Heterogeneous receptors mediate endothelin-1-induced changes in blood pressure, hematocrit, and platelet aggregation.

abstract：:The study was designed to assess the antihypertensive effect of combined angiotensin-converting enzyme (ACE) inhibition and angiotensin II type 1 receptor (AT1) antagonism in patients with essential hypertension. Twenty patients with uncontrolled ambulatory diastolic blood pressure (BP) after 6 weeks of ACE inhibitor ...

journal_title：Journal of cardiovascular pharmacology

authors： Stergiou GS,Skeva II,Baibas NM,Roussias LG,Kalkana CB,Achimastos AD,Mountokalakis TD

更新日期：2000-06-01 00:00:00

abstract：:: Interstitial fibrosis is a common pathological change in various heart diseases, especially cardiac hypertrophy. Arginine vasopressin (AVP), one of the hallmarks of heart failure, exhibits a profibrotic effect by promoting the proliferation and differentiation of cardiac fibroblasts (CFs). In contrast, angiotensin-(...

journal_title：Journal of cardiovascular pharmacology

authors： Niu X,Xue Y,Li X,He Y,Zhao X,Xu M,Zhao L

更新日期：2014-12-01 00:00:00

abstract：:Oxygen-derived free radicals and their metabolites may contribute to the extension of irreversible cellular injury, which occurs on reperfusion of the previously ischemic myocardium. Therefore, therapy directed against the toxic effects of reactive oxygen species may provide protection to the ischemic myocardium, whic...

journal_title：Journal of cardiovascular pharmacology

authors： Mitsos SE,Fantone JC,Gallagher KP,Walden KM,Simpson PJ,Abrams GD,Schork MA,Lucchesi BR

更新日期：1986-09-01 00:00:00

abstract：:Clinical trials in patients with congestive heart failure have shown a wide disparity in the hemodynamic responses to chronic therapy with newer positive inotropic drugs. Therefore, the long-term efficacy of enoximone was studied in 10 patients with severe congestive heart failure. Patients were evaluated clinically, ...

journal_title：Journal of cardiovascular pharmacology

authors： Gilfrich HJ,Witzke-Gross J,Römer A

更新日期：1989-01-01 00:00:00

abstract：:Inflammation induces cardiac fibrosis and hypertrophy in multiple cardiovascular diseases, contributing to cardiac dysfunction. We tested the hypothesis that pentoxifylline (PTX), a phosphodiesterase inhibitor with anti-inflammatory property, would attenuate cardiac fibrosis and hypertrophy, and prevent cardiac dysfun...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang X,Meng F,Song J,Zhang L,Wang J,Li D,Li L,Dong P,Yang B,Chen Y

更新日期：2016-01-01 00:00:00

abstract：:Kinins locally synthesized in the cardiovascular tissue are believed to contribute to the regulation of cardiovascular homeostasis by stimulating the endothelial cells to release nitric oxide, prostacyclin, or a hyperpolarizing factor via autocrine-paracrine mechanisms. This study was designed to investigate the actio...

journal_title：Journal of cardiovascular pharmacology

authors： Kanna T,Akata T,Izumi K,Nakashima M,Yonemitsu Y,Hashizume M,Takahashi S

更新日期：2002-11-01 00:00:00

abstract：:The different intervention trials in elderly hypertensive subjects are compatible with the hypothesis that antihypertensive drug treatment decreases cardiovascular mortality, mainly by a reduction of cerebrovascular mortality. Antihypertensive drug treatment in elderly hypertensive subjects also leads to a decrease in...

journal_title：Journal of cardiovascular pharmacology

authors： Staessen J,Fagard R,Van Hoof R,Amery A

更新日期：1988-01-01 00:00:00

abstract：:Celiprolol is a selective beta(1)-adrenoceptor antagonist with antihypertensive actions, which causes renal vasodilation by increasing tissue nitric oxide (NO) levels. The authors tested whether celiprolol increases coronary blood flow (CBF) by increasing cardiac NO release in the ischemic heart in vivo. In open-chest...

journal_title：Journal of cardiovascular pharmacology

authors： Asanuma H,Node K,Minamino T,Sanada S,Takashima S,Ueda Y,Sakata Y,Asakura M,Kim J,Ogita H,Tada M,Hori M,Kitakaze M

更新日期：2003-04-01 00:00:00

abstract：:Arrhythmias occur 24 h after occlusion of the left anterior descending (LAD) coronary artery in the canine heart and have been attributed to the abnormal spontaneous activity in subendocardial Purkinje fibers, which are markedly depolarized. The major current underlying normal automaticity in these fibers is i(f). Alt...

journal_title：Journal of cardiovascular pharmacology

authors： Lasker SM,Han D,Kline RP

更新日期：1997-05-01 00:00:00

abstract：:The electrophysiologic actions of the class III antiarrhythmic agents, GLG-V-13 and d,l-sotalol, were examined in superfused normal and ischemically injured epicardium. Both drugs produced concentration and reverse-use dependent prolongation of the action potential duration in normal myocardium without altering restin...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Scherlag BJ,Lazzara R,Garrison GL,Berlin KD

