Verapamil potentiates vagally mediated atrioventricular chronotropic responses in dogs.


:When the cervical vagus nerve is briefly stimulated, a triphasic cardiac chronotropic response ensues: the cardiac cycle length initially increases, then briefly decreases, and subsequently increases again. Verapamil, a calcium channel blocker, alters these responses to acetylcholine when the heart is in sinoatrial nodal rhythm. We investigated whether verapamil has a similar effect on parasympathetic modulation of the cardiac cycle when the heart is in atrioventricular rhythm. Atrioventricular rhythm was induced in anesthetized, open-chest dogs by infusion of sodium pentobarbital into the sinoatrial nodal artery. Verapamil was administered by bolus injection through a femoral vein. Verapamil accentuated the initial lengthening of the cardiac cycle by approximately 55% (from 301 to 466 ms). The acceleratory phase of this triphasic response and the secondary cardioinhibition were not significantly affected by verapamil. Thus, the initial action of acetylcholine at the atrioventricular node is potentiated by verapamil when the vagus is activated with brief stimuli.


J Cardiovasc Pharmacol


Wallick DW,Stuesse SL,Crafford W




Has Abstract


1988-07-01 00:00:00












  • Pressure natriuresis and long-term blood pressure control.

    abstract::The relationship between arterial pressure and the rate of Na+ excretion is regulated by a number of mechanisms- some well known, some newly discovered, and probably some yet to be discovered. These mechanisms affect either the amount of Na+ filtered at the glomerulus or its rate of reabsorption from the proximal or d...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Anderson WP,Evans RG,Malpas SC

    更新日期:1995-01-01 00:00:00

  • Effects of alcohol on isoproterenol-induced ventricular fibrillation in adult rats.

    abstract::To determine whether the pattern of alcohol consumption, intake, and withdrawal modulates the incidence of malignant ventricular arrhythmias and sudden cardiac death due to beta-adrenergic stimulation in a species susceptible to administration of isoproterenol alone, a regimen was formulated in which both continuous a...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Guideri G,Gutstein WH,Olivetti G,Anversa P

    更新日期:1988-10-01 00:00:00

  • A potent noncompetitive angiotensin II antagonist induces only competitive inhibition of angiotensin III responses.

    abstract::Sarcosyl1, cysteinyl-S-methyl8-angiotensin II [(Sar1, Cys-Me8) Ang II] was examined for antagonism of angiotensin (Ang) responses in isolated rabbit atrial and aortic tissues. (Sar1, Cys-Me8) Ang II competitively antagonized Ang II responses in aorta at a concentration of 5 nM. Concentrations of the antagonist greater...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Trachte GJ,Peach MJ

    更新日期:1983-11-01 00:00:00

  • Baroreflex control of heart rate and renin release in SHR following administration of felodipine, an antihypertensive Ca2+ antagonist.

    abstract::Baroreflex control of renin release following acute and prolonged blood pressure reduction by felodipine administration was investigated in conscious spontaneously hypertensive rats (SHR) fitted with arterial and venous catheters. Basal values of mean arterial pressure (MAP), heart rate (HR), and plasma renin activity...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Nordlander M,Horton R,Thalén P

    更新日期:1987-01-01 00:00:00

  • Electrophysiologic effects of a class I antiarrhythmic agent, cibenzoline, on the refractoriness and conduction of the human atrium in vivo.

    abstract::We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章


    authors: Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

    更新日期:1996-08-01 00:00:00

  • Electrophysiological effects of bethanidine sulfate on canine cardiac Purkinje fibers and ventricular muscle cells.

    abstract::Bethanidine sulfate is a congener of bretylium tosylate, which has been reported to have antiarrhythmic and antifibrillatory effects. We studied the effects of bethanidine on transmembrane potentials recorded from canine Purkinje fibers and ventricular muscle cells, using standard microelectrode techniques. Normal Pur...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Dangman KH,Miura DS

    更新日期:1985-01-01 00:00:00

  • Comparative study on the in vitro and in vivo activities of heparinoids derivative investigated on the animal model.

