New diagnostic options in hypertrophic cardiomyopathy.

Abstract:

:The pathophysiologic features and clinical manifestations of HCM have been elucidated by the introduction of several new diagnostic options. Knowledge of the molecular defects of HCM has advanced rapidly, and genetic screening studies have reemphasized the value of the standard electrocardiogram as an initial screening tool. Analysis of heart rate variability, late potentials, and QT dispersion were not found to be reliable prognostic markers in HCM. However, measurement of dispersion of conduction is probably a sensitive technique in identifying a high risk for sudden cardiac death. Significant developments include transthoracic and transesophageal echocardiography and their role in studying the mitral valve, early detection of left ventricular chamber dilatation, analysis of coronary flow, and intraoperative echocardiography. Finally, advances in the application of magnetic resonance imaging and positron-emission tomography are underway.

journal_name

Am Heart J

journal_title

American heart journal

authors

Posma JL,van der Wall EE,Blanksma PK,van der Wall E,Lie KI

doi

10.1016/s0002-8703(96)90018-6

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1031-41

issue

5

eissn

0002-8703

issn

1097-6744

pii

S0002-8703(96)90018-6

journal_volume

132

pub_type

杂志文章,评审
  • Angiotensin II receptor antagonists: a new approach to blockade of the renin-angiotensin system.

    abstract::A-II exerts its activity on various target tissues by binding to its receptors. The discovery of local RASs and A-II receptors within various tissues has generated interest in the clinical usefulness of RAS inhibition by directly blocking the action of A-II at the receptor level. Different A-II receptor subtypes have ...

    journal_title:American heart journal

    pub_type: 杂志文章,评审

    doi:10.1016/0002-8703(94)90061-2

    authors: Kang PM,Landau AJ,Eberhardt RT,Frishman WH

    更新日期:1994-05-01 00:00:00

  • Comparison of clinical features of non-Q wave and Q wave myocardial infarction.

    abstract::The clinical spectrum and outcome of 119 patients with acute non-Q wave myocardial infarction (NQMI) were studied, in comparison with those of 354 patients with acute Q wave myocardial infarction (QMI). The patients with NQMI had a significantly higher incidence of preinfarction angina (73% vs 63%), previous myocardia...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90056-6

    authors: Ogawa H,Hiramori K,Haze K,Saito M,Sumiyoshi T,Fukami K,Goto Y,Ikeda M

    更新日期:1986-03-01 00:00:00

  • Evaluation of a nine-lead Holter monitor for identifying and localizing ischemia and coronary artery disease detected by quantitative thallium-201 tomography.

    abstract::We devised a nine-lead Holter monitor system with a lead-switching technique to record electrocardiograms from multiple sites in the anterior and the posterior or lateral chest. Leads CM1 to CM6, high lateral (HL), low lateral (LL), and low posterior chest (LB) were used. The sensitivity, specificity, and predictive a...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(94)90595-9

    authors: Tanabe T,Yoshioka K,Ide M,Kanemoto N,Suzuki Y

    更新日期:1994-11-01 00:00:00

  • Cost-effectiveness of beta-blocker therapy with metoprolol or with carvedilol for treatment of heart failure in Canada.

    abstract:OBJECTIVE:The purpose of this study was to estimate the cost-effectiveness of beta-blocker therapy with either metoprolol or carvedilol in addition to conventional therapy for patients with heart failure (HF) in Canada. DESIGN:A Markov simulation was used to estimate the costs and life expectancy for treating patients...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1067/mhj.2001.116479

    authors: Levy AR,Briggs AH,Demers C,O'Brien BJ

    更新日期:2001-09-01 00:00:00

  • Analysis of pulmonary venous flow velocity patterns in hypertensive hearts: its complementary value in the interpretation of mitral flow velocity patterns.

