Abstract:
:To study genotoxic effects of exposure to low levels of benzene, single-strand breaks (SSB) in DNA of leukocytes and urinary levels of the oxidative DNA adduct 8-hydroxydeoxyguanosine (8OHdG) were determined in 33 men occupationally exposed to benzene from gasoline and in 33 controls. The average exposure to benzene over a shift was determined by personal air sampling in the breathing zone. The 8-hr time-weighted average exposure to benzene was 0.13 ppm (mean value, range 0.003-0.6 ppm). Exposed workers had a significant increase of SSB (p = 0.04) over the shift compared with controls. Storage time of the samples seemed to affect the results. An analysis of samples with the same storage time showed a nonsignificant increase among the workers compared with controls. Urinary 8OHdG increased over the shift among the exposed workers but not among the controls. The highest values among the exposed workers were seen in late evening, with a slight decrease the next morning. Multiple linear analysis adjusting for smoking habits showed a significant association between the exposure level of benzene during the shift and the increase of 8OHdG in the urine over the shift among exposed workers (p = 0.02). These findings indicate a genotoxic effect in humans of benzene at relatively low exposure levels, that is, about 0.1 ppm (0.3 mg/m3).
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Nilsson RI,Nordlinder RG,Tagesson C,Walles S,Järvholm BGdoi
10.1002/(SICI)1097-0274(199609)30:3<317::AID-AJIM1subject
Has Abstractpub_date
1996-09-01 00:00:00pages
317-24issue
3eissn
0271-3586issn
1097-0274pii
10.1002/(SICI)1097-0274(199609)30:3<317::AID-AJIM1journal_volume
30pub_type
杂志文章abstract:BACKGROUND:In the construction industry, a relatively high hand eczema prevalence can be expected due to exposure to irritating and allergenic agents. METHODS:As part of a regular program of voluntary medical examinations, a questionnaire including items on health symptoms and working circumstances is administered to ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1993-12-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1998-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2008-05-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
pub_type: 传,历史文章,杂志文章
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journal_title:American journal of industrial medicine
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journal_title:American journal of industrial medicine
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更新日期:1991-01-01 00:00:00
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更新日期:2006-09-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1997-09-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:American journal of industrial medicine
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:1984-01-01 00:00:00
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journal_title:American journal of industrial medicine
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更新日期:2012-07-01 00:00:00