Abstract:
BACKGROUND:It has been shown that exposure in intense exposure in swine barn facilities is associated with increased respiratory symptoms and reduction in pulmonary functions. This study investigated if systemic response could be predicted by FEV(1) response following swine barn exposure. METHODS:Naïve males were tested at baseline, low and high endotoxin and dust levels. Subjects were classified as "more responsive" (n = 9) or "less responsive" (n = 11) based on FEV(1) reduction following high endotoxin exposure. Health measures included pulmonary function testing, blood samples and nasal lavage. Environmental samples were collected from the barn. RESULTS:White blood cells and blood lymphocytes at low exposure were significantly greater in those who were "more responsive" compared to those who were "less responsive". There was a significant increase in blood lymphocytes, serum IL6, total nasal lavage cells and nasal IL8 at high exposure among "more responsive" subjects compared to "less responsive" subjects. CONCLUSIONS:Respiratory response to high-level endotoxin and dust exposure predicts evidence of inflammatory response throughout a range of endotoxin and dust exposures.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Dosman JA,Fukushima Y,Senthilselvan A,Kirychuk SP,Lawson JA,Pahwa P,Cormier Y,Hurst T,Barber EM,Rhodes CSdoi
10.1002/ajim.20339subject
Has Abstractpub_date
2006-09-01 00:00:00pages
761-6issue
9eissn
0271-3586issn
1097-0274journal_volume
49pub_type
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