Infarct size reduction: a review of clinical trials.

Abstract:

:Early studies in experimental animals and in humans indicated the need to examine the feasibility of infarct size reduction by the early treatment of patients recruited to well-designed clinical trials. The extensive experience with beta-adrenoceptor blockers and the comparatively recent data generated with the use of calcium antagonists in patients with acute myocardial infarction are reviewed. Early intravenous administration of beta-adrenoceptor blockers in suitable patients appears to produce genuine infarct size reduction (approximately 20%) compared with controls, whereas calcium channel antagonists have failed to demonstrate such an effect. Possible mechanisms for these findings are discussed.

journal_name

J Cardiovasc Pharmacol

authors

Fitzsimons TJ

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

S34-7

eissn

0160-2446

issn

1533-4023

journal_volume

14 Suppl 9

pub_type

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