    abstract::Although the Doppler mitral flow velocity pattern changes in accordance with the degree of left ventricular diastolic dysfunction, it is "normalized" in the presence of heart failure. In this study the pulmonary venous flow velocity pattern was characterized in 43 hypertensive patients with and without heart failure t...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(92)90982-2

    authors: Masuyama T,Lee JM,Yamamoto K,Tanouchi J,Hori M,Kamada T

    更新日期:1992-10-01 00:00:00

  • Effects of lidocaine on impulse formation and conduction defects in man.

    abstract::The acute electrophysiologic effects of a bolus injection of 100 mg. of lidocaine were investigated in 39 patients with impulse formation and conduction defects by means of His-bundle recording and were correlated with plasma lidocaine levels. The effects of therapeutic plasma levels on conduction intervals and refrac...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(75)90183-0

    authors: Roos JC,Dunning AJ

    更新日期:1975-06-01 00:00:00

  • Myocardial hibernation in the infarcted region cannot be assessed from the presence of stress-induced ischemia: usefulness of delayed image of exercise thallium-201 scintigraphy.

    abstract::To examine the relationship between the improvement of wall motion in infarcted regions after percutaneous transluminal coronary angioplasty (PTCA) and thallium-201 uptake in the delayed image of exercise thallium-201 scintigraphy before PTCA, 14 patients with anterior old myocardial infarction were studied. Exercise ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(93)90053-c

    authors: Yamamoto K,Asada S,Masuyama T,Nanto S,Matsumura Y,Naito J,Hirayama A,Mishima M,Naka M,Sasaki J

    更新日期:1993-01-01 00:00:00

  • Tezosentan in patients with acute heart failure: design of the Value of Endothelin Receptor Inhibition with Tezosentan in Acute heart failure Study (VERITAS).

    abstract:BACKGROUND:Endothelin 1 is a potent endogenous vasoconstrictor neurohormone, and endothelin 1 plasma concentrations predict adverse outcomes in patients with acute heart failure (AHF). Tezosentan, an intravenous endothelin receptor antagonist, improved hemodynamics in patients with AHF; however, its effects on morbidit...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2005.04.035

    authors: Teerlink JR,McMurray JJ,Bourge RC,Cleland JG,Cotter G,Jondeau G,Krum H,Metra M,O'Connor CM,Parker JD,Torre-Amione G,Van Veldhuisen DJ,Frey A,Rainisio M,Kobrin I,VERITAS Investigators.

    更新日期:2005-07-01 00:00:00

  • Enoxaparin versus tinzaparin in non-ST-segment elevation acute coronary syndromes: the EVET trial.

    abstract:BACKGROUND:Low-molecular weight heparins have different pharmacokinetic and pharmacodynamic characteristics and may vary in efficacy. We compared the efficacy of enoxaparin with that of tinzaparin in the management of non-ST-segment elevation acute coronary syndromes (NSTACS). METHODS:A total of 438 patients with NSTA...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/S0002-8703(03)00179-0

    authors: Michalis LK,Katsouras CS,Papamichael N,Adamides K,Naka KK,Goudevenos J,Sideris DA

    更新日期:2003-08-01 00:00:00

  • Evaluation of cardiac function of the fetus by inferior vena cava diameter pulse waveform.

    abstract:BACKGROUND:The diameter pulse waveforms (DPWs) are known to reflect the pressure waveforms at the target vessel. Our purpose was to clarify the usefulness of DPWs recorded noninvasively from the fetal inferior vena cava (IVC) for detecting cardiac function. METHODS:A paired ultrasonic phase-locked echo tracking system...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.06.015

    authors: Mori A,Uchida N,Ishiguro Y,Atsuko T,Kanako M,Mikio M

    更新日期:2007-10-01 00:00:00

  • A population-based analysis of the class effect of beta-blockers after myocardial infarction.

    abstract:BACKGROUND:Long-term treatment with beta-blockers reduces mortality after acute myocardial infarction (AMI). Whether beta-blockers exert a class effect is unknown. METHODS:We analyzed mortality after AMI in Canadian patients 65 years or older who were discharged from hospital with a diagnosis of AMI from April 1996 to...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2006.11.008

    authors: Rinfret S,Abrahamowicz M,Tu J,Humphries K,Eisenberg MJ,Richard H,Austin PC,Pilote L

