Combination low-dose lymphoblastoid interferon and thymosin alpha 1 therapy in the treatment of chronic hepatitis B.

abstract：:Several direct-acting antivirals (DAAs) have been approved for the treatment of chronic hepatitis C virus (HCV) infections, opening the door to highly effective interferon-free treatment regimens. Resistance-associated substitutions (RASs) have been reported both in treatment-naïve patients and following treatment wit...

journal_title：Journal of viral hepatitis

authors： Eltahla AA,Rodrigo C,Betz-Stablein B,Grebely J,Applegate T,Luciani F,Schinkel J,Dore GJ,Page K,Bruneau J,Morris MD,Cox AL,Kim AY,Shoukry NH,Lauer GM,Maher L,Hellard M,Prins M,Lloyd AR,Bull RA,InC3 Study Group.

更新日期：2017-01-01 00:00:00

abstract：:To assess the prevalence of hepatitis delta virus (H delta V) in northern India, 204 adult patients with acute and chronic liver disease who were positive for hepatitis B virus (HBV) markers were screened for anti-H delta V antibody by enzyme-linked immunosorbent assay (ELISA). Anti-H delta V antibodies were positive ...

journal_title：Journal of viral hepatitis

authors： Singh V,Goenka MK,Bhasin DK,Kochhar R,Singh K

更新日期：1995-01-01 00:00:00

abstract：:To investigate the long-term prognosis of liver disease in patients with hepatitis C virus (HCV) eradication after antiviral therapy versus those with persistent HCV infection. Four hundred and eighty patients (5259 person-years [PYs]) who received interferon-based therapy and achieved sustained virologic response and...

journal_title：Journal of viral hepatitis

authors： Tada T,Toyoda H,Kumada T,Kurisu A,Sugiyama A,Akita T,Ohisa M,Aikata H,Miki D,Chayama K,Tanaka J

更新日期：2020-11-20 00:00:00

abstract：:Serological and biochemical studies indicate that acute HBV infection is resolved in the context of an efficient cell-mediated immune (CMI) response, whereas, chronic infection is characterized by weak to undetectable CMI responses and relatively efficient humoral immunity. Because humoral immunity and CMI are regulat...

journal_title：Journal of viral hepatitis

authors： Milich DR

更新日期：1997-01-01 00:00:00

abstract：SUMMARY:Treatment of hepatitis C virus (HCV) infection with interferon (IFN)-alpha, as monotherapy or in combination with ribavirin, is associated with significant side-effects including weight loss. The aim of our study was to describe the evolution of body weight during combination antiviral treatment and to examine ...

journal_title：Journal of viral hepatitis

authors： Seyam MS,Freshwater DA,O'Donnell K,Mutimer DJ

更新日期：2005-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) chronically infects about 200 million individuals worldwide and leads to severe liver and lymphatic diseases. HCV circulates in the serum, associated with apoB-containing lipoproteins. Platelet-activating factor (PAF), a pro-inflammatory mediator, is mainly modulated by plasma PAF-acetylhydrola...

journal_title：Journal of viral hepatitis

authors： Caini P,Guerra CT,Giannini C,Giannelli F,Gragnani L,Petrarca A,Solazzo V,Monti M,Laffi G,Zignego AL

更新日期：2007-01-01 00:00:00

abstract：:Oral therapy for chronic hepatitis B remains suboptimal. Mathematical modelling of viral decay kinetics to rapidly assess potential antiviral regimens has proved valuable for human immunodeficiency virus and cytomegalovirus. We defined the kinetics of viral replication in 10 chronic hepatitis B patients randomized to ...

journal_title：Journal of viral hepatitis

authors： Wang CC,Holte S,Huang ML,Sacks SL,Engelberg R,Ferrenberg J,Shuhart M,Corey L

更新日期：2004-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) and hepatitis B virus (HBV) frequently coinfect and persist long after clinical resolution. We assessed the incidence of low-level (occult) HCV infection (OCI) after sustained virological response (SVR) to standard anti-HCV therapy in individuals with or without past exposure to HBV to recogniz...

