A double-blind, placebo-controlled, crossover trial to investigate the additive hypotensive effect of a diuretic (mefruside) to that produced by nifedipine.

abstract：:Intravenous (i.v.) administration of bromocriptine (150 micrograms/kg) in conscious normotensive rats with chronic spinal cord transection (at T5-T7), pretreated or not with i.v. propranolol (0.5 mg/kg), induced significant decreases in mean arterial blood pressure (MAP) which were greater and longer lasting than thos...

journal_title：Journal of cardiovascular pharmacology

authors： Lahlou S,Demenge P

更新日期：1992-05-01 00:00:00

abstract：:The development of numerous types of cardiovascular disease is associated with alteration of the vascular smooth muscle cell (SMC) phenotype. We have previously shown that abdominal aortic aneurysm progression in a mouse model of the disease is associated with reduced differentiation of SMCs within the lesion and that...

journal_title：Journal of cardiovascular pharmacology

authors： Adedoyin OO,Loftin CD

更新日期：2016-08-01 00:00:00

abstract：:Atherosclerosis, like several other vascular diseases, exhibits structural and functional abnormalities resulting partially from an exaggerated proliferation of vascular smooth-muscle cells (VSMCs). Ca2+ channel blockers, such as amlodipine, have been suggested to retard or even prevent the progression of atherosclero...

journal_title：Journal of cardiovascular pharmacology

authors： Stepien O,Gogusev J,Zhu DL,Iouzalen L,Herembert T,Drueke TB,Marche P

更新日期：1998-05-01 00:00:00

abstract：:Adenosine protects the ischemic myocardium by coronary vasodilation and the depression of heart rate and contractility, improving myocardial energy balance. Adenosine effects on the myocardium are mediated predominantly by the type A1 receptors. Atrial natriuretic peptide (ANP), a vasodilator and regulator of blood vo...

journal_title：Journal of cardiovascular pharmacology

authors： Salman H,Bergman M,Schlesinger H,Zahavi I,Kessler-Icekson G

更新日期：1999-07-01 00:00:00

abstract：:A brief review is given of the vasodilators that require an intact vascular endothelium to exert their relaxing effect. Then some major issues of the phenomenon of endothelium-dependent smooth muscle relaxation are discussed in more detail: The chemical structure of the endothelium-derived relaxing factor (EDRF), whic...

journal_title：Journal of cardiovascular pharmacology

authors： Förstermann U

更新日期：1986-01-01 00:00:00

abstract：:To clarify further the relationships between parathyroid glands and the development of hypertension, we studied the effect of cross-transplantation of these glands from young hypertensive rats in normotensive recipients. The parathyroid glands were isolated in 5-week-old hypertensive rats of the Lyon (male and female)...

journal_title：Journal of cardiovascular pharmacology

authors： Pernot F,Burkhard C,Gairard A

更新日期：1994-01-01 00:00:00

abstract：:Arterial hypertension complicating acute myocardial infarction (AMI) may aggravate myocardial damage, possibly through an increase in myocardial oxygen demand. This study reports the effects of clonidine in patients with hypertension complicating acute myocardial infarction. Forty patients (37 men and three women, ave...

journal_title：Journal of cardiovascular pharmacology

authors： Foresti A,Massari FM,Lotto A

更新日期：1986-01-01 00:00:00

abstract：:Roughly 40% of all diabetics, whether insulin dependent or not, develop persistent albuminuria, a decline in their glomerular filtration rate, and elevated blood pressure, i.e., diabetic nephropathy. Diabetic nephropathy is the single most important cause of end-stage renal disease in the Western world, accounting for...

journal_title：Journal of cardiovascular pharmacology

authors： Parving HH

更新日期：1992-01-01 00:00:00

abstract：:The advent of biologic therapy has enhanced our ability to augment disease in an increasingly targeted manner. The use of biologics in cardiovascular disease (CVD) has steadily increased over the past several decades. Much of the early data on biologics and CVD were derived from their use in rheumatologic populations....

journal_title：Journal of cardiovascular pharmacology

authors： Van Taunay JS,Albelda MT,Frias JC,Lipinski MJ

更新日期：2018-08-01 00:00:00

abstract：:The influence of intravenous diltiazem on hemodynamics and left ventricular function indices was studied in 14 patients with severe coronary artery disease at rest and during atrial pacing. We used a tip manometer catheter for recording left ventricular pressure tracings and a nuclear probe for measuring left ventricu...

