Cinnamaldehyde Ameliorates High-Glucose-Induced Oxidative Stress and Cardiomyocyte Injury Through Transient Receptor Potential Ankyrin 1.

abstract：:The effects of the adrenergic antihypertensive drugs propranolol, clonidine, alpha-methyldopa, urapidil, indoramin, and prazosin on the relative rate of sterol synthesis were studied in freshly isolated human mononuclear leukocytes. Incubation of cells for 6 h in a medium containing lipid-depleted serum led to a three...

journal_title：Journal of cardiovascular pharmacology

authors： Krone W,Müller-Wieland D,Greten H

更新日期：1985-11-01 00:00:00

abstract：:A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension. Following administration of a single dose, all the patients except one who was forced to be discharged from the hospital for work, continuously received doxazosin once...

journal_title：Journal of cardiovascular pharmacology

authors： Shionoiri H,Yasuda G,Yoshimura H,Umemura S,Miyajima E,Miyakawa T,Takagi N,Kaneko Y

更新日期：1987-07-01 00:00:00

abstract：:In helical strips of dog cerebral, coronary, mesenteric, and renal arteries treated with ONO3708, an inhibitor of vasoconstricting prostaglandin (PG) receptors, and previously contracted with serotonin, PGF2 alpha, PGD2 and epithio-methano thromboxane A2 (sTxA2), a TxA2 analog, caused a relaxation. The cerebral arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Toda N,Inoue S,Okamura T,Okunishi H

更新日期：1988-03-01 00:00:00

abstract：:The objective of this study was to investigate the cardioactive properties of oxybutynin, a drug that is widely prescribed for management of voiding dysfunction. Membrane currents were recorded from whole-cell-configured guinea pig ventricular myocytes, and action potentials were recorded from guinea pig and rabbit pa...

journal_title：Journal of cardiovascular pharmacology

authors： Jones SE,Kasamaki Y,Shuba LM,Ogura T,McCullough JR,McDonald TF

更新日期：2000-02-01 00:00:00

abstract：:Protein kinase C (PKC) isoforms improve endothelial nitric oxide synthase activity and contractile Ca sensitivity in blood vessels. These actions may have opposite effects on propofol-induced vasodilation. This study examines the hypothesis that propofol induces relaxation by enhancing the PKC-mediated nitric oxide sy...

journal_title：Journal of cardiovascular pharmacology

authors： Wang Y,Zhou H,Wu B,Zhou Q,Cui D,Wang L

更新日期：2015-09-01 00:00:00

abstract：:Spirapril (SCH 33844; 7-N-[1(S)-ethoxycarbonyl-3-phenylpropyl]-(S)-alanyl-1,4-dithia- 7-azaspiro[4,4]-nonane-8(S)-carboxylic acid) is a new angiotensin-converting enzyme (ACE) inhibitor. SCH 33844 diacid inhibited hydrolysis of hip-his-leu by rabbit lung ACE in a potent (Ki = 0.74 nM), selective, and noncompetitive fa...

journal_title：Journal of cardiovascular pharmacology

authors： Sybertz EJ,Watkins RW,Ahn HS,Baum T,La Rocca P,Patrick J,Leitz F

更新日期：1987-01-01 00:00:00

abstract：:PPARgamma agonists ameliorate insulin resistance and lower blood pressure. Volume expansion/edema has been observed in susceptible patients treated with these agents. Alterations of renal hemodynamics affect renal tubular reabsorption, and thus may contribute to volume expansion. This study seeks to determine whether ...

journal_title：Journal of cardiovascular pharmacology

authors： Yang B,Clifton LG,McNulty JA,Chen L,Brown KK,Baer PG

更新日期：2003-09-01 00:00:00

abstract：:Because the role of sodium channels in the initiation and maintenance of VF is not fully elucidated, we studied the significance of sodium channel activity in VF using sodium channel blockers. In nonischemic isolated feline hearts, the following electrophysiologic parameters were measured before and after application ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Schoels W,Visokovsky A,Lev-Ran V,Novikov I,Mueller M,Kraft P,Kaplinsky E,Eldar M

更新日期：2000-12-01 00:00:00

abstract：:This study determined whether flavin adenine dinucleotide (FAD) may elicit vasodilation in conscious rats via release of preformed endothelium-derived nitrosyl factors. Injections 1-6 (inj(1-6)) of FAD (2.5 micromol/kg, IV) elicited pronounced and equivalent vasodilator responses in saline-treated rats. Inj(1) of FAD ...

journal_title：Journal of cardiovascular pharmacology

authors： Hashmi-Hill MP,Sandock K,Bates JN,Robertson TP,Lewis SJ

更新日期：2007-08-01 00:00:00

abstract：:The disposition of amlodipine, a new calcium-channel blocker with a slow onset and long duration of action, has been investigated in humans and in the animal species used in the evaluation of drug efficacy and safety. Pharmacokinetic studies were conducted with nonlabeled drug using specific high-pressure liquid chrom...

