Candesartan prevents myocardial fibrosis during progression of congestive heart failure.

abstract：:The long-term efficacy of percutaneous transluminal coronary angioplasty (PTCA) is severely limited by the high incidence of vascular restenosis. Endothelin-1 (ET-1) has been implicated in the pathogenesis of this response, since circulating levels of this potent smooth-muscle mitogen are elevated after PTCA. Therefor...

journal_title：Journal of cardiovascular pharmacology

authors： Douglas SA,Ohlstein EH

更新日期：1993-01-01 00:00:00

abstract：:Chemokines are small secreted proteins with chemoattractant properties that play a key role in inflammation, metastasis, and embryonic development. We previously demonstrated a nonchemotactic role for one such chemokine pair, stromal cell-derived factor-1α and its G-protein coupled receptor, CXCR4. Stromal cell-derive...

journal_title：Journal of cardiovascular pharmacology

authors： LaRocca TJ,Schwarzkopf M,Altman P,Zhang S,Gupta A,Gomes I,Alvin Z,Champion HC,Haddad G,Hajjar RJ,Devi LA,Schecter AD,Tarzami ST

更新日期：2010-11-01 00:00:00

abstract：:We compared the beta-adrenoceptor blocking actions of bupuranolol and propranolol using the response to isoprenaline of the strength of contraction of the canine blood-perfused ventricular muscle, of the rate and strength of contraction of the isolated guinea pig heart and of a guinea pig tracheal ring preparation. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto K,Tsukada T,Matsuda H,Nakagawa Y,Imai S

更新日期：1979-03-01 00:00:00

abstract：:The pharmacokinetics of losartan and EXP3174, an active metabolite of losartan, were evaluated in the anesthetized pig after both a single intravenous dose (3 mg/kg) and during constant intravenous infusion. The pharmacodynamic activities of losartan and EXP3174 were determined during constant intravenous infusion as ...

journal_title：Journal of cardiovascular pharmacology

authors： Lankford SM,Plummer D,Hellyer P,Christ DD,Bai SA

更新日期：1997-11-01 00:00:00

abstract：:Chronic stimulation of beta-adrenoceptors with isoproterenol induces alteration of vascular reactivity and increases local pro-inflammatory cytokines. We investigated whether fenofibrate and pioglitazone, PPAR-alpha and -gamma agonists, respectively, improve the changes in vascular reactivity induced by isoproterenol....

journal_title：Journal of cardiovascular pharmacology

authors： Fukuda LE,Davel AP,Verissimo-Filho S,Lopes LR,Cachofeiro V,Lahera V,Rossoni LV

更新日期：2008-11-01 00:00:00

abstract：:In conscious rats, intrathecal (i.t.) administration of norepinephrine (NE) produced pressor responses, whereas i.t. epinephrine (Epi) caused depressor responses at low doses (0.1-1 microgram) and pressor responses at a higher dose (10 micrograms). Epi administered i.t. produced bradycardia; however, NE caused tachyca...

journal_title：Journal of cardiovascular pharmacology

authors： Gradin K,Nicholas AP,Hjemdahl P,Svensson T,Hökfelt T

更新日期：1992-09-01 00:00:00

abstract：:The antihypertensive efficacy of the calcium entry blocker nitrendipine administered as monotherapy (20-80 mg; mean, 36/day) on the average for 144 days to 46 patients with essential hypertension (WHO I and II) was investigated in relation to age, pretreatment blood pressure, and plasma renin activity. In addition, we...

journal_title：Journal of cardiovascular pharmacology

authors： Müller FB,Bolli P,Erne P,Block LH,Kiowski W,Bühler FR

更新日期：1984-01-01 00:00:00

abstract：:Few studies have addressed the possibility that brain natriuretic peptide (BNP) possesses a profile of bioactivity that is distinct from that of atrial natriuretic peptide (ANP). Accordingly, we assessed the biologic actions of BNP in the setting of maximal or near-maximal ANP-induced biologic activity. Background ANP...

journal_title：Journal of cardiovascular pharmacology

authors： Charles CJ,Espiner EA,Nicholls MG,Rademaker MT,Richards AM

更新日期：1999-02-01 00:00:00

abstract：:Twenty-four-hour urinary sodium excretion and plasma renin activity were monitored in 36 patients receiving bendrofluazide as sole antihypertensive therapy. There was no increase in urinary sodium output compared with pretreatment values during a 2-year period, and there is therefore no evidence that an increase in sa...

journal_title：Journal of cardiovascular pharmacology

authors： Swales JD,Bing RF,Swart S,Thurston H

更新日期：1984-01-01 00:00:00

abstract：:The effects of two antihypertensive agents, nifedipine (N) and captopril (C), on left ventricular (LV) mass and volume were studied in 16 patients with essential hypertension (8 treated with N and 8 with C for 6 months) by means of a complete M-mode echocardiogram monitored by two-dimensional echocardiography. Both N ...

