The effects of ACE inhibition on progression of atherosclerosis.

abstract：:The acute, 60 min blood pressure and plasma renin responses to an oral test dose of captopril given to a quietly seated patient can be used to gain information quickly on renin dependency or lack of it in a hypertensive situation. This information is verified by a baseline renin sodium profile test. These two diagnost...

journal_title：Journal of cardiovascular pharmacology

authors： Laragh JH

更新日期：1985-01-01 00:00:00

abstract：:The cardiovascular profile of a novel calcium antagonist, MPC-1304 and its active metabolites were investigated in experimental animals in vitro and in vivo, and were compared with those of other calcium antagonists or nitroglycerin (NTG). The ratio of negative chronotropic/negative inotropic effect of MPC-1304 was 23...

journal_title：Journal of cardiovascular pharmacology

authors： Kanda A,Haruno A,Miyoshi K,Tanahashi Y,Miyake H,Ichihara K,Okumura K,Nagasaka M

更新日期：1993-07-01 00:00:00

abstract：:Toll-like receptors (TLRs) are important in innate immune responses, which are crucial in collateral artery formation (arteriogenesis). TLR4⁻/⁻ mice undergoing hind limb ischemia show decreased perfusion recovery accompanied by an impaired infiltration of inflammatory cells. TLR antagonists are currently developed and...

journal_title：Journal of cardiovascular pharmacology

authors： van den Borne P,Bastiaansen AJ,de Vries MR,Quax PH,Hoefer IE,Pasterkamp G

更新日期：2014-01-01 00:00:00

abstract：:In the initial seconds after a sudden reduction in coronary blood flow, a temporary mismatch between myocardial energy demand and supply exists. The mechanisms underlying the rapidly ensuing reduction in contractile function in the ischemic myocardium are still unknown. In the presence of some residual blood flow, a s...

journal_title：Journal of cardiovascular pharmacology

authors： Ehring T,Schulz R,Heusch G

更新日期：1992-01-01 00:00:00

abstract：:As part of the Amlodipine Cardiovascular Community Trial (ACCT), which was a large multicenter study designed to assess the effects of the calcium channel blocker amlodipine besylate (Norvasc) as monotherapy for treatment of mild to moderate hypertension, we sought to determine the effects of amlodipine on regression ...

journal_title：Journal of cardiovascular pharmacology

authors： Kloner RA,Sowers JR,DiBona GF,Gaffney M,Wein M

更新日期：1995-09-01 00:00:00

abstract：:The aim of this study was to determine whether a quantitative relation exists between changes in regional myocardial blood flow (RMBF) and those in electrophysiologic determinants recorded via left ventricular endocardial and epicardial bipolar electrograms after administration of disopyramide (DP) and a class III ant...

journal_title：Journal of cardiovascular pharmacology

authors： Tanabe T,Iwamoto T,Iwata O,Aikawa M,Kusuzaki S,Handa S,Shinozaki Y,Mori H

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:The present study has been designed to investigate the effect of sodium cromoglycate and ketotifen, mast cell stabilizers in hyperhomocysteinemia-induced cardiac hypertrophy in rats. METHODS:Rats were administered L-methionine (1.7 g/kg/day PO) for 8 weeks to produce hyperhomocysteinemia. Sodium cromoglycat...

journal_title：Journal of cardiovascular pharmacology

authors： Singh AP,Singh M,Balakumar P

更新日期：2008-06-01 00:00:00

abstract：:Clopidogrel (CLO) is a clinical antiplatelet agent, about which there are major concerns because its antiplatelet efficiency decreases with insufficient metabolic activation, leading to "clopidogrel resistance." We aimed to determine the antiplatelet effects of W1, a novel molecule composed of 2-O-clopidogrel and aspi...

journal_title：Journal of cardiovascular pharmacology

authors： Ge P,Du L,Han C,Li H,Feng Y,Han J,Wang Z,Xiong L,Yuan M,Liu Y

更新日期：2017-02-01 00:00:00

abstract：:We have developed three radioimmunoassays (RIAs) of varying specificities toward the endothelin (ET) isoforms. The assays are called the endothelin-1,2[125I] assay system (RPA535), the endothelin 1-21 Specific [125I] assay system (RPA555), and the endothelin-1,2 high-sensitivity [125I] assay system (RPA545). We have f...

journal_title：Journal of cardiovascular pharmacology

authors： Capper SJ,Ella SJ,Kalinka S

更新日期：1991-01-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is a particularly useful method for evaluating the effects of antihypertensive drugs. ABPM allows the therapeutic effect of an agent to be assessed continually by a large number of measurements, and the greater number of readings contributes to the higher degree of reproduci...

