Reversal of left ventricular hypertrophy: a desirable therapeutic goal?

abstract：:LC3B is a marker of autophagic activity, and growing evidence supports its importance in myocardial hypertrophy. Thus, regulating LC3B expression may provide an important avenue to inhibit autophagy and protect against or inhibit pathological myocardial hypertrophy. To address this question, we investigated the effect...

journal_title：Journal of cardiovascular pharmacology

authors： Huang J,Pan W,Ou D,Dai W,Lin Y,Chen Y,Chen X

更新日期：2015-12-01 00:00:00

abstract：:We have previously demonstrated that endothelin-1 (ET-1) is essential to the development of neural crest-derived craniofacial and cardiovascular structures. In this study we evaluated the intrauterine growth and development of the thyroid and thymus glands in Edn1-/- homozygous mice. Edn1-/- homozygous mice were small...

journal_title：Journal of cardiovascular pharmacology

authors： Kurihara Y,Kurihara H,Maemura K,Kuwaki T,Kumada M,Yazaki Y

更新日期：1995-01-01 00:00:00

abstract：:Three agents with K(+)-channel-opening activity--nicorandil, bimakalim (EMD 52692), and EMD 56431--were tested for vasorelaxation abilities in human coronary artery and human arteria mammaria. The potency orders were bimakalim = EMD 56431 > nicorandil for relaxation in human coronary artery and bimakalim = EMD 56431 >...

journal_title：Journal of cardiovascular pharmacology

authors： Bossaller C,Auch-Schwelk W,Graf K,Gräfe M,Catadelgirmen G,Ennker J,Fleck E

更新日期：1992-01-01 00:00:00

abstract：:We have previously reported that production of endothelin (ET)-1 is markedly increased in failing hearts of rats with chronic heart failure (CHF). It was also reported that the production of angiotensin II (Ang II) is increased in the failing heart. In this study we investigated both converting enzymes of the ET-1 sys...

journal_title：Journal of cardiovascular pharmacology

authors： Kobayashi T,Miyauchi T,Sakai S,Yamaguchi I,Goto K,Sugishita Y

更新日期：1998-01-01 00:00:00

abstract：:Heart rate turbulence (HRT) denotes the baroreflex-mediated short-term oscillation of cardiac cycle lengths after spontaneous ventricular premature complexes. The physiological pattern of HRT consists of brief heart rate acceleration followed by more gradual heart rate deceleration before the heart rate returns to bas...

journal_title：Journal of cardiovascular pharmacology

authors： Bauer A,Zürn CS,Schmidt G

更新日期：2010-06-01 00:00:00

abstract：:The effect of lidocaine on the conduction of extrasystoles was studied in 8 open-chest dogs after atrioventricular nodal block. Simultaneous recording of endocardial and epicardial activation provided separate measures of endocardial (Purkinje) conduction as well as myocardial (muscle) conduction. Lidocaine (1.25--10....

journal_title：Journal of cardiovascular pharmacology

authors： Carson DL,Dresel PE

更新日期：1981-09-01 00:00:00

abstract：:The electromechanical effects of UK-68,798 (UK), a novel class III antiarrhythmic drug, were studied in guinea pig and rat papillary muscles (PMs) and atria in vitro using conventional microelectrode technique. UK (10(-8)-10(-6) M) prolonged the action potential duration (APD) by 21-58% and effective refractory period...

journal_title：Journal of cardiovascular pharmacology

authors： Tande PM,Bjørnstad H,Yang T,Refsum H

更新日期：1990-09-01 00:00:00

abstract：AIMS:To determine whether short-term treatment with trimetazidine (TMZ), an antiischemic agent that directly inhibits fatty acid oxidation and results in stimulation of glucose oxidation, may improve myocardial perfusion and left ventricular systolic function in diabetic patients with ischemic cardiomyopathy. METHODS ...

journal_title：Journal of cardiovascular pharmacology

authors： Belardinelli R,Cianci G,Gigli M,Mazzanti M,Lacalaprice F

更新日期：2008-06-01 00:00:00

abstract：:We studied the kinetics of amiodarone in three healthy volunteers after single oral (400 mg) and intravenous (150 mg) doses and in six patients with supraventricular tachycardia. Three patients were studied after the first oral dose (400 mg) and during subsequent therapy (200 mg/day); the other three after 5 mg/kg of ...

journal_title：Journal of cardiovascular pharmacology

authors： Riva E,Gerna M,Latini R,Giani P,Volpi A,Maggioni A

更新日期：1982-03-01 00:00:00

abstract：:The objective this investigation was to determine the relative importance of type I, III, and IV phosphodiesterases in the regulation of cyclic adenosine monophosphate (cAMP) in the renal circulation. In the first experimental series, four groups of isolated rat kidneys perfused with Tyrode's solution were stimulated ...

