LC3B, a Protein That Serves as an Autophagic Marker, Modulates Angiotensin II-induced Myocardial Hypertrophy.

abstract：:The goal of this study was to determine the effects of trimetazidine on all-cause mortality and heart failure hospitalizations in patients with ischemic cardiomyopathy. We performed an extension to 48 months and a post-hoc analysis of the Villa Pini d'Abruzzo trimetazidine trial; in this single-center, open-label, ran...

journal_title：Journal of cardiovascular pharmacology

authors： Di Napoli P,Di Giovanni P,Gaeta MA,Taccardi AA,Barsotti A

更新日期：2007-11-01 00:00:00

abstract：:Histamine released within walls of resistance blood vessels is suggested to mediate an active portion of baroreceptor-mediated neurogenic vasodilatation in skeletal muscle vasculature. Studies were undertaken to examine the possibility that histamine-mediated active vasodilatation could be effected, in part, by an inh...

journal_title：Journal of cardiovascular pharmacology

authors： Holcslaw TL,Lassiter D

更新日期：1987-06-01 00:00:00

abstract：:We investigated the effect of gallopamil on cardiac sarcoplasmic reticulum (SR) function. Heavy SR was prepared from bovine ventricular muscle. Oxalate-supported calcium uptake was stimulated by gallopamil at concentrations ranging from 10 to 300 nM, whereas higher concentrations were ineffective. Peak stimulation ave...

journal_title：Journal of cardiovascular pharmacology

authors： Zucchi R,Ronca-Testoni S,Limbruno U,Yu G,Galbani P,Ronca G,Mariani M

更新日期：1992-01-01 00:00:00

abstract：:A randomized open-label clinical trial was conducted to determine whether mortality, readmission, or quality of life differed between heart failure patients managed with captopril plus diuretics and those with digoxin plus diuretics. A total of 345 heart failure patients in New York Heart Association functional classe...

journal_title：Journal of cardiovascular pharmacology

authors： Cosín-Aguilar J,Marrugat J,Sanz G,Massó J,Gil M,Vargas R,Pérez-Casar F,Simarro E,De Armas D,García-García J,Azpitarte J,Diago JL,Rodrigo-Trallero G,Lekuona I,Domingo E,Marin-Huerta E

更新日期：1999-05-01 00:00:00

abstract：:The extent to which posture altered the haemodynamic response to slow calcium channel blocker nicardipine was evaluated in 22 male patients with angiographically confirmed coronary artery disease. Patients were randomly allocated to supine or upright posture and an otherwise identical protocol performed in each group....

journal_title：Journal of cardiovascular pharmacology

authors： Silke B,Verma SP,Zezulka AV,Sharma S,Goldhammer E,Jackson N,Taylor SH

更新日期：1990-07-01 00:00:00

abstract：:Despite today's standard of care, aimed at preventing homeostatic neurohormonal activation, one in every five patients recently hospitalized with congestive heart failure (CHF) will be readmitted within 30 days of discharge because of a recurrence of their symptoms and signs. In light of recent pathophysiological insi...

journal_title：Journal of cardiovascular pharmacology

authors： Kamalov G,Bhattacharya SK,Weber KT

更新日期：2010-09-01 00:00:00

abstract：:A sodium/calcium exchange mechanism that mediates both Ca2+ exit and Ca2+ entry is present in the sarcolemma of most types of muscle including mammalian cardiac muscle and vascular smooth muscle (VSM). The rate and direction of Ca2+ transport mediated by the exchanger are normally regulated primarily by: (a) the intra...

journal_title：Journal of cardiovascular pharmacology

authors： Blaustein MP

更新日期：1988-01-01 00:00:00

abstract：:An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

journal_title：Journal of cardiovascular pharmacology

authors： Haïat R,Piot O,Gallois H,Hanania G

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:The sympathetic nervous system (SNS) of the whole body, including cardiac sympathetic nerves, is activated in patients with severe congestive systolic heart failure (CHF). Carvedilol can improve clinical status in such patients. This study aimed to determine how carvedilol acts on the SNS to improve CHF. ME...

journal_title：Journal of cardiovascular pharmacology

authors： Machida M,Takechi S,Fujimoto T,Kakinoki S,Nomura A

更新日期：2012-02-01 00:00:00

abstract：:Recent evidence has shown that the kidneys produce and secrete a member of the atrial natriuretic peptide family, named urodilatin. This 32-amino acid peptide does not circulate in blood, but is secreted into urine. Urodilatin excretion closely parallels renal sodium excretion under various conditions that influence b...