journal_title：Journal of viral hepatitis

authors： Pham TN,Coffin CS,Churchill ND,Urbanski SJ,Lee SS,Michalak TI

更新日期：2012-02-01 00:00:00

abstract：:Little is known about engagement and retention in care of people diagnosed with chronic hepatitis C (HCV) in England. Establishing a cascade of care informs targeted interventions for improving case finding, referral, treatment uptake and retention in care. Using data from the sentinel surveillance of blood-borne viru...

journal_title：Journal of viral hepatitis

authors： Simmons R,Ireland G,Irving W,Hickman M,Sabin C,Ijaz S,Ramsay M,Lattimore S,Mandal S

更新日期：2018-05-01 00:00:00

abstract：:Despite the availability of a preventative vaccine, chronic hepatitis B (CHB) remains a global healthcare challenge with the risk of disease progression due to cirrhosis and hepatocellular carcinoma. Although current treatment strategies, interferon and nucleos(t)ide analogues have contributed to reducing morbidity an...

journal_title：Journal of viral hepatitis

authors： Gill US,Kennedy PTF

更新日期：2019-01-01 00:00:00

abstract：:Chronic hepatitis B infection is an important cause of liver-related mortality in China. This study assessed the efficacy and safety of entecavir in a heterogeneous patient population from a ‘real-world’ clinical practice setting in China. This prospective, observational cohort provides 48-week data on 2600 patients f...

journal_title：Journal of viral hepatitis

authors： Hou JL,Jia JD,Wei L,Zhao W,Wang YM,Cheng M,Tang X,Tan DM,Ren H,Tang H,Cohen D,Llamoso C

更新日期：2013-11-01 00:00:00

abstract：:For hepatitis B virus (HBV)-related chronic infection under treatment by nucleos(t)ide analogues (NUCs), HBsAg clearance is the ultimate therapeutic goal but very infrequent. We investigated how HBV envelope protein variability could lead to differential HBsAg clearance on NUCs. For 12 HBV genotype D patients receivin...

journal_title：Journal of viral hepatitis

authors： Velay A,Jeulin H,Eschlimann M,Malvé B,Goehringer F,Bensenane M,Frippiat JP,Abraham P,Ismail AM,Murray JM,Combet C,Zoulim F,Bronowicki JP,Schvoerer E

更新日期：2016-05-01 00:00:00

abstract：:We aimed to compare the evolution of estimated glomerular filtration rate (eGFR) in HIV-, HIV-HBV- and HBV-infected patients treated with tenofovir disoproxil fumarate (TDF). Three groups of patients receiving TDF > 12 months were recruited: 194 HIV-infected patients, 85 HIV-HBV-coinfected patients and 50 HBV-infected...

journal_title：Journal of viral hepatitis

authors： Pradat P,Le Pogam MA,Okon JB,Trolliet P,Miailhes P,Brochier C,Maynard M,Bailly F,Zoulim F,Cotte L

更新日期：2013-09-01 00:00:00

abstract：:Travel to endemic areas is one of the most frequently reported risk factors for infection with the hepatitis A virus (HAV). We evaluated the association between HAV infection and travel, by area of destination. We conducted a case-control study on all cases of HAV infection reported to the Italian National Surveillanc...

journal_title：Journal of viral hepatitis

authors： Ciccozzi M,Tosti ME,Gallo G,Ragni P,Zotti C,Lopalco P,Ara G,Sangalli M,Balocchini E,Szklo AS,Mele A,SEIEVA collaborating group.