journal_title：Journal of cardiovascular pharmacology

authors： Mallion JM,Baguet JP,Boutelant S,Tremel F,Siché JP,de Gaudemaris R

更新日期：1995-01-01 00:00:00

abstract：:To evaluate the safety and pharmacologic activity of ITF 296 in humans, three groups of healthy male normotensive subjects were studied. The first two groups (six subjects each) received, in ascending order, three dose levels of ITF 296 by 30-min intravenous infusion (group I, 0.1, 0.5, 1.0 microgram/kg/min; group II,...

journal_title：Journal of cardiovascular pharmacology

authors： Sardina M,Love R,Mizrahi J,Monzani V,Bianchini C

更新日期：1995-01-01 00:00:00

abstract：ABSTRACT:Limited data are available on the transition from subcutaneous to intravenous prostacyclin in precapillary pulmonary hypertension. We performed a retrospective analysis of all patients who were switched from subcutaneous to intravenous treprostinil with an implantable infusion pump. We included 85 consecutive,...

journal_title：Journal of cardiovascular pharmacology

authors： Steringer-Mascherbauer R,Maria L,Reinhold F,Elisabeth S,Charlotte H,Dagmar E,Uwe F,Josef A

更新日期：2021-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of hypercholesterolemia on the angiotensin II-induced contractions in the isolated aorta and iliac artery of the rabbit, with respect to the role of arachidonate metabolites. Furthermore, the effect of the angiotensin-converting enzyme inhibitor ramipril was studied ...

journal_title：Journal of cardiovascular pharmacology

authors： Dam JP,Vleeming W,Riezebos J,Post MJ,Porsius AJ,Wemer J

更新日期：1997-07-01 00:00:00

abstract：:To assess the role of angiotensin II (AII) in development of myocardial injury during ischemia and reperfusion, the effects of short-term treatment with the angiotensin-converting enzyme (ACE) inhibitor lisinopril were compared with the effects of short-term treatment with L-158,338, an AII antagonist, in isolated wor...

journal_title：Journal of cardiovascular pharmacology

authors： Werrmann JG,Cohen SM

更新日期：1994-10-01 00:00:00

abstract：:The antiarrhythmic efficacy and proarrhythmic potential of the class IC antiarrhythmic agent encainide were assessed in subacute and chronic postinfarction canine models, respectively. In conscious dogs with spontaneous premature ventricular complexes (PVCs) at 48 h after anterior myocardial infarction (MI), cumulativ...

journal_title：Journal of cardiovascular pharmacology

authors： Wallace AA,Stupienski RF 3rd,Kothstein T,Gehret JR,Lynch JJ Jr

更新日期：1993-03-01 00:00:00

abstract：:We compared the effects of angiotensin II (AII), enalapril, and losartan given by acute intravenous (i.v.) injection, on cardiac baroreflex sensitivity in two groups of conscious normotensive rabbits bred for high gain [> 5 beats/min/mm Hg] (group I) and low gain [< 4 beats/min/mm Hg] (group II) of the mean arterial b...

journal_title：Journal of cardiovascular pharmacology

authors： Weinstock M,Gorodetsky E

更新日期：1995-03-01 00:00:00

abstract：:The goal of this study was to determine the effects of trimetazidine on all-cause mortality and heart failure hospitalizations in patients with ischemic cardiomyopathy. We performed an extension to 48 months and a post-hoc analysis of the Villa Pini d'Abruzzo trimetazidine trial; in this single-center, open-label, ran...

journal_title：Journal of cardiovascular pharmacology

authors： Di Napoli P,Di Giovanni P,Gaeta MA,Taccardi AA,Barsotti A

更新日期：2007-11-01 00:00:00

abstract：:Essential hypertension is now considered a disease of pressure regulation implicating a multiplicity of physiological mechanisms. It is probably genetically predisposed and is associated with altered sensitivity to the sodium ion and a more than chance association with other clinical diseases. New concepts are emergin...

journal_title：Journal of cardiovascular pharmacology

authors： Frohlich ED

更新日期：1984-01-01 00:00:00

abstract：:Pinacidil is one of a number of new antihypertensive agents possessing an action that involves an enhanced potassium efflux in cardiac and vascular smooth muscle. An associated feature of pinacidil is a shortening of the cardiac action potential duration, which may constitute a potentially proarrhythmic effect. The pr...

journal_title：Journal of cardiovascular pharmacology

authors： Chi L,Uprichard AC,Lucchesi BR

更新日期：1990-03-01 00:00:00

abstract：:The selectivity of single oral doses of xamoterol, 200 mg, prenalterol, 50 mg, and salbutamol, 8 mg, was compared in eight healthy male volunteers by measuring their effects on sleeping heart rate, supine heart rate, blood pressure, forearm blood flow, finger tremor, and exercise heart rate in the presence and absence...

journal_title：Journal of cardiovascular pharmacology

authors： McCaffrey PM,Riddell JG,Shanks RG

更新日期：1988-05-01 00:00:00

abstract：:The objective of the study was to inquire about the mechanism(s) involved in the catabolism of S-nitrosothiols by vascular tissue under in vitro conditions. Incubations of S-nitrosocysteine (CYSNO) or S-nitrosoglutathione (GSNO) with homogenates isolated from porcine aortic smooth muscle resulted in only a marginal de...

