The impact of currently licensed therapies on viral and immune responses in chronic hepatitis B: Considerations for future novel therapeutics.

abstract：:Travel to endemic areas is one of the most frequently reported risk factors for infection with the hepatitis A virus (HAV). We evaluated the association between HAV infection and travel, by area of destination. We conducted a case-control study on all cases of HAV infection reported to the Italian National Surveillanc...

journal_title：Journal of viral hepatitis

authors： Ciccozzi M,Tosti ME,Gallo G,Ragni P,Zotti C,Lopalco P,Ara G,Sangalli M,Balocchini E,Szklo AS,Mele A,SEIEVA collaborating group.

更新日期：2002-11-01 00:00:00

abstract：:Chronic infection with the hepatitis C virus is a major health problem. Conventional therapy, with interferon-alpha is effective in only a minority of patients. The failure of current treatments has led to a major initiative to identify new antiviral agents. In the absence of a tissue culture model for hepatitis C inf...

journal_title：Journal of viral hepatitis

authors： Clarke BE

更新日期：1995-01-01 00:00:00

abstract：:Portal hypertension and splenomegaly are common in patients with cirrhosis. However, there is limited previous in vivo research on the correlation between spleen stiffness and stages of liver fibrosis. This study aimed to evaluate the diagnostic value of spleen stiffness measurement (SSM), using acoustic radiation for...

journal_title：Journal of viral hepatitis

authors： Chen SH,Li YF,Lai HC,Kao JT,Peng CY,Chuang PH,Su WP,Chiang IP

更新日期：2012-09-01 00:00:00

abstract：:Endoglin, a transforming growth factor (TGF)-beta1 co-receptor, has been associated with renal and cutaneous fibrosis, as overexpression of this protein has been observed in biopsies from patients with glomerulosclerosis and scleroderma, respectively. Our aim was to evaluate whether endoglin may be associated with hep...

journal_title：Journal of viral hepatitis

authors： Clemente M,Núñez O,Lorente R,Rincón D,Matilla A,Salcedo M,Catalina MV,Ripoll C,Iacono OL,Bañares R,Clemente G,García-Monzón C

更新日期：2006-09-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection appears to contribute to the development of insulin resistance (IR). Among the multiple determinants of IR, body mass index (BMI) is the most important. We investigated the contribution of HCV to BMI-associated IR using a transgenic mouse model expressing HCV core protein. Eight trans...

journal_title：Journal of viral hepatitis

authors： Delgado-Borrego A,Kamegaya Y,Jordan SH,Agrawal S,Valim C,Chung RT

更新日期：2011-02-01 00:00:00

abstract：:Hepatitis Be antigen (HBeAg)-negative chronic hepatitis B (CHB) is associated with hepatitis B virus (HBV) variants harbouring changes in the precore region. Most commonly, a G to A point mutation at nucleotide 1896 (m1896) creates a novel translation stop codon that prevents HBeAg production. In the Mediterranean reg...

journal_title：Journal of viral hepatitis

authors： Laras A,Koskinas J,Avgidis K,Hadziyannis SJ

更新日期：1998-07-01 00:00:00

abstract：:Many Indigenous Australians in northern Australia living with chronic hepatitis B are unaware of their diagnosis due to low screening rates. A venous blood point of care test (POCT) or oral fluid laboratory test could improve testing uptake in this region. The purpose of this study was to assess the field performance ...

journal_title：Journal of viral hepatitis

authors： Sullivan RP,Davies J,Binks P,Dhurrkay RG,Gurruwiwi GG,Bukulatjpi SM,McKinnon M,Hosking K,Littlejohn M,Jackson K,Locarnini S,Davis JS,Tong SYC

更新日期：2020-04-01 00:00:00

abstract：AIM:Elevated body mass index (BMI) in chronic hepatitis C (CHC) has been associated with reduced rates of sustained virological response (SVR). The aims of this study were to determine whether early viral kinetics (and subsequently SVR) are influenced by weight or BMI by measuring HCV RNA at week 4 using two PCR assays...

