Cell membrane cation transport systems during aldosterone antagonism.

abstract：:To elucidate the pathophysiological role of atrial natriuretic polypeptide (ANP) in diseased hearts, ANP levels in atrial and ventricular tissues and plasma were investigated in mice with congestive heart failure after viral myocarditis. The study was performed on day 14 after encephalomyocarditis viral inoculation, w...

journal_title：Journal of cardiovascular pharmacology

authors： Morii N,Nakao K,Matsumori A,Tomioka Y,Kawai C,Imura H

更新日期：1989-01-01 00:00:00

abstract：:The major aim of treatment of arterial hypertension is to reduce the increased risks of cardio-cerebrovascular morbidity and mortality that are associated with elevated blood pressure (BP). A direct relationship can be found between the level of BP and risk, even down to what is normally considered to be the "normoten...

journal_title：Journal of cardiovascular pharmacology

authors： Hansson L

更新日期：1987-01-01 00:00:00

abstract：:Intracellular [Ca2+]i overloading in cardiomyocytes is a fundamental pathogenic event associated with chronic aldosterone/salt treatment (ALDOST) and accounts for an induction of oxidative stress that leads to necrotic cell death and consequent myocardial scarring. This prooxidant response to Ca2+ overloading in cardi...

journal_title：Journal of cardiovascular pharmacology

authors： Kamalov G,Ahokas RA,Zhao W,Zhao T,Shahbaz AU,Johnson PL,Bhattacharya SK,Sun Y,Gerling IC,Weber KT

更新日期：2010-03-01 00:00:00

abstract：:The goal of this study was to determine the effects of trimetazidine on all-cause mortality and heart failure hospitalizations in patients with ischemic cardiomyopathy. We performed an extension to 48 months and a post-hoc analysis of the Villa Pini d'Abruzzo trimetazidine trial; in this single-center, open-label, ran...

journal_title：Journal of cardiovascular pharmacology

authors： Di Napoli P,Di Giovanni P,Gaeta MA,Taccardi AA,Barsotti A

更新日期：2007-11-01 00:00:00

abstract：:The relationship between arterial pressure and the rate of Na+ excretion is regulated by a number of mechanisms- some well known, some newly discovered, and probably some yet to be discovered. These mechanisms affect either the amount of Na+ filtered at the glomerulus or its rate of reabsorption from the proximal or d...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson WP,Evans RG,Malpas SC

更新日期：1995-01-01 00:00:00

abstract：:We investigated the effect of oral ibopamine (SB 7505) on myocardial and renal function in eight patients suffering from congestive heart failure. Ibopamine was administered orally 50 mg twice a day for 7 days. Systolic time intervals PEP (preejection period) and EMS (electromechanical systole) decreased significantly...

journal_title：Journal of cardiovascular pharmacology

authors： Dei Cas L,Manca C,Bernardini B,Vasini G,Visioli O

更新日期：1982-05-01 00:00:00

abstract：:The cardioprotective effects on myocardial ischemia of the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA) inhibitor, cyclopiazonic acid (CPA), were studied. We used the isolated arterially perfused interventricular septum of the rabbit heart submitted to 30-min global ischemia/30-min reperfusion. Mechanical [maximal ...

journal_title：Journal of cardiovascular pharmacology

authors： Avellanal M,Rodriguez P,Barrigon S

更新日期：1998-11-01 00:00:00

abstract：:We assessed whether local inhibition of myocardial converting enzyme by captopril and zofenopril reduces the functional and metabolic damage caused by ischemia and reperfusion. First we investigated the effects of zofenopril and captopril on the mechanical function, cellular redox state, and norepinephrine (NE) conten...

journal_title：Journal of cardiovascular pharmacology

authors： Ferrari R,Cargnoni A,Curello S,Ceconi C,Boraso A,Visioli O

更新日期：1992-01-01 00:00:00

abstract：:Previous studies have suggested that racial differences may exist in beta-adrenoceptor-mediated responsiveness. However, no clear conclusions can be drawn based on these studies because of the confounding effect of the parasympathetic nervous system on responses to isoproterenol bolus doses. In this study, we blocked ...

journal_title：Journal of cardiovascular pharmacology

authors： Johnson JA,Burlew BS,Stiles RN

更新日期：1995-01-01 00:00:00

abstract：:The short half-life, low plasma concentrations, and extensive biotransformation of prazosin suggest that it might be subject to extensive first-pass metabolism. Bioavailability, disposition, and hepatic extraction were studied in the dog. In conscious dogs whole blood prazosin concentrations were measured after oral a...

journal_title：Journal of cardiovascular pharmacology

authors： Rubin P,Yee YG,Anderson M,Blaschke T

更新日期：1979-11-01 00:00:00

abstract：:The purpose of this study was to assess the cardiovascular effects of an ultra-short-acting beta-blocker, ONO-1101, by using halothane-anesthetized beagle dogs in comparison with esmolol. ONO-1101 (n = 6) or esmolol (n = 6) was administered at four infusion rates of 0.3, 3, 30, and 300 microg/ kg/min. Each infusion wa...

