Effects of angiotensin-(1-7) on the proliferation and collagen synthesis of arginine vasopressin-stimulated rat cardiac fibroblasts: role of mas receptor-calcineurin-NF-κB signaling pathway.


:: Interstitial fibrosis is a common pathological change in various heart diseases, especially cardiac hypertrophy. Arginine vasopressin (AVP), one of the hallmarks of heart failure, exhibits a profibrotic effect by promoting the proliferation and differentiation of cardiac fibroblasts (CFs). In contrast, angiotensin-(1-7) [Ang-(1-7)] was reported to be beneficial for cardiac remodeling by its antifibrotic effect. To evaluate the effect of Ang-(1-7) on AVP-stimulated CFs and the subsequent signaling molecules involved, CFs isolated from neonatal rat hearts were incubated with AVP and treated with or without Ang-(1-7). Cell proliferation, cell cycle, collagen production, and related cellular signaling molecules were then assessed. The results showed that Ang-(1-7) dose-dependently inhibited cell proliferation and collagen production in AVP-stimulated CFs. In addition, Ang-(1-7) also significantly suppressed calcineurin activity in a dose-dependent manner in AVP-stimulated CFs, which was associated with reduced collagen production. Accordingly, the nuclear translocation and transcriptional activity of nuclear factor-kappa B (NF-κB), downstream signal of calcineurin, were also notably restrained by Ang-(1-7) in AVP-stimulated CFs. Furthermore, the inhibitory effect of Ang-(1-7) on AVP-activated calcineurin-NF-κB signaling was completely reversed by the Mas receptor antagonist A-799. These findings suggest that Ang-(1-7) exerts an antifibrotic effect by inhibiting AVP-stimulated CF proliferation and collagen synthesis by inactivating Mas receptor-calcineurin-NF-κB signaling pathway.


J Cardiovasc Pharmacol


Niu X,Xue Y,Li X,He Y,Zhao X,Xu M,Zhao L




Has Abstract


2014-12-01 00:00:00














  • Distinct role of nox1, nox2, and p47phox in unstimulated versus angiotensin II-induced NADPH oxidase activity in human venous smooth muscle cells.

    abstract::Human saphenous veins (SV) are used for coronary bypass surgery despite the higher rate of graft failure observed as compared to arteries. A higher production of reactive oxygen species (ROS) in SV than in internal mammary artery (IMA) has been incriminated as possibly implicated in graft failure. NADPH oxidase, invol...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Chose O,Sansilvestri-Morel P,Badier-Commander C,Bernhardt F,Fabiani JN,Rupin A,Verbeuren TJ

    更新日期:2008-02-01 00:00:00

  • Prophylactic effect of intravenous nicorandil on perioperative myocardial damage in patients undergoing off-pump coronary artery bypass surgery.

    abstract::Nicorandil, ATP sensitive potassium channel opener, is shown to reduce coronary events for patients with stable angina. The present study was designed to examine the protective potential of nicorandil for patients undergoing off-pump coronary artery bypass grafting. Twenty-four patients undergoing off-pump coronary ar...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ito I,Hayashi Y,Kawai Y,Kamibayashi T,Matsumiya G,Takahashi T,Matsuda H,Mashimo T

    更新日期:2004-10-01 00:00:00

  • [3H]ketanserin labels serotonin 5-HT2 and alpha 1-adrenergic receptors in human brain cortex.

    abstract::The binding of [3H]ketanserin and [125I]BE 2254 [( beta-(4-hydroxyphenyl)ethylaminomethyl]tetralone) was characterized in human brain cortex membranes. As observed in saturation experiments, [3H]ketanserin (a reportedly selective serotonin 5-HT2 ligand) and [125I]BE 2254 (a selective alpha 1-adrenergic antagonists) la...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Hoyer D,Vos P,Closse A,Palacios JM,Engel G,Davies H

    更新日期:1987-01-01 00:00:00

  • Long-term effects of carvedilol on left ventricular function, remodeling, and expression of cardiac cytokines after large myocardial infarction in the rat.

    abstract::Carvedilol (20 mg/kg, bid) or vehicle was given to rats surviving a myocardial infarction (MI) 24 h (n = 409). In rats with large MI, carvedilol partially preserved left ventricular (LV) function and intrinsic myocardial contractility and reactivity to beta-adrenergic stimulation. Carvedilol led to scar thickening, in...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Sia YT,Parker TG,Tsoporis JN,Liu P,Adam A,Rouleau JL

    更新日期:2002-01-01 00:00:00

  • Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance.

