:Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-fold selectivity for the adenosine-2 (A2) receptor subtype, were characterized in conscious and anesthetized rats. In conscious rats instrume...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199203000-00025

    authors： Lappe RW,Sheldon JH,Cox BF

    更新日期：1992-03-01 00:00:00

  • Calcium antagonist properties of diclofurime isomers. II. Molecular aspects: allosteric interactions with dihydropyridine recognition sites.

    abstract：:Trans-diclofurime has been shown to be a very potent class II calcium antagonist (see preceding report), and we have examined its molecular interactions with the different receptor sites at the Ca2+ channel. Trans-diclofurime did not affect [3H]nitrendipine binding to rat cortical membranes at 37 degrees C and showed ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-198704000-00012

    authors： Mir AK,Spedding M

    更新日期：1987-04-01 00:00:00

  • Effect of acute and chronic indoramin administration on baroreflex function and tremor in humans.

    abstract：:Several mechanisms have been suggested for the absence of reflex tachycardia in response to the hypotensive effect of the selective alpha 1-adrenoceptor antagonist indoramin, including, in animals, membrane-stabilising activity, prolongation of repolarisation time, and reduction in baroreflex sensitivity. The present ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1097/00005344-198803000-00004

    authors： Deering AH,Riddell JG,Harron DW,Shanks RG

    更新日期：1988-03-01 00:00:00

  • Long-term renal effects of isradipine, a calcium entry blocker, in essential hypertension.

    abstract：:The long-term effects (9 weeks) on renal hemodynamics of the new calcium entry blocker isradipine (PN 200-110) were assessed in 20 middle-aged male patients with essential hypertension. The study was double-blind placebo-controlled with a crossover design. Isradipine or placebo tablets were titrated from 2.5, 5, and 7...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1097/00005344-198907000-00005

    authors： Persson B,Wysocki M,Andersson OK

    更新日期：1989-07-01 00:00:00

  • Endothelin-1 and cardiotrophin-1 induce brain natriuretic peptide gene expression by distinct transcriptional mechanisms.

    abstract：:Cardiotrophin-1 (CT-1) a novel IL-6-related cytokine, induces distinct hypertrophic responses to endothelin-1 (ET-1) on cultured neonatal rat cardiac myocytes. We found that ET-1 and CT-1 show a distinct pattern of gene induction of natriuretic peptides. Elucidation of the transcriptional mechanisms of brain natriuret...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199800001-00099

    authors： Kuwahara K,Saito Y,Ogawa Y,Tamura N,Ishikawa M,Harada M,Ogawa E,Miyamoto Y,Hamanaka I,Kamitani S,Kajiyama N,Takahashi N,Nakagawa O,Masuda I,Nakao K

    更新日期：1998-01-01 00:00:00

  • Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression.

    abstract：:Enhanced renin-angiotensin activity causes hypertension and cardiac hypertrophy. The angiotensin (Ang)-converting enzyme (ACE)2/Ang(1-7)/Mas axis pathway functions against Ang II type 1 receptor (AT1R) signaling. We investigated whether olmesartan (Olm), an AT1R blocker, inhibits cardiac hypertrophy independently of b...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/FJC.0000000000000374

    authors： Tanno T,Tomita H,Narita I,Kinjo T,Nishizaki K,Ichikawa H,Kimura Y,Tanaka M,Osanai T,Okumura K

    更新日期：2016-06-01 00:00:00

  • Phosphodiesterases in the rat renal vasculature.

    abstract：:The objective this investigation was to determine the relative importance of type I, III, and IV phosphodiesterases in the regulation of cyclic adenosine monophosphate (cAMP) in the renal circulation. In the first experimental series, four groups of isolated rat kidneys perfused with Tyrode's solution were stimulated ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199712000-00015

    authors： Jackson EK,Mi Z,Carcillo JA,Gillespie DG,Dubey RK

    更新日期：1997-12-01 00:00:00

  • Heterogeneity of endothelin receptor.

    abstract：:The complex formed between endothelin (ET) and its binding protein was adequately stable to be separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) at low temperature. Cross-linking was not necessary. This simple method was applied for both qualitative (determination of molecular weight ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199100177-00028

    authors： Takasuka T,Satoh N,Horii I,Furuichi Y,Watanabe T

    更新日期：1991-01-01 00:00:00

  • Benazepril causes in hypertension a greater reduction in left ventricular mass than does nitrendipine: a randomized study using magnetic resonance imaging.

    abstract：:To assess the comparative effects of benazepril and nitrendipine monotherapies on left ventricular mass index (LVMI) in hypertensive patients with echocardiographically determined left ventricular hypertrophy, patients with diastolic blood pressure (BP) > or = 100 mm Hg were randomized to benazepril, 10 mg, or nitrend...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1097/00005344-199811000-00012

    authors： Gaudio C,Tanzilli G,Ferri FM,Villatico Campbell S,Bertocchi F,Motolese M,Campa PP

    更新日期：1998-11-01 00:00:00

  • Effects of a PPARgamma agonist, GI262570, on renal filtration fraction and nitric oxide level in conscious rats.