journal_title：Journal of viral hepatitis

authors： Pattullo V,Ravindran NC,Mazzulli T,Wong DK,Heathcote EJ

更新日期：2010-12-01 00:00:00

abstract：:Oral therapy for chronic hepatitis B remains suboptimal. Mathematical modelling of viral decay kinetics to rapidly assess potential antiviral regimens has proved valuable for human immunodeficiency virus and cytomegalovirus. We defined the kinetics of viral replication in 10 chronic hepatitis B patients randomized to ...

journal_title：Journal of viral hepatitis

authors： Wang CC,Holte S,Huang ML,Sacks SL,Engelberg R,Ferrenberg J,Shuhart M,Corey L

更新日期：2004-09-01 00:00:00

abstract：:Chemotherapy for chronic hepatitis B virus (HBV) infection is inherently difficult for a variety of reasons that are related to unusual features of both HBV replication strategy and host cell metabolism. Previous attempts to treat chronic HBV infection using nucleoside analogues have been almost universally disappoint...

journal_title：Journal of viral hepatitis

authors： Shaw T,Locarnini SA

更新日期：1999-03-01 00:00:00

abstract：:The treatment option in chronic hepatitis B (CHB) patients with persistent low-level viremia despite entecavir or tenofovir monotherapy is unclear. This study investigated the development of hepatocellular carcinoma (HCC) or cirrhosis in hepatitis B e antigen (HBeAg)-positive high viral load CHB patients, according to...

journal_title：Journal of viral hepatitis

authors： Nam JY,Chang Y,Cho H,Kang SH,Cho YY,Cho EJ,Lee JH,Yu SJ,Yoon JH,Kim YJ

更新日期：2018-05-01 00:00:00

abstract：:Hepatitis A virus (HAV) infection is still an important issue worldwide. A distinct set of viruses encode proteins that enhance viral cap-independent translation initiation driven by an internal ribosome entry site (IRES) and suppress cap-dependent host translation. Unlike cytolytic picornaviruses, replication of HAV ...

journal_title：Journal of viral hepatitis

authors： Kanda T,Gauss-Müller V,Cordes S,Tamura R,Okitsu K,Shuang W,Nakamoto S,Fujiwara K,Imazeki F,Yokosuka O

更新日期：2010-09-01 00:00:00

abstract：:To investigate the long-term prognosis of liver disease in patients with hepatitis C virus (HCV) eradication after antiviral therapy versus those with persistent HCV infection. Four hundred and eighty patients (5259 person-years [PYs]) who received interferon-based therapy and achieved sustained virologic response and...

journal_title：Journal of viral hepatitis

authors： Tada T,Toyoda H,Kumada T,Kurisu A,Sugiyama A,Akita T,Ohisa M,Aikata H,Miki D,Chayama K,Tanaka J

更新日期：2020-11-20 00:00:00

abstract：:The aim of this study was to assess the validity of categorization of chronic hepatitis B viral infection into stages or phases based upon measures of disease activity and viral load, assuming these phenotypes will be useful for prognostication and determining the need for antiviral therapy. We assessed the phenotype ...

journal_title：Journal of viral hepatitis

authors： Di Bisceglie AM,Lombardero M,Teckman J,Roberts L,Janssen HL,Belle SH,Hoofnagle JH,Hepatitis B Research Network (HBRN).

更新日期：2017-04-01 00:00:00

abstract：:We aimed to investigate the ability of HBsAg plasma level kinetics to predict therapy response by studying 23 children with infancy-acquired chronic hepatitis B (CHB) during combination sequential therapy with lead-in lamivudine (LAM) and add-on interferon-α (IFN-α) [5 responders (R = anti-HBs seroconversion) and 18 n...

journal_title：Journal of viral hepatitis

authors： Carey I,Bruce M,Horner M,Zen Y,D'Antiga L,Bansal S,Vergani D,Mieli-Vergani G

更新日期：2015-04-01 00:00:00

abstract：:Treatment of chronic hepatitis B has been greatly improved by the use of lamivudine, but mutations occur in the polymerase region of hepatitis B virus (HBV) and lamivudine-resistant mutants frequently develop. The emergence of lamivudine-resistant strains of HBV is a problem for treating chronic hepatitis B using lami...