更新日期：2002-11-01 00:00:00

abstract：:Intercellular adhesion molecule-1 (ICAM-1) plays an important role in the pathogenesis of viral hepatitis B. Several inflammatory diseases are associated with distinct polymorphisms of the ICAM-1 gene. The aims of this study were to analyse the association of ICAM-1 polymorphisms G241R and K469E with susceptibility to...

journal_title：Journal of viral hepatitis

authors： Zhang XQ,Hong XJ,Bai XJ

更新日期：2008-03-01 00:00:00

abstract：:The aim of this study was to evaluate the pharmacokinetic profile of daclatasvir (DCV) and asunaprevir (ASV) dual therapy in haemodialysis patients infected with hepatitis C virus (HCV). Eighteen haemodialysis patients and 54 patients with normal renal function were treated with DCV and ASV dual therapy for 24 weeks. ...

journal_title：Journal of viral hepatitis

authors： Kawakami Y,Imamura M,Ikeda H,Suzuki M,Arataki K,Moriishi M,Mori N,Kokoroishi K,Katamura Y,Ezaki T,Ueno T,Ide K,Masaki T,Ohdan H,Chayama K

更新日期：2016-11-01 00:00:00

abstract：:Limited data are available on direct-acting antivirals for treating hepatitis C virus (HCV) infection in patients with severe renal impairment. The aim of this study was to evaluate the effectiveness and safety of ombitasvir/paritaprevir/ritonavir (OBV/PTV/r) ± dasabuvir (DSV) ± ribavirin (RBV) in patients with stage ...

journal_title：Journal of viral hepatitis

authors： Muñoz-Gómez R,Rincón D,Ahumada A,Hernández E,Devesa MJ,Izquierdo S,Ortiz M,Hernández-Albujar A,Fernández-Rodríguez C,Calvo M,González R,Lozano M,Castellano G,Fernández-Vázquez I

更新日期：2017-06-01 00:00:00

abstract：:The establishment of an in vitro system for hepatitis C virus (HCV) propagation is essential to characterize virus replication, virus persistence and viral pathogenicity. The aim was to establish HCV replication in HepG2 cells by gene transfer of infectious HCV cDNA. First, several gene transfer methods were evaluated...

journal_title：Journal of viral hepatitis

authors： Hiramatsu N,Dash S,Gerber MA

更新日期：1997-01-01 00:00:00

abstract：:No studies have reported the long-term effects of entecavir switching in patients with multidrug resistance who developed resistance after lamivudine/adefovir sequential therapy. We evaluated the efficacy of 96 weeks of entecavir therapy in patients with resistance to lamivudine/adefovir sequential therapy. In total, ...

journal_title：Journal of viral hepatitis

authors： Kwak MS,Choi JW,Lee JS,Kim KA,Suh JH,Cho YS,Won SY,Park BK,Lee CK

更新日期：2011-10-01 00:00:00

abstract：:The short-term prognosis of patients with severe acute exacerbation of chronic hepatitis B (CHB) leading to acute liver failure is extremely poor. We have reported the efficacy of corticosteroid in combination with nucleoside analogue in the early stages, but virological efficacy has not been documented. Our aim was t...

journal_title：Journal of viral hepatitis

authors： Yasui S,Fujiwara K,Nakamura M,Miyamura T,Yonemitsu Y,Mikata R,Arai M,Kanda T,Imazeki F,Oda S,Yokosuka O

更新日期：2015-02-01 00:00:00

abstract：:Hepatitis B virus surface antigen (HBsAg) plays an important role in maintaining the tolerance and may interfere with host innate and adaptive immune responses; therefore, novel therapeutic strategies to reduce HBsAg loads in patients infected with hepatitis B virus (HBV) are emerging as an attractive but challenging ...

journal_title：Journal of viral hepatitis

authors： Xun YH,Zhang YJ,Pan QC,Mao RC,Qin YL,Liu HY,Zhang YM,Yu YS,Tang ZH,Lu MJ,Zang GQ,Zhang JM

更新日期：2014-08-01 00:00:00

abstract：:Increased infiltration of lymphocytes and induction of damage and destruction of hepatocytes by these lymphocytes are characteristic features of chronic viral hepatitis. As chemokines attract lymphocytes to inflamed tissues, we studied macrophage inflammatory protein (MIP)-3alpha, a CC chemokine, in chronic viral hepa...

