Hemodynamic response to adenosine infusion before and after coronary artery bypass surgery.

abstract：BACKGROUND:The present study has been designed to investigate the effect of sodium cromoglycate and ketotifen, mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats. METHODS:Rats were administered L-methionine (1.7 g/kg/day PO) for 8 weeks to produce hyperhomocysteinemia. Sodium cromoglycat...

journal_title：Journal of cardiovascular pharmacology

authors： Singh AP,Singh M,Balakumar P

更新日期：2008-06-01 00:00:00

abstract：:The object of this study was to differentiate losartan, an AT1-selective angiotensin II (ANG II) receptor antagonist, from enalapril, an angiotensin-converting enzyme (ACE) inhibitor, by measuring forearm vascular responses to AI, AII, and bradykinin. Eight healthy men were studied in a randomised, 4-period crossover ...

journal_title：Journal of cardiovascular pharmacology

authors： Cockcroft JR,Sciberras DG,Goldberg MR,Ritter JM

更新日期：1993-10-01 00:00:00

abstract：:The complex formed between endothelin (ET) and its binding protein was adequately stable to be separated by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE) at low temperature. Cross-linking was not necessary. This simple method was applied for both qualitative (determination of molecular weight ...

journal_title：Journal of cardiovascular pharmacology

authors： Takasuka T,Satoh N,Horii I,Furuichi Y,Watanabe T

更新日期：1991-01-01 00:00:00

abstract：:Experiments were designed to characterize cardiac alpha-adrenoceptors and the alpha-adrenoceptor-mediated positive inotropic effects in human myocardial tissue from patients with moderate New York Heart Association (NYHA) class II-III and severe (NYHA class IV) heart failure. The number of cardiac alpha-adrenoceptors ...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Feiler G,Kemkes B,Erdmann E

更新日期：1988-09-01 00:00:00

abstract：:Atherosclerosis is an inflammatory response to accumulation of cholesterol in the artery wall. Low-density lipoproteins (LDL) accumulate and are oxidized to proinflammatory compounds in the arterial intima during hypercholesterolemia, leading to activation of endothelial cells, macrophages, and T cells. We sought to d...

journal_title：Journal of cardiovascular pharmacology

authors： Johnston TP,Zhou X

更新日期：2007-04-01 00:00:00

abstract：:The effects of short-term amiodarone and dronedarone treatments on action potential characteristics and arrhythmia (ventricular tachycardia ) induced by reperfusion after global low-flow ischemia were studied in rat hearts. The actions of amiodarone and SR on recovery of coronary flow and contractile function were als...

journal_title：Journal of cardiovascular pharmacology

authors： Rochetaing A,Barbé C,Kreher P

更新日期：2001-10-01 00:00:00

abstract：:The aim of this study was to compare the hemodynamic effects of three nitric oxide (NO) donors [i.e., (+/-)-(E)-ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (FK409), (+/-)-N-[(E)-4-ethyl-3-[(Z)-hydroxyimino]-6-methyl-5-nitro-3-he ptenyl]-3-pyridinecarboxamide (FR 146801) and isosorbide dinitrate (ISDN)] in rats. In...

journal_title：Journal of cardiovascular pharmacology

authors： Kita Y,Hirasawa Y,Kato Y,Ohkubo K,Ohno M,Nishino S,Kato M,Fukuyama S

更新日期：1997-08-01 00:00:00

abstract：:We wished to determine the action of prostaglandins (PG) and to analyze pharmacologically the mechanisms of their action in isolated human uterine arteries in special reference to mediators liberated from the endothelium and subendothelial tissues. Helical strips of the human uterine artery with and without the endoth...

journal_title：Journal of cardiovascular pharmacology

authors： Kimura T,Okamura T,Yoshida Y,Toda N

更新日期：1995-08-01 00:00:00

abstract：:To evaluate the interaction between renal nerves, the atrial natriuretic peptide (ANP), and the renin-angiotensin system (RAS), electrical stimulation of renal nerves was performed in spontaneously hypertensive rats (SHR) and in their normotensive controls, Wistar Kyoto rats (WKY), before and after pharmacologic treat...

journal_title：Journal of cardiovascular pharmacology

authors： Golin R,Protasoni G,Wjinmaalen P,Sala C,Monopoli A,Casati C,Zanchetti A,Stella A

更新日期：1996-11-01 00:00:00

abstract：:Platelet aggregation induced by serotonin in plasma obtained from 9 volunteers was inhibited at 90 min and 15 h after the oral administration of ketanserin, either acutely or after one week of chronic administration. At 7 days after the last dose, a transient overreaction to serotonin occurred. Platelet reactions to e...