    abstract::Insulin resistance is associated with endothelial dysfunction and increased production of the pro-inflammatory vasoconstrictor peptide endothelin-1 (ET-1). The aim of this study was to test the hypothesis that blockade of ET receptors results in enhanced endothelium-dependent vasodilatation (EDV) in individuals with i...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Shemyakin A,Böhm F,Wagner H,Efendic S,Båvenholm P,Pernow J

    更新日期:2006-03-01 00:00:00

  • Thapsigargin inhibits the response to acetylcholine and substance P but does not interfere with the responses to endothelium-independent agents.

    abstract::We investigated the influence of the Ca(2+)-ATPase inhibitor thapsigargin (TG) on the vasorelaxant response to different endothelium-dependent and endothelium-independent relaxing agents in an isolated thoracic aorta preparation of the rabbit, precontracted by norepinephrine (NE). Pretreatment with 100 microM L-argini...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Amerini S,Filippi S,Parenti A,Ziche M,Ledda F

    更新日期:1996-07-01 00:00:00

  • Angiotensin type 1 receptor antagonism with irbesartan inhibits ventricular hypertrophy and improves diastolic function in the remodeling post-myocardial infarction ventricle.

    abstract::To evaluate the role of angiotensin II (AII) on diastolic function during post-myocardial infarction (MI) ventricular remodeling, coronary ligation or sham operation was performed in male Sprague-Dawley rats. Experimental animals were maintained on either irbesartan, a selective AT1-receptor antagonist, or no treatmen...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Ambrose J,Pribnow DG,Giraud GD,Perkins KD,Muldoon L,Greenberg BH

    更新日期:1999-03-01 00:00:00

  • Chronic hypoxia-induced cardiopulmonary changes in three rat strains: inhibition by the endothelin receptor antagonist SB 217242.

    abstract::The cardiopulmonary profile of three different rat strains was compared after exposure to hypoxia (9% O2) for 0, 7, or 14 days. In Sprague-Dawley (SD), Wistar (W), and high altitude-sensitive (HAS) rats, pulmonary arterial pressure (PAP) rose 30, 58, and 85% respectively, after 7 days of hypoxia, and by 108, 116, and ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Underwood DC,Bochnowicz S,Osborn RR,Louden CS,Hart TK,Ohlstein EH,Hay DW

    更新日期:1998-01-01 00:00:00

  • Long-term renal effects of isradipine, a calcium entry blocker, in essential hypertension.

    abstract::The long-term effects (9 weeks) on renal hemodynamics of the new calcium entry blocker isradipine (PN 200-110) were assessed in 20 middle-aged male patients with essential hypertension. The study was double-blind placebo-controlled with a crossover design. Isradipine or placebo tablets were titrated from 2.5, 5, and 7...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章


    authors: Persson B,Wysocki M,Andersson OK

    更新日期:1989-07-01 00:00:00

  • Cardiovascular and renal effects of the beta-blocker SE2395 in conscious normotensive dogs.

    abstract::The cardiac and renal hemodynamic effects of SE2395, a beta-blocking agent, were examined after intravenous administration (50 micrograms/kg) in normotensive conscious dogs. Beta-blocking action of SE2395 was evidenced by a reduction in heart rate and cardiac output without change in the mean arterial pressure. An inc...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Walker BR,Erickson AL,Prost JF,Rochat C,Burke TJ

    更新日期:1985-11-01 00:00:00

  • Vasoactive peptide-regulated gene expression during osteoblastic differentiation.

    abstract::The formation of bone occurs via a series of events that are regulated by various hormones and cytokines. We previously reported that endothelin (ET) inhibits the mineralization by osteoblastic cells and natriuretic peptide (NP) promotes osteoblastic differentiation. Therefore, we attempted to identify the genes induc...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Inoue A,Kamiya A,Ishiji A,Hiruma Y,Hirose S,Hagiwara H

    更新日期:2000-11-01 00:00:00

  • Is the ECG measure RSh a promising technique for detecting class I antiarrhythmic drug action in men?

    abstract::Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章


    authors: Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

    更新日期:1995-10-01 00:00:00

  • Possible mechanism of the vasodepressor effect of endokinin a/b in anesthetized rats.

    abstract::We investigated the mechanism of the vasodepressor effect of endokinin A/B. An intravenous (IV) bolus of endokinin A/B (0.05-0.3 nmol/kg) dose-dependently decreased mean arterial pressure in thiobutabarbital-anesthetized rats. The magnitude of the response was unaffected by IV pretreatment with NG-nitro-L-arginine met...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Abdelrahman AM,Syyong H,Tjahjadi A,Pang CC

