Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently.

abstract：:The new converting enzyme inhibitor cilazapril, or RO 31-2848, was evaluated in 14 healthy male volunteers. In a pilot study in two subjects, the inhibiting capacity of single oral doses of 5 and 10 mg on the pressure and heart rate response to exogenous angiotensin I was assessed. Both doses reduced the blood pressur...

journal_title：Journal of cardiovascular pharmacology

authors： Fasanella d'Amore T,Bussien JP,Nussberger J,Waeber B,Turini GA,Brunner HR,Kler L,Francis RJ

更新日期：1987-01-01 00:00:00

abstract：:The in vivo effects of two unsurmountable angiotensin II type 1 (AT1) antagonists, irbesartan (150 mg) and candesartan (8 mg), were studied in a double-blind, randomized, crossover study in 18 healthy men. The drugs' direct vascular effects were assessed as the rightward shift (dose ratio - 1) of angiotensin dose-effe...

journal_title：Journal of cardiovascular pharmacology

authors： Belz GG,Butzer R,Kober S,Mutschler E

更新日期：2002-04-01 00:00:00

abstract：:Lisinopril (LIS) is a lysine analog of enalaprilat, the active metabolite of enalapril, an angiotensin-converting enzyme inhibitor (ACEI). Unlike enalapril, the precursor of enalaprilat, LIS is not a prodrug but has equal ACEI efficacy and potency and a slightly longer duration of action after oral administration. Sho...

journal_title：Journal of cardiovascular pharmacology

authors： Pool JL,Gennari J,Goldstein R,Kochar MS,Lewin AJ,Maxwell MH,McChesney JA,Mehta J,Nash DT,Nelson EB

更新日期：1987-01-01 00:00:00

abstract：:Allopurinol reduces formation of cytotoxic free radicals during myocardial ischemia/reperfusion in animals. To evaluate the effect of allopurinol on cardiac performance and metabolism after coronary bypass in humans, we divided 33 patients into two groups: 15 patients (controls) received no allopurinol and 18 patients...

journal_title：Journal of cardiovascular pharmacology

authors： Castelli P,Condemi AM,Brambillasca C,Fundarò P,Botta M,Lemma M,Vanelli P,Santoli C,Gatti S,Riva E

更新日期：1995-01-01 00:00:00

abstract：:The increased production of nitric oxide (NO) has been implicated as the basis for myocardial dysfunction and the lack of response to vasoconstrictors during endotoxin shock induced by lipopolysaccharide (LPS). Our objective was to evaluate and compare NO production in major organs of rats treated with LPS, 1 or 14 mg...

journal_title：Journal of cardiovascular pharmacology

authors： Lecour S,Maupoil V,Siri O,Tabard A,Rochette L

更新日期：1999-01-01 00:00:00

abstract：:We studied the inotropic and possible antioxidant effects of levosimendan in human atrial strips, before and after induction of oxidative stress induced by H2O2. Levosimendan (10(-9) to 10(-6) M) increased contractions induced by electrical stimulation (ES) in human atrial strips. The maximal positive inotropic effect...

journal_title：Journal of cardiovascular pharmacology

authors： Sahin AS,Görmüş N,Duman A

更新日期：2007-10-01 00:00:00

abstract：:Endothelin-1 (ET-1) stimulated cAMP formation in Chinese hamster ovary cells stably expressing human wild-type ET(A) (CHO/hET(A) cells) and inhibited the formation in cells expressing human wild-type ETB (CHO/hETB cells), suggesting a selective coupling of hET(A) and hETB with G alpha s and G alpha i, respectively. To...

journal_title：Journal of cardiovascular pharmacology

authors： Ninomiya H,Takagi Y,Miwa S,Masaki T

更新日期：1995-01-01 00:00:00

abstract：:We studied the kinetics of amiodarone in three healthy volunteers after single oral (400 mg) and intravenous (150 mg) doses and in six patients with supraventricular tachycardia. Three patients were studied after the first oral dose (400 mg) and during subsequent therapy (200 mg/day); the other three after 5 mg/kg of ...

journal_title：Journal of cardiovascular pharmacology

authors： Riva E,Gerna M,Latini R,Giani P,Volpi A,Maggioni A

更新日期：1982-03-01 00:00:00

abstract：:In patients on chronic hemodialysis hypotensive episodes are frequently encountered during the course of treatment and the prevalence of atherosclerosis is increased. Endothelin-1 (ET-1), an endothelium-derived peptide with vasoconstrictive and mitogenic effects on smooth muscles, is involved in vascular tone regulati...

journal_title：Journal of cardiovascular pharmacology

authors： Stefanidis I,Wurth P,Mertens PR,Ikonomov V,Philippidis G,Golphinopoulos S,Makropoulos V,Liakopoulos V,Mann H,Heintz B

更新日期：2004-11-01 00:00:00

abstract：:We investigated the interaction between nitroxy groups and angiotensin-converting enzyme (ACE) inhibitors to assess the role of sulfhydryl groups and adenosine triphosphate (ATP)-sensitive potassium channels in vasodilation of human coronary resistance vessels in vitro. Coronary resistance vessels were resected from t...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi K,Ohyanagi M,Kobayashi S,Iwasaki T,Miyamoto T