journal_title：Journal of cardiovascular pharmacology

authors： De Clerck F,Xhonneux B

更新日期：1985-01-01 00:00:00

abstract：:This study investigated the role of perivascular adipose tissue (PVAT) in the beneficial effects of andrographolide on vascular reactivity in endotoxaemic rats. After being challenged by lipopolysaccharide (4 mg/kg intraperitoneally), the rats were treated with andrographolide (1 mg/kg intraperitoneally). The response...

journal_title：Journal of cardiovascular pharmacology

authors： Hai-Mei L,Song-Yin H,Run-Mei L,Xiao-Huang X,Le-Quan Z,Xiao-Ping L,Jin-Wen X

更新日期：2013-08-01 00:00:00

abstract：:Cardiac endothelial nitric oxide synthase (ecNOS) was suppressed and inducible NOS (iNOS) enhanced at the decompensated heart failure stage in 18-week-old Dahl salt-sensitive (DS) hypertensive rats to which a high-salt diet had been administered from the age of 6 weeks. Nicorandil (NIC) enhanced ecNOS by activating Ad...

journal_title：Journal of cardiovascular pharmacology

authors： Horinaka S,Kobayashi N,Yagi H,Mori Y,Matsuoka H

更新日期：2006-05-01 00:00:00

abstract：:In humans, three endothelin (ET) isoforms are predicted to exist by analysis of genomic DNA. However, evidence for the presence of all three mature ET peptides and their precursors remains unclear. Our aim was to identify the ET isoforms present in human heart, using radioimmunoassay (RIA) and reverse-phase high-perfo...

journal_title：Journal of cardiovascular pharmacology

authors： Plumpton C,Champeney R,Ashby MJ,Kuc RE,Davenport AP

更新日期：1993-01-01 00:00:00

abstract：:We wished to determine whether pharmacologic inhibition of the exaggerated sympathetic nerve activity in congestive heart failure (CHF) could restore the renal response to exogenous atrial natriuretic peptide (ANP) administration. Left ventricular (LV) myocardial infarction was induced in Sprague-Dawley rats (n = 16) ...

journal_title：Journal of cardiovascular pharmacology

authors： Feng QP,Hedner T,Hedner J,Pettersson A

更新日期：1990-11-01 00:00:00

abstract：:Alterations in the function and structure of the blood vessel wall account for most clinical events in the coronary and cerebrovascular circulation such as myocardial infarction and stroke. Cardiovascular drugs may exert beneficial effects on the vascular wall both at the level of the endothelium and vascular smooth m...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Spieker LE,Noll G,Cosentino F

更新日期：2001-12-01 00:00:00

abstract：:In this study the contribution of alternating architecture and Ca2+ handling of mitochondria to cytosolic Ca2+ homeostasis was elucidated under normoglycemic and hyperglycemic (HGC) conditions in the human endothelial cell line EA.hy926. Exposure of endothelial cells to hyperglycemic medium elevated basal cytosolic fr...

journal_title：Journal of cardiovascular pharmacology

authors： Paltauf-Doburzynska J,Malli R,Graier WF

更新日期：2004-10-01 00:00:00

abstract：:Primary pulmonary hypertension continues to be a fatal disease. We have recently demonstrated that long-term inhibition of Rho-kinase, an effector of the small GTPase Rho, is effective for the treatment of pulmonary hypertension (PH) in rats and humans. Prostacyclin has been clinically used for the treatment of PH wit...

journal_title：Journal of cardiovascular pharmacology

authors： Abe K,Morikawa K,Hizume T,Uwatoku T,Oi K,Seto M,Ikegaki I,Asano T,Kaibuchi K,Shimokawa H

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Prostacyclin mimetics are vasodilatory agents used in the treatment of pulmonary arterial hypertension. The direct effects of prostanoids on right-ventricular (RV) function are unknown. We aimed to investigate the direct effects of prostacyclin mimetics on RV function in hearts with and without RV hypertroph...

journal_title：Journal of cardiovascular pharmacology

authors： Holmboe S,Andersen A,Johnsen J,Nielsen JM,Nørregaard R,Bøtker HE,Clapp LH,Nielsen-Kudsk JE

更新日期：2017-01-01 00:00:00

abstract：:Low density lipoprotein (LDL) oxidation plays a crucial role in the development and progression of atherosclerosis and is enhanced in patients with essential hypertension. This finding has stimulated a search for antihypertensive drugs with high intrinsic antioxidant properties. We investigated the antihypertensive an...

journal_title：Journal of cardiovascular pharmacology

authors： Maggi E,Marchesi E,Covini D,Negro C,Perani G,Bellomo G

更新日期：1996-04-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is a particularly useful method for evaluating the effects of antihypertensive drugs. ABPM allows the therapeutic effect of an agent to be assessed continually by a large number of measurements, and the greater number of readings contributes to the higher degree of reproduci...