    更新日期:2007-02-01 00:00:00

  • Morbidity and mortality rates in elderly patients undergoing percutaneous coronary transluminal angioplasty.

    abstract::Although successful dilatation of a target lesion by means of percutaneous transluminal coronary angioplasty (PTCA) can be attained as frequently in elderly as in younger patients, elderly patients have a higher risk of complications. Furthermore, cohorts of patients older than 75 years and undergoing PTCA include mor...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(94)90267-4

    authors: Lindsay J Jr,Reddy VM,Pinnow EE,Little T,Pichard AD

    更新日期:1994-10-01 00:00:00

  • Patterns of inflammation associated with peripheral arterial disease: the InCHIANTI study.

    abstract:OBJECTIVE:To determine whether peripheral arterial disease is associated with high circulating levels of pro-inflammatory cytokines, independent of confounders. METHODS:Participants were 955 men and women aged 60 years and older representative of the population in 2 Italian communities (107 with peripheral arterial di...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2004.09.032

    authors: McDermott MM,Guralnik JM,Corsi A,Albay M,Macchi C,Bandinelli S,Ferrucci L

    更新日期:2005-08-01 00:00:00

  • Heart rate recovery is more strongly associated with the metabolic syndrome, waist circumference, and insulin sensitivity in women than in men among the elderly in the general population.

    abstract:BACKGROUND:Low heart rate recovery (HRR) at exercise test and the metabolic syndrome (MetS) are both predictors of cardiovascular morbidity and mortality. We studied in 75-year-old women and men, representative of the general population, the relationship between (1) HRR and the MetS, (2) HRR and the individual componen...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.06.025

    authors: Nilsson G,Hedberg P,Jonason T,Lönnberg I,Ohrvik J

    更新日期:2007-09-01 00:00:00

  • PLN-encoded phospholamban mutation in a large cohort of hypertrophic cardiomyopathy cases: summary of the literature and implications for genetic testing.

    abstract:BACKGROUND:hypertrophic cardiomyopathy (HCM) is a major cause of sudden death in young athletes and one of the most common inherited cardiovascular diseases, affecting 1 in 500 individuals. Often viewed as a disease of the cardiac sarcomere, mutations in genes encoding myofilament proteins are associated with disease p...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2010.08.001

    authors: Landstrom AP,Adekola BA,Bos JM,Ommen SR,Ackerman MJ

    更新日期:2011-01-01 00:00:00

  • CD34(+) cell infusion after ST elevation myocardial infarction is associated with improved perfusion and is dose dependent.

    abstract:BACKGROUND:the objective of the study was to determine whether the effects of infarct-related artery (IRA) infusion of autologous bone marrow-derived CD34(+) cells after ST elevation myocardial infarction (STEMI) are dependent on the dose (quantity and mobility) of the cells infused. Beneficial effects of IRA infusion ...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2010.09.025

    authors: Quyyumi AA,Waller EK,Murrow J,Esteves F,Galt J,Oshinski J,Lerakis S,Sher S,Vaughan D,Perin E,Willerson J,Kereiakes D,Gersh BJ,Gregory D,Werner A,Moss T,Chan WS,Preti R,Pecora AL

    更新日期:2011-01-01 00:00:00

  • Elevated vascular endothelial growth factor levels are associated with aortopulmonary collateral vessels in patients before and after the Fontan procedure.

    abstract:BACKGROUND:Aortopulmonary collaterals (APCs) are frequently observed before and after the Fontan procedure. However, the mechanism of the development of APCs is unknown. We hypothesized that one or several antiangiogenic and/or angiogenic growth factors might play a role in the development of APCs. METHODS:Eighty-five...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/j.ahj.2007.03.009

    authors: Mori Y,Shoji M,Nakanishi T,Fujii T,Nakazawa M

    更新日期:2007-06-01 00:00:00

  • Mid-cavity obstruction in apical hypertrophy: Doppler evidence of diastolic intraventricular gradient with higher apical pressure.

