Abstract:
:This commentary challenges a recently published perception that Dr. Le Roy Upson Gardner had not actually discovered in 1942 that inhaled chrysotile fibers could induce malignant neoplasia in mice. The handwritten laboratory notes and some of Dr. Gardner's slides have recently been found. They verify that the tumors he saw in the mice included truly malignant neoplasms. Gardner had by then also accumulated 11 cases of human lung cancer (two mesotheliomas) derived from Quebec asbestos miners and millers. An inhalation study designed by Dr. Gardner and conducted between 1951 and 1954, using cancer-insusceptible mice, yielded neoplasia risk ratio of 5.7 compared with control animals. The studies also showed that the primary effect of chrysotile is to cause epithelial proliferation in alveoli adjacent to bronchioles. Chrysotile type asbestos bodies were shown to remain only transiently ferruginous, but even though invisible in direct light they can be visualized at high magnification through use of phase contrast and polarized light micrography.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Schepers GWdoi
10.1002/ajim.4700270413subject
Has Abstractpub_date
1995-04-01 00:00:00pages
593-606issue
4eissn
0271-3586issn
1097-0274journal_volume
27pub_type
传,历史文章,杂志文章abstract::The association between lead absorption and objective psychological performance tests in five groups with different levels of lead absorption was studied in the following groups: (1) a control, non-lead-exposed group; (2) cable splicers, (3) cable manufactures, and (4) secondary lead smelter workers. The following per...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700010320
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Radiographic shadows of coal workers' pneumoconiosis (CWP) are commonly described as predominantly in the upper lung zones. METHODS:We evaluated the lung distribution of small opacities on surveillance chest radiographs (CXRs) taken between 1981 and 2010 among 2,467 underground US coal miners. All had evide...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22049
更新日期:2012-09-01 00:00:00
abstract::In the course of a health screening for construction carpenters, 127 subjects underwent blood lead testing, administration of detailed questionnaires, and in vivo measurement of bone lead levels with a 109Cd K-X-ray fluorescence (K-XRF) instrument. The mean age of subjects was 48.5 (SD = 9.8) years. Blood lead levels ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700260211
更新日期:1994-08-01 00:00:00
abstract::This paper reviews the epidemiologic evidence of cancer risks among workers in aluminum reduction plants with emphasis on associations with specific work areas and exposures. Studies of workers manufacturing carbon products outside the aluminum industry were also reviewed since the work environment is similar to that ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700220412
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Work-related musculoskeletal disorders (MSDs) of the upper extremities are a major problem globally, though most relevant studies have been reported from high income countries. AIMS AND METHODS:The prevalence of neck and shoulder pain and its association with work-related physical and psychosocial factors a...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20562
更新日期:2008-05-01 00:00:00
abstract::The relationship between various occupational exposures and brain cancer was investigated in a case-control study using mortality data from 202 males who died in East Texas from gliomas in 1969-1978 and 238 male controls randomly selected from all deaths in East Texas in 1969-1978. Using the occupational classificatio...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700130603
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Farmworkers in the US largely consist of young undocumented Hispanics with a median education of 6 years and limited English skills. The High Plains Intermountain Center for Agricultural Health and Safety bilingual pesticide risk reduction program, which complied with the Worker Protection Standard for migra...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20136
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Workers in foundry and pottery are exposed to a mixture of chemicals and silica, which is suspected to cause genetic alterations. METHODS:To investigate the potential hazard associated with the occupational exposure to silica, DNA damage in the peripheral lymphocytes of 30 foundry and 22 pottery workers wer...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10222
更新日期:2003-06-01 00:00:00
abstract::Methods to collect epidemiologic data include, among other means, self-administered questionnaires and personal and telephone interviews. In some studies, these data collection methods are used simultaneously. However, little is known about the comparability of the data obtained, thus, the validity of pooling data. A ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199705)31:5<653::aid-ajim2
更新日期:1997-05-01 00:00:00
abstract:BACKGROUND:Work-related injuries in commercial fishing are of concern internationally. To better identify the causes of injury, this study coded occupational injuries by working processes in commercial fishing for fresh market fish. METHODS:A classification system of the work processes was developed by participation i...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20163
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Noise exposure in the sawmill industry is an area of concern. This study documents the level of noise exposure in nine sawmills in the province of Alberta, Canada. METHODS:Personal noise monitoring data were collected in nine Alberta sawmills, in winter and in summer (n = 213). Exposures were considered in ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10173
更新日期:2003-02-01 00:00:00
abstract::Cause-specific mortality was evaluated by period of hire for 37,682 male chemical workers in order to test the hypothesis that employees hired during World War II (1941-1945) were at increased risk for selected causes of death. One recent study of refinery workers reported that those hired during the war years had exp...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700150308
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:The impact of long working hours on health has been of major concern since the late 19th Century. Working hours are again increasing in the US. METHODS:An overview of historical, sociological, and health-related research presented at an international conference on long working hours is discussed as an intro...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.20383
更新日期:2006-11-01 00:00:00