journal_title：Journal of viral hepatitis

authors： Natsuizaka M,Hige S,Ono Y,Ogawa K,Nakanishi M,Chuma M,Yoshida S,Asaka M

更新日期：2005-03-01 00:00:00

abstract：:The aim of this study was to evaluate the Chiron branched DNA (bDNA) assay for detection of serum hepatitis B virus (HBV) DNA in patients with chronic hepatitis B lacking hepatitis B e antigen (HBeAg) and undergoing interferon (IFN) therapy. Results obtained with the bDNA assay were compared with those obtained using ...

journal_title：Journal of viral hepatitis

authors： Habersetzer F,Zoulim F,Jusot JF,Zhang X,Trabaud MA,Chevallier P,Chevallier M,Ahmed SN,Sepetjan M,Comanor L,Minor J,Trépo C

更新日期：1998-11-01 00:00:00

abstract：:No studies have reported the long-term effects of entecavir switching in patients with multidrug resistance who developed resistance after lamivudine/adefovir sequential therapy. We evaluated the efficacy of 96 weeks of entecavir therapy in patients with resistance to lamivudine/adefovir sequential therapy. In total, ...

journal_title：Journal of viral hepatitis

authors： Kwak MS,Choi JW,Lee JS,Kim KA,Suh JH,Cho YS,Won SY,Park BK,Lee CK

更新日期：2011-10-01 00:00:00

abstract：:Although the incidence of new hepatitis C virus (HCV) infection has fallen, HCV-related complications are on the rise. Our aim was to assess and describe the 2005-2009 national inpatient mortality and resource utilization trends for patients with HCV. Data from the National Inpatient Sample (NIS) and the National Hosp...

journal_title：Journal of viral hepatitis

authors： Younossi ZM,Otgonsuren M,Henry L,Arsalla Z,Stepnaova M,Mishra A,Venkatesan C,Hunt S

更新日期：2015-02-01 00:00:00

abstract：:We have recently shown that the replication of an HCV-poliovirus (PV) chimera that is dependent upon the hepatitis C virus (HCV) 5' untranslated region (UTR) can be inhibited by treatment with ribozymes targeting HCV RNA. To determine the antiviral effects of anti-HCV ribozyme treatment in combination with type 1 inte...

journal_title：Journal of viral hepatitis

authors： Macejak DG,Jensen KL,Pavco PA,Phipps KM,Heinz BA,Colacino JM,Blatt LM

更新日期：2001-11-01 00:00:00

abstract：:The aims of the present study were to evaluate the efficacy and tolerability of ledipasvir/sofosbuvir (LDV/SOF) with or without ribavirin in the treatment of chronic hepatitis C (CHC) in patients with advanced liver disease and to analyse whether the use of LDV/SOF treatment is associated with a new occurrence of hepa...

journal_title：Journal of viral hepatitis

authors： Idilman R,Demir M,Aladag M,Erol C,Cavus B,Iliaz R,Koklu H,Cakaloglu Y,Sahin M,Ersoz G,Koksal İ,Karasu Z,Ozgenel M,Turan İ,Gunduz F,Ataseven H,Akdogan M,Kiyici M,Koksal AS,Akhan S,Gunsar F,Tabak F,Kaymakoglu S

更新日期：2019-06-01 00:00:00

abstract：:In southwestern China, small but substantial numbers of patients with acute hepatitis were found without known hepatropic viral infections (hepatitis A, B, C, D or E, cytomegalovirus, Epstein-Barr virus) and were receiving no hepatotoxic drugs. Prevalence of antibodies, both neutralizing and specific immunoglobulin (I...

journal_title：Journal of viral hepatitis

authors： Meng G,Lan Y,Nakagawa M,Maehara T,Mitani K,Tomiyama T,Che XG,Ohkubo A

更新日期：1997-07-01 00:00:00

abstract：:We systematically reviewed the evidence for long-term effectiveness and cost-effectiveness of antiviral treatment in patients with chronic hepatitis C. We performed a systematic literature search on the long-term effectiveness and cost-effectiveness of AVT in hepatitis C (1990-March 2007), and included health technolo...

