Andrographolide protects against lipopolysaccharide-induced vascular hyporeactivity by suppressing the expression of inducible nitric oxide in periaortic adipose.

abstract：:Endothelin (ET) receptor subtypes in human prostate with benign prostatic hyperplasia were investigated by binding and functional studies. In the displacement experiment, LU224332 [endothelin-A/-B (ET(A)/ET(B)) nonselective antagonist] competed for [125I]ET-1 binding with a monophasic curve. On the other hand, LU13525...

journal_title：Journal of cardiovascular pharmacology

authors： Hiraoka Y,Oshita M,Morikawa K,Nagata O,Hahn KJ,Hahn A,Okada K,Taniguchi T,Muramatsu I

更新日期：2000-11-01 00:00:00

abstract：:The clinical pharmacokinetics and pharmacodynamics of enalapril and its de-esterified active metabolite, MK 422, were determined in eight patients with congestive cardiomyopathy and five patients with hypertension. After administration of single doses of 2.5, 5, and 10 mg enalapril in the congestive heart failure pati...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JB,Taylor A,Abernethy D,O'Meara M,Farmer J,Young J,Nelson E,Pool J,Mitchell JR

更新日期：1985-07-01 00:00:00

abstract：:The distribution of 3H-digoxin has been measured in a large number of tissues from the central, autonomic, and peripheral nervous system after the induction of ventricular tachycardia by infusing digoxin into anesthetized dogs. In most parts of the nervous system the tissue digoxin concentration was close to that in t...

journal_title：Journal of cardiovascular pharmacology

authors： Frazer G,Binnion P

更新日期：1981-11-01 00:00:00

abstract：:The effect of olmesartan medoxomil (OLM), an angiotensin II receptor blocker (ARB), on advanced nephropathy and mortality was evaluated in Zucker Diabetic Fatty (ZDF) rats, a type 2 diabetes model. OLM was administered from 36 weeks of age, when the animals developed advanced proteinuria. OLM effectively suppressed th...

journal_title：Journal of cardiovascular pharmacology

authors： Mizuno M,Sada T,Kato M,Fukushima Y,Terashima H,Koike H

更新日期：2006-10-01 00:00:00

abstract：:The degree of cardiac and vascular beta-adrenoceptor blockade of bisoprolol and atenolol was determined by the chronotropic dose 25 (CD25) of isoproterenol (the dose of an intravenous isoproterenol bolus required to increase resting heart rate by 25 beats/min) and by the increase in forearm blood flow (venous occlusio...

journal_title：Journal of cardiovascular pharmacology

authors： Bolli P,Müller FB,Linder L,Ji BH,Bühler FR

更新日期：1986-01-01 00:00:00

abstract：:The elimination of an acute oral saline load is markedly blunted in adult Sabra hypertension-prone (SBH) rats compared with hypertension-resistant Sabra normotensive (SBN) rats. Within 2 h, urinary output and the excretion of sodium and potassium are significantly reduced, while urine osmolality is markedly elevated i...

journal_title：Journal of cardiovascular pharmacology

authors： Mekler J,Ben-Ishay D,Garthoff B,Kazda S

更新日期：1987-01-01 00:00:00

abstract：:Besides generating renal damage, hypertension plays an important role in the progression of diabetic nephropathy. The fructose-fed rat is a well-established model both of high blood pressure and renal impairment, which is similar to diabetic nephropathy. To clarify the relationship between hypertension, glucose metabo...

journal_title：Journal of cardiovascular pharmacology

authors： Bernobich E,Cosenzi A,Campa C,Zennaro C,Sasso F,Paoletti S,Bellini G

更新日期：2004-09-01 00:00:00

abstract：:To investigate the effects of endothelin blockade initiated immediately after the onset of myocardial infarction on survival and left ventricular remodeling, treatment with the nonselective receptor antagonist TAK-044 (n = 22) or saline (n = 19) for 3 weeks was initiated immediately after coronary ligation in rats. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi C,Kagaya Y,Namiuchi S,Takeda M,Fukuchi M,Otani H,Ninomiya M,Yamane Y,Kohzuki M,Watanabe J,Shirato K

更新日期：2001-07-01 00:00:00

abstract：:Fourteen patients with mild to moderate essential hypertension were randomized, after a baseline placebo period of 4 weeks, to receive the angiotensin converting enzyme (ACE) inhibitor quinapril or a placebo. During a 12 week, double-blind phase, the dosage of quinapril was increased from 10 to 40 mg twice daily being...

journal_title：Journal of cardiovascular pharmacology

authors： Säynävälammi P,Pörsti I,Pörsti P,Nurmi AK,Seppälä E,Manninen V,Vapaatalo H

