Coronary arterial lesions in dogs treated with an endothelin receptor antagonist.

abstract：:Ranolazine was previously shown to stimulate cardiac glucose oxidation. Dichloroacetate (DCA) also does and was shown to improve exercise capacity in animals, but it has long-term toxicity problems. To test the hypothesis that ranolazine would increase exercise performance in the chronic heart failure (CHF) condition,...

journal_title：Journal of cardiovascular pharmacology

authors： Aaker A,McCormack JG,Hirai T,Musch TI

更新日期：1996-09-01 00:00:00

abstract：:NSP-513, a novel potent and selective phosphodiesterase 3 (PDE 3) inhibitor, and cilostazol, a previously developed PDE 3 inhibitor, were compared with respect to antiplatelet, antithrombotic, and hemodynamic effects. In the in vitro antiplatelet aggregation studies, NSP-513 and cilostazol inhibited collagen-induced c...

journal_title：Journal of cardiovascular pharmacology

authors： Hirose H,Mashiko S,Kimura T,Ishida F,Mochizuki N,Nishibe T,Nishikibe M

更新日期：2000-04-01 00:00:00

abstract：:Endothelial cells and smooth muscle cells are the major cells that constitute blood vessels, and endothelial cells line the lumen of blood vessels. These 2 types of cells also play an integral role in the regional specialization of vascular structure. On the basis of these observations, we designed our study to invest...

journal_title：Journal of cardiovascular pharmacology

authors： Bertrand-Thiebault C,Masson C,Siest G,Batt AM,Visvikis-Siest S

更新日期：2007-05-01 00:00:00

abstract：:Apoptosis, a genetically controlled programmed cell death, has been found to play a role in ischemic reperfusion injury in several animal species including rats and rabbits. To examine whether this also is true for other animals, a surgically relevant model was established using an isolated in situ swine heart. Hearts...

journal_title：Journal of cardiovascular pharmacology

authors： Maulik N,Yoshida T

更新日期：2000-11-01 00:00:00

abstract：:Increased expression of plasminogen activator inhibitor type-I (PAI-1) in vessel walls seems to accelerate atherosclerosis. Angiotensin II can increase the synthesis of PAI-1. Inhibition of this process may facilitate migration of vascular smooth muscle cells (VSMCs) stabilizing atherosclerotic plaques. To determine w...

journal_title：Journal of cardiovascular pharmacology

authors： French CJ,Zaman AK,Sobel BE

更新日期：2011-08-01 00:00:00

abstract：:The autonomic nervous system exerts broad control over the involuntary functions of the human body through complex equilibrium between sympathetic and parasympathetic tone. Imbalance in this equilibrium is associated with a multitude of cardiovascular outcomes, including mortality. The cardiovascular static state of t...

journal_title：Journal of cardiovascular pharmacology

authors： Sigurdsson MI,Waldron NH,Bortsov AV,Smith SB,Maixner W

更新日期：2018-03-01 00:00:00

abstract：:To study the role of intrinsic sympathomimetic activity (ISA) in beta-blocker-induced changes of beta-adrenoceptors, the effects of administration of several beta-blockers for 9 days on lymphocyte beta 2-adrenoceptor density--assessed by 125iodocyanopindolol binding--were investigated in 47 normotensive volunteers. Pr...

journal_title：Journal of cardiovascular pharmacology

authors： Daul A,Wang XL,Borchard U,Bock KD,Brodde OE

更新日期：1986-01-01 00:00:00

abstract：:To gain insight with regard to the mode of action of calcium antagonists on the vasculature, we examined the effects of nifedipine, isradipine, felodipine, verapamil, gallopamil, and amlodipine on vasoconstrictor-induced prostacyclin synthesis in vitro. Cultured rat aortic smooth muscle cells were seeded after two to ...

journal_title：Journal of cardiovascular pharmacology

authors： Vallotton MB,Gerber-Wicht C,Dolci W,Rivest RW

更新日期：1990-04-01 00:00:00

abstract：:The sensitivity of smooth muscle from aortas of spontaneously hypertensive rats (SHR), renal hypertensive rats: two kidney-one clip and one kidney-one clip (2K-1C, 1K-1C) and DOCA salt hypertensive rats to the relaxant effect of nifedipine (NIF) was studied. A parallel leftward shift of the concentration-relaxation cu...

journal_title：Journal of cardiovascular pharmacology

authors： Cattaneo EA,Rinaldi GJ,Gende OA,Venosa RA,Cingolani HE

更新日期：1986-09-01 00:00:00

abstract：:Low doses of ethanol can produce negative functional effects in ventricular myocytes. This may be related to the nitric oxide-cyclic GMP signal transduction system. We tested the hypothesis that ethanol stimulated endothelial nitric oxide synthase and this caused the negative functional effects in cardiac myocytes. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang S,Grover GJ,Stokes H,Scholz PM,Weiss HR