journal_title：Journal of cardiovascular pharmacology

authors： van Dijk RB,Blanksma PK,van Gilst WH,Lie KI

更新日期：1993-08-01 00:00:00

abstract：:Acute angiotensin-converting enzyme inhibitors (ACEIs) have been found to induce natriuresis in humans as well as in experimental animals. However, the tubular sites involved have not been precisely evaluated in humans. Using both free-water and lithium clearance, the latter as a marker of proximal tubular reabsorptio...

journal_title：Journal of cardiovascular pharmacology

authors： Hannedouche T,Delgado A,Gnionsahe A,Lacour B,Grunfeld JP

更新日期：1989-01-01 00:00:00

abstract：:Cultured vascular smooth muscle cells derived by enzymatic dissociation of rabbit aortic media were used for study of alpha 1-adrenergic receptors (AAR) and receptor-coupled calcium flux. AAR were characterized by binding of the alpha 1-selective radioligand [3H]prazosin, and norepinephrine-stimulated 45calcium efflux...

journal_title：Journal of cardiovascular pharmacology

authors： Colucci WS,Brock TA,Atkinson WJ,Alexander RW,Gimbrone MA Jr

更新日期：1985-01-01 00:00:00

abstract：:The authors studied the involvement of IKr potassium current in ventricular fibrillation during perfusion. Electrophysiologic parameters were measured before and after dofetilide administration (2.5, 7.5, and 12.5 x 10-7 M, n = 8) in isolated perfused feline hearts. During pacing, these parameters included epicardial ...

journal_title：Journal of cardiovascular pharmacology

authors： Amitzur G,Shenkar N,Leor J,Novikov I,Eldar M

更新日期：2003-06-01 00:00:00

abstract：:Oxidative stress might exert deleterious cardiovascular effects. The aim of the present study was to compare the antioxidative effects of carvedilol and atenolol. Levels of oxidized low-density lipoprotein cholesterol (ox-LDL), vitamin E, and thiobarbituric acid reactive substances (TBARS) were measured. In a prospect...

journal_title：Journal of cardiovascular pharmacology

authors： Jonsson G,Abdelnoor M,Seljeflot I,Arnesen H,Hostmark AT,Kjeldsen SE,Os I,Westheim AS

更新日期：2007-01-01 00:00:00

abstract：:Hypertension, atherosclerosis, arteriosclerosis, and cardiomyopathy account for 80% of all diabetic deaths. A paucity of data exists concerning reactivity of the diabetic vasculature to vasopressor substances. The purpose of this investigation was to determine the influence of short-term (4-5 weeks) diabetes on the re...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson CV,Carrier GO

更新日期：1983-03-01 00:00:00

abstract：:Calcium is a signaling element of general importance to cells. In muscle, its key function is the activation of troponin C, which is essential for the contraction of myofibrils in skeletal and heart muscles, and of myosin light chain kinase, which is essential for the contraction of smooth muscles. Calcium modulates t...

journal_title：Journal of cardiovascular pharmacology

authors： Carafoli E

更新日期：1988-01-01 00:00:00

abstract：:The mechanism by which enoximone, a reported phosphodiesterase inhibitor, inhibits the oxidation of long-chain fatty acids was studied in isolated rat heart mitochondria using a series of 14C-labeled substrates. Enoximone decreased palmitate oxidation in a time- and concentration-dependent manner. Fifty percent inhibi...

journal_title：Journal of cardiovascular pharmacology

authors： Abdel-aleem S,Youssef J,Badr M,Morgan P,Frangakis C

更新日期：1992-06-01 00:00:00

abstract：:To determine whether the pattern of alcohol consumption, intake, and withdrawal modulates the incidence of malignant ventricular arrhythmias and sudden cardiac death due to beta-adrenergic stimulation in a species susceptible to administration of isoproterenol alone, a regimen was formulated in which both continuous a...

journal_title：Journal of cardiovascular pharmacology

authors： Guideri G,Gutstein WH,Olivetti G,Anversa P

更新日期：1988-10-01 00:00:00

abstract：:Autoradiographical images of whole body sections from control mice (29 +/- 3 days old) revealed high ETA densities within the cardiovascular system, with ETB receptors predominating in the kidney. A similar distribution of ETA receptors was found in ETB-deficient mice (25 +/- 2 days old) but the density was reduced in...

journal_title：Journal of cardiovascular pharmacology

authors： Davenport AP,Kuc RE

更新日期：2004-11-01 00:00:00

abstract：:We compared the beta-adrenoceptor blocking actions of bupuranolol and propranolol using the response to isoprenaline of the strength of contraction of the canine blood-perfused ventricular muscle, of the rate and strength of contraction of the isolated guinea pig heart and of a guinea pig tracheal ring preparation. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Hashimoto K,Tsukada T,Matsuda H,Nakagawa Y,Imai S