journal_title：Journal of cardiovascular pharmacology

authors： Jackson EK,Mi Z,Carcillo JA,Gillespie DG,Dubey RK

更新日期：1997-12-01 00:00:00

abstract：:Torsades de pointes ventricular tachycardia (VT) has been reported in patients taking the nonsedating antihistamine, terfenadine. We performed electrophysiologic studies of 14 isolated guinea pig hearts using the Langendorff technique to assess whether terfenadine exerted actions that could be responsible for inducing...

journal_title：Journal of cardiovascular pharmacology

authors： Pinney SP,Koller BS,Franz MR,Woosley RL

更新日期：1995-01-01 00:00:00

abstract：:Aspirin for secondary cardiovascular disease prevention is well established, but treatment discontinuation, often because of gastrointestinal mucosal injury or symptoms, can lead to increased risk for cardiovascular events. Proton pump inhibitor therapy is recommended for aspirin-treated patients at gastrointestinal r...

journal_title：Journal of cardiovascular pharmacology

authors： Goldstein JL,Scheiman JM,Fort JG,Whellan DJ

更新日期：2016-08-01 00:00:00

abstract：:We have evaluated the effects of indoramin, an alpha-adrenoreceptor blocking drug, used as sole therapy in a group of 27 patients with essential hypertension. Blood pressure and heart rate were measured continuously over prolonged ambulatory periods using an established invasive technique before and after six weeks of...

journal_title：Journal of cardiovascular pharmacology

authors： Gould BA,Mann S,Davies AB,Altman DG,Raftery EB

更新日期：1983-05-01 00:00:00

abstract：:This study assessed the possible local nociceptive and hyperalgesic properties of endothelin-1 (ET-1) in the rat knee-joint incapacitation test, in which animals are placed for 1 min/h on a revolving (3 rpm) metal cylinder and nociception is measured as the time the hindpaw of the injected limb was off the cylinder (i...

journal_title：Journal of cardiovascular pharmacology

authors： De-Melo JD,Tonussi CR,D'Orléans-Juste P,Rae GA

更新日期：1998-01-01 00:00:00

abstract：:Angiopeptin (AP: BIM23014C), a cyclic analogue of the peptide hormone somatostatin, inhibits intimal hyperplasia after balloon angioplasty. This inhibition has been attributed to a direct inhibitory effect on smooth muscle cell (SMC) proliferation. However, the SMC that proliferate in the intima and contribute to inti...

journal_title：Journal of cardiovascular pharmacology

authors： Mooradian DL,Fernandes B,Diglio CA,Lester BR

更新日期：1995-04-01 00:00:00

abstract：:Previous animal experiments suggest that the increase in the amplitude from the R-wave to the S-wave (RSh) may be more sensitive than other ECG measures to sodium channel blocking drug actions. We measured RSh of three orthogonal leads at baseline and during intravenous pharmacologic stimulation with adenosine, ajmali...

journal_title：Journal of cardiovascular pharmacology

authors： Wolzt M,Schmetterer L,Gouya G,Zanaschka G,Eichler HG

更新日期：1995-10-01 00:00:00

abstract：:The cardiovascular profile of a novel calcium antagonist, MPC-1304 and its active metabolites were investigated in experimental animals in vitro and in vivo, and were compared with those of other calcium antagonists or nitroglycerin (NTG). The ratio of negative chronotropic/negative inotropic effect of MPC-1304 was 23...

journal_title：Journal of cardiovascular pharmacology

authors： Kanda A,Haruno A,Miyoshi K,Tanahashi Y,Miyake H,Ichihara K,Okumura K,Nagasaka M

更新日期：1993-07-01 00:00:00

abstract：:Statins are known to have cholesterol-independent pleiotropic effects, such as upregulation of the enzyme ecto-5'-nucleotidase. These effects may contribute to the protective effect of statins against ischemia and reperfusion (IR). Interestingly, pleiotropic effects have been shown to differ between hydrophilic and li...

journal_title：Journal of cardiovascular pharmacology

authors： Wouters CW,Wever KE,Bronckers I,Hopman MT,Smits P,Thijssen DH,Rongen GA

更新日期：2012-01-01 00:00:00

abstract：:Low doses of ethanol can produce negative functional effects in ventricular myocytes. This may be related to the nitric oxide-cyclic GMP signal transduction system. We tested the hypothesis that ethanol stimulated endothelial nitric oxide synthase and this caused the negative functional effects in cardiac myocytes. Th...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang S,Grover GJ,Stokes H,Scholz PM,Weiss HR

更新日期：2005-09-01 00:00:00

abstract：:Anesthesia inhibits arterial baroreflex functions such as baroreflex sensitivity (BRS). The main objective of the present study was to determine the time course of BRS recovery from anesthesia and to determine whether BRS recovery is synchronous with the recovery of consciousness and blood pressure (BP). Experiments w...

journal_title：Journal of cardiovascular pharmacology

authors： Yi-Ming W,Shu H,Miao CY,Shen FM,Jiang YY,Su DF

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid t...

journal_title：Journal of cardiovascular pharmacology

authors： Liu C,Liu K,COPE-ADHF Study Group.

