Alpha1-adrenoceptor antagonist effect of (+/-)-dobutamine in rat isolated gastric artery preparation.

abstract：:We wished to determine whether pharmacologic inhibition of the exaggerated sympathetic nerve activity in congestive heart failure (CHF) could restore the renal response to exogenous atrial natriuretic peptide (ANP) administration. Left ventricular (LV) myocardial infarction was induced in Sprague-Dawley rats (n = 16) ...

journal_title：Journal of cardiovascular pharmacology

authors： Feng QP,Hedner T,Hedner J,Pettersson A

更新日期：1990-11-01 00:00:00

abstract：OBJECTIVE:Genetic loci predict <5% of variation in low-density lipoprotein cholesterol (LDL-C) response to statins. Cholestanol and desmosterol are plasma markers of cholesterol absorption and synthesis, respectively. Because statins lower LDL-C by inhibiting cholesterol synthesis, we studied the relationship between c...

journal_title：Journal of cardiovascular pharmacology

authors： Hoenig MR,Walker PJ,Gurnsey C,Beadle K,Johnson L

更新日期：2010-10-01 00:00:00

abstract：:Histamine receptors are present in adrenergic terminals, and histamine is reported to inhibit release of the neurotransmitter norepinephrine (NE) at certain neuroeffector junctions. However, a physiological role for histamine in modifying adrenergic neurotransmission has not been established. To examine the interactio...

journal_title：Journal of cardiovascular pharmacology

authors： Muldoon SM,Freas W,Mahla ME,Donlon MA

更新日期：1987-05-01 00:00:00

abstract：:Biological aging is an independent risk factor for many cardiovascular diseases; some are treated with beta-blockers that may protect dysfunctional endothelium during aging by increasing NO, decreasing ONOO, and restoring NO/ONOO balance. A nanotechnological approach was used to simultaneously monitor NO and ONOO prod...

journal_title：Journal of cardiovascular pharmacology

authors： Funovic P,Korda M,Kubant R,Barlag RE,Jacob RF,Mason RP,Malinski T

更新日期：2008-02-01 00:00:00

abstract：:The pharmacologic properties of a novel nonpeptide endothelin (ET) receptor antagonist, S-1255 ([R]-[+]-2-[benzo(1,3)dioxol-5-yl]-6-isopropyl-4-[4-methoxyphenyl]-2H-chromene-3-carboxylic acid), was studied. [3H]S-1255 specifically bound to porcine aortic smooth muscle membranes expressing only ET(A) receptors with a K...

journal_title：Journal of cardiovascular pharmacology

authors： Iwasaki T,Mihara S,Shimamura T,Kawakami M,Masui M,Hayasaki-Kajiwara Y,Naya N,Ninomiya M,Fujimoto M,Nakajima M

更新日期：2001-04-01 00:00:00

abstract：:We wished to determine if the previously observed cardioprotective effects of monophosphoryl lipid A (MLA, 65 micrograms/kg intravenously, i.v.), an endotoxin derivative, were time related and mediated by an enhancement of antioxidant defense mechanisms, i.e., myocardial catalase and superoxide dismutase (SOD) activit...

journal_title：Journal of cardiovascular pharmacology

authors： Yao Z,Rasmussen JL,Hirt JL,Mei DA,Pieper GM,Gross GJ

更新日期：1993-10-01 00:00:00

abstract：:Diazepam (DZP) is commonly used in treatment of patients with acute ischemic syndromes to allay anxiety, but benzodiazepines reduce myocardial contractility and increase myocardial blood flow. To investigate the antiischemic effect of DZP, we studied 13 patients with a positive exercise test and angiographically docum...

journal_title：Journal of cardiovascular pharmacology

authors： Rossetti E,Fragasso G,Xuereb RG,Xuereb M,Margonato A,Chierchia SL

更新日期：1994-07-01 00:00:00

abstract：:Clinical trials in patients with congestive heart failure have shown a wide disparity in the hemodynamic responses to chronic therapy with newer positive inotropic drugs. Therefore, the long-term efficacy of enoximone was studied in 10 patients with severe congestive heart failure. Patients were evaluated clinically, ...

journal_title：Journal of cardiovascular pharmacology

authors： Gilfrich HJ,Witzke-Gross J,Römer A

更新日期：1989-01-01 00:00:00

abstract：:Buchang NaoXinTong (NXT) is a Chinese medicine that has been used for many years for treatment of patients with coronary heart disease (CHD) in China. Statins substantially reduce hypercholesterolemia and CHD mortality and morbidity. However, there is still a lot of CHD patients who do not respond well to statin thera...

journal_title：Journal of cardiovascular pharmacology

authors： Yang X,Li Y,Sun L,Liu Y,Ma C,Chen Y,Tan H,Li Q,Li X,Wang Y,Duan Y,Zhao B,Han J