更新日期：2005-09-01 00:00:00

abstract：:The effects of potent coronary vasodilator, 2- phenylaminoadenosine (CV-1808), on coronary circulatory failure and thromboxane (TX) A2 release were studied during coronary occlusion (for 60 min) and subsequent reperfusion (for 60 min) in anesthetized dogs. During coronary reperfusion, reactive hyperemic response was a...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe M,Terashita Z,Nishikawa K,Hirata M

更新日期：1984-05-01 00:00:00

abstract：:Glycogen synthase kinase (GSK)-3beta inhibitors play an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that GSK-3beta inhibitors protect against myocardial ischemia-reperfusion injury. However, the precise mechanisms remain unclear. We aimed to investigate the roles of inflam...

journal_title：Journal of cardiovascular pharmacology

authors： Gao HK,Yin Z,Zhou N,Feng XY,Gao F,Wang HC

更新日期：2008-09-01 00:00:00

abstract：:Vascular endothelial cell (EC) wound healing was characterized on an EC-synthesized extracellular matrix (ECM) previously treated with enzymes and antibodies specific for ECM components. Using a computer-assisted video-microscope recording system capable of automatic EC recognition, we learned whether components of th...

journal_title：Journal of cardiovascular pharmacology

authors： Herman IM

更新日期：1993-01-01 00:00:00

abstract：:In primarily cultured pig coronary smooth muscle cells, extracellular adenosine triphosphate (ATP; 10(-9) to 10(-3) M) dose-dependently increases intracellular calcium ([Ca2+]i). The [Ca2+]i transients measured by fura-2 fluorescence consist of peak and plateau phases with [Ca2+]i values of 191.84 +/- 5.67 nM (n = 10)...

journal_title：Journal of cardiovascular pharmacology

authors： Seiler L,Matyas S,Fleckenstein-Grün G

更新日期：1999-05-01 00:00:00

abstract：:The renin-angiotensin system affects blood pressure and regional blood flow through endocrine, paracrine, and autocrine influences. The circulating endocrine renin-angiotensin system (RAS) is activated for acute cardiovascular homeostasis. The recent demonstration of a local renin-angiotensin system in the blood vesse...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1987-01-01 00:00:00

abstract：:To elucidate the role of potassium channel activation in muscarinic inhibition of atrial contractility, we studied the influence of K+ channel blockers on the effects of the muscarinic agonist carbachol in isolated guinea pig auricles. We tested BaCl2, tetraethylammoniumchloride (TEA), and 9-aminotetrahydroacridine (T...

journal_title：Journal of cardiovascular pharmacology

authors： Groschner K,Kukovetz WR

更新日期：1989-10-01 00:00:00

abstract：:The propyl derivative of ajmaline, N-n-propylajamaline (prajmalium), is an antiarrhythmic compound that lacks the commonly reported negative inotropic effects of all others under clinical use. The present study was undertaken to establish and understand its effects at the cellular level in mammalian preparations. Elec...

journal_title：Journal of cardiovascular pharmacology

authors： Alvarez JL,Rubio L,Garrido G,Vassort G

更新日期：1992-07-01 00:00:00

abstract：:We wished to determine whether pharmacologic inhibition of the exaggerated sympathetic nerve activity in congestive heart failure (CHF) could restore the renal response to exogenous atrial natriuretic peptide (ANP) administration. Left ventricular (LV) myocardial infarction was induced in Sprague-Dawley rats (n = 16) ...

journal_title：Journal of cardiovascular pharmacology

authors： Feng QP,Hedner T,Hedner J,Pettersson A

更新日期：1990-11-01 00:00:00

abstract：:Activation of polymorphonuclear neutrophils (PMNs) during cardiopulmonary bypass (CPB) is a wellknown phenomenon. This study aimed to determine if activated PMNs are sequestered and degranulated within the myocardium at reperfusion in patients undergoing coronary artery bypass grafting (CABG). Nineteen patients underg...

journal_title：Journal of cardiovascular pharmacology

authors： Dhôte-Burger P,Vuilleminot A,Lecompte T,Pasquier C,Bara L,Julia P,Chardigny C,Fabiani JN

更新日期：1995-01-01 00:00:00

abstract：:Increased levels of endothelin (ET) have been demonstrated in the ischemic brain, and ET receptor antagonism has been shown to improve outcome in cerebral ischemia. However, no previous work has been carried out evaluating the role of ET and its antagonism in brain trauma as compared to experimental stroke. In this st...

journal_title：Journal of cardiovascular pharmacology

authors： Barone FC,Ohlstein EH,Hunter AJ,Campbell CA,Hadingham SH,Parsons AA,Yang Y,Shohami E