journal_title：Journal of cardiovascular pharmacology

authors： Sugiyama A,Takahara A,Hashimoto K

更新日期：1999-07-01 00:00:00

abstract：:We briefly review and compare the current knowledge of growth mechanisms for the mitogenic response of endothelial cells and smooth-muscle cells to injury. For the endothelium, this focuses on the evidence that growth control involves two components: an endogenous inhibition mechanism, which can be overcome either by ...

journal_title：Journal of cardiovascular pharmacology

authors： Schwartz SM,Liaw L

更新日期：1993-01-01 00:00:00

abstract：ABSTRACT:The NLRP3 inflammasome has been implicated in the development and progression of heart failure. The aim of this study was to determine the safety of an oral inhibitor of the NLRP3 inflammasome, dapansutrile (OLT1177), in patients with heart failure and reduced ejection fraction (HFrEF). This was a phase 1B, ra...

journal_title：Journal of cardiovascular pharmacology

authors： Wohlford GF,Van Tassell BW,Billingsley HE,Kadariya D,Canada JM,Carbone S,Mihalick VL,Bonaventura A,Vecchié A,Chiabrando JG,Bressi E,Thomas G,Ho AC,Marawan AA,Dell M,Trankle CR,Turlington J,Markley R,Abbate A

更新日期：2020-10-24 00:00:00

abstract：INTRODUCTION:We investigated the efficacy of carvedilol for preventing the recurrence of atrial fibrillation and reducing QT prolongation induced by bepridil. METHODS:We assigned 144 subjects with persistent atrial fibrillation. The subjects were divided into 3 groups: carvedilol plus bepridil, candesartan plus beprid...

journal_title：Journal of cardiovascular pharmacology

authors： Kawamura M,Munetsugu Y,Tanno K,Kobayashi Y

更新日期：2013-01-01 00:00:00

abstract：:Baboons were given eight doses of clonidine hydrochloride (0.04--40 micrograms/kg) via indwelling femoral venous catheters. Systolic and diastolic blood pressures and heart rates were assessed for time course, magnitude of change, time-to-peak change, and duration of effect at each dosage level. The response to clonid...

journal_title：Journal of cardiovascular pharmacology

authors： Turkkan JS,Lukas SE,Harris AH

更新日期：1982-09-01 00:00:00

abstract：:Proliferation of medial smooth muscle cells (SMC) plays a major role in restenosis after coronary angioplasty and can be inhibited by heparin. Platelets stimulate SMC proliferation, and their aggregation after angioplasty can be reduced by the direct thrombin inhibitor hirudin. In a porcine coronary stent-angioplasty ...

journal_title：Journal of cardiovascular pharmacology

authors： Buchwald AB,Hammerschmidt S,Stevens J,Göring J,Nebendahl K,Unterberg C

更新日期：1996-10-01 00:00:00

abstract：:Calcium sensitizers increase myocardial contractile function without affecting Ca2+ homeostasis, which might be beneficial in the treatment of patients with heart failure. However, it remains uncertain whether Ca sensitizers induce quantitatively similar inotropic responses in control and failing hearts. To compare th...

journal_title：Journal of cardiovascular pharmacology

authors： Tsutsui H,Kinugawa S,Ide T,Hayashidani S,Suematsu N,Satoh S,Nakamura R,Egashira K,Takeshita A

更新日期：2001-01-01 00:00:00

abstract：:Diazepam (DZP) is commonly used in treatment of patients with acute ischemic syndromes to allay anxiety, but benzodiazepines reduce myocardial contractility and increase myocardial blood flow. To investigate the antiischemic effect of DZP, we studied 13 patients with a positive exercise test and angiographically docum...

journal_title：Journal of cardiovascular pharmacology

authors： Rossetti E,Fragasso G,Xuereb RG,Xuereb M,Margonato A,Chierchia SL

更新日期：1994-07-01 00:00:00

abstract：:Coronary hemodynamics (blood flow, coronary reserve, myocardial oxygen consumption) were analyzed in both experimental and clinical hypertension. Significantly reduced coronary reserve was found in hypertensive patients with left ventricular hypertrophy. Medial hypertrophy of small coronary vessels associated with a m...

journal_title：Journal of cardiovascular pharmacology

authors： Strauer BE,Schwartzkopff B,Motz W,Vogt M

更新日期：1991-01-01 00:00:00

abstract：:Acute bromocriptine administration reduced sitting and standing blood pressure and produced severe orthostatic hypotension in 12 normal subjects. Concomitantly, there was an increase in venous distensibility and basal blood flow, and a decrease in peripheral vascular resistance, as determined by forearm plethysmograph...

