Respiratory response to endotoxin and dust predicts evidence of inflammatory response in volunteers in a swine barn.

Abstract:

BACKGROUND:It has been shown that exposure in intense exposure in swine barn facilities is associated with increased respiratory symptoms and reduction in pulmonary functions. This study investigated if systemic response could be predicted by FEV(1) response following swine barn exposure. METHODS:Naïve males were tested at baseline, low and high endotoxin and dust levels. Subjects were classified as "more responsive" (n = 9) or "less responsive" (n = 11) based on FEV(1) reduction following high endotoxin exposure. Health measures included pulmonary function testing, blood samples and nasal lavage. Environmental samples were collected from the barn. RESULTS:White blood cells and blood lymphocytes at low exposure were significantly greater in those who were "more responsive" compared to those who were "less responsive". There was a significant increase in blood lymphocytes, serum IL6, total nasal lavage cells and nasal IL8 at high exposure among "more responsive" subjects compared to "less responsive" subjects. CONCLUSIONS:Respiratory response to high-level endotoxin and dust exposure predicts evidence of inflammatory response throughout a range of endotoxin and dust exposures.

journal_name

Am J Ind Med

authors

Dosman JA,Fukushima Y,Senthilselvan A,Kirychuk SP,Lawson JA,Pahwa P,Cormier Y,Hurst T,Barber EM,Rhodes CS

doi

10.1002/ajim.20339

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

761-6

issue

9

eissn

0271-3586

issn

1097-0274

journal_volume

49

pub_type

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