    更新日期:2005-09-01 00:00:00

  • Beneficial action of beraprost sodium, a prostacyclin analog, in stroke-prone rats.

    abstract::Beraprost sodium is a stable analog of the vasodilator, platelet antiaggregatory eicosanoid, prostacyclin. Experiments were performed to determine whether long-term therapy with beraprost produces vascular protective effects in saline-drinking stroke-prone spontaneously hypertensive rats (SHRSPs). Oral beraprost at 30...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Stier CT Jr,Chander PN,Belmonte A,Inamdar RS,Mistry M

    更新日期:1997-09-01 00:00:00

  • Modulation of ventricular fibrillation in isolated perfused heart by dofetilide.

    abstract::The authors studied the involvement of IKr potassium current in ventricular fibrillation during perfusion. Electrophysiologic parameters were measured before and after dofetilide administration (2.5, 7.5, and 12.5 x 10-7 M, n = 8) in isolated perfused feline hearts. During pacing, these parameters included epicardial ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Amitzur G,Shenkar N,Leor J,Novikov I,Eldar M

    更新日期:2003-06-01 00:00:00

  • A proarrhythmic response to sodium channel blockade: modulation of the vulnerable period in guinea pig ventricular myocardium.

    abstract::The vulnerable period (VP) is an interval of time during the cardiac cycle within which premature stimulation may lead to trains of responses (one: many stimulus-response coupling). Although the VP parallels the recovery of sodium channel availability, modulators of its boundaries remain unclear. Numerical studies of ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Nesterenko VV,Lastra AA,Rosenshtraukh LV,Starmer CF

    更新日期:1992-05-01 00:00:00

  • Effects of felodipine, a new dihydropyridine vasodilator, on regional myocardial blood flow during acute coronary occlusion in the pig.

    abstract::We studied the effects of felodipine [4-(2,3-dichlorophenyl)-1,4-dihydropyridine-2,6-dimethyl 3,5-dicarboxylic 3-ethylester and 5-methylester] on the coronary vascular bed of pig hearts with an ischemic region in the left ventricle following ligation of the left anterior descending coronary artery. At an infusion rate...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Sjöquist PO,Adler G,Duker G,Almgren O

    更新日期:1983-03-01 00:00:00

  • Salicylate reduces ventricular dysfunction and arrhythmias during reperfusion in isolated rat hearts.

    abstract::Recent studies have shown the ability of salicylic acid (SA) to trap hydroxyl radicals (OH.) generated during reperfusion in ischemic myocardium. Since OH. is implicated in the pathogenesis of reperfusion injury, we examined the effect of SA on reperfusion-induced arrhythmias and postischemic ventricular dysfunction. ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Liu XK,Tosaki A,Engleman RM,Das DK

    更新日期:1992-02-01 00:00:00

  • Resolvin D1 Reduces Infarct Size Through a Phosphoinositide 3-Kinase/Protein Kinase B Mechanism.

    abstract::This study was designed to determine if Resolvin D1 (RvD1), a pro-resolution metabolite of the omega-3 polyunsaturated fatty acid docosahexaenoic acid, could decrease myocardial infarct size with delivered at the onset of ischemia. Male Sprague Dawley rats underwent 40 minutes of myocardial ischemia followed by reperf...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Gilbert K,Bernier J,Bourque-Riel V,Malick M,Rousseau G

    更新日期:2015-07-01 00:00:00

  • Pharmacokinetics of intravenous enoximone in dialysis patients.

    abstract::The new vasodilator and inotropic drug enoximone was given to dialysis patients as a single intravenous dose of 1 mg/kg. Plasma concentrations were measured up to 240 min. The mother compound enoximone reached a high plasma concentration intravenously, followed by a quick decline of the plasma concentration curve (t1/...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Fiegel P,Trenk D,Jaehnchen E,Dieterich HA

    更新日期:1989-01-01 00:00:00

  • Carvedilol is effective and safe in combination with bepridil for persistent atrial fibrillation and decreases the QT prolongation induced by bepridil therapy.

    abstract:INTRODUCTION:We investigated the efficacy of carvedilol for preventing the recurrence of atrial fibrillation and reducing QT prolongation induced by bepridil. METHODS:We assigned 144 subjects with persistent atrial fibrillation. The subjects were divided into 3 groups: carvedilol plus bepridil, candesartan plus beprid...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Kawamura M,Munetsugu Y,Tanno K,Kobayashi Y

    更新日期:2013-01-01 00:00:00

  • Functional bases for individualities among vascular smooth muscles.