更新日期：2017-01-01 00:00:00

abstract：:We examined the electromechanical effects of two class III antiarrhythmic agents, dofetilide (UK-68,798) and D-sotalol, in acidic myocardium. Right ventricular papillary muscle preparations isolated from guinea pigs were divided into three groups (n = 6 per group): (a) drug-free, (b) dofetilide (10 nM), and (c) D-sota...

journal_title：Journal of cardiovascular pharmacology

authors： Yang T,Tande PM,Refsum H

更新日期：1992-12-01 00:00:00

abstract：:Endothelial dysfunction is the pathophysiologic principle involved in the initiation and progression of arteriosclerosis, thus endothelial function serves as a "barometer" for cardiovascular health that can be used for the evaluation of new therapeutic strategies. This review provides an introduction to the concept of...

journal_title：Journal of cardiovascular pharmacology

authors： Heiss C,Schroeter H,Balzer J,Kleinbongard P,Matern S,Sies H,Kelm M

更新日期：2006-01-01 00:00:00

abstract：:In this study, we used the spontaneously beating, isolated rat right atrium as an in vitro model to study arrhythmogenic effects of electrical stimulation. A tetrapolar platinum electrode was used for stimulation and recording of atrial electrical activity at 36.5 degrees C (spontaneous rate, 4.9+/-0.3 Hz). A flutter-...

journal_title：Journal of cardiovascular pharmacology

authors： Godoy CM,Bassani RA,Bassani JW

更新日期：1999-10-01 00:00:00

abstract：:The vulnerable period (VP) is an interval of time during the cardiac cycle within which premature stimulation may lead to trains of responses (one: many stimulus-response coupling). Although the VP parallels the recovery of sodium channel availability, modulators of its boundaries remain unclear. Numerical studies of ...

journal_title：Journal of cardiovascular pharmacology

authors： Nesterenko VV,Lastra AA,Rosenshtraukh LV,Starmer CF

更新日期：1992-05-01 00:00:00

abstract：:We studied the influence of prostacyclin (PGI2) on the contractile performance of isolated mammalian ventricular muscle. PGI2 had no direct influence on myocardial contractility, as evidenced by experiments on single cardiac cells and papillary muscle. Moreover, PGI2 did not interfere with the inotropic action of isop...

journal_title：Journal of cardiovascular pharmacology

authors： Couttenye MM,De Clerck NM,Herman AG,Brutsaert DL

更新日期：1985-09-01 00:00:00

abstract：:Rapamycin (RP; rapamune, sirolimus) is a potent inhibitor of vascular smooth muscle cell proliferation and migration. RP was demonstrated to reduce vascular neointimal formation in different animal models of vascular smooth muscle cell proliferation, and clinical use of RP-eluting stents promotes significant reduction...

journal_title：Journal of cardiovascular pharmacology

authors： Neto Mde M,Di Marco GS,Casarini DE,Lima VC,Campos AH

更新日期：2007-02-01 00:00:00

abstract：:Hypertonic solutions of 0.3 M sodium chloride (NaCl) infused into the third ventricle (ICV) for 20 min in urethane-anesthetized rats consistently elevated mean aortic pressure by approximately 10 mm Hg. Heart rate and sympathetic nerve activity diminished slightly during the first few minutes but then accelerated to a...

journal_title：Journal of cardiovascular pharmacology

authors： Buñag RD,Miyajima E

更新日期：1984-09-01 00:00:00

abstract：:Vasopressin secretion is stimulated by hyperosmolality, hypovolemia, or hypotension and is inhibited by hypoosmolality, hypervolemia, or hypertension. These osmotic and hemodynamic influences are mediated by neuronal afferents that originate in separate osmoreceptors or baroreceptors but ultimately converge to act on ...

journal_title：Journal of cardiovascular pharmacology

authors： Robertson GL,Ganguly A

更新日期：1986-01-01 00:00:00

abstract：:The phosphodiesterase inhibitor UK 61260 exhibits positive inotropic activity in animal studies and is under clinical investigation for treatment of congestive heart failure (CHF). We examined the lusitropic and inotropic responses to UK 61260 in electrically driven (1 Hz, 37 degrees C) human auricular trabeculae (AUT...

journal_title：Journal of cardiovascular pharmacology

authors： Schwinger RH,Böhm M,La Rosée K,Schmidt U,Erdmann E

更新日期：1992-06-01 00:00:00

abstract：ABSTRACT:Establishing efficient perfusion into the myocardium is the main purpose in patients with acute coronary syndrome, but the process of reperfusion is not without risk and can damage the myocardium paradoxically. Unfortunately, there is no effective treatment for reperfusion injury, and efforts to find an effici...