更新日期：1979-03-01 00:00:00

abstract：:This study investigated whether glibenclamide exerts a defibrillatory action and if this action is mediated by a blockade of ATP-sensitive K+ channels (K(ATP)) or by an anti-free radical mechanism. Aerobically perfused isolated rat hearts were subjected to 10 min of pacing-induced ventricular fibrillation (VF) followe...

journal_title：Journal of cardiovascular pharmacology

authors： Csonka C,Onody A,Csont T,Ferdinandy P

更新日期：2003-06-01 00:00:00

abstract：:An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

journal_title：Journal of cardiovascular pharmacology

authors： Haïat R,Piot O,Gallois H,Hanania G

更新日期：1999-06-01 00:00:00

abstract：:Chronic rapid right ventricular pacing (RRVP) at 250 beats/min produces low cardiac output (CO) heart failure, marked reduction in total vascular capacitance, and a shift in volume centrally. The effect of converting enzyme inhibition with captopril on cardiac preload was investigated in this model of heart failure. E...

journal_title：Journal of cardiovascular pharmacology

authors： Ogilvie RI,Zborowska-Sluis D

更新日期：1994-09-01 00:00:00

abstract：:The aim of this study was to determine whether tumor necrosis factor (TNF)-alpha would impair basal and stimulated endothelium-dependent vasomotion in human resistance vessel. Changes in baseline and acetylcholine (ACh)-induced forearm vascular resistance (FVR) were measured plethysmographically before and after a low...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura M,Yoshida H,Arakawa N,Saitoh S,Satoh M,Hiramori K

更新日期：2000-10-01 00:00:00

abstract：:Independent determinations of Ca2+ by two indicators showed that subcellular Ca2+ activity (intracellular free calcium concentration) was heterogeneous in rat myocardial cells. Arsenazo III (Az III), a membrane-impermeant absorbance indicator for Ca2+, was loaded into cardiac muscle via liposomes and calcium quantitat...

journal_title：Journal of cardiovascular pharmacology

authors： Hermsmeyer K,Mason R,Puga A,Erne P

更新日期：1991-01-01 00:00:00

abstract：:The effect of CGS 26303, an endothelin-converting enzyme inhibitor, on the prevention and reversal of cerebral vasospasm was investigated in a rabbit model of subarachnoid hemorrhage (SAH). In the prevention study, rabbits were injected with 3 ml of autologous blood in the cisterna magna and treatment with CGS 26303 i...

journal_title：Journal of cardiovascular pharmacology

authors： Kwan AL,Bavbek M,Jeng AY,Toyoda T,Kassell NF,Lee KS

更新日期：1998-01-01 00:00:00

abstract：:Proliferation of medial smooth muscle cells (SMC) plays a major role in restenosis after coronary angioplasty and can be inhibited by heparin. Platelets stimulate SMC proliferation, and their aggregation after angioplasty can be reduced by the direct thrombin inhibitor hirudin. In a porcine coronary stent-angioplasty ...

journal_title：Journal of cardiovascular pharmacology

authors： Buchwald AB,Hammerschmidt S,Stevens J,Göring J,Nebendahl K,Unterberg C

更新日期：1996-10-01 00:00:00

abstract：:Many radioligands used to study neurotransmitter receptors label multiple subtypes or multiple classes of receptors. Frequently, two subtypes or classes of receptors coexist in the same tissue and exhibit only slightly different affinities for a radioligand. A new analytical method has been developed to quantitate the...

journal_title：Journal of cardiovascular pharmacology

authors： McGonigle P

更新日期：1988-01-01 00:00:00

abstract：:The majority of patients with implanted cardioverter defibrillators (ICD) require antiarrhythmic (AR) drugs. ARs may increase defibrillation energy requirements. This study investigated the effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy needs. In 24 isolated rabbit hearts, the 50 an...

journal_title：Journal of cardiovascular pharmacology

authors： Anvari A,Mast F,Schmidinger H,Schuster E,Allessie M

更新日期：1997-04-01 00:00:00

abstract：:Current drug screening methods are insufficiently predictive of clinical toxicity and efficacy. Recent advances in stem cell technology have the potential to improve drug screening. For tests of cardiotoxicity and efficacy of cardioactive drugs, cardiomyocytes derived from human embryonic stem cells and/or human induc...

journal_title：Journal of cardiovascular pharmacology

authors： Laposa RR

更新日期：2011-09-01 00:00:00