    abstract::This review deals with cellular factors that contribute to individualities of vascular smooth-muscle function in different organ systems and at different levels of the vascular tree. Particular attention has been given to: membrane receptors responsive to catecholamines, serotonin, angiotensin II, dopamine, and acetyl...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Bell DR,Webb RC,Bohr DF

    更新日期:1985-01-01 00:00:00

  • Plasma histamine and catecholamine levels during hypotension induced by morphine and compound 48/80.

    abstract::Histamine receptors are present in adrenergic terminals, and histamine is reported to inhibit release of the neurotransmitter norepinephrine (NE) at certain neuroeffector junctions. However, a physiological role for histamine in modifying adrenergic neurotransmission has not been established. To examine the interactio...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Muldoon SM,Freas W,Mahla ME,Donlon MA

    更新日期:1987-05-01 00:00:00

  • Effects of intravenous diltiazem on cardiocirculatory dynamics and cardiac output distribution in conscious spontaneously hypertensive rats.

    abstract::The effects of the calcium channel blocker, diltiazem hydrochloride (DZ), on conscious, resting spontaneously hypertensive rats (SHR) were evaluated and compared with results from parallel studies on Wistar-Kyoto (WKY) controls. DZ was administered as a continuous, cumulative infusion at rates equal to 0.40, 2.00, and...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Flaim SF,Newman ED,Annibali JA

    更新日期:1986-03-01 00:00:00

  • Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice.

    abstract::Epoxyeicosatrienoic acids, substrates for soluble epoxide hydrolase (sEH), exhibit vasodilatory and antihypertrophic activities. Inhibitors of sEH might therefore hold promise as heart failure therapeutics. We examined the ability of sEH inhibitors GSK2188931 and GSK2256294 to modulate cardiac hypertrophy, fibrosis, a...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Morgan LA,Olzinski AR,Upson JJ,Zhao S,Wang T,Eisennagel SH,Hoang B,Tunstead JR,Marino JP Jr,Willette RN,Jucker BM,Behm DJ

    更新日期:2013-04-01 00:00:00

  • Antianginal and anti-ischemic efficacy of nicorandil in comparison with isosorbide-5-mononitrate and isosorbide dinitrate: results from two multicenter, double-blind, randomized studies with stable coronary heart disease patients.

    abstract::The purpose of the two double-blind studies summarized in this article was to compare the antianginal and anti-ischemic effects of nicorandil with those of two different nitrate preparations. A total of 129 patients with stable New York Heart Association functional class II or III coronary heart disease were enrolled ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Döring G

    更新日期:1992-01-01 00:00:00

  • Sulfhydryl group in angiotensin converting enzyme inhibitors and superoxide radical formation.

    abstract::The superoxide radical scavenging effects of the SH group in the captopril molecule has been proposed to be the basis of the "cadioprotective" effect of this angiotensin converting enzyme (ACE) inhibitor in animal models of myocardial injury. We determined the effects of captopril, another ACE inhibitor with an SH gro...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Mehta JL,Nicolini FA,Lawson DL

    更新日期:1990-11-01 00:00:00

  • Trimazosin: relationships between hypotensive effect, vascular responsiveness, and drug and metabolite concentrations.

    abstract::The relationships between the effects on blood pressure and vascular responsiveness, and the whole blood concentration of the antihypertensive drug trimazosin and its major metabolite were investigated in six normotensive male volunteers following 100 mg i.v. and 200 mg p.o. administration. Pressor responses to intrav...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vincent J,Elliott HL,Meredith PA,Reid JL

    更新日期:1985-09-01 00:00:00

  • Contribution of endogenous endothelin-1 and endothelin-A-receptors to the hypertensive state of endothelin-B heterozygous (+/-) knockout mice.

    abstract::We observed that heterozygous knockout (+/-, KO) of either endothelin-A- (ET(A)) or -B- (ET(B)) receptors significantly reduced the pressor responses to systemically administered endothelin-1 (ET-1) in ET(A) or ET(B) (+/-) KO mice when compared to wild-type (WT) mice (data not shown). Also, we observed that basal mean...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Berthiaume N,Yanagisawa M,D'Orléans-Juste P

    更新日期:2000-11-01 00:00:00

  • Cardiac swelling-induced chloride current is enhanced by endothelin.

    abstract::Endothelins (ETs) are a family of peptide hormones that act on G protein-coupled ET(A) and ET(B) receptors. ETs exert inotropic and chronotropic actions in the heart. Myocardial ischemia is associated with increased plasma levels of ET and cell swelling. We examined the effect of ETs on dog atrial swelling-induced chl...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Du XY,Sorota S

    更新日期:2000-05-01 00:00:00