journal_title：Journal of viral hepatitis

authors： Yamauchi K,Akbar SM,Horiike N,Michitaka K,Onji M

更新日期：2002-05-01 00:00:00

abstract：:Even with pegylated (PEG) interferons (IFN), therapy of chronic hepatitis C (genotype 1) remains unsatisfactory. The initial viral response to IFN identifies patients infected with IFN resistant viruses not responding to standard IFN/ribavirin therapy. The impact of primary IFN unresponsiveness for PEG-IFN-alpha-2a/ri...

journal_title：Journal of viral hepatitis

authors： Jessner W,Stauber R,Hackl F,Datz C,Watkins-Riedel T,Hofer H,Gangl A,Kessler H,Ferenci P

更新日期：2003-01-01 00:00:00

abstract：:The use of tenofovir disoproxil fumarate (TDF) is associated with a risk of renal dysfunction. We investigated whether TDF is associated with the deterioration of renal function in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) requiring frequent computed tomography (CT) evaluations and t...

journal_title：Journal of viral hepatitis

authors： Jeon MY,Lee JS,Lee HW,Kim BK,Park JY,Kim DY,Han KH,Ahn SH,Kim SU

更新日期：2020-09-01 00:00:00

abstract：:This study assessed the association of HIV RNA with indirect markers of liver injury including FIB-4 index, liver enzymes and platelet counts in a high-risk Hispanic population. The data were derived from a prospective study that included 138 HIV/hepatitis C (HCV)-coinfected and 68 HIV-infected participants without he...

journal_title：Journal of viral hepatitis

authors： Forrester JE,Rhee MS,McGovern BH,Sterling RK,Knox TA,Terrin N

更新日期：2012-02-01 00:00:00

abstract：:The study was undertaken to investigate the features and clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP) and precore (PC) mutations in hepatitis B-related acute-on-chronic liver failure (HB-ACLF). Samples from 75 patients with HB-ACLF and without pre-existing liver cirrhosis and 3...

journal_title：Journal of viral hepatitis

authors： Ren X,Xu Z,Liu Y,Li X,Bai S,Ding N,Zhong Y,Wang L,Mao P,Zoulim F,Xu D

更新日期：2010-12-01 00:00:00

abstract：:It is unclear whether the achievement of virologic response modifies the risk of hepatocellular carcinoma (HCC) differently in chronic hepatitis B (CHB) and chronic hepatitis C (CHC). Our aim was to compare the risk of HCC between patients with CHB and CHC who achieved virological response. We analysed data from patie...

journal_title：Journal of viral hepatitis

authors： Kim GA,Han S,Kim HD,An J,Lim YS

更新日期：2017-11-01 00:00:00

abstract：:Seroconversion from hepatitis B surface antigen (HBsAg) to antibodies against HBsAg (anti-HBs) usually indicates resolution of hepatitis B virus (HBV) infection. Here, two HBV-infected patients with seroconversion to anti-HBs were found to be persistently positive for HBeAg and HBV DNA. Immunohistology of liver biopsi...

journal_title：Journal of viral hepatitis

authors： Zhang ZH,Li L,Zhao XP,Glebe D,Bremer CM,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Gerlich W,Roggendorf M,Li X,Lu M,Yang DL

更新日期：2011-06-01 00:00:00

abstract：:Hepatitis delta virus (HDV) RNA editing controls the formation of hepatitis-delta-antigen-S and -L and therefore indirectly regulates HDV replication. Editing is thought to be catalysed by the adenosine deaminase acting on RNA1 (ADAR1) of which two different forms exist, interferon (IFN)-alpha-inducible ADAR1-L and co...

journal_title：Journal of viral hepatitis

authors： Hartwig D,Schütte C,Warnecke J,Dorn I,Hennig H,Kirchner H,Schlenke P

更新日期：2006-03-01 00:00:00

abstract：:The treatment of hepatitis C is expensive, difficult and arduous from the patient's perspective. It is similarly difficult for the clinician to decide who and when to treat. If hepatitis C is viewed from the liver's perspective we need only treat those patients who will develop the complications of chronic liver disea...

journal_title：Journal of viral hepatitis

authors： Dillon JF

更新日期：2004-09-01 00:00:00