Diltiazem inhibits the late increase in extracellular potassium by maintaining glycolytic ATP synthesis during myocardial ischemia.

abstract：:We designed an experimental animal study to study the effects of dopamine (DA) on diastolic function in hypothermia. DA was applied at five incremental infusion rates in 6 sheep during normothermia and moderate hypothermia (29 degrees C). Left ventricular end-diastolic pressure (LVEDP) was increased during hypothermia...

journal_title：Journal of cardiovascular pharmacology

authors： Schröder T,Hering JP,Heidelmeyer CF,Pahl R,Sipinková I,Hellige G

更新日期：1994-05-01 00:00:00

abstract：:The aim of the study was to compare the effects of atenolol (50 mg b.i.d.), verapamil (80 mg b.i.d.), xamoterol (200 mg b.i.d.), and matching placebo on heart rate (HR) and exercise tolerance in digitalised patients with chronic atrial fibrillation. Each treatment was taken for 4 weeks, and digoxin was continued throu...

journal_title：Journal of cardiovascular pharmacology

authors： Lewis RV,McMurray J,McDevitt DG

更新日期：1989-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of candesartan on arterial baroreflex sensitivity (BRS) and sympathetic activity in patients with mild heart failure (HF). Arterial pressure, heart rate, plasma renin activity, plasma angiotensin II and noradrenaline, and muscle sympathetic nerve activity (MSNA)...

journal_title：Journal of cardiovascular pharmacology

authors： Hikosaka M,Yuasa F,Yuyama R,Mimura J,Kawamura A,Motohiro M,Iwasaki M,Sugiura T,Iwasaka T

更新日期：2002-12-01 00:00:00

abstract：:Severe pulmonary arterial hypertension (PAH) is characterized by clustered proliferation of endothelial cells (ECs) in the lumina of small size pulmonary arteries resulting in concentric obliteration of the lumina and formation of complex vascular structures known as plexiform lesions. This debilitating disease occurs...

journal_title：Journal of cardiovascular pharmacology

authors： Tofovic SP

更新日期：2010-12-01 00:00:00

abstract：:Oxidative stress is believed to play a role in diabetes-induced vascular complications. In this study, we tested whether chronic treatment with a known hydroxyl radical scavenger, dimethylthiourea (DMTU), could prevent endothelial dysfunction in diabetes. Lewis strain rats were made diabetic by an intravenous injectio...

journal_title：Journal of cardiovascular pharmacology

authors： Pieper GM,Siebeneich W,Roza AM,Jordan M,Adams MB

更新日期：1996-12-01 00:00:00

abstract：:This selective review of a few of the advances made in recent years indicates that we are entering a new era in cardiovascular pharmacology. Drugs with novel mechanisms of action, and modifications of existing drugs, are being developed in constantly increasing numbers. The clinical evaluation of these drugs will be a...

journal_title：Journal of cardiovascular pharmacology

authors： Goldberg LI

更新日期：1984-01-01 00:00:00

abstract：:Epidemiological studies indicate that there are biological interrelationships between blood pressure and blood lipids that may influence the mechanisms whereby hypertension is associated with an increased risk of coronary artery disease. Serotonin (5-HT) and thromboxane A2, which are released from aggregating platelet...

journal_title：Journal of cardiovascular pharmacology

authors： Fetkovska N

更新日期：1992-01-01 00:00:00

abstract：:We investigated the effects of a newly synthesized dihydropyridine (DHP) derivative (NZ-105) on intracellular Ca transients and contraction in ferret ventricular muscles, using the aequorin method. Low concentrations of NZ-105 (10(-9)-10(-7) M) showed no significant effects on the light signal of aequorin and tension ...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara S,Hongo K,Tanaka T,Tanaka E

更新日期：1994-08-01 00:00:00

abstract：:In humans, three endothelin (ET) isoforms are predicted to exist by analysis of genomic DNA. However, evidence for the presence of all three mature ET peptides and their precursors remains unclear. Our aim was to identify the ET isoforms present in human heart, using radioimmunoassay (RIA) and reverse-phase high-perfo...

journal_title：Journal of cardiovascular pharmacology

authors： Plumpton C,Champeney R,Ashby MJ,Kuc RE,Davenport AP

更新日期：1993-01-01 00:00:00

abstract：:Inhibition of plasma angiotensin II generation does not fully explain the chronic hypotensive effects of angiotensin-converting enzyme (ACE) inhibitors. Therefore, the pattern of tissue ACE inhibition in rats was studied after oral administration of perindopril, a new ACE inhibitor. Tissue ACE was measured by quantita...

journal_title：Journal of cardiovascular pharmacology

authors： Sakaguchi K,Jackson B,Chai SY,Mendelsohn FA,Johnson CI

更新日期：1988-12-01 00:00:00

abstract：:Effects of diltiazem on coronary vascular functional integrity were assessed in isolated rabbit hearts during reperfusion after 30 min of global, no-flow ischemia. External detection of radiolabeled albumin, [125I]bovine serum albumin ([125I]BSA), and compartmental-model analysis were used to estimate the mean transit...

