当前位置： SCI文献检索 > JOURNAL OF CARDIOVASCULAR PHARMACOLOGY期刊下所有文献 > Bepridil blockade of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery.

Bepridil blockade of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery.

Abstract：

:The effect of the new vasodilatory and antianginal compound, bepridil (CERM-1978), was examined on the electrical activity of the vascular smooth muscle of isolated dog coronary arteries. Tetraethylammonium (10 mM) was used to induce excitability in the muscle in the form of Ca2+-dependent overshooting action potentials, whose inward current is carried almost exclusively by Ca2+ ion through voltage-dependent slow channels. Bepridil (5 X 10(-7)--1 X 10(--5) M) produced a dose-dependent depression of the rate of rise and amplitude of these Ca2+ spikes. Complete blockade of the action potentials occurred at 1 X 10(-5) M bepridil. These effects of bepridil were antagonized by elevation of external Ca2+ concentration ([CA]o). The effects of bepridil were substantially reversed by washout after about 30 min. Bepridil (10(-5) M) also produced a small but significant (p less than 0.05) increase in resting membrane resistance (input resistance increased from a mean of 10.1 to 12.4 m omega), accompanied by a small but significant (p less than 0.05) depolarization of 6 mV (from a mean of --51 to --45 mV). These latter effects are consistent with a diminution of the resting K+ conductance (gK) by bepridil. It is concluded that the vasodilatory and antianginal properties of bepridil may be explained by the action of this drug in depressing and blocking the Ca2+ influx into the cells, presumably by acting directly on the voltage-dependent slow channels in the cell membrane, and thereby lowering [Ca]i and thus the degree of contraction. Bepridil has Ca2+-antagonistic (or Ca2+ entry blocking or slow channel blocking) properties much like verapamil, but it is somewhat less potent than verapamil in this action (i.e., complete blockade occurred at 10(-5) M bepridil vs. 2 X 10(-6) M verapamil).

journal_name

J Cardiovasc Pharmacol

journal_title

Journal of cardiovascular pharmacology

authors

Harder DR,Sperelakis N

doi

10.1097/00005344-198107000-00024

subject

Has Abstract

pub_date

1981-07-01 00:00:00

pages

906-14

issue

4

eissn

0160-2446

issn

1533-4023

journal_volume

3

pub_type

杂志文章

相关文献

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY文献大全
  • Pressure natriuresis and long-term blood pressure control.

    abstract：:The relationship between arterial pressure and the rate of Na+ excretion is regulated by a number of mechanisms- some well known, some newly discovered, and probably some yet to be discovered. These mechanisms affect either the amount of Na+ filtered at the glomerulus or its rate of reabsorption from the proximal or d...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Anderson WP,Evans RG,Malpas SC

    更新日期：1995-01-01 00:00:00

  • Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine.

    abstract：:To explore endothelium-dependent relaxation and the L-arginine (L-ARG)-nitric oxide (NO) pathway during chronic hypoxia, we examined isolated rings from large conduit pulmonary arteries and aorta from rats exposed to either room air (N), 3-week hypoxia (H), or 3-week H followed by 72-h recovery to normoxia (room air)....

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199312000-00018

    authors： Carville C,Raffestin B,Eddahibi S,Blouquit Y,Adnot S

    更新日期：1993-12-01 00:00:00

  • Predominant alpha 1-adrenoceptor-mediated contraction in the human internal mammary artery.

    abstract：:alpha-Adrenoceptor agonists and antagonists are widely used perioperatively for internal mammary artery (IMA)-coronary artery bypass operations. To determine subtypes of alpha-adrenoceptors in the human IMA, we studied responses of isolated human IMA segments to alpha-adrenoceptor agonists, antagonists, and electrical...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：

    authors： He GW,Shaw J,Hughes CF,Yang CQ,Thomson DS,McCaughan B,Hendle PN,Baird DK

    更新日期：1993-02-01 00:00:00

  • Effects of prazosin and phenoxybenzamine on alpha- and beta-receptor-mediated responses in intestinal resistance and capacitance vessels.

