Effects of a PPARgamma agonist, GI262570, on renal filtration fraction and nitric oxide level in conscious rats.

abstract：:Mikania laevigata, popularly known in Brazil as guaco, is widely used for respiratory disorders. As this plant is rich in coumarins, there is evidence of indications that it may cause bleeding and therefore should not be used concomitantly with anticoagulants. The basis of this information is very theoretical, with no...

journal_title：Journal of cardiovascular pharmacology

authors： Leite PM,Miranda APN,Amorim JM,Duarte RCF,Bertolucci SKV,Carvalho MDG,Castilho RO

更新日期：2019-12-01 00:00:00

abstract：:Endothelin-1 (ET-1) stimulated cAMP formation in Chinese hamster ovary cells stably expressing human wild-type ET(A) (CHO/hET(A) cells) and inhibited the formation in cells expressing human wild-type ETB (CHO/hETB cells), suggesting a selective coupling of hET(A) and hETB with G alpha s and G alpha i, respectively. To...

journal_title：Journal of cardiovascular pharmacology

authors： Ninomiya H,Takagi Y,Miwa S,Masaki T

更新日期：1995-01-01 00:00:00

abstract：:Calcium sensitizers may influence myocardial energetics by their action on calcium turnover and on crossbridge behavior. Using a myothermal method, the effects of the Ca2+ sensitizer EMD-53998 on calcium cycling, crossbridge behavior, and myocardial energy turnover were compared with the effects of an increase in extr...

journal_title：Journal of cardiovascular pharmacology

authors： Hasenfuss G,Pieske B,Kretschmann B,Holubarsch C,Alpert NR,Just H

更新日期：1995-01-01 00:00:00

abstract：:Twenty-four-hour urinary sodium excretion and plasma renin activity were monitored in 36 patients receiving bendrofluazide as sole antihypertensive therapy. There was no increase in urinary sodium output compared with pretreatment values during a 2-year period, and there is therefore no evidence that an increase in sa...

journal_title：Journal of cardiovascular pharmacology

authors： Swales JD,Bing RF,Swart S,Thurston H

更新日期：1984-01-01 00:00:00

abstract：:[125I]Endothelin-1 (ET-1) was administered intravenously into rats, and binding sites in various tissues were examined by electron-microscopic radioautography. Labeling was observed predominantly on the glomerular fenestrated endothelial cells of kidney, alveolar capillary endothelial cells of lung, fat-storing cells ...

journal_title：Journal of cardiovascular pharmacology

authors： Furuya S,Naruse S,Nakayama T,Furuya K,Nokihara K

更新日期：1991-01-01 00:00:00

abstract：:The relationship between sodium sensitivity and borderline hypertension was explored in 63 subjects. Thirty percent of those with borderline hypertension and 15% of normal subjects increased mean arterial pressure by more than 5% when daily sodium intake was increased from 10 to 200 mEq. While most displayed an increa...

journal_title：Journal of cardiovascular pharmacology

authors： Sullivan JM

更新日期：1986-01-01 00:00:00

abstract：:To evaluate the possible role of endothelin in the development and/or maintenance of hypertension in Dahl rats, we examined the responsiveness of isolated vascular smooth muscle and glomerular mesangial cells, as well as deendothelialized vascular ring preparations to endothelin-1 (ET-1). Production of immunoreactive ...

journal_title：Journal of cardiovascular pharmacology

authors： Goligorsky MS,Iijima K,Morgan M,Yanagisawa M,Masaki T,Lin L,Nasjletti A,Kaskel F,Frazer M,Badr KF

更新日期：1991-01-01 00:00:00

abstract：:The cardiovascular properties of Ro 13-6438 (R-6-chloro-1,5-dihydro-3- methylimidazo -[2,1-b] quinazolin -2[ 3H]-one), a novel nonglycoside , noncatechol cardiotonic agent, were investigated in vitro and in vivo by both intravenous and oral administration. Ro 13-6438 increased tension development of isolated guinea pi...

journal_title：Journal of cardiovascular pharmacology

authors： Eigenmann R,Gerold M,Holck M

更新日期：1984-05-01 00:00:00

abstract：:The influence of intravenous diltiazem on hemodynamics and left ventricular function indices was studied in 14 patients with severe coronary artery disease at rest and during atrial pacing. We used a tip manometer catheter for recording left ventricular pressure tracings and a nuclear probe for measuring left ventricu...

journal_title：Journal of cardiovascular pharmacology

authors： van Dijk RB,Blanksma PK,van Gilst WH,Lie KI

更新日期：1993-08-01 00:00:00

abstract：:Lisinopril (LIS) is a lysine analog of enalaprilat, the active metabolite of enalapril, an angiotensin-converting enzyme inhibitor (ACEI). Unlike enalapril, the precursor of enalaprilat, LIS is not a prodrug but has equal ACEI efficacy and potency and a slightly longer duration of action after oral administration. Sho...