journal_title：Journal of cardiovascular pharmacology

authors： Mallion JM,Baguet JP,Boutelant S,Tremel F,Siché JP,de Gaudemaris R

更新日期：1995-01-01 00:00:00

abstract：:The ongoing COVID-19 pandemic has produced serious turmoil world-wide. Lung injury causing acute respiratory distress syndrome seems to be a most dreaded complication occurring in ∼30%. Older patients with cardiovascular comorbidities and acute respiratory distress syndrome have an increased mortality. Although the pr...

journal_title：Journal of cardiovascular pharmacology

authors： Manolis AS,Manolis TA,Manolis AA,Melita H

更新日期：2020-10-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive disease of the pulmonary vasculature characterized by elevated pulmonary artery pressure. Currently, there is no cure for this disease, and treatment is palliative. PAH therapies target 3 main pathways: prostacyclin, endothelin, and nitric oxide. The 3 distinct th...

journal_title：Journal of cardiovascular pharmacology

authors： Gokhman R,Smithburger PL,Kane-Gill SL,Seybert AL

更新日期：2010-12-01 00:00:00

abstract：:Three consecutive periods in the natural history of atherosclerosis are amenable to medical treatment. Plaque development is the main target of prevention, which also aims at slowing the progression of already existing plaques. The control of several established risk factors (high blood cholesterol, high blood pressur...

journal_title：Journal of cardiovascular pharmacology

authors： Capron L

更新日期：1995-01-01 00:00:00

abstract：:Foods and beverages rich in flavonoids are being heralded as potential preventive agents for a range of pathologic conditions, ranging from hypertension to coronary heart disease to stroke and dementia. We and others have demonstrated that short-term ingestion of cocoa, particularly rich in the subclass of flavonoids ...

journal_title：Journal of cardiovascular pharmacology

authors： Fisher ND,Sorond FA,Hollenberg NK

更新日期：2006-01-01 00:00:00

abstract：SUMMARY:The present study reports the effects of apomorphine (APO) on blood pressure and the principal site of action of this agonist in 4-week deoxycorticosterone-acetate (DOCA)-hypertensive conscious rats. In these preprations, intravenous (i.v.) administration of APO (0.50-1 mg/kg) induced short-lasting and dose-dep...

journal_title：Journal of cardiovascular pharmacology

authors： Toscano CF,Lahlou S

更新日期：2003-12-01 00:00:00

abstract：:Several antiarrhythmic agents with Na-channel blocking action have been shown to inhibit cardiac K(ATP) channels. We used cibenzoline to examine its precise target site using patch-clamp techniques and receptor binding assays in guinea-pig ventricular myocytes. Exposure of myocytes to a glucose-free perfusate containi...

journal_title：Journal of cardiovascular pharmacology

authors： Horie M,Watanuki M,Tsuji K,Ishida H,Ishida-Takahashi A,Yuzuki Y,Seino Y,Sasayama S

更新日期：2000-03-01 00:00:00

abstract：:A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell a...

journal_title：Journal of cardiovascular pharmacology

authors： Anavekar SN,Christophidis N,Louis WJ,Doyle AE

更新日期：1981-03-01 00:00:00

abstract：:In a prospective randomized study, we assessed the electrophysiologic effects and the efficacy of ajmaline versus propafenone in patients with accessory pathways (APs). During initiated atrioventricular (AV) reentrant tachycardia or atrial fibrillation (AF), ajmaline (1 mg/kg as bolus followed by infusion of 15 microg...

journal_title：Journal of cardiovascular pharmacology

authors： Chen X,Borggrefe M,Martinez-Rubio A,Hief C,Haverkamp W,Hindricks G,Breithardt G

更新日期：1994-10-01 00:00:00

abstract：:The effects of cibenzoline were examined in the dog with multifocal ventricular arrhythmias 24 h after ligation of the left anterior descending coronary artery, and on isolated, superfused canine cardiac tissues which were studied using standard microelectrode techniques. In the intact dog, 5 mg/kg cibenzoline consist...

journal_title：Journal of cardiovascular pharmacology

authors： Dangman KH

更新日期：1984-03-01 00:00:00

abstract：:A number of studies using endothelin (ET) precursors, commonly termed big ETs, have revealed the presence of endothelin-converting enzyme (ECE) activity in various vascular and nonvascular preparations. Since then, more than one ECE has been cloned. It has also been observed that big ET-1 and big ET-3 are not converte...

journal_title：Journal of cardiovascular pharmacology

authors： Rizzi A,Calo G,Battistini B,Regoli D

更新日期：1998-01-01 00:00:00