Impaired vasodilatation response to amrinone in the forearm of patients with congestive heart failure: role of endothelium-derived nitric oxide.


:Recent in vitro experiments have shown that amrinone enhances the release of nitric oxide (NO) from the endothelium and induces NO mediated vasodilatation. This in vivo study examined whether amrinone causes vasodilatation mediated by endothelium-derived NO, and whether this effect is attenuated in patients with endothelial dysfunction. Eight patients with congestive heart failure and 10 age- and sex-matched healthy volunteers were studied. Forearm blood flow (FBF) was measured before and during infusion of drugs of acetylcholine, amrinone, and nitroglycerin in incremental doses. After the completion of these measurements, 100 micromol of N(G)-monomethyl-L-arginine (L-NMMA) was infused intraarterially. Thereafter, FBF measurement in response to incremental doses of amrinone was repeated. Infusion of incremental doses of amrinone caused a comparable increase in amrinone plasma concentration in both groups. Baseline FBF was 3.2+/-0.79 ml/min/100 ml in controls vs. 2.91+/-0.79 ml/min/100 ml in patients (p = 0.43). In both groups, FBF increased in response to acetylcholine, amrinone, and nitroglycerin. During infusion of the highest dose of nitroglycerin, FBF was not different between the two groups (p = 0.51); however, FBF during infusion of the highest doses of acetylcholine and amrinone was significantly less in patients than in controls: 9.75+/-2.69 vs. 24.87+/-8.65 ml/min/100 ml (p < 0.001) and 3.79+/-1.21 vs. 7.15+/-2.06 ml/min/100 ml (p < 0.001), respectively. L-NMMA significantly depressed the increase in FBF in response to amrinone in controls, but not in patients. In conclusion, the selective PDE III inhibitor, amrinone, has endothelium-derived NO-mediated vasodilating effects in addition to direct effects. This property may be impaired in patients with endothelial dysfunction.


J Cardiovasc Pharmacol


Sakane T,Ishibashi Y,Shimada T,Takahashi N,Sugamori T,Hirano Y,Ohata S,Inoue SI,Nakamura K,Murakami Y




Has Abstract


2000-08-01 00:00:00












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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Smith D,Hornstra J,Rocha M,Jansen G,Assaraf Y,Lasry I,Blom H,Smulders YM

    更新日期:2017-10-01 00:00:00

  • Electrophysiologic actions of d,l-sotalol and GLG-V-13 in ischemically injured canine epicardium.

    abstract::The electrophysiologic actions of the class III antiarrhythmic agents, GLG-V-13 and d,l-sotalol, were examined in superfused normal and ischemically injured epicardium. Both drugs produced concentration and reverse-use dependent prolongation of the action potential duration in normal myocardium without altering restin...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Patterson E,Scherlag BJ,Lazzara R,Garrison GL,Berlin KD

    更新日期:2007-09-01 00:00:00

  • In Vitro Anticoagulant Activity of Mikania laevigata: Deepening the Study of the Possible Interaction Between Guaco and Anticoagulants.

    abstract::Mikania laevigata, popularly known in Brazil as guaco, is widely used for respiratory disorders. As this plant is rich in coumarins, there is evidence of indications that it may cause bleeding and therefore should not be used concomitantly with anticoagulants. The basis of this information is very theoretical, with no...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Leite PM,Miranda APN,Amorim JM,Duarte RCF,Bertolucci SKV,Carvalho MDG,Castilho RO

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  • Rapid Switch From Subcutaneous to Intravenous Treprostinil in Precapillary Pulmonary Hypertension by Pump Implantation.

    abstract:ABSTRACT:Limited data are available on the transition from subcutaneous to intravenous prostacyclin in precapillary pulmonary hypertension. We performed a retrospective analysis of all patients who were switched from subcutaneous to intravenous treprostinil with an implantable infusion pump. We included 85 consecutive,...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Steringer-Mascherbauer R,Maria L,Reinhold F,Elisabeth S,Charlotte H,Dagmar E,Uwe F,Josef A

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  • Maternal cocaine administration during pregnancy induces apoptosis in fetal rat heart.