abstract::A cross-sectional prevalence study of 120 public school custodians was carried out. The purposes were 1) to investigate the prevalence of asbestos-related disease in a group of custodians at risk for asbestos exposure in public schools and 2) to determine the proportion with disease attributable to exposures in school...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700190305
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Falls are the leading cause of fatalities in construction. The Safety Pays, Falls Cost campaign aims to prevent falls in residential construction. A critical component of our social marketing approach was to involve 70 partners in reaching target audiences. METHODS:We assessed partner engagement April 2012-...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22458
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate cancer incidence in the membership a largely Hispanic farmworker labor union in California, the United Farmworkers of America (UFW) and to examine cancer-site specific distributions as well as histology and stage of cancer at diagnosis in this group. METHODS:An elec...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1125
更新日期:2001-11-01 00:00:00
abstract::Occupational diseases are now being assessed at the cellular and molecular levels; this presents new opportunities for prevention and control [Calleman et al., 1978; Ong et al., 1987; Stejskal et al., 1989; Welch and Cullen, 1988; Garry et al., 1989]. The key to these opportunities is the ability to detect biological ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700200402
更新日期:1991-01-01 00:00:00
abstract::Certain refining processes were investigated to determine their influence on the dermal carcinogenic activity of petroleum-derived lubricating oil distillates. Specifically, the effects of solvent refining, hydroprocessing, a combination of both processes, and the blending of oils processed using each technique were e...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700050403
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Studies comparing different forms of asbestos are rare, and limited by the failure to compare results with unexposed populations. We compare autoimmune responses among former workers and residents of the crocidolite mining and milling town of Wittenoom, Western Australia, with an unexposed population. METHO...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22863
更新日期:2018-07-01 00:00:00
abstract::Eight healthy volunteers were exposed to purified lipopolysaccharide (LPS) by controlled inhalation. Bronchoalveolar lavage (BAL) 3 hours after exposure revealed a pronounced neutrophilia, increase in lymphocytes, fibronectin concentration, and decrease in alveolar macrophage phagocytosis, as compared to a reference B...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700250127
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The mortality experience of iron and steel workers from modern plants in developing countries has not been extensively described. METHODS:Mortality at two Korean iron and steel manufacturing complexes was analyzed using Poisson regression methods with both direct and indirect standardization. Work histories...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20197
更新日期:2005-09-01 00:00:00
abstract:BACKGROUND:Many professional emergency responders (ERs) who belong to the Korean National Emergency Management Agency (NEMA) have been cross-trained and serve multiple roles. As such, firefighters and other ERs in Korea are exposed to similar occupational hazards. This study was conducted to estimate cancer morbidity i...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22068
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Around the globe, work has a heavy impact on health. To better advise policy makers, we assessed the global burden of disease and injury due to selected occupational hazards. This article presents an overview, and describes the methodology employed in the companion studies. METHODS:Using the World Health Or...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20211
更新日期:2005-12-01 00:00:00
abstract::Process and office workers at a Swedish paper mill (n = 274) and dairy workers (n = 45) were investigated with questionnaires regarding skin symptoms. In the second part of the study, subjects reporting skin symptoms and a random sample of subjects without symptoms were examined and investigated with patch testing. Pr...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230506
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the health effects of exposure mainly to 1-bromopropane, which is an alternative to ozone-depleting solvents, and to establish biomarkers for assessing 1-bromopropane exposure. METHODS:Twenty-four female and 13 male workers of a 1-bromopropane-factory were interviewed, ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10320
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Aspartame (APM) is a well-known intense artificial sweetener used in more than 6,000 products. Among the major users of aspartame are children and women of childbearing age. In previous lifespan experiments conducted on Sprague-Dawley rats we have shown that APM is a carcinogenic agent in multiple sites and ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20896
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:We developed a systematic, data-driven approach to estimate metrics of occupational exposure to lead to aid in epidemiologic analyses in a case-control study of kidney cancer. METHODS:Probability of exposure to ten lead sources was assigned using decision rules developed from an extensive literature review ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22912
更新日期:2018-11-01 00:00:00
abstract:BACKGROUND:The risk of breast cancer was investigated in a large dynamic population-based cohort of all 1.1 million economically active women in Norway with potential exposure to 50 Hz magnetic fields at the censuses of 1960, 1970, and 1980. METHODS:The follow-up period for the cohort was 1961-1992. For each woman, da...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199907)36:1<147::aid-ajim2
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:This study investigated the relationship between weekly working hours and the occurrence of cerebro-cardiovascular diseases using a case-crossover study design. METHODS:We investigated average working hours during the 7 days before the onset of illness (hazard period) and average weekly working hours betwee...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22688
更新日期:2017-09-01 00:00:00
abstract::The present case-control study was conducted in an effort to determine if work in the chemical industry is related to excesses of certain hematopoietic and lymphoid neoplasms. Cases who died from non-Hodgkin's lymphoma, multiple myeloma, and leukemia were matched by race, gender, age, year of death, and county of resi...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199701)31:1<21::aid-ajim4>
更新日期:1997-01-01 00:00:00