journal_title：Journal of cardiovascular pharmacology

authors： Johns DW,Ayers CR,Carey RM

更新日期：1984-07-01 00:00:00

abstract：:Six elderly male (65-75 years), seven elderly female (64-88 years), 15 young male (22-38 years), and nine young female (25-37 years) volunteers, all of normal body weight and clinically without cardiac or renal dysfunction, received a single 25-mg intravenous dose of lidocaine. Plasma concentrations of lidocaine were ...

journal_title：Journal of cardiovascular pharmacology

authors： Abernethy DR,Greenblatt DJ

更新日期：1983-11-01 00:00:00

abstract：:Acute occlusion of a coronary artery can result in myocardial infarction-a leading cause of premature death. Prompt restoration of blood flow to the myocardium can prevent excessive death of cardiomyocytes and improve clinical outcome. Although the major mechanism of cell death after reperfusion is necrosis, it is now...

journal_title：Journal of cardiovascular pharmacology

authors： Rauf A,Shah M,Yellon DM,Davidson SM

更新日期：2019-09-01 00:00:00

abstract：:We investigated the effects of nifedipine on cyclic GMP turnover and the pertinent enzyme activities in cultured coronary smooth muscle cells (SMC). Nifedipine at high concentrations slightly decreased basal soluble guanylate cyclase activity and inhibited the action of sodium nitroprusside (SNP) but had no effect on ...

journal_title：Journal of cardiovascular pharmacology

authors： Kishi Y,Watanabe T,Makita T,Sakita S,Watanabe R,Ashikaga T,Numano F

更新日期：1995-10-01 00:00:00

abstract：:Pressure overload has an important role in heart failure, inducing excessive autophagy in cardiac myocytes that is considered to be pathogenic. Resveratrol has been reported to improve cardiac dysfunction induced by pressure overload, but it has been unclear whether resveratrol ameliorates cardiac dysfunction by regul...

journal_title：Journal of cardiovascular pharmacology

authors： Wang L,Gao M,Chen J,Yang Z,Sun J,Wang Z,Huang X,Yuan T,Shen X,Xian S

更新日期：2015-10-01 00:00:00

abstract：:Dobutamine is frequently used for acute therapy in heart failure. In the present study, the hemodynamic effects of long-term intermittent dobutamine therapy were investigated in conscious rats with heart failure. Rats with healed myocardial infarctions received two i.p. injections of dobutamine per day for 2 weeks. He...

journal_title：Journal of cardiovascular pharmacology

authors： Schoemaker RG,Debets JJ,Struyker-Boudier HA,Smits JF

更新日期：1991-06-01 00:00:00

abstract：:Diabetic nephropathy is a major cause of end-stage renal failure and the mortality rate due to this disease is continuously progressing worldwide. The multifaceted signalling mechanisms have been identified to be involved in the pathogenesis of diabetic nephropathy. Despite the modern therapies like antidiabetics, ant...

journal_title：Journal of cardiovascular pharmacology

authors： Balakumar P,Arora MK,Reddy J,Anand-Srivastava MB

更新日期：2009-08-01 00:00:00

abstract：:A contribution by active vasodilation to the hypotensive effect of medroxalol was investigated in anesthetized dogs and reserpinized pithed rats. In anesthetized dogs, intravenous doses of medroxalol, which decreased blood pressure and heart rate, also produced a dose-related vasodilation in the isolated perfused grac...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Hsieh CP,Spedding M

更新日期：1983-01-01 00:00:00

abstract：:Activation of adrenoceptors of the alpha 2-subtype can cause an inhibitory or an excitatory response, depending on the cellular system affected. At the plasma membrane, where the extracellular signal is transduced via the alpha 2-adrenoceptor into an intracellular signal, only one transduction process has clearly been...

journal_title：Journal of cardiovascular pharmacology

authors： Jakobs KH

更新日期：1985-01-01 00:00:00

abstract：:The acute effects of doxorubicin on coronary perfusion and left ventricular pressures and intracellular phosphate metabolite levels, the latter obtained by 31P nuclear magnetic resonance, were measured simultaneously in isolated, isovolumic rat hearts (Langendorf preparation) perfused at constant flow. Nineteen experi...

journal_title：Journal of cardiovascular pharmacology

authors： Pelikan PC,Weisfeldt ML,Jacobus WE,Miceli MV,Bulkley BH,Gerstenblith G

更新日期：1986-09-01 00:00:00

abstract：:Coronary artery disease is the most important cause of morbidity and mortality in Western countries. Its pathogenesis is unknown but involves an enhanced vasoconstriction and increased interaction of platelets and monocytes with the vessel wall, as well as proliferation, migration, and extracellular matrix formation o...

journal_title：Journal of cardiovascular pharmacology

authors： Lüscher TF,Noll G

更新日期：1994-01-01 00:00:00