journal_title：Journal of cardiovascular pharmacology

authors： Tilton RG,Williamson EK,Cole PA,Larson KB,Kilo C,Williamson JR

更新日期：1985-05-01 00:00:00

abstract：:Amylin is a 37-amino acid peptide that shares considerable homology with calcitonin gene-related peptide (CGRP). Both peptides exert glycoregulatory actions and produce vasodilation of the cardiovascular system. We wished to determine if amylin exerts vasodilatory action in the perfused mesenteric arterial bed in a ma...

journal_title：Journal of cardiovascular pharmacology

authors： Westfall TC,Curfman-Falvey M

更新日期：1995-12-01 00:00:00

abstract：:The ongoing COVID-19 pandemic has produced serious turmoil world-wide. Lung injury causing acute respiratory distress syndrome seems to be a most dreaded complication occurring in ∼30%. Older patients with cardiovascular comorbidities and acute respiratory distress syndrome have an increased mortality. Although the pr...

journal_title：Journal of cardiovascular pharmacology

authors： Manolis AS,Manolis TA,Manolis AA,Melita H

更新日期：2020-10-01 00:00:00

abstract：:The in vivo vasoconstrictor effect of endothelin-1 (ET-1) was investigated on feline and canine basilar arteries. The basilar artery caliber was angiographically measured after either vertebral artery perfusion or cisternal injection of the peptide. In both cats and dogs, ET-1 (5-500 pmol) induced a dose-dependent bas...

journal_title：Journal of cardiovascular pharmacology

authors： Shigeno T,Mima T,Takakura K,Yanagisawa M,Saito A,Goto K,Masaki T

更新日期：1989-01-01 00:00:00

abstract：:Pinacidil is one of a number of new antihypertensive agents possessing an action that involves an enhanced potassium efflux in cardiac and vascular smooth muscle. An associated feature of pinacidil is a shortening of the cardiac action potential duration, which may constitute a potentially proarrhythmic effect. The pr...

journal_title：Journal of cardiovascular pharmacology

authors： Chi L,Uprichard AC,Lucchesi BR

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:A cause-effect relationship has been established between MMP activation and left ventricular (LV) remodeling following myocardial infarction. The goal of the present study was to examine a selective MMP inhibitor (sMMPi) strategy that effectively spared MMP-1, -3, and -7 with effect to regional and global le...

journal_title：Journal of cardiovascular pharmacology

authors： Apple KA,Yarbrough WM,Mukherjee R,Deschamps AM,Escobar PG,Mingoia JT,Sample JA,Hendrick JW,Dowdy KB,McLean JE,Stroud RE,O'Neill TP,Spinale FG

更新日期：2006-02-01 00:00:00

abstract：:The pharmacologic properties of a novel nonpeptide endothelin (ET) receptor antagonist, S-1255 ([R]-[+]-2-[benzo(1,3)dioxol-5-yl]-6-isopropyl-4-[4-methoxyphenyl]-2H-chromene-3-carboxylic acid), was studied. [3H]S-1255 specifically bound to porcine aortic smooth muscle membranes expressing only ET(A) receptors with a K...

journal_title：Journal of cardiovascular pharmacology

authors： Iwasaki T,Mihara S,Shimamura T,Kawakami M,Masui M,Hayasaki-Kajiwara Y,Naya N,Ninomiya M,Fujimoto M,Nakajima M

更新日期：2001-04-01 00:00:00

abstract：:The pharmacological characterization of a nonpeptide endothelin (ET)-receptor antagonist, PABSA [(R)-(--)-2-(benzo[1,3]dioxol-5-yl)-N-(4-isopropyl-phenylsulfon yl)-2-(6-methyl-2-propylpyridin-3-yloxy)-acetamide hydrochloride] was studied. PABSA competitively inhibited the binding of [125I]-ET-1 to A7r5 cells expressin...

journal_title：Journal of cardiovascular pharmacology

authors： Iwasaki T,Mihara S,Shimamura T,Kawakami M,Hayasaki-Kajiwara Y,Naya N,Fujimoto M,Nakajima M

更新日期：1999-07-01 00:00:00

abstract：:We studied the influence of prostacyclin (PGI2) on the contractile performance of isolated mammalian ventricular muscle. PGI2 had no direct influence on myocardial contractility, as evidenced by experiments on single cardiac cells and papillary muscle. Moreover, PGI2 did not interfere with the inotropic action of isop...

journal_title：Journal of cardiovascular pharmacology

authors： Couttenye MM,De Clerck NM,Herman AG,Brutsaert DL

更新日期：1985-09-01 00:00:00

abstract：:To evaluate whether the combination of nifedipine with chlorthalidone exerts an additive antihypertensive effect when compared to single-drug treatment, 66 uncomplicated essential hypertensives, whose diastolic blood pressure was greater than 100 and less than 115 mm Hg at the end of a 1-month washout placebo period, ...