journal_title：Journal of cardiovascular pharmacology

authors： Pool JL,Gennari J,Goldstein R,Kochar MS,Lewin AJ,Maxwell MH,McChesney JA,Mehta J,Nash DT,Nelson EB

更新日期：1987-01-01 00:00:00

abstract：:The cardioprotective effects on myocardial ischemia of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) inhibitor, cyclopiazonic acid (CPA), were studied. We used the isolated arterially perfused interventricular septum of the rabbit heart submitted to 30-min global ischemia/30-min reperfusion. Mechanical [maximal ...

journal_title：Journal of cardiovascular pharmacology

authors： Avellanal M,Rodriguez P,Barrigon S

更新日期：1998-11-01 00:00:00

abstract：:The vasoconstrictor effects of endothelin-1 (ET-1) and norepinephrine (NE) were compared in the exteriorized rat mesentery in situ. ET-1 was 1,000 times more potent than NE in constricting both arterioles and venules. Vasoconstrictions induced by ET-1 lasted much longer than those caused by the catecholamine. At nonre...

journal_title：Journal of cardiovascular pharmacology

authors： Fortes ZB,de Nucci G,Garcia-Leme J

更新日期：1989-01-01 00:00:00

abstract：:We assessed whether local inhibition of myocardial converting enzyme by captopril and zofenopril reduces the functional and metabolic damage caused by ischemia and reperfusion. First we investigated the effects of zofenopril and captopril on the mechanical function, cellular redox state, and norepinephrine (NE) conten...

journal_title：Journal of cardiovascular pharmacology

authors： Ferrari R,Cargnoni A,Curello S,Ceconi C,Boraso A,Visioli O

更新日期：1992-01-01 00:00:00

abstract：:Heart failure is unique among the major cardiovascular disorders in that it alone is increasing in prevalence while there has been a striking decrease in other conditions. Some of this can be attributed to the aging of the U.S. and European populations. The ability to salvage patients with myocardial damage is also a ...

journal_title：Journal of cardiovascular pharmacology

authors： Greenberg B

更新日期：2001-11-01 00:00:00

abstract：:The pharmacologic profile of SK-1080, a nonpeptide AT1-selective angiotensin-receptor antagonist, was investigated by receptor-binding studies, functional in vitro assays with rabbit and rat aorta, and in vivo experiments in pithed rats. SK-1080 inhibited the specific binding of [125I]-[Sar1, Ile8]-angiotensin II to h...

journal_title：Journal of cardiovascular pharmacology

authors： Lee SH,Jung YS,Lee BH,Yun SI,Yoo SE,Shin HS

更新日期：1999-03-01 00:00:00

abstract：:The influence of isoniazid (ISO) preincubation on the relaxant effects of a group of nitrovasodilators was examined in norepinephrine-contracted rat aortic rings with and without endothelium. ISO displaced to the left the dose-response curves to all nitrovasodilators and increased the negative logarithm of their media...

journal_title：Journal of cardiovascular pharmacology

authors： Vidrio H,Fernández G

更新日期：1998-09-01 00:00:00

abstract：:There is increasing interest in initial therapy of hypertension with sympatholytic agents and the influence of antihypertensive therapy on cardiac and renal function. We treated 26 men with essential hypertension with either guanabenz alone (n = 14) or propranolol alone (n = 12) and assessed blood pressure and renal p...

journal_title：Journal of cardiovascular pharmacology

authors： Mosley C,O'Connor DT,Taylor A,Slutsky RA,Cervenka J

更新日期：1984-01-01 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) is a widely used vehicle for water-insoluble substances and exerts a wide range of pharmacologic effects including anti-inflammatory and free radical scavenging properties. Additionally, in an animal model, DMSO inhibited cholesterol-induced atherosclerosis. Despite such profound pharmacologi...

journal_title：Journal of cardiovascular pharmacology

authors： Laskar A,Yuan XM,Li W

更新日期：2010-09-01 00:00:00

abstract：:The relative efficacies of 240 mg/day diltiazem and 20 mg/day nitrendipine were compared in a placebo-controlled, randomized, crossover study of 48 patients who had both moderate systemic hypertension and stable angina pectoris. Hemodynamic indices were measured by impedance cardiography and echocardiography and bicyc...

journal_title：Journal of cardiovascular pharmacology

authors： Andreyev N,Bichkov I,Skutelis A,Andreyeva T

更新日期：1991-01-01 00:00:00

abstract：:The goal of this study was to determine the effects of trimetazidine on all-cause mortality and heart failure hospitalizations in patients with ischemic cardiomyopathy. We performed an extension to 48 months and a post-hoc analysis of the Villa Pini d'Abruzzo trimetazidine trial; in this single-center, open-label, ran...