更新日期：1988-07-01 00:00:00

abstract：:The ongoing COVID-19 pandemic has produced serious turmoil world-wide. Lung injury causing acute respiratory distress syndrome seems to be a most dreaded complication occurring in ∼30%. Older patients with cardiovascular comorbidities and acute respiratory distress syndrome have an increased mortality. Although the pr...

journal_title：Journal of cardiovascular pharmacology

authors： Manolis AS,Manolis TA,Manolis AA,Melita H

更新日期：2020-10-01 00:00:00

abstract：:Long-term effects of antihypertensive treatment on various electrocardiogram (ECG) voltages and the association between ECG findings at randomization and subsequent mortality were evaluated in the double-blind, placebo-controlled trial of elderly hypertensive patients, conducted by the European Working Party on High B...

journal_title：Journal of cardiovascular pharmacology

authors： Van Hoof R,Staessen J,Fagard R,Thijs L,Amery A

更新日期：1991-01-01 00:00:00

abstract：:Acute angiotensin-converting enzyme inhibitors (ACEIs) have been found to induce natriuresis in humans as well as in experimental animals. However, the tubular sites involved have not been precisely evaluated in humans. Using both free-water and lithium clearance, the latter as a marker of proximal tubular reabsorptio...

journal_title：Journal of cardiovascular pharmacology

authors： Hannedouche T,Delgado A,Gnionsahe A,Lacour B,Grunfeld JP

更新日期：1989-01-01 00:00:00

abstract：:Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

journal_title：Journal of cardiovascular pharmacology

authors： Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

更新日期：2018-10-01 00:00:00

abstract：:The effects of bufuralol and its carbinol metabolite have been compared with those of propranolol in the anaesthetised and conscious cat and dog. Bufuralol and its carbinol metabolite are nonselective beta-adrenoceptor antagonists; the former has equivalent potency to propranolol, whereas the latter is six times more ...

journal_title：Journal of cardiovascular pharmacology

authors： Blaber LC,Burden DT,Eigenmann R,Gerold M

更新日期：1984-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) has been proven to activate two types of Ca2+-permeable nonselective cation channels (designated NSCC-1 and NSCC-2) and a store-operated Ca2+ channel (SOCC) in rabbit internal carotid artery vascular smooth muscle cells (ICA VSMCs). Ca2+ influx through these channels plays an essential role for ET-...

journal_title：Journal of cardiovascular pharmacology

authors： Kawanabe Y,Hashimoto N,Masaki T

更新日期：2002-08-01 00:00:00

abstract：:To investigate the effects of ramipril, a new angiotensin converting enzyme inhibitor, on autonomic function, autonomic function tests were performed in eight healthy male subjects, aged 22-26 years, after single oral administration of 5 mg of ramipril or placebo, in a randomized, double-blind, crossover design. Measu...

journal_title：Journal of cardiovascular pharmacology

authors： Sugimoto K,Kumagai Y,Tateishi T,Seguchi H,Ebihara A

更新日期：1989-01-01 00:00:00

abstract：:The object of this study was to differentiate losartan, an AT1-selective angiotensin II (ANG II) receptor antagonist, from enalapril, an angiotensin-converting enzyme (ACE) inhibitor, by measuring forearm vascular responses to AI, AII, and bradykinin. Eight healthy men were studied in a randomised, 4-period crossover ...

journal_title：Journal of cardiovascular pharmacology

authors： Cockcroft JR,Sciberras DG,Goldberg MR,Ritter JM

更新日期：1993-10-01 00:00:00

abstract：:Nebivolol is a highly selective and lipophilic beta1-adrenergic receptor antagonist with vasodilating characteristics attributed mainly to endothelial generation of nitric oxide (NO). Coincidently, rapid vascular vasodilating effects of estradiol are also widely reported and membrane-initiated signaling by estrogen re...

journal_title：Journal of cardiovascular pharmacology

authors： Garbán HJ,Buga GM,Ignarro LJ

更新日期：2004-05-01 00:00:00

abstract：:The pressor responses to selective alpha 1-adrenoceptor agonists (cirazoline and methoxamine) and to alpha 2-adrenoceptor agonists (UK-14,304 and B-HT 933) were investigated in pithed, streptozotocin-induced diabetic rats and age-matched control animals. Three months after induction of diabetes, the basal values of di...

journal_title：Journal of cardiovascular pharmacology

authors： Heijnis JB,Mathy MJ,Pfaffendorf M,van Zwieten PA

更新日期：1992-10-01 00:00:00

abstract：:Calcium channel blockade appears to be at least as effective as beta-blockade in the treatment of anginal syndromes, but whether a similar protective effect is afforded against sudden death is unknown. In order to compare experimental antifibrillatory effects of calcium channel blockade (diltiazem), beta-adrenoceptor ...