    abstract::We have previously demonstrated that cocaine induces apoptosis in primary cultures of fetal rat cardiomyocytes. The current study was designed to determine whether cocaine administered to the mother during pregnancy induced apoptosis in fetal rat heart. Pregnant rats were treated with cocaine subcutaneously (30 and 60...

    journal_title:Journal of cardiovascular pharmacology

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    authors: Xiao Y,Xiao D,He J,Zhang L

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  • Blood pressure response to the first 36 hours of heart failure therapy with perindopril versus captopril. French General Hospitals National College of Cardiologists.

    abstract::An open randomized hospital study conducted in 169 centers in France compared the blood pressure response to the first 36 h of treatment with perindopril (PER), 2 mg once daily, with that to captopril (CAP), 6.25 mg t.i.d., in 725 patients (mean age, 70 years; men, 67%) with echocardiographic left ventricular systolic...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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    journal_title:Journal of cardiovascular pharmacology

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    journal_title:Journal of cardiovascular pharmacology

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  • Calcium antagonists in comparison: view of the pharmacologist.

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Borchard U

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  • Long-term results of the Spanish trial on treatment and survival of patients with predominantly mild heart failure.

    abstract::A randomized open-label clinical trial was conducted to determine whether mortality, readmission, or quality of life differed between heart failure patients managed with captopril plus diuretics and those with digoxin plus diuretics. A total of 345 heart failure patients in New York Heart Association functional classe...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


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  • Effects of prolonged administration of oxprenolol on severity of ischaemic arrhythmias, enzyme leakage, infarct size, and intracellular cardiac muscle action potentials.

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    journal_title:Journal of cardiovascular pharmacology

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  • Acute effects of nisoldipine, propranolol, and their combination in patients with chronic stable angina: a double-blind, randomized, cross-over, placebo-controlled study.

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


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  • Interaction of lacidipine with its receptor binding site supports a slow onset and long duration of action.

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    journal_title:Journal of cardiovascular pharmacology

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  • Why do patients die after myocardial infarction?

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Julian DG

    更新日期:1991-01-01 00:00:00

  • Felodipine is more effective than hydrochlorothiazide when added to a beta-blocker in treating elderly hypertensive patients.

    abstract::This randomized, double-blind, parallel-group study compared felodipine and hydrochlorothiazide (HCT) given in addition to a beta-blocker in 134 elderly hypertensive patients aged 56-79 years (mean of 66 +/- 5 years). In the felodipine-treated group (n = 57), supine blood pressure (BP) was reduced from 171 +/- 16/101 ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1990-01-01 00:00:00

  • The effect of flutamide on systemic and renal hemodynamics in Zucker diabetic rats: paradoxic renal vasodilator response to endothelin-1 and TXA2 receptor activation in female sex.

    abstract:BACKGROUND:There is increasing evidence that endogenous sex hormones regulate vascular reactivity, and testosterone may contribute to the worse prognosis for renal disease in men. Male Zucker diabetic rats exhibit improved renal hemodynamic responses after castration. It is, however, unclear whether endogenous testoste...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Ajayi AA,Fidelis P

    更新日期:2006-11-01 00:00:00

  • Metoprolol and Nebivolol Prevent the Decline of the Redox Status of Low-Molecular-Weight Aminothiols in Blood Plasma of Rats During Acute Cerebral Ischemia.

    abstract::Cerebral ischemia has previously been shown to cause a systemic decrease in levels of the reduced forms of low-molecular-weight aminothiols [cysteine (Cys), homocysteine (Hcy), and glutathione (GSH)] in blood plasma. In this study, we examined the effect of beta-adrenergic receptor (β-AR) antagonists metoprolol (Met) ...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Ivanov AV,Alexandrin VV,Paltsyn AA,Virus ED,Nikiforova KA,Bulgakova PO,Sviridkina NB,Svetlana Alexandrovna Apollonova,Kubatiev AA

    更新日期:2018-10-01 00:00:00

  • Intracellular resistance in rat papillary muscle: interaction between cyclic AMP and calcium.

    abstract::The influence of isoproterenol (10(-9)M) and high calcium solution (6 mM) on the intracellular longitudinal resistance (ri) on rat papillary muscle was investigated. The muscles were stimulated at 1 Hz. Isoproterenol (10(-5)M) reduced ri within 10 s while high calcium solution (6 mM) increased ri appreciably. In muscl...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Xiao RP,De Mello WC