journal_title：Journal of cardiovascular pharmacology

authors： Sheiban I,Arcaro G,Covi G,Accardi R,Zenorini C,Lechi A

更新日期：1987-01-01 00:00:00

abstract：:The adrenal medulla and pheochromocytomas are known to secrete various neuropeptides and vasoactive peptides. On the other hand, the production and secretion of peptides by adrenocortical tumors have not been studied in detail. The study reported here therefore set out to examine these two functions for two vasoactive...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Yoshinoya A,Murakami O,Totsune K,Shibahara S

更新日期：2000-11-01 00:00:00

abstract：:To assess dose-related effects of enalapril, we treated eight hospitalized hypertensive patients receiving constant sodium intake with incremental doses of this new angiotensin converting-enzyme blocking drug. After a few days of placebo treatment, enalapril was given in single daily doses, starting with 1.25 mg and i...

journal_title：Journal of cardiovascular pharmacology

authors： de Leeuw PW,Birkenhäger WH

更新日期：1986-01-01 00:00:00

abstract：:There is general agreement that the sympathetic nervous system is involved in the development of hypertension in spontaneously hypertensive rats (SHR). However, in a previous study we established that chronic administration of the selective alpha 1-adrenoceptor antagonist terazosin to SHR failed to prevent this phenom...

journal_title：Journal of cardiovascular pharmacology

authors： Young RL,Jonsson JR,Mano MT,Frewin DB,Head RJ

更新日期：1993-05-01 00:00:00

abstract：:The aim of this study was to examine the electrophysiological effects of isoprenaline, phenylephrine, and noradrenaline on sheep Purkinje fibers in vitro, superfused either with a normal or with a modified physiological salt solution (PSS) designed to mimic some of the conditions occurring during mild myocardial ische...

journal_title：Journal of cardiovascular pharmacology

authors： Boachie-Ansah G,Kane KA,Parratt JR

更新日期：1989-02-01 00:00:00

abstract：:The aim of the present study was to investigate the putative role of endothelin (ET) in mediating ischemia/hypoxia-induced ANP release utilizing exogenous ET-1 or ET receptor antagonists (BQ-123 or Bosentan). Isolated rat hearts with non-distended atria were perfused using a Langendorff apparatus and heart rate mainta...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang Y,Oliver JR,Horowitz JD

更新日期：2004-02-01 00:00:00

abstract：:The propyl derivative of ajmaline, N-n-propylajamaline (prajmalium), is an antiarrhythmic compound that lacks the commonly reported negative inotropic effects of all others under clinical use. The present study was undertaken to establish and understand its effects at the cellular level in mammalian preparations. Elec...

journal_title：Journal of cardiovascular pharmacology

authors： Alvarez JL,Rubio L,Garrido G,Vassort G

更新日期：1992-07-01 00:00:00

abstract：:Sixteen nonhospitalized men, average age 41.3 years with essential hypertension (WHO I-II) were given nifedipine slow-release tablets of 20 mg twice daily for 48 weeks. Both supine and standing blood pressure values were significantly reduced, but heart rate was not significantly changed by the drug. A significant dec...

journal_title：Journal of cardiovascular pharmacology

authors： Landmark K

更新日期：1985-01-01 00:00:00

abstract：:We wished to determine the action of prostaglandins (PG) and to analyze pharmacologically the mechanisms of their action in isolated human uterine arteries in special reference to mediators liberated from the endothelium and subendothelial tissues. Helical strips of the human uterine artery with and without the endoth...

journal_title：Journal of cardiovascular pharmacology

authors： Kimura T,Okamura T,Yoshida Y,Toda N

更新日期：1995-08-01 00:00:00

abstract：:Endothelin-1 (ET-1) influences vascular function by modulating intracellular free Ca2+ concentration ([Ca2+]i) in smooth muscle. This study investigated the effects of ET-1 on [Ca2+]i and contractile responses in resistance vessels of young prehypertensive (5 week) and adult hypertensive (17 week) spontaneously hypert...

journal_title：Journal of cardiovascular pharmacology

authors： Touyz RM,Deng LY,Schiffrin EL

更新日期：1995-01-01 00:00:00

abstract：:The effects of bufuralol and its carbinol metabolite have been compared with those of propranolol in the anaesthetised and conscious cat and dog. Bufuralol and its carbinol metabolite are nonselective beta-adrenoceptor antagonists; the former has equivalent potency to propranolol, whereas the latter is six times more ...