更新日期：2007-09-01 00:00:00

abstract：:This study was designed to investigate the effect of end-organ damage (EOD), the initial blood pressure levels, and baroreflex sensitivity (BRS) on the blood pressure-lowering effect of nifedipine in spontaneously hypertensive rats (SHRs). Nifedipine was intravenously administered at a dose of 1 mg/kg. BP was continuo...

journal_title：Journal of cardiovascular pharmacology

authors： Lu LH,Xie HH,Cai GJ,Shen FM,Su DF

更新日期：2005-12-01 00:00:00

abstract：:We studied 12 patients receiving either chronic oral (p.o.) maintenance bretylium and/or acute intravenous (i.v.) bretylium to evaluate drug efficacy and pharmacokinetics. All patients were survivors of ventricular tachycardia or fibrillation. A new assay for bretylium was applied, and it proved sensitive and reliable...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson JL,Patterson E,Wagner JG,Johnson TA,Lucchesi BR,Pitt B

更新日期：1981-05-01 00:00:00

abstract：:Primary pulmonary hypertension continues to be a fatal disease. We have recently demonstrated that long-term inhibition of Rho-kinase, an effector of the small GTPase Rho, is effective for the treatment of pulmonary hypertension (PH) in rats and humans. Prostacyclin has been clinically used for the treatment of PH wit...

journal_title：Journal of cardiovascular pharmacology

authors： Abe K,Morikawa K,Hizume T,Uwatoku T,Oi K,Seto M,Ikegaki I,Asano T,Kaibuchi K,Shimokawa H

更新日期：2005-02-01 00:00:00

abstract：:T89 (Dantonic) is a modern herbal medicine currently used in Chinese hospitals for the management of ischemic heart disease. This dose-escalation clinical trial aims to assess tolerability of Western people to T89. Healthy Australian adults of non-Asian background orally took a single dosage of 6, 8, 10, 12, 13, 14, 1...

journal_title：Journal of cardiovascular pharmacology

authors： Ling S,Luo RZ,Nheu L,Guo ZX,Sun H,Komesaroff PA

更新日期：2012-12-01 00:00:00

abstract：:We examined the influence of the new angiotensin-converting enzyme inhibitor (ACEI) fosinopril on function and perfusion of the diabetic rat heart. Streptozotocin-diabetic rats (60 mg/kg body weight) were treated with fosinopril (10 mg/kg body weight/day) for 4 months. Cardiac performance was analyzed in the isolated ...

journal_title：Journal of cardiovascular pharmacology

authors： Rösen P,Rump AF,Rösen R

更新日期：1996-01-01 00:00:00

abstract：:We compared left ventricular (LV) hemodynamics, LV muscle mass (LVMM), and LV geometry of 13 spontaneously hypertensive rats (SHRs) treated for 20 weeks with nifedipine (30 mg/kg/day) with those of 11 age-matched untreated SHRs. LVMM, LVMM related to end-diastolic volume (LVMM/EDV), LV pressure (PLV), systolic wall st...

journal_title：Journal of cardiovascular pharmacology

authors： Motz W,Ploeger M,Ringsgwandl G,Goeldel N,Garthoff B,Kazda S,Strauer BE

更新日期：1983-01-01 00:00:00

abstract：:Both in the periphery and in the central nervous system, alpha-adrenoceptors can be subdivided into alpha 1-types. alpha 1-Receptors are sensitive to low concentrations of the agonists phenylephrine and methoxamine, and of the antagonists corynanthine and prazosin. alpha 1-Receptors are sensitive to low concentrations...

journal_title：Journal of cardiovascular pharmacology

authors： Starke K,Docherty JR

更新日期：1982-01-01 00:00:00

abstract：:Although myocardial ischemia is associated with regional cardiac sympathetic nerve deterioration, it remains unknown whether acute hindlimb ischemia impairs muscle sympathetic nerve function. In the study presented here we implanted dialysis probes in the adductor muscle of anesthetized rabbits and measured dialysate ...

journal_title：Journal of cardiovascular pharmacology

authors： Tokunaga N,Yamazaki T,Akiyama T,Sano S,Mori H

更新日期：2003-12-01 00:00:00

abstract：:We investigated the effects of nifedipine on cyclic GMP turnover and the pertinent enzyme activities in cultured coronary smooth muscle cells (SMC). Nifedipine at high concentrations slightly decreased basal soluble guanylate cyclase activity and inhibited the action of sodium nitroprusside (SNP) but had no effect on ...

journal_title：Journal of cardiovascular pharmacology

authors： Kishi Y,Watanabe T,Makita T,Sakita S,Watanabe R,Ashikaga T,Numano F

更新日期：1995-10-01 00:00:00

abstract：:Antecubital venous plasma neuropeptide Y-like immunoreactivity (NPY-LI) and catecholamines were analyzed in six healthy volunteers performing a graded bicycle exercise without medication and after acute administration of clonidine, phentolamine, and nifedipine. During the control exercise, plasma noradrenaline (NA), a...