    abstract：:Previous studies have suggested that prazosin is a selective post-synaptic alpha-receptor blocker. It has also been suggested that it may have greater blocking actions on arterioles than on venous beds. These aspects have been investigated in cats anesthetized with pentobarbital. Prazosin had no effect on conductance ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-198109000-00015

    authors： Patel P,Bose D,Greenway C

    更新日期：1981-09-01 00:00:00

  • Terikalant and barium decrease the area of vulnerability to ventricular fibrillation induction by T-wave shocks.

    abstract：:The area of vulnerability (AOV) to ventricular fibrillation (VF) induction by high-voltage shocks has been proposed as a measure of vulnerability to VF. Biphasic shocks spanning the T wave and ranging between 50 V and the upper limit of vulnerability (ULV) to VF were delivered before and after terikalant (1 mg/kg) and...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200202000-00011

    authors： Qi X,Varma P,Newman D,Mamalias N,Dorian P

    更新日期：2002-02-01 00:00:00

  • Effects of calcium sensitizers on intracellular calcium handling and myocardial energetics.

    abstract：:Calcium sensitizers may influence myocardial energetics by their action on calcium turnover and on crossbridge behavior. Using a myothermal method, the effects of the Ca2+ sensitizer EMD-53998 on calcium cycling, crossbridge behavior, and myocardial energy turnover were compared with the effects of an increase in extr...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：

    authors： Hasenfuss G,Pieske B,Kretschmann B,Holubarsch C,Alpert NR,Just H

    更新日期：1995-01-01 00:00:00

  • The serotonin transporter is present and functional in peripheral arterial smooth muscle.

    abstract：:We tested the hypothesis that the 5-HT transporter (5-HTT) is present and functional in peripheral arterial smooth muscle. In aorta and mesenteric resistance arteries, real time RT-PCR and western analyses indicated the presence of 5-HTT mRNA and a 74 kDa 5-HTT protein. Immunohistochemistry localized the transporter t...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200406000-00006

    authors： Ni W,Thompson JM,Northcott CA,Lookingland K,Watts SW

    更新日期：2004-06-01 00:00:00

  • Attenuation of experimental subarachnoid hemorrhage-induced cerebral vasospasm by CGS 26303, an endothelin-converting enzyme inhibitor.

    abstract：:The effect of CGS 26303, an endothelin-converting enzyme inhibitor, on the prevention and reversal of cerebral vasospasm was investigated in a rabbit model of subarachnoid hemorrhage (SAH). In the prevention study, rabbits were injected with 3 ml of autologous blood in the cisterna magna and treatment with CGS 26303 i...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199800001-00089

    authors： Kwan AL,Bavbek M,Jeng AY,Toyoda T,Kassell NF,Lee KS

    更新日期：1998-01-01 00:00:00

  • Resveratrol Mitigates High-Fat Diet-Induced Vascular Dysfunction by Activating the Akt/eNOS/NO and Sirt1/ER Pathway.

    abstract：:We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2 diabetes with increased body...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/FJC.0000000000000621

    authors： Huang JP,Hsu SC,Li DE,Chen KH,Kuo CY,Hung LM

    更新日期：2018-11-01 00:00:00

  • Endothelin-1 limits vascular smooth muscle beta-adrenergic receptor sensitivity by a PKC-dependent pathway.

    abstract：:Endothelin-1 reduces the chronotropic and inotropic effects of the beta-adrenoceptor agonist isoproterenol in rabbit isolated atria. Vascular interactions between endothelin-1 and isoproterenol have not been reported. Rings of the rabbit aorta without endothelium were mounted on myographs to measure isometric tension....