journal_title：Journal of cardiovascular pharmacology

authors： Kakavand H,Aghakouchakzadeh M,Coons J,Talasaz AH

更新日期：2021-01-04 00:00:00

abstract：:Forty patients (aged 28-66 years) with essential hypertension were randomized to 14 weeks of treatment with diltiazem or hydrochlorothiazide (HCTZ) in a double-blind, parallel study design. A significant reduction in supine body weight (-6.0 +/- 1.5 lb; p less than 0.001) and increase in pulse (+6 +/- 2 beats/min; p l...

journal_title：Journal of cardiovascular pharmacology

authors： Swartz SL

更新日期：1987-04-01 00:00:00

abstract：:Felodipine, a dihydropyridine calcium antagonist, was used to treat eight patients with severe uncontrolled hypertension: five had essential hypertension, two had renovascular disease, and one chronic pyelonephritis. Mean blood pressure (BP) was 221 +/- 14/120 +/- 4 mm Hg despite treatment with three or more antihyper...

journal_title：Journal of cardiovascular pharmacology

authors： Herlitz H,Granérus G,Aurell M

更新日期：1990-01-01 00:00:00

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:Fifteen patients with stable angina participated in a 12-week crossover study to evaluate the efficacy of nifedipine and nitroglycerin patches. There was an initial 2-week drug washout period followed by a 2-week control period when patients received no other antianginal treatment other than sublingual nitroglycerin f...

journal_title：Journal of cardiovascular pharmacology

authors： Eldridge JE,Burdick DC,Jones RH,Hossack KF

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Numerous studies have demonstrated that fibroblast growth factor-2 (FGF-2) signaling may play a pivotal role in the development of pulmonary arterial hypertension (PAH). Excessive endothelial FGF-2 contributes to smooth muscle hyperplasia and disease progression. PD173074 is a potent FGF receptor 1 (FGFR-1) ...

journal_title：Journal of cardiovascular pharmacology

authors： Zheng Y,Ma H,Hu E,Huang Z,Cheng X,Xiong C

更新日期：2015-11-01 00:00:00

abstract：:Aspirin for secondary cardiovascular disease prevention is well established, but treatment discontinuation, often because of gastrointestinal mucosal injury or symptoms, can lead to increased risk for cardiovascular events. Proton pump inhibitor therapy is recommended for aspirin-treated patients at gastrointestinal r...

journal_title：Journal of cardiovascular pharmacology

authors： Goldstein JL,Scheiman JM,Fort JG,Whellan DJ

更新日期：2016-08-01 00:00:00

abstract：ABSTRACT:Lipid metabolism disorder and inflammatory response are considered to be the major causes of atherosclerogenesis. Astragalin, the most important functional component of flavonoid obtained from persimmon leaves, has the hypolipidemic effects. However, it is unknown, how astragalin protects against atheroscleros...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao ZW,Zhang M,Wang G,Zou J,Gao JH,Zhou L,Wan XJ,Zhang DW,Yu XH,Tang CK

更新日期：2020-10-30 00:00:00

abstract：:Serotonin, applied to helical strips of larger vessels such as coronary arteries, acts as a potent vasoconstrictor in vitro. In contrast, in vivo serotonin causes a remarkable decrease in total peripheral resistance. To differentiate the influence of serotonin on resistances of large and small vessels, experiments wer...

journal_title：Journal of cardiovascular pharmacology

authors： Meschig R,Breuer J,Arnold G

更新日期：1985-01-01 00:00:00

abstract：:The effects of purified baicalin and baicalein from the traditional Chinese herb, Huangqin, on contractions induced by phenylephrine, U46619, and high extracellular K+ were investigated in isolated rat mesenteric arteries. Both baicalin (1-100 microM) and baicalein (1-50 microM) potentiated the contractile response to...

journal_title：Journal of cardiovascular pharmacology

authors： Tsang SY,Chen ZY,Yao XQ,Huang Y

更新日期：2000-08-01 00:00:00

abstract：:Structurally and pharmacologically diverse vasodilators are known to lower blood pressure, increase heart rate, and produce acute injury to right coronary arteries in the dog. Administration of low concentrations of endothelin-1 (ET-1) to anesthetized dogs causes coronary vasoconstriction and reductions in coronary bl...

journal_title：Journal of cardiovascular pharmacology

authors： Louden C,Nambi P,Branch C,Gossett K,Pullen M,Eustis S,Solleveld HA

更新日期：1998-01-01 00:00:00

abstract：:The effects of cibenzoline were examined in the dog with multifocal ventricular arrhythmias 24 h after ligation of the left anterior descending coronary artery, and on isolated, superfused canine cardiac tissues which were studied using standard microelectrode techniques. In the intact dog, 5 mg/kg cibenzoline consist...

journal_title：Journal of cardiovascular pharmacology

authors： Dangman KH

更新日期：1984-03-01 00:00:00