journal_title：Journal of cardiovascular pharmacology

authors： Stopher DA,Beresford AP,Macrae PV,Humphrey MJ

更新日期：1988-01-01 00:00:00

abstract：:Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

journal_title：Journal of cardiovascular pharmacology

authors： Liu XK,Tosaki A,Engleman RM,Das DK

更新日期：1992-02-01 00:00:00

abstract：:We designed an experimental animal study to study the effects of dopamine (DA) on diastolic function in hypothermia. DA was applied at five incremental infusion rates in 6 sheep during normothermia and moderate hypothermia (29 degrees C). Left ventricular end-diastolic pressure (LVEDP) was increased during hypothermia...

journal_title：Journal of cardiovascular pharmacology

authors： Schröder T,Hering JP,Heidelmeyer CF,Pahl R,Sipinková I,Hellige G

更新日期：1994-05-01 00:00:00

abstract：:In a prospective randomized study, we assessed the electrophysiologic effects and the efficacy of ajmaline versus propafenone in patients with accessory pathways (APs). During initiated atrioventricular (AV) reentrant tachycardia or atrial fibrillation (AF), ajmaline (1 mg/kg as bolus followed by infusion of 15 microg...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Borggrefe M,Martinez-Rubio A,Hief C,Haverkamp W,Hindricks G,Breithardt G

更新日期：1994-10-01 00:00:00

abstract：:Aldosterone is increased in diabetes and contributes to the development of diabetic nephropathy. The authors hypothesized that reduction in aldosterone production in diabetes by amlodipine or aliskiren improves diabetic kidney disease by attenuating renal oxidative stress and fibrosis. Normoglycemic and streptozotocin...

journal_title：Journal of cardiovascular pharmacology

authors： Matavelli LC,Siragy HM

更新日期：2013-01-01 00:00:00

abstract：:Atherosclerosis is an inflammatory response to accumulation of cholesterol in the artery wall. Low-density lipoproteins (LDL) accumulate and are oxidized to proinflammatory compounds in the arterial intima during hypercholesterolemia, leading to activation of endothelial cells, macrophages, and T cells. We sought to d...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Zhou X

更新日期：2007-04-01 00:00:00

abstract：:Abdominal aortic aneurysms (AAA) is a multifactorial vascular disease with a high rate of mortality and brings heavy burden to both human and society. The pathological process behind AAA is complex. Elastin degradation, chronic inflammation, and vascular smooth muscle cell phenotypic modulation are involved in AAA for...

journal_title：Journal of cardiovascular pharmacology

authors： Li D,Ma J,Wang L,Xin S

更新日期：2020-03-01 00:00:00

abstract：:Endothelin (ET)-related peptides robustly stimulated [3H]-inositol phosphate (IP) formation in cultured cerebellar granule cells, astrocytes, and C6 glioma cells. Their agonist selectivities were ET-1 = ET-2 greater than or equal to sarafotoxin S6b greater than ET-3 greater than big ET-1 for granule cells and ET-1 gre...

journal_title：Journal of cardiovascular pharmacology

authors： Chuang DM,Lin WW,Lee CY

更新日期：1991-01-01 00:00:00

abstract：:Our study was designed to investigate the role of resident cardiac mast cells in the cardioprotective effect of ischemic preconditioning. Ischemic/compound 48/80 preconditioning and treatment with compound 48/80, a mast cell degranulator (1 microg/ml), produced cardioprotective and antiarrhythmic effects in isolated p...

journal_title：Journal of cardiovascular pharmacology

authors： Parikh V,Singh M

更新日期：1997-08-01 00:00:00

abstract：:We investigated the effect of apstatin (an aminopeptidase P inhibitor) on bradykinin-induced inositol 1,4,5-triphosphate (IP3) formation and glucose uptake in isolated neonatal rat cardiomyocytes. Apstatin enhanced bradykinin-induced IP3 formation in a dose-dependent manner. We found that 1 microM Hoe 140 (a bradykini...

journal_title：Journal of cardiovascular pharmacology

authors： Kudoh A,Kudoh E,Katagai H,Takazawa T

更新日期：2001-05-01 00:00:00

abstract：:Tetrahydrobiopterin is the reduced unconjugated pterin that serves as an essential cofactor for the normal enzymatic function of the aromatic amino acid hydroxylases and for the nitric oxide synthases (NOS). Its role in the latter biochemistry is being increasing appreciated, as depletion or oxidation of BH4 results i...

journal_title：Journal of cardiovascular pharmacology

authors： Moens AL,Kass DA

更新日期：2007-09-01 00:00:00

abstract：:Cardiovascular medicine is based on high-technology management of end-stage disease. Preventive medicine is preferable but, before magnetic resonance (MR), there was no noninvasive, safe, repeatable method of detecting occlusive vascular disease, which accounts for more deaths than any other disease at a presymptomati...