    abstract::In this study we compared the antithrombotic and anticoagulant properties of sodium and calcium derivatives of pentosan polysulfate (Na-PPS, Ca-PPS), unfractionated heparin (UFH), and low-molecular-weight heparin (Fraxiparin). The antithrombotic effects of these agents have been investigated in an experimental thrombo...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Giedrojć J,Klimiuk M,Radziwon P,Kłoczko J,Bielawiec M,Breddin HK

    更新日期:1999-09-01 00:00:00

  • Coronary and systemic hemodynamic effects of tetramethylpyrazine in the dog.

    abstract::The hemodynamic effects of tetramethylpyrazine were examined in 27 anesthetized open chest dogs with electromagnetic flowmeter probes on the left circumflex coronary artery and ascending aorta. Tetramethylpyrazine, 2-15 mg/kg i.v., caused prominent systemic and coronary vasodilation, with a maximum reduction of mean a...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Dai XZ,Bache RJ

    更新日期:1985-09-01 00:00:00

  • Characterization of distinct angiotensin II binding sites in rat adrenal gland and bovine cerebellum using selective nonpeptide antagonists.

    abstract::We investigated the characteristics of 125I-AII binding to rat adrenal and bovine cerebellar membranes in the presence and absence of new nonpeptide angiotensin II (AII) receptor ligands. The imidazole AII ligands, DUP753 and WL19, both produced biphasic competition curves to 125I-AII binding in rat adrenal glomerulos...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Wiest SA,Rampersaud A,Zimmerman K,Steinberg MI

    更新日期:1991-02-01 00:00:00

  • Altered expression of ETB-receptor mRNA in the lung of rats with pulmonary hypertension.

    abstract::To investigate the pathophysiologic role(s) of endothelin-1 (ET-1) in pulmonary hypertension, we studied the expression of ETB-receptor mRNA in the lung and venous plasma concentrations of ET-1 in rats with monocrotaline-induced pulmonary hypertension (PH). Three weeks after s.c. injection of monocrotaline (60 mg/kg),...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Yorikane R,Miyauchi T,Sakai S,Sakurai T,Yamaguchi I,Sugishita Y,Goto K

    更新日期:1993-01-01 00:00:00

  • Cilazapril and captopril accelerate recovery from hypoxia in myocardial cell aggregates in culture.

    abstract::We wished to determine whether angiotensin-converting enzyme (ACE) inhibition alters the effect of hypoxia and reoxygenation directly on the cardiac myocyte; to compare two different ACE inhibitors, one with and one without a sulfhydryl group (i.e., captopril and cilazapril), and to examine the potential interaction o...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Rabkin SW

    更新日期:1992-03-01 00:00:00

  • Interaction of the beta adrenergic receptor antagonist bucindolol with serotonergic receptors.

    abstract::Bucindolol is a nonselective beta-adrenergic receptor antagonist that has additional vasodilating properties. Because some beta-adrenergic receptor antagonists such as cyanopindolol are used as 5-HT1A/5-HT1B receptor antagonists, we tested the hypothesis that bucindolol can interact with 5-HT receptors. Both in vitro ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Watts SW,Fink GD,Silver PJ,Cushing DJ

    更新日期:2000-01-01 00:00:00

  • Effects of prazosin and phenoxybenzamine on alpha- and beta-receptor-mediated responses in intestinal resistance and capacitance vessels.

    abstract::Previous studies have suggested that prazosin is a selective post-synaptic alpha-receptor blocker. It has also been suggested that it may have greater blocking actions on arterioles than on venous beds. These aspects have been investigated in cats anesthetized with pentobarbital. Prazosin had no effect on conductance ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Patel P,Bose D,Greenway C

    更新日期:1981-09-01 00:00:00

  • Studies of the heart using magnetic resonance.

    abstract::Cardiovascular medicine is based on high-technology management of end-stage disease. Preventive medicine is preferable but, before magnetic resonance (MR), there was no noninvasive, safe, repeatable method of detecting occlusive vascular disease, which accounts for more deaths than any other disease at a presymptomati...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Longmore D,Forbat S

    更新日期:1992-01-01 00:00:00

  • Antithrombotic potential of GW813893: a novel, orally active, active-site directed factor Xa inhibitor.