journal_title：Journal of cardiovascular pharmacology

authors： Gerzer R,Drummer C

更新日期：1993-01-01 00:00:00

abstract：:Reviewed herein are data supporting the hypothesis that insulin and the sympathoadrenal system are involved in the pathogenesis of hypertension in the obese. Data from the Normative Aging Study, a population-based cohort followed in Boston, confirm other epidemiologic reports of a direct relationship between upper-bod...

journal_title：Journal of cardiovascular pharmacology

authors： Landsberg L

更新日期：1994-01-01 00:00:00

abstract：:The aim of this study was to investigate whether the HMG-CoA reductase inhibitor cerivastatin alters the nitric oxide (NO) bioavailability of porcine aortic endothelial cell cultures and of native porcine coronary endothelium, after short-term (minutes) and long-term (24-hour) treatment with cerivastatin (electrochemi...

journal_title：Journal of cardiovascular pharmacology

authors： Berkels R,Nouri SK,Taubert D,Bartels H,Roesen P,Roesen R,Klaus W

更新日期：2003-09-01 00:00:00

abstract：:Increased sodium absorption in the gut is one mechanism contributing to hypertensive blood pressure values. The sodium-proton-exchanger subtype 3 (NHE3) is an important mediator of intestinal sodium absorption. The compound SAR is a new specific NHE3 inhibitor with extremely low oral absorbability leading to decreased...

journal_title：Journal of cardiovascular pharmacology

authors： Linz B,Hohl M,Reil JC,Böhm M,Linz D

更新日期：2016-03-01 00:00:00

abstract：:The effects of the calcium channel blocker, diltiazem hydrochloride (DZ), on conscious, resting spontaneously hypertensive rats (SHR) were evaluated and compared with results from parallel studies on Wistar-Kyoto (WKY) controls. DZ was administered as a continuous, cumulative infusion at rates equal to 0.40, 2.00, and...

journal_title：Journal of cardiovascular pharmacology

authors： Flaim SF,Newman ED,Annibali JA

更新日期：1986-03-01 00:00:00

abstract：:Rats of the genetically hypertensive (GH) strain do not have an increased body sodium content or increased natriuresis of hypertension. Spontaneously hypertensive rats (SHR), on the other hand, have an increased body sodium content and an increased rate of excretion of a sodium load. They also have an increased appeti...

journal_title：Journal of cardiovascular pharmacology

authors： Simpson FO,Ledingham JM,Phelan EL

更新日期：1984-01-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00

abstract：:The increased production of nitric oxide (NO) has been implicated as the basis for myocardial dysfunction and the lack of response to vasoconstrictors during endotoxin shock induced by lipopolysaccharide (LPS). Our objective was to evaluate and compare NO production in major organs of rats treated with LPS, 1 or 14 mg...

journal_title：Journal of cardiovascular pharmacology

authors： Lecour S,Maupoil V,Siri O,Tabard A,Rochette L

更新日期：1999-01-01 00:00:00

abstract：:Sotalol is a beta-blocker with class III antiarrhythmic properties that has recently been used in children for the treatment of supraventricular and ventricular arrhythmias. However, little is known about its electrophysiologic effects on the immature heart. Using intracardiac electrocardiographic recordings and stimu...

journal_title：Journal of cardiovascular pharmacology

authors： Houyel L,Fournier A,Ducharme G,Chartrand C,Davignon A

更新日期：1992-01-01 00:00:00

abstract：:We assessed the contribution of angiotensin-(1-7) [Ang-(1-7)] to captopril-induced cardiovascular protection in spontaneously hypertensive rats (SHRs) chronically treated with the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (SHR-l). NG-nitro-L-arginine methyl ester (80 mg/L) administration for 3 ...

journal_title：Journal of cardiovascular pharmacology

authors： Benter IF,Yousif MH,Al-Saleh FM,Raghupathy R,Chappell MC,Diz DI

更新日期：2011-05-01 00:00:00

abstract：:The mode of action of Crataegus extracts in the treatment of heart failure is still under examination. WS 1442, a standardized special extract from Crataegus leaves with flowers, exerts direct positive inotropic effects. This study was designed to investigate the mode of inotropic action of WS 1442 in human myocardium...

journal_title：Journal of cardiovascular pharmacology

authors： Schwinger RH,Pietsch M,Frank K,Brixius K

更新日期：2000-05-01 00:00:00

abstract：:Efficacy of flecainide was investigated in 50 patients with sustained ventricular tachycardia (n = 38) or ventricular fibrillation (n = 12) during a 4-week in-hospital and 1-year follow-up period. Furthermore, the predictive value of programmed electrical stimulation, Holter monitoring, and exercise testing on outcome...