更新日期：2000-10-01 00:00:00

abstract：:We investigated the effects of a class I antiarrhythmic drug, cibenzoline, on human atrial muscle in vivo. Electrophysiologic measurements were performed in 44 patients (mean age 49 +/- 15 years), before and after an intravenous infusion of cibenzoline 1.4 mg/kg in 5 min. Extrastimuli at a basic cycle length (BCL) of ...

journal_title：Journal of cardiovascular pharmacology

authors： Esato M,Shimizu A,Chun YH,Tatsuno H,Yamagata T,Matsuzaki M

更新日期：1996-08-01 00:00:00

abstract：:Pressure overload has an important role in heart failure, inducing excessive autophagy in cardiac myocytes that is considered to be pathogenic. Resveratrol has been reported to improve cardiac dysfunction induced by pressure overload, but it has been unclear whether resveratrol ameliorates cardiac dysfunction by regul...

journal_title：Journal of cardiovascular pharmacology

authors： Wang L,Gao M,Chen J,Yang Z,Sun J,Wang Z,Huang X,Yuan T,Shen X,Xian S

更新日期：2015-10-01 00:00:00

abstract：:Dilevalol, the stereoisomer of labetalol, was given in repeated incremental intravenous bolus injections to 10 patients with severe hypertension requiring urgent blood pressure lowering. The mean cumulative dose of dilevalol was 445 +/- 165 mg. Blood pressure was reduced from 201 +/- 33/131 +/- 13 to 150 +/- 12/109 +/...

journal_title：Journal of cardiovascular pharmacology

authors： Bursztyn M,Gavras I,Blasucci DJ,Gavras H

更新日期：1989-05-01 00:00:00

abstract：:Numerous studies have demonstrated that immune effector mechanisms cause serious heart diseases, among which are heart transplant rejection, myocarditis, and the resulting dilated cardiomyopathy, as well as Chagas' disease. Whereas different effectors of the immune system can affect cardiac function, this review prima...

journal_title：Journal of cardiovascular pharmacology

authors： Binah O

更新日期：2001-08-01 00:00:00

abstract：:We examined a relation between cyclic guanosine monophosphate (cGMP) production in thoracic aorta, as an indicator probably reflecting the vascular response, and the vascular as well as plasma levels of nicorandil administered orally to rats. Nicorandil (3 mg/kg) given orally was rapidly absorbed, reaching the maximal...

journal_title：Journal of cardiovascular pharmacology

authors： Sakai K,Moriyasu M,Kitajima S,Akima M,Kamachi S,Tanikawa M

更新日期：1998-04-01 00:00:00

abstract：:Chronic heart failure (HF) is associated with increased systemic (plasma) and reduced local (myocardial) adenosine levels. The final biological action of adenosine in a particular organ or cell population may depend on the relative degree of expression and signaling efficiency of individual adenosine receptor (AR) sub...

journal_title：Journal of cardiovascular pharmacology

authors： Del Ry S,Cabiati M,Martino A,Simioniuc A,Morales MA,Picano E

更新日期：2011-08-01 00:00:00

abstract：:Using constant infusion technique and a water-loading procedure, we investigated renal hemodynamic and excretional variables in 15 essential hypertensive patients [diastolic blood pressure (DBP) 102 +/- 10 mm Hg] after 3 weeks of placebo and after 16 weeks of treatment with a postjunctional alpha 1-adrenoceptor-antago...

journal_title：Journal of cardiovascular pharmacology

authors： Krusell LR,Christensen CK,Pedersen OL

更新日期：1992-09-01 00:00:00

abstract：SUMMARY:The present study reports the effects of apomorphine (APO) on blood pressure and the principal site of action of this agonist in 4-week deoxycorticosterone-acetate (DOCA)-hypertensive conscious rats. In these preprations, intravenous (i.v.) administration of APO (0.50-1 mg/kg) induced short-lasting and dose-dep...

journal_title：Journal of cardiovascular pharmacology

authors： Toscano CF,Lahlou S

更新日期：2003-12-01 00:00:00

abstract：:We have previously demonstrated that endothelin-1 (ET-1) is essential to the development of neural crest-derived craniofacial and cardiovascular structures. In this study we evaluated the intrauterine growth and development of the thyroid and thymus glands in Edn1-/- homozygous mice. Edn1-/- homozygous mice were small...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara Y,Kurihara H,Maemura K,Kuwaki T,Kumada M,Yazaki Y

更新日期：1995-01-01 00:00:00

abstract：:The terminal phases of volume-overload heart failure are characterised by eccentric ventricular hypertrophy. Relatively little attention has been directed to exploring the mechanisms involved in this development. The increase in diastolic wall stress leads to replication of the sarcomeres in series. The hypertrophied ...

