Coupling mechanisms of alpha 2-adrenoceptors.

abstract：:We determined involvement of nitric oxide (NO) derived from perivascular nerve in venous relaxation. In helical strips of dog superficial temporal veins contracted with prostaglandin F2 alpha (PGF2 alpha) nicotine produced a contraction, which was reversed to a relaxation by prazosin. The relaxation was partially atte...

journal_title：Journal of cardiovascular pharmacology

authors： Toda N,Yoshida K,Okamura T

更新日期：1995-05-01 00:00:00

abstract：:The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) and atria in vitro using conventional microelectrode technique. UK (10(-8)-10(-6) M) prolonged the action potential duration (APD) by 21-58% and effective refractory period...

journal_title：Journal of cardiovascular pharmacology

authors： Tande PM,Bjørnstad H,Yang T,Refsum H

更新日期：1990-09-01 00:00:00

abstract：:Vascular smooth muscle cell (VSMC) proliferation is pivotal in the progression of hypertension, atherosclerosis, and restenosis. Resveratrol is a grape polyphenol that is implicated as an important contributor to red wine's vascular protective effects. Its antimitogenic action on VSMC is attributed to an array of plei...

journal_title：Journal of cardiovascular pharmacology

authors： Ekshyyan VP,Hebert VY,Khandelwal A,Dugas TR

更新日期：2007-07-01 00:00:00

abstract：:Phosphoinositide (PI) turnover, chronotropic and inotropic responses to alpha 1-adrenoceptor activation, and alpha 1-adrenoceptor density were studied in atria from rats with left ventricular myocardial infarction (LVMI) and noninfarcted rats. LVMI was produced after surgical ligation of the left coronary artery in 8-...

journal_title：Journal of cardiovascular pharmacology

authors： Rowley KG,Tung LH,Hodsman GP,Howes LG,Jarrott B,Beart PM,Louis WJ

更新日期：1991-03-01 00:00:00

abstract：:Intravenous diltiazem (10-300 micrograms/kg), verapamil (10-300 micrograms/kg), nifedipine (1-100 micrograms/kg) and nicardipine (1-100 micrograms/kg) inhibited the tachycardia caused by cardiac sympathetic nerve stimulation (SNS, 0.5-4 Hz) in decentralized hearts of anesthetized dogs. The dose range of each drug requ...

journal_title：Journal of cardiovascular pharmacology

authors： Satoh E,Mukaiyama O,Kimura T,Satoh S

更新日期：1990-10-01 00:00:00

abstract：:Dihydropyridine calcium antagonists play an important role in the treatment of arterial hypertension. In many centers, they are used as first-line treatment. Since impaired renal function can be a complication of long-standing blood pressure elevation, the usefulness of dihydropyridine calcium antagonists in hypertens...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson LH

更新日期：1989-01-01 00:00:00

abstract：:A single dose of doxazosin, a long-acting postsynaptic alpha 1-adrenoceptor antagonist, was administered to seven patients with essential hypertension. Following administration of a single dose, all the patients except one who was forced to be discharged from the hospital for work, continuously received doxazosin once...

journal_title：Journal of cardiovascular pharmacology

authors： Shionoiri H,Yasuda G,Yoshimura H,Umemura S,Miyajima E,Miyakawa T,Takagi N,Kaneko Y

更新日期：1987-07-01 00:00:00

abstract：:Cardiotrophin-1 (CT-1) a novel IL-6-related cytokine, induces distinct hypertrophic responses to endothelin-1 (ET-1) on cultured neonatal rat cardiac myocytes. We found that ET-1 and CT-1 show a distinct pattern of gene induction of natriuretic peptides. Elucidation of the transcriptional mechanisms of brain natriuret...

journal_title：Journal of cardiovascular pharmacology

authors： Kuwahara K,Saito Y,Ogawa Y,Tamura N,Ishikawa M,Harada M,Ogawa E,Miyamoto Y,Hamanaka I,Kamitani S,Kajiyama N,Takahashi N,Nakagawa O,Masuda I,Nakao K

更新日期：1998-01-01 00:00:00

abstract：:Phosphatidylinositol 4,5-bisphosphate hydrolysis at the plasma membrane by phospholipase C is one of the major hormone regulated intracellular signaling systems. The system generates the diffusible second messenger IP3 and the membrane bound messenger diacylglycerol. Spatial regulation of this system has been thought ...

journal_title：Journal of cardiovascular pharmacology

authors： Smrcka AV

更新日期：2015-03-01 00:00:00

abstract：:Torsades de pointes ventricular tachycardia (VT) has been reported in patients taking the nonsedating antihistamine, terfenadine. We performed electrophysiologic studies of 14 isolated guinea pig hearts using the Langendorff technique to assess whether terfenadine exerted actions that could be responsible for inducing...