journal_title：Journal of viral hepatitis

authors： Sroczynski G,Esteban E,Conrads-Frank A,Schwarzer R,Mühlberger N,Wright D,Zeuzem S,Siebert U

更新日期：2010-01-01 00:00:00

abstract：:The objectives of this study were to investigate the prevalence of infections with hepatotrophic viruses in an anti-human immunodeficiency virus (HIV)-positive population from Buenos Aires and to compare it among the main risk groups for HIV infection. Four hundred and eighty-four consecutive patients attending the HI...

journal_title：Journal of viral hepatitis

authors： Fainboim H,González J,Fassio E,Martínez A,Otegui L,Eposto M,Cahn P,Marino R,Landeira G,Suaya G,Gancedo E,Castro R,Brajterman L,Laplumé H

更新日期：1999-01-01 00:00:00

abstract：:Serological and biochemical studies indicate that acute HBV infection is resolved in the context of an efficient cell-mediated immune (CMI) response, whereas, chronic infection is characterized by weak to undetectable CMI responses and relatively efficient humoral immunity. Because humoral immunity and CMI are regulat...

journal_title：Journal of viral hepatitis

authors： Milich DR

更新日期：1997-01-01 00:00:00

abstract：:Little is known about engagement and retention in care of people diagnosed with chronic hepatitis C (HCV) in England. Establishing a cascade of care informs targeted interventions for improving case finding, referral, treatment uptake and retention in care. Using data from the sentinel surveillance of blood-borne viru...

journal_title：Journal of viral hepatitis

authors： Simmons R,Ireland G,Irving W,Hickman M,Sabin C,Ijaz S,Ramsay M,Lattimore S,Mandal S

更新日期：2018-05-01 00:00:00

abstract：:Infection with the hepatitis C virus (HCV) remains chronic in 75% of infected individuals, in whom it can cause liver inflammation and progressive fibrosis leading to cirrhosis in 20% of patients. A sustained viral response (SVR) to HCV therapy, i.e. undetectable plasma HCV RNA 6 months after the end of treatment, lea...

journal_title：Journal of viral hepatitis

authors： Bräu N

更新日期：2004-05-01 00:00:00

abstract：:In chronic hepatitis C, transient elastography (TE) accurately identifies cirrhosis, but its ability to assess significant fibrosis (Metavir > or = F2) is variable. Constitutional and liver disease-related factors may influence TE and here we examined the variables associated with differences. Three hundred consecutiv...

journal_title：Journal of viral hepatitis

authors： Calvaruso V,Cammà C,Di Marco V,Maimone S,Bronte F,Enea M,Dardanoni V,Manousou P,Pleguezuelo M,Xirouchakis E,Attanasio M,Dusheiko G,Burroughs AK,Craxì A

更新日期：2010-07-01 00:00:00

abstract：:Mixed cryoglobulinaemia, when not secondary to other well-defined immunological disorders, is commonly associated with hepatitis C virus (HCV) infection. However, a minority of cases lack evidence of HCV infection and are, therefore, defined as 'true essential' mixed cryoglobulinaemias. We thoroughly investigated thre...

journal_title：Journal of viral hepatitis

authors： Casato M,Lilli D,Donato G,Granata M,Conti V,Del Giudice G,Rivanera D,Scagnolari C,Antonelli G,Fiorilli M

更新日期：2003-11-01 00:00:00

abstract：:Autoantibodies are commonly detected in chronic hepatitis C (HCV) but their significance remains uncertain. We assessed the prevalence of anti-nuclear (ANA) and anti-smooth muscle (ASM) antibodies within a cohort of 963 treatment-naïve HCV patients. We also assessed for differences between autoantibody-positive and au...

journal_title：Journal of viral hepatitis

authors： Williams MJ,Lawson A,Neal KR,Ryder SD,Irving WL,Trent HCV Group.

更新日期：2009-05-01 00:00:00