journal_title：Journal of cardiovascular pharmacology

authors： Salvetti A,Magagna A,Innocenti P,Ponzanelli F,Cagianelli A,Cipriani M,Gandolfi E,Del Prato C,Ballestra AM,Saba P

更新日期：1991-02-01 00:00:00

abstract：:When the cervical vagus nerve is briefly stimulated, a triphasic cardiac chronotropic response ensues: the cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. Verapamil, a calcium channel blocker, alters these responses to acetylcholine when the heart is in sinoatrial no...

journal_title：Journal of cardiovascular pharmacology

authors： Wallick DW,Stuesse SL,Crafford W

更新日期：1988-07-01 00:00:00

abstract：:At present, endothelin (ET) receptor classification remains controversial. We investigated the presence of atypical ETA receptors in human saphenous veins (SV). Human SV was obtained from 24 patients undergoing coronary artery bypass grafting. Vessels were set up in organ baths, stretched to a tension of 6 g, and left...

journal_title：Journal of cardiovascular pharmacology

authors： Pate MA,Chester AH,Brown TJ,Roach AG,Yacoub MH

更新日期：1998-01-01 00:00:00

abstract：:In this report, alterations between the electrical and mechanical responses of isolated neonatal and adult canine ventricular muscle preparations before and after ouabain exposure are described. No significant differences were observed between the two age groups in the concentration-dependent effects of ouabain on inc...

journal_title：Journal of cardiovascular pharmacology

authors： Lathrop DA,Varró A,Gaum WE,Kaplan S

更新日期：1989-11-01 00:00:00

abstract：:Acute exposure of human saphenous vein or internal thoracic artery endothelium to either morphine [27.4 +/- 3.7 and 35.4 +/- 4.1 nM nitric oxide (NO), respectively] or anandamide (18.3 +/- 2.2 and 24.3 +/- 3.0 nM, respectively) results in NO release, whereas exposure to the human immunodeficiency virus envelope protei...

journal_title：Journal of cardiovascular pharmacology

authors： Stefano GB,Salzet M,Bilfinger TV

更新日期：1998-06-01 00:00:00

abstract：:This study examined whether the adenosine potentiator, 5-aminoimidazole-4-carboxamide riboside (AICAr), could limit tissue necrosis during acute myocardial infarction in rabbit hearts with minimal coronary collateral flow. Forty-four rabbits underwent 45 min of ischemia with or without coronary reperfusion for 180 min...

journal_title：Journal of cardiovascular pharmacology

authors： Dorion M,Rouleau J,Kingma JG Jr

更新日期：1992-01-01 00:00:00

abstract：:Adenosine protects the ischemic myocardium by coronary vasodilation and the depression of heart rate and contractility, improving myocardial energy balance. Adenosine effects on the myocardium are mediated predominantly by the type A1 receptors. Atrial natriuretic peptide (ANP), a vasodilator and regulator of blood vo...

journal_title：Journal of cardiovascular pharmacology

authors： Salman H,Bergman M,Schlesinger H,Zahavi I,Kessler-Icekson G

更新日期：1999-07-01 00:00:00

abstract：:Doxorubicin (DOX), a potent antineoplastic agent, poses limitations for its therapeutic use due to the associated risk of developing cardiomyopathy and congestive heart failure. The cardiotoxicity of doxorubicin is associated with oxidative stress and apoptosis. We have recently shown that Spirulina, a blue-green alga...

journal_title：Journal of cardiovascular pharmacology

authors： Khan M,Varadharaj S,Shobha JC,Naidu MU,Parinandi NL,Kutala VK,Kuppusamy P

更新日期：2006-01-01 00:00:00

abstract：:The exact mechanism of mechano-electrical feedback and stretch-induced arrhythmias is unknown, but the role of stretch-activated ion channels and specific calcium channels has been proposed. The aim of the present study was to test the hypothesis that stretch-activated ion channels and not calcium channels contribute ...

journal_title：Journal of cardiovascular pharmacology

authors： Eckardt L,Kirchhof P,Mönnig G,Breithardt G,Borggrefe M,Haverkamp W

更新日期：2000-12-01 00:00:00

abstract：:Populations with a high sodium intake have a high prevalence of hypertension and a high mortality and morbidity due to cerebrovascular disease. Within populations, however, it is very difficult to demonstrate a significant correlation between sodium intake and blood pressure. Experimental evidence exists demonstrating...

journal_title：Journal of cardiovascular pharmacology

authors： Kesteloot H

更新日期：1984-01-01 00:00:00

abstract：:The formation of bone occurs via a series of events that are regulated by various hormones and cytokines. We previously reported that endothelin (ET) inhibits the mineralization by osteoblastic cells and natriuretic peptide (NP) promotes osteoblastic differentiation. Therefore, we attempted to identify the genes induc...

journal_title：Journal of cardiovascular pharmacology

authors： Inoue A,Kamiya A,Ishiji A,Hiruma Y,Hirose S,Hagiwara H

更新日期：2000-11-01 00:00:00