journal_title：Journal of cardiovascular pharmacology

authors： Anastasiou-Nana M,Nanas J,Menlove RL,Anderson JL

更新日期：1984-09-01 00:00:00

abstract：:We examined the electromechanical effects of two class III antiarrhythmic agents, dofetilide (UK-68,798) and D-sotalol, in acidic myocardium. Right ventricular papillary muscle preparations isolated from guinea pigs were divided into three groups (n = 6 per group): (a) drug-free, (b) dofetilide (10 nM), and (c) D-sota...

journal_title：Journal of cardiovascular pharmacology

authors： Yang T,Tande PM,Refsum H

更新日期：1992-12-01 00:00:00

abstract：:This study examined the effect of Vitis vinifera grape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg·kg·d ACH09 orally); HF (24% fat); HF+ AC...

journal_title：Journal of cardiovascular pharmacology

authors： Emiliano AF,de Cavalho LC,da Silva Cristino Cordeiro V,da Costa CA,de Oliveira PB,Queiroz EF,Col Moreira DD,Boaventura GT,de Moura RS,Resende AC

更新日期：2011-09-01 00:00:00

abstract：:We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production an...

journal_title：Journal of cardiovascular pharmacology

authors： Kim YD,Farhat MY,Myers AK,Kouretas P,DeGroot KW,Pacquing A,Ramwell PW,Suyderhoud JP,Lees DE

更新日期：1998-09-01 00:00:00

abstract：:Aldosterone is increased in diabetes and contributes to the development of diabetic nephropathy. The authors hypothesized that reduction in aldosterone production in diabetes by amlodipine or aliskiren improves diabetic kidney disease by attenuating renal oxidative stress and fibrosis. Normoglycemic and streptozotocin...

journal_title：Journal of cardiovascular pharmacology

authors： Matavelli LC,Siragy HM

更新日期：2013-01-01 00:00:00

abstract：:The effects of dopamine on the force of contraction and on cylic adenosine monophosphate (AMP) levels were investigated in isolated electrically driven left atria (32 degrees C, 1 Hz) and papillary muscles (37 degrees C, 0.5 Hz) of the rabbit. In both preparations only the combined application of phentolamine (10(-6) ...

journal_title：Journal of cardiovascular pharmacology

authors： Brodde OE,Inui J,Motomura S,Schümann HJ

更新日期：1980-09-01 00:00:00

abstract：:The actions of prostacyclin and its synthetic analog iloprost on the release and action of platelet-derived serotonin (5-HT) and thromboxane (TX) A2 were studied in vitro. Washed human platelet suspensions (WPS) (4 X 10(8) platelets/ml) were stimulated with arachidonic acid (AA) (30 mumol/L) and the incubate transferr...

journal_title：Journal of cardiovascular pharmacology

authors： Schrör K,Verheggen R

更新日期：1986-05-01 00:00:00

abstract：:BMY 20064 is a dihydropyridine Ca2+ entry blocker with potent and selective alpha 1-adrenoceptor antagonist properties. The drug was equal in potency to nifedipine as a Ca2+ entry blocker in depolarized smooth muscle preparations. It was less active than nifedipine in antagonizing Ca2+-induced contractions of isolated...

journal_title：Journal of cardiovascular pharmacology

authors： Stanton HC,Rosenberger LB,Hanson RC,Fleming JS,Poindexter GS

更新日期：1988-04-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) crosses the blood-brain barrier when administered intravenously and accumulates in the brain. In this study, we investigated whether CoQ10 protects against ischemia-reperfusion injury by measuring neurological function and brain infarct volumes in a rat model of transient focal cerebral ischemia. ...

journal_title：Journal of cardiovascular pharmacology

authors： Belousova M,Tokareva OG,Gorodetskaya E,Kalenikova EI,Medvedev OS

更新日期：2016-02-01 00:00:00

abstract：:The pathogenic mechanism of nicotine, a major product of smoking, on vascular endothelial cells is not well defined yet. The purpose of this study was to determine whether chronic exposure to nicotine alters angiogenic activity in human umbilical vein endothelial cells and to identify a potential role for endothelial ...

journal_title：Journal of cardiovascular pharmacology

authors： Park HS,Cho K,Park YJ,Lee T

更新日期：2011-03-01 00:00:00

abstract：:Lisinopril (LIS) is a lysine analog of enalaprilat, the active metabolite of enalapril, an angiotensin-converting enzyme inhibitor (ACEI). Unlike enalapril, the precursor of enalaprilat, LIS is not a prodrug but has equal ACEI efficacy and potency and a slightly longer duration of action after oral administration. Sho...

journal_title：Journal of cardiovascular pharmacology

authors： Pool JL,Gennari J,Goldstein R,Kochar MS,Lewin AJ,Maxwell MH,McChesney JA,Mehta J,Nash DT,Nelson EB

更新日期：1987-01-01 00:00:00