journal_title：Journal of cardiovascular pharmacology

authors： Blaber LC,Burden DT,Eigenmann R,Gerold M

更新日期：1984-01-01 00:00:00

abstract：:The effects of captopril on systolic function and diastolic myocardial expansion were assessed in an open-chest multiple occlusion model of myocardial stunning. Captopril was given as a 0.25 mg/kg bolus followed by a continuous infusion at 0.25 mg/kg/h for the duration of the stunning protocol, which was initiated 30 ...

journal_title：Journal of cardiovascular pharmacology

authors： Eng C,Weil BJ,Sonnenblick EH

更新日期：1993-04-01 00:00:00

abstract：:Serotonin (5-hydroxytryptamine, 5-HT) mediates vasoconstriction and vasodilation in normal coronary circulation of various animal species. In the presence of coronary artery disease, serotonin may inhibit coronary collateral formation and stimulate predominantly vasoconstriction. We tested the effect of ketanserin, a ...

journal_title：Journal of cardiovascular pharmacology

authors： Hartford CG,Rogers GG,Marcos EF,Rosendorff C

更新日期：1993-01-01 00:00:00

abstract：:Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type 1 receptor (AT1R) mediates the established actions of angiotensin II (Ang II), and changes in its expression have been reported in cardiac fibroblasts after myocardial infarc...

journal_title：Journal of cardiovascular pharmacology

authors： Vivar R,Soto C,Copaja M,Mateluna F,Aranguiz P,Muñoz JP,Chiong M,Garcia L,Letelier A,Thomas WG,Lavandero S,Díaz-Araya G

更新日期：2008-08-01 00:00:00

abstract：:Previous studies have suggested the presence of nitric oxide synthase (NOS) enzyme in human platelets. We herein provide definitive evidence for the presence of both endothelial constitutive NOS (ecNOS) and inducible NOS (iNOS) isoforms and their mRNA in human platelets. Total RNA was isolated from human platelets, an...

journal_title：Journal of cardiovascular pharmacology

authors： Chen LY,Mehta JL

更新日期：1996-01-01 00:00:00

abstract：:In isolated rat tail arteries perfused with Krebs-Henseleit solution, ouabain, in concentrations of less than 10(-5) M, caused a concentration-dependent, noncompetitive inhibition of the vasoconstrictor response to phenylephrine. Concentrations of 10(-8) and 10(-6) M caused 30 and 61% inhibition, respectively. The inh...

journal_title：Journal of cardiovascular pharmacology

authors： Armsworth SJ,Marwood JF,Stokes GS

更新日期：1985-07-01 00:00:00

abstract：:This study was designed to examine whether physiologically tolerable insulin, which maintains lower blood glucose, can protect the myocardium against ischemia/reperfusion (I/R) injury in a preclinical large animal model. Adult dogs were subjected to 50 minutes of myocardial ischemia (80% reduction in coronary blood fl...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang HX,Zang YM,Huo JH,Liang SJ,Zhang HF,Wang YM,Fan Q,Guo WY,Wang HC,Gao F

更新日期：2006-12-01 00:00:00

abstract：:During the healing phase of evolving myocardial infarction, inflammatory cells invade the affected region and produce metabolites that may influence electrophysiological parameters and the genesis of malignant arrhythmias. We have recently shown an increased synthetic capacity within an evolving infarct for thromboxan...

journal_title：Journal of cardiovascular pharmacology

authors： Kramer JB,Davis AG,Dean R Jr,McCluskey ER,Needleman P,Corr PB

更新日期：1985-11-01 00:00:00

abstract：:The cardiac and renal hemodynamic effects of SE2395, a beta-blocking agent, were examined after intravenous administration (50 micrograms/kg) in normotensive conscious dogs. Beta-blocking action of SE2395 was evidenced by a reduction in heart rate and cardiac output without change in the mean arterial pressure. An inc...

journal_title：Journal of cardiovascular pharmacology

authors： Walker BR,Erickson AL,Prost JF,Rochat C,Burke TJ

更新日期：1985-11-01 00:00:00

abstract：:Ghrelin is a novel growth hormone (GH)-releasing peptide, isolated from the stomach, which is identified as an endogenous ligand for GH secretagogues receptor. Although both ghrelin and its specific receptor are expressed in blood vessels, the cardiovascular effects of ghrelin remain unknown. To clarify whether ghreli...

journal_title：Journal of cardiovascular pharmacology

authors： Okumura H,Nagaya N,Enomoto M,Nakagawa E,Oya H,Kangawa K

更新日期：2002-06-01 00:00:00

abstract：:The angiotensin II receptor-1 blockers have generally been shown to have antiatherogenic effects, and dendritic cells (DCs) are the most efficient antigen presenting cells that play an active role in the development of atherosclerosis through inflammatory-immune responses. Here, we tested the hypothesis that the antia...

journal_title：Journal of cardiovascular pharmacology

authors： Huang D,Lu H,Liu H,Yao K,Sun A,Zou Y,Ge J

更新日期：2012-08-01 00:00:00