Reduction of myocardial ischemic reperfusion injury by sialylated glycosphingolipids, gangliosides.

abstract：:Using selective endothelin (ET) receptor antagonists, we investigated which ET receptor subtypes mediate the changes in blood pressure and hematocrit produced by intraarterial injection of ET-1 in the anesthetized rabbit. In addition, the receptor through which ET-1 stimulates the release of prostacyclin (PGI2) and, h...

journal_title：Journal of cardiovascular pharmacology

authors： McMurdo L,Lidbury PS,Corder R,Thiemermann C,Vane JR

更新日期：1993-01-01 00:00:00

abstract：:Ambulatory blood pressure monitoring (ABPM) is increasingly used in the clinical evaluation of hypertension. However, a number of limitations restrict its routine use. One of the limitations is a lack of definite conclusions about ambulatory blood pressure normality, because of the shortcomings of previous studies on ...

journal_title：Journal of cardiovascular pharmacology

authors： Sega G,Bravi C,Cesana G,Valagussa F,Mancia G,Zanchetti A

更新日期：1994-01-01 00:00:00

abstract：:This study examined the effect of Vitis vinifera grape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg·kg·d ACH09 orally); HF (24% fat); HF+ AC...

journal_title：Journal of cardiovascular pharmacology

authors： Emiliano AF,de Cavalho LC,da Silva Cristino Cordeiro V,da Costa CA,de Oliveira PB,Queiroz EF,Col Moreira DD,Boaventura GT,de Moura RS,Resende AC

更新日期：2011-09-01 00:00:00

abstract：:Inhibition of angiotensin-converting enzyme (ACEI) after myocardial infarction reduces remodeling of the surviving myocardium. The cellular signaling mechanisms contributing to remodeling are not fully elucidated. Goal of the current study was to test whether protein kinase C (PKC) is regulated in the surviving myocar...

journal_title：Journal of cardiovascular pharmacology

authors： Simonis G,Braun MU,Kirrstetter M,Schön SP,Strasser RH

更新日期：2003-05-01 00:00:00

abstract：:We investigated the effects of nifedipine on cyclic GMP turnover and the pertinent enzyme activities in cultured coronary smooth muscle cells (SMC). Nifedipine at high concentrations slightly decreased basal soluble guanylate cyclase activity and inhibited the action of sodium nitroprusside (SNP) but had no effect on ...

journal_title：Journal of cardiovascular pharmacology

authors： Kishi Y,Watanabe T,Makita T,Sakita S,Watanabe R,Ashikaga T,Numano F

更新日期：1995-10-01 00:00:00

abstract：:The effects of divalent cations on human platelet vasopressin receptor binding characteristics and effects of receptor occupancy on endogenous protein phosphorylation were investigated. Binding of vasopressin to its receptor is modulated by both the nature and the concentration of ions. Whatever the cation present, gu...

journal_title：Journal of cardiovascular pharmacology

authors： Thibonnier M,Hinko A,Pearlmutter AF

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:Some patients with atrial fibrillation (AF) received underdoses of non-vitamin K antagonist oral anticoagulants (NOACs) in the real world. Underdosing is defined as administration of a dose lower than the manufacturer recommended dose. OBJECTIVES:To identify the efficacy and safety of underdosing NOACs as p...

journal_title：Journal of cardiovascular pharmacology

authors： Yamaji H,Murakami T,Hina K,Higashiya S,Kawamura H,Murakami M,Kamikawa S,Komatsubara I,Kusachi S

更新日期：2017-02-01 00:00:00

abstract：:The amplifier properties associated with the structural changes in the heart and resistance vessels in chronic hypertension together play a major role in maintaining the elevated blood pressure (BP) in chronic hypertension, which is greater than that of the initiating cause. In patients with primary hypertension, long...

journal_title：Journal of cardiovascular pharmacology

authors： Korner PI,Bobik A,Jennings GL,Angus JA,Anderson WP

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study was to compare the effects of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the angiotensin II antagonist losartan on insulin sensitivity and plasma fibrinogen in overweight hypertensive patients. Twenty-eight overweight mild to moderate [diastolic blood pressure (DBP) >90 and...

journal_title：Journal of cardiovascular pharmacology

authors： Fogari R,Zoppi A,Lazzari P,Preti P,Mugellini A,Corradi L,Lusardi P

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:A substantial proportion of patients with heart failure have a normal ejection fraction and diastolic dysfunction. However, there are few data available to guide the therapy of these patients. The effects of statins on cardiac remodeling are well documented in animal models and it is reported that statin the...

journal_title：Journal of cardiovascular pharmacology

authors： Xu Z,Okamoto H,Akino M,Onozuka H,Matsui Y,Tsutsui H

更新日期：2008-01-01 00:00:00

abstract：:It is controversial whether myocardial hypertrophy in essential hypertension represents an adaptive physiologic or pathological response to increased pressure load imposed on the heart. Cardiac structural adaptations in endurance athletes fulfill the criteria of physiologic hypertrophy: maintained cardiac performance ...