    abstract:BACKGROUND:Factor Xa (FXa) has been a target of considerable interest for drug development efforts aimed at suppressing thrombosis. In this report, a new orally active, small molecule, active-site directed FXa inhibitor, GW813893, has been profiled in a succession of in vitro and in vivo assays involved in its preclini...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Abboud MA,Needle SJ,Burns-Kurtis CL,Valocik RE,Koster PF,Amour AJ,Chan C,Brown D,Chaudry L,Zhou P,Patikis A,Patel C,Pateman AJ,Young RJ,Watson NS,Toomey JR

    更新日期:2008-07-01 00:00:00

  • Molecular mechanisms regulating the vascular endothelial cell motile response to injury.

    abstract::Vascular endothelial cell (EC) wound healing was characterized on an EC-synthesized extracellular matrix (ECM) previously treated with enzymes and antibodies specific for ECM components. Using a computer-assisted video-microscope recording system capable of automatic EC recognition, we learned whether components of th...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Herman IM

    更新日期:1993-01-01 00:00:00

  • Influence of nifedipine on ventricular function and myocardial hypertrophy in spontaneously hypertensive rats.

    abstract::We compared left ventricular (LV) hemodynamics, LV muscle mass (LVMM), and LV geometry of 13 spontaneously hypertensive rats (SHRs) treated for 20 weeks with nifedipine (30 mg/kg/day) with those of 11 age-matched untreated SHRs. LVMM, LVMM related to end-diastolic volume (LVMM/EDV), LV pressure (PLV), systolic wall st...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Motz W,Ploeger M,Ringsgwandl G,Goeldel N,Garthoff B,Kazda S,Strauer BE

    更新日期:1983-01-01 00:00:00

  • Serotonin-induced vasoconstriction in the perfused canine femoral artery can be blocked in vivo by ketanserin.

    abstract::Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Meschig R,Breuer J,Arnold G

    更新日期:1985-01-01 00:00:00

  • Blood pressure effects of intravenous apomorphine in conscious deoxycorticosterone-acetate salt-hypertensive rats.

    abstract:SUMMARY:The present study reports the effects of apomorphine (APO) on blood pressure and the principal site of action of this agonist in 4-week deoxycorticosterone-acetate (DOCA)-hypertensive conscious rats. In these preprations, intravenous (i.v.) administration of APO (0.50-1 mg/kg) induced short-lasting and dose-dep...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Toscano CF,Lahlou S

    更新日期:2003-12-01 00:00:00

  • Potential of the Cardiovascular Drug Levosimendan in the Management of Amyotrophic Lateral Sclerosis: An Overview of a Working Hypothesis.

    abstract::Levosimendan is a calcium sensitizer that promotes myocyte contractility through its calcium-dependent interaction with cardiac troponin C. Administered intravenously, it has been used for nearly 2 decades to treat acute and advanced heart failure and to support the heart function in various therapy settings character...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Al-Chalabi A,Heunks LMA,Papp Z,Pollesello P

    更新日期:2019-11-01 00:00:00

  • The effects of bufuralol, a beta-adrenoceptor antagonist with predominant beta 2-adrenoceptor agonistic activity, in the cat and the dog.

    abstract::The effects of bufuralol and its carbinol metabolite have been compared with those of propranolol in the anaesthetised and conscious cat and dog. Bufuralol and its carbinol metabolite are nonselective beta-adrenoceptor antagonists; the former has equivalent potency to propranolol, whereas the latter is six times more ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Blaber LC,Burden DT,Eigenmann R,Gerold M

    更新日期:1984-01-01 00:00:00

  • Modulators of calcium and potassium channels: their effects on endothelin-1 binding to cardiac membranes.

    abstract::Endothelin-1 (ET-1) causes long-lasting vasoconstriction associated with a prolonged elevation of intracellular free Ca2+. Because this may be mediated through an effect on membrane ion channels, we investigated the effects of the dihydropyridine calcium channel antagonist nifedipine; two structurally distinct K+ chan...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Haynes WG,Waugh CJ,Dockrell ME,Olverman HJ,Williams BC,Webb DJ