journal_title：Journal of cardiovascular pharmacology

authors： Di Napoli P,Di Giovanni P,Gaeta MA,Taccardi AA,Barsotti A

更新日期：2007-11-01 00:00:00

abstract：:Cyclosporine (CsA) treatment in solid organ transplantation has represented one of the greatest advances in the past 20 years, reducing acute rejection and increasing long-term survival. However, CsA has an important side effect, producing renal vasoconstriction and systemic hypertension. The main histological finding...

journal_title：Journal of cardiovascular pharmacology

authors： Rodicio JL

更新日期：2000-01-01 00:00:00

abstract：:Inflammation plays a central role in the pathogenesis of atherosclerosis. This study investigated whether the proteasome inhibitor has the same preventive effect on the formation of accelerated atherosclerosis in rabbits with uremia compared with a NF-kappaB inhibitor. New Zealand white rabbits were subjected to five-...

journal_title：Journal of cardiovascular pharmacology

authors： Feng B,Zhang Y,Mu J,Ye Z,Zeng W,Qi W,Luo Z,Guo Y,Yang X,Yuan F

更新日期：2010-02-01 00:00:00

abstract：:Cardiovascular medicine is based on high-technology management of end-stage disease. Preventive medicine is preferable but, before magnetic resonance (MR), there was no noninvasive, safe, repeatable method of detecting occlusive vascular disease, which accounts for more deaths than any other disease at a presymptomati...

journal_title：Journal of cardiovascular pharmacology

authors： Longmore D,Forbat S

更新日期：1992-01-01 00:00:00

abstract：:Hemodynamic responses to intravenous (i.v.) injection of DPMA [N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl] adenosine); PD 125,944], a potent adenosine agonist with a 32-fold selectivity for the adenosine-2 (A2) receptor subtype, were characterized in conscious and anesthetized rats. In conscious rats instrume...

journal_title：Journal of cardiovascular pharmacology

authors： Lappe RW,Sheldon JH,Cox BF

更新日期：1992-03-01 00:00:00

abstract：:Endothelin-1 reduces the chronotropic and inotropic effects of the beta-adrenoceptor agonist isoproterenol in rabbit isolated atria. Vascular interactions between endothelin-1 and isoproterenol have not been reported. Rings of the rabbit aorta without endothelium were mounted on myographs to measure isometric tension....

journal_title：Journal of cardiovascular pharmacology

authors： Gilbert P,Thorin E

更新日期：2003-10-01 00:00:00

abstract：:Glycogen synthase kinase (GSK)-3beta inhibitors play an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that GSK-3beta inhibitors protect against myocardial ischemia-reperfusion injury. However, the precise mechanisms remain unclear. We aimed to investigate the roles of inflam...

journal_title：Journal of cardiovascular pharmacology

authors： Gao HK,Yin Z,Zhou N,Feng XY,Gao F,Wang HC

更新日期：2008-09-01 00:00:00

abstract：:The effect of atrial natriuretic peptide (ANP) on cytosolic free calcium ([Ca2+]i) was studied in monolayers of cultured vascular smooth muscle (VSM) cells loaded with a fluorescent calcium indicator, fura-2. ANP (atriopeptin III, 10(-8) M) decreased the resting level of [Ca2+]i and sustained rises in [Ca2+]i followin...

journal_title：Journal of cardiovascular pharmacology

authors： Takeuchi K,Abe K,Yasujima M,Sato M,Kasai Y,Tsunoda K,Hagino T,Kanazawa M,Yoshinaga K

更新日期：1989-01-01 00:00:00

abstract：:Prostaglandins (PG) E2, E2, E2 alpha, and I2 [prostacyclin (PGI2)] were tested in vitro on collateral arteries that enlarge following chronic occlusion of the femoral artery in the dog. After contraction with an ED50 dose of KCl, serial doses of a PG were added. Collateral arteries relaxed significantly to PGI2 (10(-7...

journal_title：Journal of cardiovascular pharmacology

authors： Williams PB,Joyner JH

更新日期：1982-09-01 00:00:00

abstract：:Both in the periphery and in the central nervous system, alpha-adrenoceptors can be subdivided into alpha 1-types. alpha 1-Receptors are sensitive to low concentrations of the agonists phenylephrine and methoxamine, and of the antagonists corynanthine and prazosin. alpha 1-Receptors are sensitive to low concentrations...

journal_title：Journal of cardiovascular pharmacology

authors： Starke K,Docherty JR

更新日期：1982-01-01 00:00:00

abstract：:Pressure overload has an important role in heart failure, inducing excessive autophagy in cardiac myocytes that is considered to be pathogenic. Resveratrol has been reported to improve cardiac dysfunction induced by pressure overload, but it has been unclear whether resveratrol ameliorates cardiac dysfunction by regul...

journal_title：Journal of cardiovascular pharmacology

authors： Wang L,Gao M,Chen J,Yang Z,Sun J,Wang Z,Huang X,Yuan T,Shen X,Xian S

更新日期：2015-10-01 00:00:00