journal_title：Journal of cardiovascular pharmacology

authors： Schmieder RE,Messerli FH

更新日期：1990-01-01 00:00:00

abstract：:The distribution of 3H-digoxin has been measured in a large number of tissues from the central, autonomic, and peripheral nervous system after the induction of ventricular tachycardia by infusing digoxin into anesthetized dogs. In most parts of the nervous system the tissue digoxin concentration was close to that in t...

journal_title：Journal of cardiovascular pharmacology

authors： Frazer G,Binnion P

更新日期：1981-11-01 00:00:00

abstract：:Effects of FK409 were investigated in perfused guinea-pig Langendorff hearts subjected to ischemia and reperfusion. Nitric oxide electrode, fluorometry, and 31P nuclear magnetic resonance imaging were used to monitor changes in cellular high-phosphorous energy and nitric oxide and Ca2+ content in the heart together wi...

journal_title：Journal of cardiovascular pharmacology

authors： Cao Y,Hotta Y,Shioi K,Nagata Y,Kawai N,Ishikawa N

更新日期：2001-10-01 00:00:00

abstract：:This article reviews the relation of cardiac cellular Na+ load and increased force of contraction. Digitalis glycosides and naturally occurring Na+ channel activators are considered. DPI201-106 was described as the first synthetic organic molecule with cardioselective Na+ channel-activating properties and investigated...

journal_title：Journal of cardiovascular pharmacology

authors： Scholtysik G

更新日期：1989-01-01 00:00:00

abstract：:In the present study we characterized the effects of and receptors for endothelins (ETs) in the guinea pig mesenteric arterial and venous vasculatures. Endothelin-1 (ET-1) (10-500 pmol) induced a dose-dependent increase of perfusion pressure of the arterial and venous beds. ET-2 (10-500 pmol) also induced a dose-depen...

journal_title：Journal of cardiovascular pharmacology

authors： Berthiaume N,Claing A,Yano M,D'Orléans-Juste P

更新日期：1995-01-01 00:00:00

abstract：:Platelet GPIIb/IIIa antagonists are not only used to prevent platelet aggregation, but also in combination with thrombolytic agents for the treatment of coronary thrombi. Recent data indicate a potential of abciximab alone to dissolve thrombi in vivo. We investigated the potential of abciximab, eptifibatide, and tirof...

journal_title：Journal of cardiovascular pharmacology

authors： Moser M,Bertram U,Peter K,Bode C,Ruef J

更新日期：2003-04-01 00:00:00

abstract：:A double-blind randomised, parallel, placebo-controlled study was performed in patients with congestive heart failure, at 13 centres in 10 countries, to assess the efficacy and safety of lisinopril, a new angiotensin-converting enzyme inhibitor. After a 2-week run-in period, 130 patients receiving digoxin and/or diure...

journal_title：Journal of cardiovascular pharmacology

authors： Chalmers JP,West MJ,Cyran J,De La Torre D,Englert M,Kramar M,Lewis GR,Maranhao MF,Myburgh DP,Schuster P

更新日期：1987-01-01 00:00:00

abstract：:The purpose of this study was to investigate the renal effects of aranidipine, a novel calcium channel blocker of the dihydropyridine type, and its active metabolite in anesthetized dogs and conscious spontaneously hypertensive rats (SHRs). When infused into the renal artery in anesthetized dogs, aranidipine (0.03 mic...

journal_title：Journal of cardiovascular pharmacology

authors： Ichihara K,Okumura K,Kamei H,Nagasaka M,Kanda A,Kanno T,Miyoshi K,Miyake H

更新日期：1998-02-01 00:00:00

abstract：:The renin-angiotensin system (RAS) plays an important role in blood pressure control and in water and salt homeostasis. It is involved in the pathophysiology of hypertension and structural alterations of the vasculature, kidney, and heart, including neointima formation, nephrosclerosis, postinfarction remodeling, and ...

journal_title：Journal of cardiovascular pharmacology

authors： Stroth U,Unger T

更新日期：1999-01-01 00:00:00

abstract：:The relationship between arterial pressure and the rate of Na+ excretion is regulated by a number of mechanisms- some well known, some newly discovered, and probably some yet to be discovered. These mechanisms affect either the amount of Na+ filtered at the glomerulus or its rate of reabsorption from the proximal or d...

journal_title：Journal of cardiovascular pharmacology

authors： Anderson WP,Evans RG,Malpas SC

更新日期：1995-01-01 00:00:00

abstract：:Milrinone, a newly developed analogue of amrinone, possesses potent positive inotropic effects. Electrophysiologic actions of the drug have thus far been reported in only one study conducted on canine Purkinje fibers. The present study used microelectrode techniques to evaluate the electrophysiologic effects of milrin...