    abstract::Three cases of apical left ventricular hypertrophy demonstrating a sequestered small left ventricular apical cavity with complete systolic and partial diastolic intraventricular obstruction are described. Doppler studies revealed that flow from the apical chamber is aborted during early systole with further emptying d...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(88)90730-2

    authors: Zoghbi WA,Haichin RN,Quinones MA

    更新日期:1988-12-01 00:00:00

  • Ventriculoatrial conduction in swine during cardiac pacing: animal model for retrograde conduction.

    abstract::Studies on cardiac conduction disorders and pacemaker tachycardias are usually conducted in patients because the phenomenon of ventriculoatrial (retrograde) conduction resulting from ectopic beats and pacing the ventricles has only been reported in humans. This study was conducted to characterize the ventriculoatrial ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(84)90621-5

    authors: Bowman TA,Hughes HC

    更新日期:1984-08-01 00:00:00

  • Ultrasound guide wire-directed stent deployment.

    abstract::A new mechanically rotated 20 MHz intravascular ultrasound guide wire (0.032 inch) with a transducer core was placed through the central lumen of a peripheral arterial balloon-expandable stent. Using an anesthetized canine model, 11 stents were then deployed into the iliac or femoral arteries. Eight stents were succes...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:

    authors: Tenaglia AN,Kisslo K,Kelly S,Hamm MA,Crowley R,Davidson CJ

    更新日期:1993-05-01 00:00:00

  • Knowledge to action: Rationale and design of the Patient-Centered Care Transitions in Heart Failure (PACT-HF) stepped wedge cluster randomized trial.

    abstract:INTRODUCTION:Heart Failure (HF) is a common cause of hospitalization in older adults. The transition from hospital to home is high-risk, and gaps in transitional care can increase the risk of re-hospitalization and death. Combining health care services supported by meta-analyses, we designed the PACT-HF transitional ca...

    journal_title:American heart journal

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ahj.2017.12.013

    authors: Van Spall HGC,Lee SF,Xie F,Ko DT,Thabane L,Ibrahim Q,Mitoff PR,Heffernan M,Maingi M,Tjandrawidjaja MC,Zia MI,Panju M,Perez R,Simek KD,Porepa L,Graham ID,Haynes RB,Haughton D,Connolly SJ

    更新日期:2018-05-01 00:00:00

  • Drug-eluting stents for the treatment of bifurcation lesions: a randomized comparison between paclitaxel and sirolimus stents.

    abstract:BACKGROUND:Drug-eluting stents have been shown to reduce restenosis in many types of lesions. The purpose of this article is to assess the efficacy of sirolimus- and paclitaxel-eluting stents in patients with bifurcation lesions. METHODS:Between June 2003 and October 2004, 205 patients were enrolled in a prospective r...

    journal_title:American heart journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ahj.2006.10.017

    authors: Pan M,Suárez de Lezo J,Medina A,Romero M,Delgado A,Segura J,Ojeda S,Mazuelos F,Hernandez E,Melian F,Pavlovic D,Esteban F,Herrador J

    更新日期:2007-01-01 00:00:00

  • Sensitivity and specificity of echocardiographic identification of patients eligible for safe early discharge after acute myocardial infarction.

    abstract::In a prospective clinical trial of 195 consecutive unselected patients with acute myocardial infarction (AMI), systematic blinded clinical and echocardiographic examinations were performed by two observers on day 5. The purpose was to define low-risk patients with regard to in-hospital and 2-month mortality and predic...

    journal_title:American heart journal

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-8703(92)90963-v

    authors: Launbjerg J,Berning J,Fruergaard P,Appleyard M

    更新日期:1992-10-01 00:00:00

  • Incidence, underlying conditions, and outcomes of patients receiving acute renal replacement therapies in tertiary cardiac intensive care units: An analysis from the Critical Care Cardiology Trials Network Registry.

    abstract:BACKGROUND:The prevalence of renal disease in cardiac intensive care units (CICUs) is increasing, but little is known about the utilization, concurrent therapies, and outcomes of patients requiring acute renal replacement therapy (RRT) in this specialized environment. METHODS:In the Critical Care Cardiology Trials Net...

    journal_title:American heart journal

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ahj.2020.01.005

    authors: van Diepen S,Tymchak W,Bohula EA,Park JG,Daniels LB,Phreaner N,Barnett CF,Kenigsberg BB,DeFilippis A,Singam NS,Barsness GW,Jentzer JC,Ternus B,Morrow DA,Katz JN,Critical Care Cardiology Trials Network Investigators.