    更新日期:1991-05-01 00:00:00

  • Bremazocine causes sympatho-inhibition and hypotension in rabbits by activating peripheral kappa-receptors.

    abstract::We have studied the effects of bremazocine on the peripheral sympathetic nervous system and the arterial blood pressure of pithed rabbits with electrically (2 Hz) stimulated sympathetic outflow, and compared them with the effects of Leu-enkephalin and fentanyl. The 3H-noradrenaline plasma clearance and the plasma conc...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


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    更新日期:1986-05-01 00:00:00

  • Endothelin 1-induced pressor response and vasopressin release in rats with heart failure.

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Rossi NF,Chen H,Musch TI

    更新日期:2002-07-01 00:00:00

  • Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study.

    abstract::The mechanisms by which tolerance to organic nitrates develops are still poorly understood. Enhanced oxidative stress, i.e., increased free radical production following organic nitrate administration, has been recently suggested as a possible mechanism. A randomized, double-blind, crossover study assessed in 18 health...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:2003-02-01 00:00:00

  • Prophylactic effect of intravenous nicorandil on perioperative myocardial damage in patients undergoing off-pump coronary artery bypass surgery.

    abstract::Nicorandil, ATP sensitive potassium channel opener, is shown to reduce coronary events for patients with stable angina. The present study was designed to examine the protective potential of nicorandil for patients undergoing off-pump coronary artery bypass grafting. Twenty-four patients undergoing off-pump coronary ar...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


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  • Antihypertensive effect of canrenone in a model where endogenous ouabain-like factors are present.

    abstract::The effect of canrenone, an antialdosterone and partial ouabain-agonist drug, was studied in rats that developed volume expansion and hypertension after renal mass reduction and excess Na+ intake (RRM-salt). The RRM-salt was characterized by: (1) increased endogenous "digitalis-like" compounds in plasma [cross reactiv...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: de Mendonça M,Grichois ML,Pernollet MG,Wauquier I,Trouillet-Thormann B,Meyer P,Devynck MA,Garay R

    更新日期:1988-01-01 00:00:00

  • Cardiac outcome prevention effectiveness of glucocorticoids in acute decompensated heart failure: COPE-ADHF study.

    abstract:INTRODUCTION:Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid t...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Liu C,Liu K,COPE-ADHF Study Group.

    更新日期:2014-04-01 00:00:00

  • Changes in the pathophysiologic profile of blood pressure determinants during short-term enalapril administration.

    abstract::To assess dose-related effects of enalapril, we treated eight hospitalized hypertensive patients receiving constant sodium intake with incremental doses of this new angiotensin converting-enzyme blocking drug. After a few days of placebo treatment, enalapril was given in single daily doses, starting with 1.25 mg and i...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: de Leeuw PW,Birkenhäger WH

    更新日期:1986-01-01 00:00:00

  • Comparative effects of loratadine and terfenadine on cardiac K+ channels.

    abstract::Nonsedating H1-receptor antagonists appear to have wide and variable effects on the QT interval, mediated through modulation of cardiac K+ channels. By using the whole-cell patch-clamp technique, we examined the effects of terfenadine, loratadine, and descarboethoxyloratadine on a large family of K+ channels in ventri...

    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Ducic I,Ko CM,Shuba Y,Morad M

    更新日期:1997-07-01 00:00:00

  • Beneficial effects of amiodarone and dronedarone (SR 33589b), when applied during low-flow ischemia, on arrhythmia and functional parameters asssessed during reperfusion in isolated rat hearts.

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Rochetaing A,Barbé C,Kreher P

    更新日期:2001-10-01 00:00:00

  • Endocannabinoids and the heart.

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章,评审


    authors: Hiley CR

    更新日期:2009-04-01 00:00:00

  • The selectivity of xamoterol, prenalterol, and salbutamol as assessed by their effects in the presence and absence of ICI 118,551.

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1988-05-01 00:00:00

  • Stem cells for drug screening.

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    journal_title:Journal of cardiovascular pharmacology

    pub_type: 杂志文章


    authors: Laposa RR

    更新日期:2011-09-01 00:00:00