journal_title：Journal of cardiovascular pharmacology

authors： Taylor SH

更新日期：1987-01-01 00:00:00

abstract：:Isolated perfused rat kidney was used to examine the possible mechanisms involved in the hypotensive/vasodilator actions of cryptolepine. In kidneys preconstricted by phenylephrine (PE 5-7.5 x 10(-7) M), cryptolepine at bolus doses of 2.5, 5, and 10 micrograms elicited dose-dependent reductions in perfusion pressure b...

journal_title：Journal of cardiovascular pharmacology

authors： Oyekan AO

更新日期：1994-04-01 00:00:00

abstract：:With increasing age, cardiac beta-adrenoceptor function decreases. To study possible mechanisms underlying this process, we assessed in right atrial appendages from 52 patients of different ages (group A, < 20 years, mean age 3.7 +/- 1.0 years, n = 20; group B, 20-50 years, mean age, 37.9 +/- 2.3 years, n = 9; group C...

journal_title：Journal of cardiovascular pharmacology

authors： Brodde OE,Zerkowski HR,Schranz D,Broede-Sitz A,Michel-Reher M,Schäfer-Beisenbusch E,Piotrowski JA,Oelert H

更新日期：1995-07-01 00:00:00

abstract：:Several lines of evidence support a fundamental role for voltage-gated sodium channels in mediating ischemic Na rise. We examined the effect of the novel anti-ischemic compound KC 12291 on veratridine-stimulated and lysophosphatidylcholine (LPC)-induced sustained sodium current (I(NAL)) mediated by sodium channels in ...

journal_title：Journal of cardiovascular pharmacology

authors： Tamareille S,Le Grand B,John GW,Feuvray D,Coulombe A

更新日期：2002-09-01 00:00:00

abstract：:Cardiovascular function is regulated by short-term and long-term neurohormonal and autocrine-paracrine mechanisms that act synergistically or sequentially. Structural adaptive changes that occur progressively over time also contribute to the long-term outcome. The renin-angiotensin system (RAS) can operate as both an ...

journal_title：Journal of cardiovascular pharmacology

authors： Dzau VJ

更新日期：1989-01-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is increasingly used in the clinical evaluation of hypertension. However, a number of limitations restrict its routine use. One of the limitations is a lack of definite conclusions about ambulatory blood pressure normality, because of the shortcomings of previous studies on ...

journal_title：Journal of cardiovascular pharmacology

authors： Sega G,Bravi C,Cesana G,Valagussa F,Mancia G,Zanchetti A

更新日期：1994-01-01 00:00:00

abstract：:The effect of atrial natriuretic peptide (ANP) on cytosolic free calcium ([Ca2+]i) was studied in monolayers of cultured vascular smooth muscle (VSM) cells loaded with a fluorescent calcium indicator, fura-2. ANP (atriopeptin III, 10(-8) M) decreased the resting level of [Ca2+]i and sustained rises in [Ca2+]i followin...

journal_title：Journal of cardiovascular pharmacology

authors： Takeuchi K,Abe K,Yasujima M,Sato M,Kasai Y,Tsunoda K,Hagino T,Kanazawa M,Yoshinaga K

更新日期：1989-01-01 00:00:00

abstract：:We investigated the effect of oral ibopamine (SB 7505) on myocardial and renal function in eight patients suffering from congestive heart failure. Ibopamine was administered orally 50 mg twice a day for 7 days. Systolic time intervals PEP (preejection period) and EMS (electromechanical systole) decreased significantly...

journal_title：Journal of cardiovascular pharmacology

authors： Dei Cas L,Manca C,Bernardini B,Vasini G,Visioli O

更新日期：1982-05-01 00:00:00

abstract：:Intracerebroventricular injections of endothelin-1 (ET-1) are reported to cause dose-related increases in sympathetic nerve activity and blood pressure in anesthetized normotensive rats. These studies were performed to determine the following: which endothelin receptor, A or B, is involved in mediating sympathetic and...

journal_title：Journal of cardiovascular pharmacology

authors： Nakamura K,Sasaki S,Moriguchi J,Morimoto S,Miki S,Kawa T,Itoh H,Nakata T,Takeda K,Nakagawa M

更新日期：1999-06-01 00:00:00

abstract：:The genes for endothelin (ET) and their receptors are candidates for essential hypertension. Those for ET-1, ET-2 and the ET(A) receptor were selected for mutation scanning, and associated studies comparing untreated hypertensive patients and matched controls. A number of silent polymorphisms were found, resulting fro...

journal_title：Journal of cardiovascular pharmacology

authors： Brown MJ,Sharma P,Stevens PA

更新日期：2000-01-01 00:00:00

abstract：:Few studies have addressed the possibility that brain natriuretic peptide (BNP) possesses a profile of bioactivity that is distinct from that of atrial natriuretic peptide (ANP). Accordingly, we assessed the biologic actions of BNP in the setting of maximal or near-maximal ANP-induced biologic activity. Background ANP...

journal_title：Journal of cardiovascular pharmacology

authors： Charles CJ,Espiner EA,Nicholls MG,Rademaker MT,Richards AM

更新日期：1999-02-01 00:00:00