Abstract：
:To assess the cardiac functional reserve of elderly hypertensive patients with left ventricular hypertrophy (LVH) we studied cardiac function after isometric exercise and beta-adrenergic stimulation. Forty-five elderly hypertensive and 16 normotensive patients (NC group) were recruited for the study. The hypertensive patients were divided into two groups: those with LVH (n = 17) mass index (LV mass index greater than 130 g/m2; H1 group) and those without LVH (n = 28) (H2 group). Echocardiographic studies were performed before and after isometric exercise (handgrip) and isoproterenol (ISP) administration. We measured the LV mass index, fractional shortening (FS), isovolumic relaxation time (IRT), and the ratio of late and early diastolic transmitral flow velocity (A/E). The FS at rest in the H1 group was significantly higher than those in the H2 and NC groups. In the H1 group, the IRT was elongated and A/E was greater than in the NC group, which indicated the impaired diastolic function in the H1 group. After the HG stress, the FS in the H1 group significantly decreased whereas it did not change in the H2 or NC groups. The FS increased in all three groups after the infusion of ISP, although the increment of FS was smaller in the H1 group. In conclusion, (a) diastolic function was impaired whereas systolic function was supranormal at rest in the hypertrophied heart of the elderly hypertensive patients and (b) when exercise or pharmacological stress was loaded, the systolic function deteriorated, suggesting the impairment of cardiac reserve in those patients.
journal_name
J Cardiovasc Pharmacoljournal_title
Journal of cardiovascular pharmacologyauthors
Suzuki Y,Kuwajima I,Hoshino S,Kanemaru A,Shimozawa T,Matsushita S,Kuramoto Kdoi
10.1097/00005344-199117002-00030subject
Has Abstractpub_date
1991-01-01 00:00:00pages
S129-32eissn
0160-2446issn
1533-4023journal_volume
17 Suppl 2pub_type
杂志文章abstract：:Five-year morbidity and mortality in the Hypertension Detection and Follow-Up Program (HDFP) were stratified by age groups at entry to the study and by Stepped Care (SC) and Referred Care (RC) treatment groups. Although the incidence of stroke increased with age in both treatment groups, the greatest reduction in stro...
journal_title：Journal of cardiovascular pharmacology
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更新日期：1985-01-01 00:00:00
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更新日期：2005-02-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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更新日期：2000-04-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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更新日期：1992-01-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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journal_title：Journal of cardiovascular pharmacology
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doi：10.1097/00005344-199301000-00009
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journal_title：Journal of cardiovascular pharmacology
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更新日期：1996-02-01 00:00:00
abstract：:Platelet-derived growth factor (PDGF), a potent mitogen and chemoattractant for smooth muscle cells and fibroblasts in culture, is believed to play an important role in the formation of proliferative lesions of arterio-sclerosis. PDGF appears as three different dimeric isoforms: AA, AB, and BB. These were recently fou...
journal_title：Journal of cardiovascular pharmacology
pub_type： 杂志文章
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更新日期：1989-01-01 00:00:00
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更新日期：1984-01-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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更新日期：1986-01-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
pub_type： 杂志文章
doi：10.1097/00005344-197905000-00005
更新日期：1979-05-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
pub_type： 杂志文章
doi：10.1097/00005344-198712000-00013
更新日期：1987-12-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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更新日期：1996-04-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
pub_type： 杂志文章
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更新日期：1986-03-01 00:00:00
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更新日期：1989-01-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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journal_title：Journal of cardiovascular pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1990-01-01 00:00:00
abstract：:Hibernating myocardium is characterized by chronic reduction of myocardial blood flow due to obstructive coronary artery disease, causing reversible left ventricular dysfunction and flow-metabolism mismatch. The condition is unstable and increasing demand may lead to further left ventricular dysfunction or necrosis ca...
journal_title：Journal of cardiovascular pharmacology
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journal_title：Journal of cardiovascular pharmacology
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journal_title：Journal of cardiovascular pharmacology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title：Journal of cardiovascular pharmacology
pub_type： 临床试验,杂志文章
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journal_title：Journal of cardiovascular pharmacology
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更新日期：1992-09-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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更新日期：2001-07-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
pub_type： 临床试验,杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
pub_type： 杂志文章,评审
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更新日期：2009-04-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
pub_type： 杂志文章,评审
doi：10.1097/00005344-198806124-00004
更新日期：1988-01-01 00:00:00
abstract：:The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...
journal_title：Journal of cardiovascular pharmacology
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doi：10.1097/00005344-198804000-00012
更新日期：1988-04-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology
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更新日期：1991-08-01 00:00:00