    abstract：:PPARgamma agonists ameliorate insulin resistance and lower blood pressure. Volume expansion/edema has been observed in susceptible patients treated with these agents. Alterations of renal hemodynamics affect renal tubular reabsorption, and thus may contribute to volume expansion. This study seeks to determine whether ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200309000-00016

    authors： Yang B,Clifton LG,McNulty JA,Chen L,Brown KK,Baer PG

    更新日期：2003-09-01 00:00:00

  • Vasoactive peptide-regulated gene expression during osteoblastic differentiation.

    abstract：:The formation of bone occurs via a series of events that are regulated by various hormones and cytokines. We previously reported that endothelin (ET) inhibits the mineralization by osteoblastic cells and natriuretic peptide (NP) promotes osteoblastic differentiation. Therefore, we attempted to identify the genes induc...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200036051-00084

    authors： Inoue A,Kamiya A,Ishiji A,Hiruma Y,Hirose S,Hagiwara H

    更新日期：2000-11-01 00:00:00

  • Modification of stretch-induced shortening of repolarization by streptomycin in the isolated rabbit heart.

    abstract：:The exact mechanism of mechano-electrical feedback and stretch-induced arrhythmias is unknown, but the role of stretch-activated ion channels and specific calcium channels has been proposed. The aim of the present study was to test the hypothesis that stretch-activated ion channels and not calcium channels contribute ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200012000-00005

    authors： Eckardt L,Kirchhof P,Mönnig G,Breithardt G,Borggrefe M,Haverkamp W

    更新日期：2000-12-01 00:00:00

  • Resveratrol Ameliorates Pressure Overload-induced Cardiac Dysfunction and Attenuates Autophagy in Rats.

    abstract：:Pressure overload has an important role in heart failure, inducing excessive autophagy in cardiac myocytes that is considered to be pathogenic. Resveratrol has been reported to improve cardiac dysfunction induced by pressure overload, but it has been unclear whether resveratrol ameliorates cardiac dysfunction by regul...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/FJC.0000000000000290

    authors： Wang L,Gao M,Chen J,Yang Z,Sun J,Wang Z,Huang X,Yuan T,Shen X,Xian S

    更新日期：2015-10-01 00:00:00

  • Drug block of I(kr): model systems and relevance to human arrhythmias.

    abstract：:The long QT-related arrhythmia torsades de pointes (TdP) can arise with mutations in HERG and during treatment with drugs that block cardiac I Kr, the current encoded by HERG. Multiple test systems have been used to assess drug block of I Kr. This study evaluated the I Kr blocking potency of a series of antiarrhythmic...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200111000-00010

    authors： Yang T,Snyders D,Roden DM

    更新日期：2001-11-01 00:00:00

  • Protein Kinase C Isoforms Distinctly Regulate Propofol-induced Endothelium-dependent and Endothelium-independent Vasodilation.

    abstract：:Protein kinase C (PKC) isoforms improve endothelial nitric oxide synthase activity and contractile Ca sensitivity in blood vessels. These actions may have opposite effects on propofol-induced vasodilation. This study examines the hypothesis that propofol induces relaxation by enhancing the PKC-mediated nitric oxide sy...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/FJC.0000000000000275

    authors： Wang Y,Zhou H,Wu B,Zhou Q,Cui D,Wang L

    更新日期：2015-09-01 00:00:00

  • Long-term treatment of hypertension with methyldopa. I. Study objectives and design.

    abstract：:In this retrospective study, a group of 435 patients provided meaningful analyses of blood pressure and dosage data for treatment periods of up to 4.5 years. The protocol, study objectives, and pretreatment demographic characteristics of the group are summarized in this report, which is the first in a series in this i...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 临床试验,杂志文章

    doi：

    authors： Itskovitz HD,Menduke H

    更新日期：1981-01-01 00:00:00

  • Relationship between plasma diltiazem and cardiovascular responses in conscious dogs.

    abstract：:Conscious dogs were given diltiazem hydrochloride (DTZ) orally for 5 successive days at doses of 1, 3, and 10 mg/kg/day. During the 5th day, cardiovascular responses were monitored at various timed intervals after dosing. Arterial blood was sampled concomitantly for drug analysis. DTZ produced a dose-related decrease ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-198305000-00021

    authors： Browne RK,Dimmitt DC,Miller LD,Korol B

    更新日期：1983-05-01 00:00:00

  • Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel.

    abstract：BACKGROUND:Guanfu base A (GFA) and Guanfu base G (GFG) are chemicals isolated from Aconitum coreanum. The potassium channel encoded by the human ether-a-go-go related gene (HERG) plays an important role in repolarization of the cardiac action potential. The purpose of the present study was to investigate the effects of...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/FJC.0b013e318236e380

    authors： Huang X,Yang Y,Zhu J,Xu D,Peng J,Liu J

    更新日期：2012-01-01 00:00:00

  • Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking.

    abstract：:The signaling impact of a human beta1-adrenergic receptor (beta1 AR) polymorphism at residue 49 of the aminoterminus (Ser-to-Gly substitution) was studied by recombinantly expressing each receptor. The two receptors displayed identical agonist and antagonist binding affinities. Furthermore, basal and agonist-stimulate...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200202000-00001

    authors： Rathz DA,Brown KM,Kramer LA,Liggett SB

    更新日期：2002-02-01 00:00:00

  • Emerging pathophysiological concepts in hypertension.

    abstract：:Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emergin...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Frohlich ED

    更新日期：1984-01-01 00:00:00