    更新日期:1993-01-01 00:00:00

  • Effect of congestive heart failure treatment on incidence and prognosis of ventricular tachyarrhythmias.

    abstract::The prognosis for patients with congestive heart failure (CHF) is poor, with a mortality exceeding 50% within 5 years from diagnosis. This poor prognosis remains despite improved pharmacological therapy. Because the prevalence of sudden death among these patients is high, reported to exceed 40%, the prognostic importa...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Birgersdotter-Green U,Rosenqvist M,Rydén L

    更新日期:1991-01-01 00:00:00

  • Vascular levels and cGMP-increasing effects of nicorandil administered orally to rats.

    abstract::We examined a relation between cyclic guanosine monophosphate (cGMP) production in thoracic aorta, as an indicator probably reflecting the vascular response, and the vascular as well as plasma levels of nicorandil administered orally to rats. Nicorandil (3 mg/kg) given orally was rapidly absorbed, reaching the maximal...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Sakai K,Moriyasu M,Kitajima S,Akima M,Kamachi S,Tanikawa M

    更新日期:1998-04-01 00:00:00

  • Depressor effect of intrathecal neuropeptide Y (NPY) Is mediated by Y2 subtype of NPY receptors.

    abstract::The effect of intrathecal administration of neuropeptide Y (NPY), NPY COOH-terminal fragments as well as an NPY Y1 receptor ligand on arterial blood pressure (ABP) of anesthetized rat was studied. NPY and all NPY COOH-terminal fragments tested (NPY11-36, NPY14-36 and NPY18-36), believed to act through Y2 receptors pro...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Chen X,Westfall TC

    更新日期:1993-05-01 00:00:00

  • Vascular smooth muscle energetics.

    abstract::ATP utilization (delta approximately P) during an isometric contraction has been studied in terms of both measurements of oxygen consumption and lactate production as well as of the tissue nucleotide and metabolite levels. The contribution of breakdown of preformed ATP and phosphocreatine (PCr) pools to delta approxim...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Paul RJ,Krisanda JM,Lynch RM

    更新日期:1984-01-01 00:00:00

  • Properties and mechanisms of production and action of endothelium-derived relaxing factor.

    abstract::A brief review is given of the vasodilators that require an intact vascular endothelium to exert their relaxing effect. Then some major issues of the phenomenon of endothelium-dependent smooth muscle relaxation are discussed in more detail: The chemical structure of the endothelium-derived relaxing factor (EDRF), whic...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Förstermann U

    更新日期:1986-01-01 00:00:00

  • Double-blind comparison of amlodipine and hydrochlorothiazide in patients with mild to moderate hypertension.

    abstract::Amlodipine, a new long-acting dihydropyridine calcium antagonist, was compared with hydrochlorothiazie (HCTZ) in 145 patients with mild to moderate hypertension. After 4 weeks of single-blind placebo runin, patients were randomly allocated to receive amlodipine (2.5-10 mg once daily, n = 97) or HCTZ (25-100 mg once da...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Burris JF,Ames RP,Applegate WB,Ram CV,Davidov ME,Mroczek WJ

    更新日期:1988-01-01 00:00:00

  • Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model.

    abstract::The pharmacokinetics of losartan and EXP3174, an active metabolite of losartan, were evaluated in the anesthetized pig after both a single intravenous dose (3 mg/kg) and during constant intravenous infusion. The pharmacodynamic activities of losartan and EXP3174 were determined during constant intravenous infusion as ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Lankford SM,Plummer D,Hellyer P,Christ DD,Bai SA

    更新日期:1997-11-01 00:00:00

  • Effects of nicorandil and its interaction with isoproterenol on force of contraction and cyclic nucleotide levels of canine atrial muscle: comparison with carbachol.

    abstract::Experiments were carried out on isolated canine right atria to investigate the effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil, SG-75) and its interaction with beta-adrenoceptor stimulation on the cyclic nucleotide levels accompanying inotropic changes. The results were compared with those during muscari...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Endoh M,Iijima T

    更新日期:1983-09-01 00:00:00