journal_title：Journal of cardiovascular pharmacology

authors： Longmore D,Forbat S

更新日期：1992-01-01 00:00:00

abstract：:This report summarizes the most important results of 11 studies regarding efficacy and safety of bisoprolol in patients with stable angina pectoris due to coronary heart disease. Assessments carried out 2-3 h after the administration of the beta 1-selective adrenoceptor blocking agent bisoprolol revealed that the dose...

journal_title：Journal of cardiovascular pharmacology

authors： Wagner G

更新日期：1986-01-01 00:00:00

abstract：:The sympathetic drive to the cardiovascular system depends on the integrity of neurons in the medulla oblongata. The adrenergic neurons of the C1-area of the cortical ventrolateral medulla are tonically active and provide the background excitation of the spinal preganglionic neurons, which relay to the postganglionic ...

journal_title：Journal of cardiovascular pharmacology

authors： Reis DJ

更新日期：1985-01-01 00:00:00

abstract：:In view of recent findings on the anatomic heterogeneity of rapid vasodilation via estrogen receptor (ER)-dependent mechanisms, it is obvious that with regard to human physiology and disease much of it is still unknown, and research in this area is urgently needed. This is also important because chronic drug therapy w...

journal_title：Journal of cardiovascular pharmacology

authors： Barton M,Meyer MR,Prossnitz ER

更新日期：2013-07-01 00:00:00

abstract：:Epoxyeicosatrienoic acids, substrates for soluble epoxide hydrolase (sEH), exhibit vasodilatory and antihypertrophic activities. Inhibitors of sEH might therefore hold promise as heart failure therapeutics. We examined the ability of sEH inhibitors GSK2188931 and GSK2256294 to modulate cardiac hypertrophy, fibrosis, a...

journal_title：Journal of cardiovascular pharmacology

authors： Morgan LA,Olzinski AR,Upson JJ,Zhao S,Wang T,Eisennagel SH,Hoang B,Tunstead JR,Marino JP Jr,Willette RN,Jucker BM,Behm DJ

更新日期：2013-04-01 00:00:00

abstract：:To elucidate the role of potassium channel activation in muscarinic inhibition of atrial contractility, we studied the influence of K+ channel blockers on the effects of the muscarinic agonist carbachol in isolated guinea pig auricles. We tested BaCl2, tetraethylammoniumchloride (TEA), and 9-aminotetrahydroacridine (T...

journal_title：Journal of cardiovascular pharmacology

authors： Groschner K,Kukovetz WR

更新日期：1989-10-01 00:00:00

abstract：:Previous studies have suggested the presence of nitric oxide synthase (NOS) enzyme in human platelets. We herein provide definitive evidence for the presence of both endothelial constitutive NOS (ecNOS) and inducible NOS (iNOS) isoforms and their mRNA in human platelets. Total RNA was isolated from human platelets, an...

journal_title：Journal of cardiovascular pharmacology

authors： Chen LY,Mehta JL

更新日期：1996-01-01 00:00:00

abstract：ABSTRACT:The NLRP3 inflammasome has been implicated in the development and progression of heart failure. The aim of this study was to determine the safety of an oral inhibitor of the NLRP3 inflammasome, dapansutrile (OLT1177), in patients with heart failure and reduced ejection fraction (HFrEF). This was a phase 1B, ra...

journal_title：Journal of cardiovascular pharmacology

authors： Wohlford GF,Van Tassell BW,Billingsley HE,Kadariya D,Canada JM,Carbone S,Mihalick VL,Bonaventura A,Vecchié A,Chiabrando JG,Bressi E,Thomas G,Ho AC,Marawan AA,Dell M,Trankle CR,Turlington J,Markley R,Abbate A

更新日期：2020-10-24 00:00:00

abstract：:We determined involvement of nitric oxide (NO) derived from perivascular nerve in venous relaxation. In helical strips of dog superficial temporal veins contracted with prostaglandin F2 alpha (PGF2 alpha) nicotine produced a contraction, which was reversed to a relaxation by prazosin. The relaxation was partially atte...

journal_title：Journal of cardiovascular pharmacology

authors： Toda N,Yoshida K,Okamura T

更新日期：1995-05-01 00:00:00

abstract：:Statins are known to have cholesterol-independent pleiotropic effects, such as upregulation of the enzyme ecto-5'-nucleotidase. These effects may contribute to the protective effect of statins against ischemia and reperfusion (IR). Interestingly, pleiotropic effects have been shown to differ between hydrophilic and li...

journal_title：Journal of cardiovascular pharmacology

authors： Wouters CW,Wever KE,Bronckers I,Hopman MT,Smits P,Thijssen DH,Rongen GA

更新日期：2012-01-01 00:00:00