journal_title：Journal of cardiovascular pharmacology

authors： Pinney SP,Koller BS,Franz MR,Woosley RL

更新日期：1995-01-01 00:00:00

abstract：:Acute hemodynamic effects of 5 and 10 mg i.v. UD-CG 115 BS (pimobendan) were studied by right and left heart catheterization in idiopathic dilated cardiomyopathy (NYHA classes II and III; 5 mg = group I, n = 6; 10 mg = group II, n = 6). Effects on left ventricular function were evaluated by left ventricular angiograms...

journal_title：Journal of cardiovascular pharmacology

authors： Permanetter B,Sebening H,Hartmann F,Klein G

更新日期：1989-01-01 00:00:00

abstract：:From the membrane fraction of cultured human renal adenocarcinoma (ACHN) cells, two endothelin-2-converting enzymes (ECE-2A and ECE-2B) were solubilized with detergent Lubrol PX and separated by hydrophobic butyl fast-performance liquid chromatography. The pH range of the converting activity of ECE-2B for big endothel...

journal_title：Journal of cardiovascular pharmacology

authors： Shinmi O,Yorimitsu K,Moroi K,Nishiyama M,Sugita Y,Saito T,Inagaki Y,Masaki T,Kimura S

更新日期：1993-01-01 00:00:00

abstract：:We investigated the effect of oral ibopamine (SB 7505) on myocardial and renal function in eight patients suffering from congestive heart failure. Ibopamine was administered orally 50 mg twice a day for 7 days. Systolic time intervals PEP (preejection period) and EMS (electromechanical systole) decreased significantly...

journal_title：Journal of cardiovascular pharmacology

authors： Dei Cas L,Manca C,Bernardini B,Vasini G,Visioli O

更新日期：1982-05-01 00:00:00

abstract：:In fetal human left ventricular endocardial endothelial cells (EECLs), both plasma membrane (PM) ET(A)R and ET(B)R were reported to mediate ET-1-induced increase of intracellular calcium [Ca](i); however, this effect was mediated by ET(A)R in right EECs (EECRs). In this study, we verified whether, as for the PM, nucle...

journal_title：Journal of cardiovascular pharmacology

authors： Jules F,Avedanian L,Al-Khoury J,Keita R,Normand A,Bkaily G,Jacques D

更新日期：2015-07-01 00:00:00

abstract：:Epicardial coronary arteries dilate after release of a transient coronary occlusion in awake chronically instrumented dogs but not in anesthetized dogs studied acutely after surgery. To determine whether anesthesia or surgical trauma is responsible for this lack of reactive dilation, we evaluated the effect of anesthe...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz JS,Bache RJ

更新日期：1987-01-01 00:00:00

abstract：:Guinea pig papillary muscles were preincubated in the presence of 5 x 10(-9) mol/L unlabeled noradrenaline or adrenaline then incubated with (3H)-noradrenaline and superfused. Electrical field stimulation with 180 pulses delivered at 1 or 3 Hz was used to induce overflow of radioactivity. Comparison of the effects of ...

journal_title：Journal of cardiovascular pharmacology

authors： Valenta B,Singer EA

更新日期：1991-02-01 00:00:00

abstract：:NADPH oxidases have recently been shown to contribute to the pathogenesis of hypertension. The development of specific inhibitors of these enzymes has focused attention on their potential therapeutic use in hypertensive disease. Two of the most specific inhibitors, gp91ds-tat and apocynin, have been shown to decrease ...

journal_title：Journal of cardiovascular pharmacology

authors： Williams HC,Griendling KK

更新日期：2007-07-01 00:00:00

abstract：:Activating IK1 channels is considered to be a promising antiarrhythmic strategy. Zacopride has been identified as a selective IK1 channel agonist and can suppress triggered arrhythmias. Whether this drug also exerts a beneficial effect on cardiac remodeling is unknown, and the present study sought to address this ques...

journal_title：Journal of cardiovascular pharmacology

authors： Liu CF,Liu QH,Liu EL,Zhai XW,Zhang L,Luo TE,Zhang WF,Feng QL,Cui XL,Zhao ZQ,Cao JM,Wu BW

更新日期：2014-10-01 00:00:00

abstract：:Atherosclerosis is a complex vascular disease initiated by abnormal accumulation of plasma lipoproteins in the subendothelial space. Elevated levels of plasma triglycerides (TG) and low-density lipoprotein (LDL)-cholesterol as well as low concentrations of high-density lipoprotein (HDL) play a causal role in the devel...

journal_title：Journal of cardiovascular pharmacology

authors： Declercq V,Yeganeh B,Moshtaghi-Kashanian GR,Khademi H,Bahadori B,Moghadasian MH