更新日期：2000-11-01 00:00:00

abstract：:Celiprolol is reported to be a new cardioselective beta blocker with novel ancillary properties including vasodilator effects. The purpose of this study was to investigate whether celiprolol possesses a direct vasodilatory effect on human vasculature in vivo and in vitro. We studied the in vivo effects of intra-arteri...

journal_title：Journal of cardiovascular pharmacology

authors： Hughes A,Martin G,Goldberg P,Thom S,Sever P

更新日期：1987-11-01 00:00:00

abstract：:Carvedilol is a dual-acting drug designed to produce two complementary effects: beta-blockade and vasodilation. These effects are induced in the same dose range, a prerequisite for utilizing both properties in an appropriate manner. The vasodilation is mediated predominantly by specific alpha 1-adrenoceptor blockade. ...

journal_title：Journal of cardiovascular pharmacology

authors： Sponer G,Strein K,Bartsch W,Müller-Beckmann B

更新日期：1992-01-01 00:00:00

abstract：:The elimination of an acute oral saline load is markedly blunted in adult Sabra hypertension-prone (SBH) rats compared with hypertension-resistant Sabra normotensive (SBN) rats. Within 2 h, urinary output and the excretion of sodium and potassium are significantly reduced, while urine osmolality is markedly elevated i...

journal_title：Journal of cardiovascular pharmacology

authors： Mekler J,Ben-Ishay D,Garthoff B,Kazda S

更新日期：1987-01-01 00:00:00

abstract：:Genetic hypertension [essential hypertension (EH) in humans and spontaneous hypertension in rats (SHRs)] is associated with an altered vascular structure, expressed in resistance vessels (small arteries) as an increased media:lumen ratio. The vascular smooth muscle cells appear normal and there is no cellular hypertro...

journal_title：Journal of cardiovascular pharmacology

authors： Mulvany MJ

更新日期：1992-01-01 00:00:00

abstract：:Several recent studies demonstrate that T lymphocytes and monocytes enter the vessel wall during pathologic conditions and accumulate both in atherosclerotic and arteritic lesions. This brief review summarizes our phenotypic analysis of such T lymphocytes. Effects of T lymphocytes and their secretory products (lymphok...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson GK,Holm J,Jonasson L,Seifert PS,Stemme S

更新日期：1989-01-01 00:00:00

abstract：:21-Aminosteroids are a group of new synthetic compounds developed as antiperoxidants. Although several studies have demonstrated their cardioprotective properties in acute ischemic models, none has assessed their long-term benefits after chronic myocardial infarction. In this investigation, we examined the cardioprote...

journal_title：Journal of cardiovascular pharmacology

authors： Ngo PL,Chen H,Qi S,Paquette F,Dumont L

更新日期：1999-12-01 00:00:00

abstract：:The vasodilatory properties of prostacyclin were studied in 12 intubated patients who underwent coronary artery bypass surgery. When infused in doses of 2.5, 5, 10, and 20 ng/kg/min, prostacyclin produced a dose-dependent decrease in systemic vascular resistance from 2,702 +/- 143 to 1,654 +/- 106 dynes/cm5/m2 (p less...

journal_title：Journal of cardiovascular pharmacology

authors： Chelly JE,Fabiani JN,Tricot AM,Abry B,Carpentier A

更新日期：1987-02-01 00:00:00

abstract：:The area of vulnerability (AOV) to ventricular fibrillation (VF) induction by high-voltage shocks has been proposed as a measure of vulnerability to VF. Biphasic shocks spanning the T wave and ranging between 50 V and the upper limit of vulnerability (ULV) to VF were delivered before and after terikalant (1 mg/kg) and...

journal_title：Journal of cardiovascular pharmacology

authors： Qi X,Varma P,Newman D,Mamalias N,Dorian P

更新日期：2002-02-01 00:00:00

abstract：:The structure-activity relationships of phosphoramidon analogues for inhibition of endothelin-converting enzyme (ECE), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE) were compared. Phosphoramidon inhibited ECE, NEP, and ACE activities with IC50 values of 3.5, 0.034, and 78 microM, respectiv...

journal_title：Journal of cardiovascular pharmacology

authors： Kukkola PJ,Savage P,Sakane Y,Berry JC,Bilci NA,Ghai RD,Jeng AY

更新日期：1995-01-01 00:00:00

abstract：:The exercise response to a single oral dose (25 mg) of a new beta-blocking agent that also has potent vasodilating properties, carvedilol, was assessed in 15 patients with stable exertional angina, positive exercise tests (greater than or equal to 1 mm ST depression) and coronary artery disease. A placebo-controlled, ...

journal_title：Journal of cardiovascular pharmacology

authors： Kaski JC,Rodriguez-Plaza L,Brown J,Maseri A

更新日期：1987-01-01 00:00:00