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200310000-00012

    authors： Gilbert P,Thorin E

    更新日期：2003-10-01 00:00:00

  • Role of brain amine transmitters and some neuromodulators in blood pressure, heart rate, and baroreflex control.

    abstract：:We studied the acute effects of transmitter release induced by intracisternal (i.c.) 6-hydroxydopamine (6-OHDA) from mainly noradrenergic (NA) neurons and by 5,6-dihydroxytryptamine (5,6-DHT) from serotonergic (5HT) neurons. Each group of neurons affects blood pressure and heart rate in conscious rabbits through both ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： Korner PI,Head GA,Badoer E,Bobik A,Angus JA

    更新日期：1987-01-01 00:00:00

  • Effect of phenytoin on serum lipoproteins in middle-aged men.

    abstract：:We assessed the effect of phenytoin on serum lipids and lipoproteins in a group of 20 male volunteers. Nine of the subjects were healthy, and 11 had coronary heart disease. Their mean age was 44 +/- 7 years. Phenytoin was given at daily doses of 200-350 mg for a period of 4-9 months. Serum total cholesterol increased ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-198101000-00019

    authors： Kaukola S,Manninen V,Neuvonen PJ,Mälkönen M,Ehnholm C

    更新日期：1981-01-01 00:00:00

  • Characterization of the endothelin receptor subtypes in human prostate.

    abstract：:Endothelin (ET) receptor subtypes in human prostate with benign prostatic hyperplasia were investigated by binding and functional studies. In the displacement experiment, LU224332 [endothelin-A/-B (ET(A)/ET(B)) nonselective antagonist] competed for [125I]ET-1 binding with a monophasic curve. On the other hand, LU13525...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200036051-00074

    authors： Hiraoka Y,Oshita M,Morikawa K,Nagata O,Hahn KJ,Hahn A,Okada K,Taniguchi T,Muramatsu I

    更新日期：2000-11-01 00:00:00

  • Osmoregulation and baroregulation of plasma vasopressin in essential hypertension.

    abstract：:Vasopressin secretion is stimulated by hyperosmolality, hypovolemia, or hypotension and is inhibited by hypoosmolality, hypervolemia, or hypertension. These osmotic and hemodynamic influences are mediated by neuronal afferents that originate in separate osmoreceptors or baroreceptors but ultimately converge to act on ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-198600087-00017

    authors： Robertson GL,Ganguly A

    更新日期：1986-01-01 00:00:00

  • The Impact of Novel Anticoagulants: Should All AF Patients Now Be Anticoagulated?

    abstract：:Atrial Fibrillation (AF) is accompanied by an increased risk for thromboembolic events in most affected patients. Current guidelines therefore recommend antithrombotic therapy with vitamin K antagonist (VKA) or non VKA oral anticoagulant (NOAC) in the majority of AF patients. Current AF treatment guidelines recommend ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章,评审

    doi：10.1097/FJC.0000000000000297

    authors： Hammwöhner M,Goette A

    更新日期：2015-12-01 00:00:00

  • Effects of converting enzyme inhibitors on coronary flow and myocardial ischemia.

    abstract：:The regulation of coronary hemodynamics is a complex process. One important factor that interferes with the regulation of coronary tone is the pathophysiological state of the vessels: stimuli that in normal vessels provoke no or only a slight vasoconstriction may cause a severe vasoconstriction in diseased vessels. Th...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章,评审

    doi：

    authors： van Gilst WH,Tio RA,van Wijngaarden J,de Graeff PA,Wesseling H

    更新日期：1992-01-01 00:00:00

  • The combination of chlorthalidone with nifedipine does not exert an additive antihypertensive effect in essential hypertensives: a crossover multicenter study.

    abstract：:To evaluate whether the combination of nifedipine with chlorthalidone exerts an additive antihypertensive effect when compared to single-drug treatment, 66 uncomplicated essential hypertensives, whose diastolic blood pressure was greater than 100 and less than 115 mm Hg at the end of a 1-month washout placebo period, ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1097/00005344-199102000-00021

    authors： Salvetti A,Magagna A,Innocenti P,Ponzanelli F,Cagianelli A,Cipriani M,Gandolfi E,Del Prato C,Ballestra AM,Saba P

    更新日期：1991-02-01 00:00:00

  • Role of ouabain-like factors in hypertension: effects of ouabain and certain endogenous ouabain-like factors in hypertension.