更新日期：2005-07-01 00:00:00

abstract：:The selectivity of single oral doses of xamoterol, 200 mg, prenalterol, 50 mg, and salbutamol, 8 mg, was compared in eight healthy male volunteers by measuring their effects on sleeping heart rate, supine heart rate, blood pressure, forearm blood flow, finger tremor, and exercise heart rate in the presence and absence...

journal_title：Journal of cardiovascular pharmacology

authors： McCaffrey PM,Riddell JG,Shanks RG

更新日期：1988-05-01 00:00:00

abstract：:Long-term exposure of endothelial cells to molsidomine in vivo and in vitro improves the thromboresistance of endothelial cells, judging from the inhibition of platelet aggregation by endothelial cells in autologous plasma. In cultured endothelial cells, the present studies attempted (a) to show that platelets influen...

journal_title：Journal of cardiovascular pharmacology

authors： Berenger-Bahuet FP,Rolland PH

更新日期：1989-01-01 00:00:00

abstract：:Current drug screening methods are insufficiently predictive of clinical toxicity and efficacy. Recent advances in stem cell technology have the potential to improve drug screening. For tests of cardiotoxicity and efficacy of cardioactive drugs, cardiomyocytes derived from human embryonic stem cells and/or human induc...

journal_title：Journal of cardiovascular pharmacology

authors： Laposa RR

更新日期：2011-09-01 00:00:00

abstract：:The dependency of arteriolar tone on calcium influx was studied in 11 patients with essential hypertension (EHT) and compared to 11 age-matched normotensive (NT) subjects by measuring the forearm blood flow (FAF) response to intraarterial infusion of the calcium channel blocker verapamil (Verap) and the nonspecific va...

journal_title：Journal of cardiovascular pharmacology

authors： Hulthén UL,Bolli P,Amann FW,Kiowski W,Bühler FR

更新日期：1982-01-01 00:00:00

abstract：:We investigated the effects of nifedipine on cyclic GMP turnover and the pertinent enzyme activities in cultured coronary smooth muscle cells (SMC). Nifedipine at high concentrations slightly decreased basal soluble guanylate cyclase activity and inhibited the action of sodium nitroprusside (SNP) but had no effect on ...

journal_title：Journal of cardiovascular pharmacology

authors： Kishi Y,Watanabe T,Makita T,Sakita S,Watanabe R,Ashikaga T,Numano F

更新日期：1995-10-01 00:00:00

abstract：:Several studies suggested that dopamine may be one of the inhibitory modulators of aldosterone secretion. Metoclopramide, a selective antagonist for dopamine D-2 receptors, increases both basal plasma aldosterone levels and the aldosterone response to angiotensin II (Ang II) in rats and humans kept on a high sodium in...

journal_title：Journal of cardiovascular pharmacology

authors： Missale C,Lombardi C,De Cotiis R,Memo M,Carruba MO,Spano PF

更新日期：1989-01-01 00:00:00

abstract：:In this study we compared the antithrombotic and anticoagulant properties of sodium and calcium derivatives of pentosan polysulfate (Na-PPS, Ca-PPS), unfractionated heparin (UFH), and low-molecular-weight heparin (Fraxiparin). The antithrombotic effects of these agents have been investigated in an experimental thrombo...

journal_title：Journal of cardiovascular pharmacology

authors： Giedrojć J,Klimiuk M,Radziwon P,Kłoczko J,Bielawiec M,Breddin HK

更新日期：1999-09-01 00:00:00

abstract：:(+/-)-Dobutamine at concentrations < or =10(-5) M did not evoke contractions of rat gastric artery segments. However, when the tissues were contracted with methoxamine, (+/-)-dobutamine evoked concentration-dependent relaxation. The relaxant responses were not significantly affected by propranolol. In the same prepara...

journal_title：Journal of cardiovascular pharmacology

authors： Oriowo MA

更新日期：1999-11-01 00:00:00

abstract：:Glycogen synthase kinase (GSK)-3beta inhibitors play an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that GSK-3beta inhibitors protect against myocardial ischemia-reperfusion injury. However, the precise mechanisms remain unclear. We aimed to investigate the roles of inflam...

journal_title：Journal of cardiovascular pharmacology

authors： Gao HK,Yin Z,Zhou N,Feng XY,Gao F,Wang HC

更新日期：2008-09-01 00:00:00

abstract：:Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emergin...

journal_title：Journal of cardiovascular pharmacology

authors： Frohlich ED

更新日期：1984-01-01 00:00:00

abstract：:The hemodynamic effects of tetramethylpyrazine were examined in 27 anesthetized open chest dogs with electromagnetic flowmeter probes on the left circumflex coronary artery and ascending aorta. Tetramethylpyrazine, 2-15 mg/kg i.v., caused prominent systemic and coronary vasodilation, with a maximum reduction of mean a...

journal_title：Journal of cardiovascular pharmacology

authors： Dai XZ,Bache RJ

更新日期：1985-09-01 00:00:00