journal_title：Journal of cardiovascular pharmacology

authors： van Wijk LM,Crijns HJ,Kingma HJ,van Gilst WH,van Gelder IC,Wesseling H,Lie KI

更新日期：1990-06-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNFalpha) is an inflammatory cytokine involved in atherogenesis. Adipose tissue is an important source of endogenous TNFalpha production. The aim of this study was to evaluate the effect of atorvastatin on TNFalpha serum concentration and mRNA expressions of subcutaneous adipose in hyperch...

journal_title：Journal of cardiovascular pharmacology

authors： Zhao SP,Wu ZH,Wu J,Hong SC,Deng P

更新日期：2005-08-01 00:00:00

abstract：:Aldosterone is increased in diabetes and contributes to the development of diabetic nephropathy. The authors hypothesized that reduction in aldosterone production in diabetes by amlodipine or aliskiren improves diabetic kidney disease by attenuating renal oxidative stress and fibrosis. Normoglycemic and streptozotocin...

journal_title：Journal of cardiovascular pharmacology

authors： Matavelli LC,Siragy HM

更新日期：2013-01-01 00:00:00

abstract：:The cardiac electrophysiology of flecainide a new antiarrhythmic agent, was studied in open-chested dogs. At plasma concentrations of 0.4 to 0.7 microgram/ml, flecainide significantly prolonged atrioventricular (AV) conduction. At plasma concentrations greater than 6.5 micrograms/ml, flecainide caused delay throughout...

journal_title：Journal of cardiovascular pharmacology

authors： Hodess AB,Follansbee WP,Spear JF,Moore EN

更新日期：1979-07-01 00:00:00

abstract：:Defibrillation strength shocks delivered within an action potential (AP) delay repolarization. Shock-induced AP duration extension (APDE) may prolong refractoriness and terminate or prevent reinitiation of reentry, favoring defibrillation. This study examined LY-190147 (LY) effects on defibrillation threshold (DFT) in...

journal_title：Journal of cardiovascular pharmacology

authors： Beatch GN,Dickenson DR,Wood RH,Tang AS

更新日期：1996-02-01 00:00:00

abstract：:We studied the hemodynamic effects of four doses of milrinone, administered by intravenous (i.v.) infusion alone and after autonomic blockade with prazosin, propranolol, atropine, and clonidine. Plasma concentrations of milrinone (50-600 ng/ml) were similar to those used for the treatment of cardiac failure and were u...

journal_title：Journal of cardiovascular pharmacology

authors： Hasking GJ,Dewar E,Nelson L,Oddie CJ,Bobik A,Jennings GL

更新日期：1987-05-01 00:00:00

abstract：:We determined stimulation rates of cardiac adenylate cyclase activity by isoproterenol and impromidine in particulate sarcolemmal membrane preparations from human papillary muscles resected during open heart replacement of mitral and aortic valves. In addition, specific receptor binding studies with [3H]dihydroalpreno...

journal_title：Journal of cardiovascular pharmacology

authors： Baumann G,Mercader D,Busch U,Felix SB,Loher U,Ludwig L,Sebening H,Heidecke CD,Hagl S,Sebening F,Blömer H

更新日期：1983-07-01 00:00:00

abstract：:The pharmacokinetics and dose proportionality of trandolapril, a new angiotensin-converting enzyme (ACE) inhibitor, were investigated in 12 healthy male volunteers in a four-way randomized crossover study over the therapeutic dose range, 0.5-4 mg. Trandolapril is rapidly absorbed, with a single elimination half-life (...

journal_title：Journal of cardiovascular pharmacology

authors： Lenfant B,Mouren M,Bryce T,De Lauture D,Strauch G

更新日期：1994-01-01 00:00:00

abstract：:Inclacumab is a novel monoclonal antibody directed against P-selectin in development for the prevention and treatment of atherosclerotic cardiovascular diseases. It is likely to be used concomitantly with heparin in patients undergoing percutaneous coronary intervention. Coadministration of both drugs may potentially ...

journal_title：Journal of cardiovascular pharmacology

authors： Schmitt C,Mudie N,Ciorciaro C,Gaudreault J

更新日期：2015-04-01 00:00:00

abstract：:The distribution of 3H-digoxin has been measured in a large number of tissues from the central, autonomic, and peripheral nervous system after the induction of ventricular tachycardia by infusing digoxin into anesthetized dogs. In most parts of the nervous system the tissue digoxin concentration was close to that in t...

journal_title：Journal of cardiovascular pharmacology

authors： Frazer G,Binnion P

更新日期：1981-11-01 00:00:00