journal_title：Journal of cardiovascular pharmacology

authors： Kostka P,Xu B,Skiles EH

更新日期：1999-04-01 00:00:00

abstract：:Endothelial dysfunction is the pathophysiologic principle involved in the initiation and progression of arteriosclerosis, thus endothelial function serves as a "barometer" for cardiovascular health that can be used for the evaluation of new therapeutic strategies. This review provides an introduction to the concept of...

journal_title：Journal of cardiovascular pharmacology

authors： Heiss C,Schroeter H,Balzer J,Kleinbongard P,Matern S,Sies H,Kelm M

更新日期：2006-01-01 00:00:00

abstract：:We undertook a systematic comparison of the effects of diltiazem and nifedipine and a nonspecific vasodilator, sodium nitroprusside, on renal perfusion, function, and activation of potentially relevant neurohormonal systems in the anesthetized dog. These agents were employed to reduce blood pressure to two levels, a m...

journal_title：Journal of cardiovascular pharmacology

authors： Blackshear JL,Orlandi C,Williams GH,Hollenberg NK

更新日期：1986-01-01 00:00:00

abstract：:The formation of bone occurs via a series of events that are regulated by various hormones and cytokines. We previously reported that endothelin (ET) inhibits the mineralization by osteoblastic cells and natriuretic peptide (NP) promotes osteoblastic differentiation. Therefore, we attempted to identify the genes induc...

journal_title：Journal of cardiovascular pharmacology

authors： Inoue A,Kamiya A,Ishiji A,Hiruma Y,Hirose S,Hagiwara H

更新日期：2000-11-01 00:00:00

abstract：:Monophasic action potentials (MAPs) were utilized to examine the basis for cesium-induced arrhythmia in the dog. Cesium chloride (1 mmol/kg i.v.) produced an immediate prolongation of MAP (250 +/- 11 to 396 +/- 34 ms, p less than 0.05). Coupled premature ventricular beats (345 +/- 46 ms) and polymorphic ventricular ta...

journal_title：Journal of cardiovascular pharmacology

authors： Patterson E,Szabo B,Scherlag BJ,Lazzara R

更新日期：1990-02-01 00:00:00

abstract：:Diabetes mellitus is associated with significant morbidity and mortality caused by the micro- and macro-vascular complications that all too frequently develop during the lifetime of the diabetic patient. In attempts to treat the complications of diabetes, several different treatment strategies have been investigated. ...

journal_title：Journal of cardiovascular pharmacology

authors： Savage S,Miller LA,Schrier RW

更新日期：1991-01-01 00:00:00

abstract：:Peptide 6A, a degradation of B beta chain of fibrinogen, is known to increase coronary and femoral blood flow. In this study, we examined the effects of peptide 32, an analogue of peptide 6A on coronary blood flow in anesthetized dogs. Intracoronary administration of equimolar amounts of peptide 32 and peptide 6A show...

journal_title：Journal of cardiovascular pharmacology

authors： Saldeen TG,Nichols WW,Saldeen K,Wallin R,Mehta JL

更新日期：1994-01-01 00:00:00

abstract：:The pulmonary vascular reactivity to endothelin-1 (ET-1) was assessed in rats previously exposed to 11% O2 (hypoxic) or room air (controls) for 3 weeks. In isolated control lung preparations studied during conditions of increased tone by U46619 (50 pmol/min) and treated with meclofenamate (3 microM), low doses of ET-1...

journal_title：Journal of cardiovascular pharmacology

authors： Eddahibi S,Raffestin B,Braquet P,Chabrier PE,Adnot S

更新日期：1991-01-01 00:00:00

abstract：:We have studied the effect of ramipril (10 mg/kg daily by gastric gavage) on the development of neointima 2 and 14 days after injury to rat aorta with a balloon catheter. In treated animals, there was no significant inhibition of the early mitotic reaction after injury (synthesis of DNA, as reflected by aortic thymidi...

journal_title：Journal of cardiovascular pharmacology

authors： Capron L,Heudes D,Chajara A,Bruneval P

更新日期：1991-08-01 00:00:00

abstract：:Endothelium-derived relaxing factor (EDRF) and donors of nitric oxide (NO) (glyceryl trinitrate, SIN-1--a metabolite of molsidomine--S-nitroso-N-acetyl-penicillamine, and sodium nitroprusside) but not prostacyclin and its analog, iloprost, relax strips of rabbit aorta. Strips of human coronary artery also relax when e...

journal_title：Journal of cardiovascular pharmacology

authors： Gryglewski RJ,Korbut R,Trabka-Janik E,Zembowicz A,Trybulec M

更新日期：1989-01-01 00:00:00