    更新日期:2020-04-01 00:00:00

  • Radionuclide angiographic evaluation of left ventricular performance at rest and during exercise in patients with aortic regurgitation.

    abstract::Radionuclide angiographic evaluation of LV performance at rest and during exercise in patients with AR have shown that an abnormal EF response to exercise may be observed in asymptomatic patients with normal resting LV function. The EF response to exercise has been correlated with a number of clinical and exercise mea...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(86)90019-0

    authors: Iskandrian AS,Heo J

    更新日期:1986-06-01 00:00:00

  • Effects of physiologic load of pregnancy on left ventricular contractility and remodeling.

    abstract::Left ventricular (LV) adaptation to the hemodynamic load of pregnancy has been studied with load-sensitive ejection-phase indexes, but the results of these studies are conflicting. The aim of this study was to examine the effects of the hemodynamic load of pregnancy on the contractile state of the left ventricle by us...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(97)70247-3

    authors: Geva T,Mauer MB,Striker L,Kirshon B,Pivarnik JM

    更新日期:1997-01-01 00:00:00

  • Three-dimensional echocardiographic evaluation of left ventricular volume: comparison of Doppler myocardial imaging and standard gray-scale imaging with cineventriculography--an in vitro and in vivo study.

    abstract:BACKGROUND:Standard gray-scale imaging (GSI), three-dimensional (3D) echocardiography has been shown to be superior to two-dimensional echocardiography in measuring left ventricular volume. However, the often relatively poor quality of transthoracic gray-scale data can limit the potential application of this technique....

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(98)70061-4

    authors: Lange A,Palka P,Nowicki A,Olszewski R,Anderson T,Adamus J,Sutherland GR,Fox KA

    更新日期:1998-06-01 00:00:00

  • Atrial septal defect resulting from mitral balloon valvuloplasty: relation of defect morphology to transseptal balloon catheter delivery.

    abstract::Percutaneous balloon mitral valvuloplasty has been shown to be an effective means of reducing mitral valve gradient and increasing mitral valve area in patients with mitral stenosis. Most techniques currently employed for performing this procedure involve delivery of one or two balloon valvuloplasty catheters through ...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/s0002-8703(05)80279-0

    authors: Fields CD,Slovenkai GA,Isner JM

    更新日期:1990-03-01 00:00:00

  • Acute positive inotropic intervention: the phosphodiesterase inhibitors.

    abstract::Phosphodiesterase inhibitors that are selective for cAMP-specific cardiac and vascular PDE III comprise a new group of agents for the treatment of heart failure, which at present are limited to clinical shortterm intravenous use and research uses only. Although both intravenous amrinone and milrinone are FDA approved,...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(91)90078-v

    authors: DiBianco R

    更新日期:1991-06-01 00:00:00

  • Myocardial infarct size reduction by the synergistic effect of hyperbaric oxygen and recombinant tissue plasminogen activator.

    abstract::Fasting mongrel dogs underwent hyperbaric oxygen treatment (HBOT), recombinant tissue plasminogen activator (rt-PA) treatment, and simultaneous HBOT and rt-PA treatment following prior experimental left anterior descending coronary artery occlusion for 2 hours. Thrombosis in and around a copper coil was recorded angio...

    journal_title:American heart journal

    pub_type: 杂志文章

    doi:10.1016/0002-8703(90)90194-3

    authors: Thomas MP,Brown LA,Sponseller DR,Williamson SE,Diaz JA,Guyton DP

    更新日期:1990-10-01 00:00:00