journal_title：Journal of cardiovascular pharmacology

authors： Pernow J,Lundberg JM,Kaijser L

更新日期：1988-01-01 00:00:00

abstract：:We conducted an intracardiac study of the electrophysiologic effects and kinetics of intravenous nicardipine (N) in 16 patients with or without impaired cardiac conduction, using a randomized, double-blind, crossover design versus placebo (P). N or P were infused intravenously over 5 min: the dose of N was 9.46 +/- 3....

journal_title：Journal of cardiovascular pharmacology

authors： David D,Guize L,Leheuzey JY,Lavergne T,Loria Y,Ourbak P

更新日期：1990-01-01 00:00:00

abstract：:A significant reduction of maximal vasodilation capacity at the calf in relation to the severity of the hypertensive state has been demonstrated in essential hypertension. The aim of this study was to evaluate the behavior of calf blood flow and vascular resistance in borderline hypertensives (BH) in comparison with n...

journal_title：Journal of cardiovascular pharmacology

authors： Novo S,Pinto A,Alaimo G,Galati D,Strano A

更新日期：1986-01-01 00:00:00

abstract：:We investigated the mechanism of the vasodepressor effect of endokinin A/B. An intravenous (IV) bolus of endokinin A/B (0.05-0.3 nmol/kg) dose-dependently decreased mean arterial pressure in thiobutabarbital-anesthetized rats. The magnitude of the response was unaffected by IV pretreatment with NG-nitro-L-arginine met...

journal_title：Journal of cardiovascular pharmacology

authors： Abdelrahman AM,Syyong H,Tjahjadi A,Pang CC

更新日期：2005-09-01 00:00:00

abstract：:The dependency of arteriolar tone on calcium influx was studied in 11 patients with essential hypertension (EHT) and compared to 11 age-matched normotensive (NT) subjects by measuring the forearm blood flow (FAF) response to intraarterial infusion of the calcium channel blocker verapamil (Verap) and the nonspecific va...

journal_title：Journal of cardiovascular pharmacology

authors： Hulthén UL,Bolli P,Amann FW,Kiowski W,Bühler FR

更新日期：1982-01-01 00:00:00

abstract：:We have studied the effect of ramipril (10 mg/kg daily by gastric gavage) on the development of neointima 2 and 14 days after injury to rat aorta with a balloon catheter. In treated animals, there was no significant inhibition of the early mitotic reaction after injury (synthesis of DNA, as reflected by aortic thymidi...

journal_title：Journal of cardiovascular pharmacology

authors： Capron L,Heudes D,Chajara A,Bruneval P

更新日期：1991-08-01 00:00:00

abstract：:Interspersed between cardiac myocytes, cardiac fibroblasts serve mainly as a structural support during ventricular wall thickening from embryogenesis until adulthood. Cardiac fibroblasts, however, may also serve as a source of mitogens, extracellular matrix proteins, cytokines, and growth factors that could affect the...

journal_title：Journal of cardiovascular pharmacology

authors： Ottaviano FG,Yee KO

更新日期：2011-05-01 00:00:00

abstract：:A randomized, double-blind, crossover trial was carried out in 17 hypertensive patients to evaluate the hypotensive efficacy and safety of verapamil. Verapamil in doses of 120 mg thrice daily was compared with pindolol in doses of 7.5 mg twice daily. A thiazide diuretic was given with both drugs. Blood pressure fell a...

journal_title：Journal of cardiovascular pharmacology

authors： Anavekar SN,Christophidis N,Louis WJ,Doyle AE

更新日期：1981-03-01 00:00:00

abstract：:We studied the effect of 2-week treatment with estradiol 17beta on myocardial glutathione concentration in dogs and isolated perfused rat heart subjected to brief coronary ischemia and reperfusion. Estradiol protected against ischemia/reperfusion-induced myocardial systolic shortening and malonylaldehyde production an...

journal_title：Journal of cardiovascular pharmacology

authors： Kim YD,Farhat MY,Myers AK,Kouretas P,DeGroot KW,Pacquing A,Ramwell PW,Suyderhoud JP,Lees DE

更新日期：1998-09-01 00:00:00

abstract：:Acute occlusion of a coronary artery can result in myocardial infarction-a leading cause of premature death. Prompt restoration of blood flow to the myocardium can prevent excessive death of cardiomyocytes and improve clinical outcome. Although the major mechanism of cell death after reperfusion is necrosis, it is now...

journal_title：Journal of cardiovascular pharmacology

authors： Rauf A,Shah M,Yellon DM,Davidson SM

更新日期：2019-09-01 00:00:00

abstract：:Atherosclerosis, like several other vascular diseases, exhibits structural and functional abnormalities resulting partially from an exaggerated proliferation of vascular smooth-muscle cells (VSMCs). Ca2+ channel blockers, such as amlodipine, have been suggested to retard or even prevent the progression of atherosclero...

journal_title：Journal of cardiovascular pharmacology

authors： Stepien O,Gogusev J,Zhu DL,Iouzalen L,Herembert T,Drueke TB,Marche P

更新日期：1998-05-01 00:00:00