journal_title：Journal of cardiovascular pharmacology

authors： Davidenko J,Antzelevitch C

更新日期：1985-03-01 00:00:00

abstract：:Qian Yang He Ji (QYHJ) is a traditional Chinese medicine composed of Digitalis purpurea, Uncaria gambir, Fructus tribuli terrestris, and Ligustrum lucidum. Here, we explored whether combining an antihypertensive angiotensin II receptor blocker (ARB) therapy with QYHJ can improve the arterial functionality of hypertens...

journal_title：Journal of cardiovascular pharmacology

authors： Xu Y,Yan H,Yao MJ,Ma J,Jia JM,Ruan FX,Yao ZC,Huang HM,Zheng J,Chen T,Lv H,Endler AM

更新日期：2013-05-01 00:00:00

abstract：:We assessed the contribution of angiotensin-(1-7) [Ang-(1-7)] to captopril-induced cardiovascular protection in spontaneously hypertensive rats (SHRs) chronically treated with the nitric oxide synthesis inhibitor NG-nitro-L-arginine methyl ester (SHR-l). NG-nitro-L-arginine methyl ester (80 mg/L) administration for 3 ...

journal_title：Journal of cardiovascular pharmacology

authors： Benter IF,Yousif MH,Al-Saleh FM,Raghupathy R,Chappell MC,Diz DI

更新日期：2011-05-01 00:00:00

abstract：:The positive inotropic effect of DPI 201-106 has been studied in isolated, electrically driven papillary muscles of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WK). The positive inotropic effect of isoprenaline (Iso) and Ca2+ was studied for comparison. The maximal positive inotropic effect of Iso was...

journal_title：Journal of cardiovascular pharmacology

authors： Böhm M,Diet F,Erdmann E

更新日期：1988-04-01 00:00:00

abstract：:Data from 49 men and 48 women included in the Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study in Perth, Western Australia, were analyzed. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were positively correlated (p less than 0.01) with urine sodium, creatine, taurine, histidine, and...

journal_title：Journal of cardiovascular pharmacology

authors： Burke V,Jamrozik K,Beilin LJ

更新日期：1990-01-01 00:00:00

abstract：:Vasoconstrictor responses to intraluminal and extraluminal 5-hydroxytryptamine (5-HT) were studied in isolated mesenteric resistance arteries of Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHRs). Third-order branches of mesenteric arteries were dissected free and mounted on glass cannulae in organ cha...

journal_title：Journal of cardiovascular pharmacology

authors： Dohi Y,Lüscher TF

更新日期：1991-08-01 00:00:00

abstract：:The comparative contributions of arachidonic acid (AA) metabolites and 5-hydroxytryptamine (5-HT) to the delay of reperfusion and rate of reocclusion after coronary thrombolysis with streptokinase were assessed in dogs using (a) single TXA2 synthase inhibition; (b) single 5-HT2-receptor blockade; (c) dual TXA2 synthas...

journal_title：Journal of cardiovascular pharmacology

authors： Vandeplassche G,Hermans C,Van Dael L,Wouters L,De Clerck F

更新日期：1993-01-01 00:00:00

abstract：:Recent studies have suggested that central nervous mechanisms are involved in the enhanced sympathetic drive observed in heart failure (HF). Nitric oxide (NO) in the brainstem has been shown to reduce sympathetic nerve activity. The aim of this study was to determine whether the expression of neuronal nitric oxide syn...

journal_title：Journal of cardiovascular pharmacology

authors： Hirooka Y,Shigematsu H,Kishi T,Kimura Y,Ueta Y,Takeshita A

更新日期：2003-12-01 00:00:00

abstract：:The ongoing COVID-19 pandemic has produced serious turmoil world-wide. Lung injury causing acute respiratory distress syndrome seems to be a most dreaded complication occurring in ∼30%. Older patients with cardiovascular comorbidities and acute respiratory distress syndrome have an increased mortality. Although the pr...

journal_title：Journal of cardiovascular pharmacology

authors： Manolis AS,Manolis TA,Manolis AA,Melita H

更新日期：2020-10-01 00:00:00

abstract：:In this study we compared the antithrombotic and anticoagulant properties of sodium and calcium derivatives of pentosan polysulfate (Na-PPS, Ca-PPS), unfractionated heparin (UFH), and low-molecular-weight heparin (Fraxiparin). The antithrombotic effects of these agents have been investigated in an experimental thrombo...

journal_title：Journal of cardiovascular pharmacology

authors： Giedrojć J,Klimiuk M,Radziwon P,Kłoczko J,Bielawiec M,Breddin HK

更新日期：1999-09-01 00:00:00