Abstract:
:To investigate the long-term prognosis of liver disease in patients with hepatitis C virus (HCV) eradication after antiviral therapy versus those with persistent HCV infection. Four hundred and eighty patients (5259 person-years [PYs]) who received interferon-based therapy and achieved sustained virologic response and 848 patients (3853 PYs) with persistent HCV infection were included. In the analysis of 1-year liver disease state transition probability matrices using Markov chain models, progression to cirrhosis from the chronic hepatitis state was observed (0.00%-0.63%) in patients with HCV eradication. Among patients with chronic hepatitis or cirrhosis and HCV eradication, hepatocellular carcinoma (HCC) development was observed in males aged ≥ 50 years (0.97%-1.96%) and females aged ≥ 60 years (0.26%-5.00%). Additionally, in patients with cirrhosis and HCV eradication, improvement to chronic hepatitis was also observed (4.94%-10.64%). Conversely, in patients with chronic hepatitis and persistent HCV infection, progression to cirrhosis was observed in males aged ≥ 30 years and female aged ≥ 40 years (0.44%-1.99%). In males aged ≥ 40 years and female aged ≥ 50 years with cirrhosis, the transition probability for HCC was relatively high (4.17%-14.02%). Under the assumption of either chronic hepatitis or cirrhosis at age 40 or 60 years as the starting condition for simulation over the next 30 or 40 years, respectively, the probability of HCC was higher in patients with persistent HCV infection than those with HCV eradication. In conclusion, HCV eradication can reduce the risk of developing cirrhosis or HCC in patients with chronic HCV infection.
journal_name
J Viral Hepatjournal_title
Journal of viral hepatitisauthors
Tada T,Toyoda H,Kumada T,Kurisu A,Sugiyama A,Akita T,Ohisa M,Aikata H,Miki D,Chayama K,Tanaka Jdoi
10.1111/jvh.13444subject
Has Abstractpub_date
2020-11-20 00:00:00eissn
1352-0504issn
1365-2893pub_type
杂志文章abstract::Recently, attention has been focussed on adiponectin and its changes in different types of chronic liver disease. Its relation to hepatic fibrosis and insulin resistance in post-hepatitis liver disease is not clear. The aim of this study was to clarify the adiponectin changes in genotype 4 hepatitis C virus (HCV)-infe...
journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,评审
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abstract::GS-9857, an inhibitor of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A, demonstrates potent activity against HCV genotypes 1-6 and improved coverage against commonly encountered NS3 resistance-associated variants (RAVs). In this study, the safety, tolerability, antiviral activity and pharmacokinetics (PK...
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,评审
doi:10.1111/jvh.12859
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/jvh.12483
更新日期:2016-03-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/jvh.12207
更新日期:2014-10-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/j.1365-2893.2006.00815.x
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journal_title:Journal of viral hepatitis
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pub_type: 杂志文章,评审
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journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章,随机对照试验
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