更新日期：2014-04-01 00:00:00

abstract：:The concentrations of cyclic nucleotides were measured by radioimmunoassay in the plasma of dogs with aconitine-induced atrial fibrillation and of patients with paroxysmal atrial fibrillation. The concentration of cyclic GMP in the plasma of dogs was significantly elevated 30 and 60 min after the onset of atrial fibri...

journal_title：Journal of cardiovascular pharmacology

authors： Mizuno K,Ogawa K

更新日期：1981-11-01 00:00:00

abstract：:A contribution by active vasodilation to the hypotensive effect of medroxalol was investigated in anesthetized dogs and reserpinized pithed rats. In anesthetized dogs, intravenous doses of medroxalol, which decreased blood pressure and heart rate, also produced a dose-related vasodilation in the isolated perfused grac...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Hsieh CP,Spedding M

更新日期：1983-01-01 00:00:00

abstract：:Chronic stimulation of beta-adrenoceptors with isoproterenol induces alteration of vascular reactivity and increases local pro-inflammatory cytokines. We investigated whether fenofibrate and pioglitazone, PPAR-alpha and -gamma agonists, respectively, improve the changes in vascular reactivity induced by isoproterenol....

journal_title：Journal of cardiovascular pharmacology

authors： Fukuda LE,Davel AP,Verissimo-Filho S,Lopes LR,Cachofeiro V,Lahera V,Rossoni LV

更新日期：2008-11-01 00:00:00

abstract：:In 22 patients with stable myocardial ischemia, we prospectively studied the short- and long-term effects of isosorbide-5-mononitrate (5-ISMN) on dipyridamole-induced myocardial ischemia, the ability of dipyridamole-stress echocardiography to evaluate nitrate tolerance, and the role of activation of the neurohumoral s...

journal_title：Journal of cardiovascular pharmacology

authors： Longobardi G,Ferrara N,Leosco D,Abete P,Iannuzzi GL,Acanfora D,Furgi G,Nicolino A,Pinna G,Rengo F

更新日期：2000-07-01 00:00:00

abstract：:The vascular effects of cardamonin and alpinetin from Alpinia henryi K. Schum. were examined in the rat isolated mesenteric arteries. 1H and 13C nuclear magnetic resonance spectra showed that cardamonin is present in trans-form, and single-crystal radiographic structure revealed that alpinetin is present in S configur...

journal_title：Journal of cardiovascular pharmacology

authors： Wang ZT,Lau CW,Chan FL,Yao X,Chen ZY,He ZD,Huang Y

更新日期：2001-05-01 00:00:00

abstract：:Thirty-two hypertensive subjects with diastolic blood pressure greater than 95 mm Hg were treated with ramipril over a period of 3 months. To determine the effective decrease of blood pressure and for reliable and reproducible demonstration of regression of myocardial hypertrophy during ramipril treatment, we performe...

journal_title：Journal of cardiovascular pharmacology

authors： Eichstaedt H,Danne O,Langer M,Cordes M,Schubert C,Felix R,Schmutzler H

更新日期：1989-01-01 00:00:00

abstract：:Recent studies have suggested that central nervous mechanisms are involved in the enhanced sympathetic drive observed in heart failure (HF). Nitric oxide (NO) in the brainstem has been shown to reduce sympathetic nerve activity. The aim of this study was to determine whether the expression of neuronal nitric oxide syn...

journal_title：Journal of cardiovascular pharmacology

authors： Hirooka Y,Shigematsu H,Kishi T,Kimura Y,Ueta Y,Takeshita A

更新日期：2003-12-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a critical role in maintenance of the endothelial integrity and vascular homeostasis, as well as in neovascularization. Dysfunctional EPCs are believed to contribute to the endothelial dysfunction and are closely related to the development of various cardiovascular diseases, su...

journal_title：Journal of cardiovascular pharmacology

authors： Peng J,Liu B,Ma QL,Luo XJ

更新日期：2015-01-01 00:00:00

abstract：:Large controlled trials have shown that intake of fish oil (marine n-3 fatty acids, eicosapentaenoic acid, and docosahexaenoic acid), whether from dietary sources or fish oil supplements, may exhibit beneficial effects on total and cardiovascular disease mortality. Stabilization of cell membranes and suppression of ca...

journal_title：Journal of cardiovascular pharmacology

authors： de Leiris J,de Lorgeril M,Boucher F

更新日期：2009-11-01 00:00:00