    abstract：:Several reports suggest the presence of sodium-potassium pump inhibitor in plasma and various tissues, particularly during volume-expanded state and low-renin hypertension. It has been hypothesized that by inhibiting the cardiovascular muscle-cell Na(+)-K+ pump, this inhibitor can constrict blood vessels, enhance vaso...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199322002-00005

    authors： Yuan C,Manunta P,Chen S,Hamlyn JM,Haddy FJ,Pamnani MB

    更新日期：1993-01-01 00:00:00

  • Beneficial effects of a new prostacyclin analogue, KP-10614, on acute myocardial infarction in rats.

    abstract：:The potential therapeutic value of a new prostacyclin analogue, (4z, 16s)-4,5,18,18,19,19-hexadehydro-16,20-dimethyl-delta 6(9a)- 9-(O)-methano-PGI1 (KP-10614), was studied in acute myocardial infarction in rats. Myocardial infarction was induced by ligation of the left coronary artery and ischemic injury was followed...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199210000-00017

    authors： Kanayama T,Kimura Y,Tamao Y,Mizogami S

    更新日期：1992-10-01 00:00:00

  • Effects of tilisolol, a nonselective beta-adrenergic blocker, on the membrane currents of isolated guinea pig ventricular myocytes.

    abstract：:The effects of tilisolol, a nonselective beta-adrenoceptor blocker, on transmembrane ionic currents were studied in single guinea pig ventricular myocytes by using the whole-cell voltage clamp technique. In the absence of beta-adrenergic stimulation, 10 microM tilisolol, a concentration higher than that used in the cl...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199705000-00005

    authors： Takagi S,Kihara Y,Mitsuiye T,Wang Z,Sasayama S

    更新日期：1997-05-01 00:00:00

  • New dihydropyridine calcium channel antagonist, pranidipine, attenuates hypertensive renal injury in Dahl salt-sensitive rats.

    abstract：:Interest in the cardiovascular protective effects of calcium channel antagonists has increased in the past decade. We investigated prevention of vascular wall remodeling by the long-acting calcium channel antagonist pranidipine in 12-week-old Dahl salt-sensitive (SS) rats with high-salt-induced (4% NaCl) hypertension....

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199406000-00016

    authors： Uehara Y,Kawabata Y,Ohshima N,Hirawa N,Takada S,Numabe A,Nagata T,Goto A,Yagi S,Omata M

    更新日期：1994-06-01 00:00:00

  • Expression of endothelin and ETB receptors in the megakaryoblastic MEG-01 cell line.

    abstract：:The presence of endothelin (ET) receptors and the nature of the subtype and expression of ET were investigated in the human megakaryoblastic cell line MEG-01. By the RT-PCR procedure, we have shown that both ETA and ETB receptor subtype mRNAs are expressed in the cells. However, binding experiments have shown that the...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：

    authors： Hamroun D,Mathieu MN,Clain E,Germani E,Laliberté MF,Laliberté F,Chevillard C

    更新日期：1995-01-01 00:00:00

  • Distinct roles of second and third intracellular loops of human endothelin receptors in the selective activation of G alpha s/G alpha i.

    abstract：:Endothelin-1 (ET-1) stimulated cAMP formation in Chinese hamster ovary cells stably expressing human wild-type ET(A) (CHO/hET(A) cells) and inhibited the formation in cells expressing human wild-type ETB (CHO/hETB cells), suggesting a selective coupling of hET(A) and hETB with G alpha s and G alpha i, respectively. To...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：

    authors： Ninomiya H,Takagi Y,Miwa S,Masaki T

    更新日期：1995-01-01 00:00:00

  • Salusins protect neonatal rat cardiomyocytes from serum deprivation-induced cell death through upregulation of GRP78.

    abstract：:Salusin-alpha and salusin-beta are newly identified bioactive peptides with hemodynamic and mitogenic activities. Recent studies have shown that salusins improve calcium uptake and protein synthesis in neonatal rat cardiomyocytes, suggesting that salusins may be regulatory factors for myocardial growth and hypertrophy...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/01.fjc.0000242059.89430.ac

    authors： Xiao-Hong Y,Li L,Yan-Xia P,Hong L,Wei-Fang R,Yan L,An-Jing R,Chao-Shu T,Wen-Jun Y

    更新日期：2006-08-01 00:00:00

  • Contractility of the tail artery in rats treated with bezafibrate and fed atherogenic diet.

    abstract：:Bezafibrate, a potent hypolipidemic agent, was studied as potentially preventive in the atherosclerosis-associated vascular hyperresponsiveness to alpha-adrenoceptors agonists in rats. Contractile responses to norepinephrine (NE) were determined in isolated tail arteries of rats fed an atherogenic or a standard diet. ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-199311000-00014

    authors： Trzeciak HI,Okopień B,Kozłowski A,Chociłowska D,Bara A

    更新日期：1993-11-01 00:00:00

  • High-fat diet alters K+-currents in porcine coronary arteries and adenosine sensitivity during metabolic inhibition.

    abstract：:Coronary arteries from animals on normal diets (ND) exhibit well-maintained responses to dilators under ischemic conditions. The reported altered metabolic requirements and K+-currents in blood vessels from hypercholesterolemic animals fed high-fat diets (HF) led us to hypothesize that under metabolically depressed co...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-200404000-00004

    authors： Franke R,Yang Y,Rubin LJ,Magliola L,Jones AW

    更新日期：2004-04-01 00:00:00

  • Nitrendipine treatment in so-called therapy-resistant arterial hypertension; effect as monotherapy and in combination with propranolol on blood pressure, heart rate, other hemodynamic parameters, plasma renin activity, and catecholamines.

    abstract：:Twenty-three patients [mean age 49.7 +/- 5.6 years (WHO II-III)] with severe hypertension and not responding to previous drug treatment were included in the study to evaluate the effect of nitrendipine (NTP) as monotherapy and also in combination with propranolol (PRO). After a control period of 10 days, NTP was start...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：10.1097/00005344-198806124-00033

    authors： Faulhaber HD,Gruner R,Homuth V,Naumann E,Menz M,Hartrodt W,Schmidt J,Mohnike W

    更新日期：1988-01-01 00:00:00

  • SC-36602, a new antiarrhythmic agent: comparison of its cardiovascular profile with that of other antiarrhythmic drugs.

    abstract：:The cardiovascular profile of SC-36602, a new class 1A/1B antiarrhythmic agent, was compared to those of disopyramide, lidocaine, mexiletine, flecainide, encainide, lorcainide, and quinidine. These drugs were compared at their respective canine antiarrhythmic doses in a hemodynamic evaluation using anesthetized dogs. ...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：

    authors： Frederick LG,Hatley FR,McDonald SJ,Stamm MH,Garthwaite SM

    更新日期：1988-06-01 00:00:00

  • Coronary vascular changes in the progression and regression of hypertensive heart disease.

    abstract：:Coronary hemodynamics (blood flow, coronary reserve, myocardial oxygen consumption) were analyzed in both experimental and clinical hypertension. Significantly reduced coronary reserve was found in hypertensive patients with left ventricular hypertrophy. Medial hypertrophy of small coronary vessels associated with a m...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 杂志文章

    doi：

    authors： Strauer BE,Schwartzkopff B,Motz W,Vogt M

    更新日期：1991-01-01 00:00:00

  • Increased plasma concentration of natriuretic peptides by selective beta1-blocker bisoprolol.

    abstract：:Beta-blocker therapy has been shown to be associated with an increase in the plasma concentration of A-type natriuretic peptide (ANP). Whether the plasma concentration of B-type natriuretic peptide (BNP), which is mainly derived from ventricular tissue, is also increased and whether this increase is caused by increase...

    journal_title：Journal of cardiovascular pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1097/00005344-200310000-00002

    authors： van den Meiracker AH,Lameris TW,van de Ven LL,Boomsma F

    更新日期：2003-10-01 00:00:00