Metformin inhibits hepatitis B virus protein production and replication in human hepatoma cells.

abstract：:CH-C negatively affects work productivity (WP), creating a large economic burden. The aim of this study was to model the impact of sustained virologic response (SVR) on WP in CHC genotype 1 (GT1) patients in five European countries (EU5). Work Productivity and Activity Index-Specific Health Problem questionnaire was a...

journal_title：Journal of viral hepatitis

authors： Younossi Z,Brown A,Buti M,Fagiuoli S,Mauss S,Rosenberg W,Serfaty L,Srivastava A,Smith N,Stepanova M,Beckerman R

更新日期：2016-03-01 00:00:00

abstract：:The study was undertaken to investigate the features and clinical implications of hepatitis B virus (HBV) genotypes, basal core promoter (BCP) and precore (PC) mutations in hepatitis B-related acute-on-chronic liver failure (HB-ACLF). Samples from 75 patients with HB-ACLF and without pre-existing liver cirrhosis and 3...

journal_title：Journal of viral hepatitis

authors： Ren X,Xu Z,Liu Y,Li X,Bai S,Ding N,Zhong Y,Wang L,Mao P,Zoulim F,Xu D

更新日期：2010-12-01 00:00:00

abstract：:Controversial results have been reported concerning the correlation between serum levels of IgM antibodies to hepatitis B core antigen (IgM HBcAb) and the histological activity of chronic hepatitis B. In this study, paired serum samples and liver biopsies were collected from 200 consecutive chronic hepatitis B patient...

journal_title：Journal of viral hepatitis

authors： Colloredo G,Bellati G,Sonzogni A,Zavaglia C,Fracassetti O,Leandro G,Ghislandi R,Minola E,Ideo G

更新日期：1999-11-01 00:00:00

abstract：:The aim of this study was to evaluate the pharmacokinetic profile of daclatasvir (DCV) and asunaprevir (ASV) dual therapy in haemodialysis patients infected with hepatitis C virus (HCV). Eighteen haemodialysis patients and 54 patients with normal renal function were treated with DCV and ASV dual therapy for 24 weeks. ...

journal_title：Journal of viral hepatitis

authors： Kawakami Y,Imamura M,Ikeda H,Suzuki M,Arataki K,Moriishi M,Mori N,Kokoroishi K,Katamura Y,Ezaki T,Ueno T,Ide K,Masaki T,Ohdan H,Chayama K

更新日期：2016-11-01 00:00:00

abstract：:Favourable efficacy and safety profiles for simeprevir in combination with pegylated interferon alpha (PEG-IFNα) and ribavirin (triple therapy) have been shown in clinical trials. This study was carried out to evaluate the effectiveness of simeprevir-based triple therapy for patients with prior telaprevir treatment fa...

journal_title：Journal of viral hepatitis

authors： Ogawa E,Furusyo N,Dohmen K,Kajiwara E,Kawano A,Nomura H,Takahashi K,Satoh T,Azuma K,Nakamuta M,Koyanagi T,Kotoh K,Shimoda S,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

更新日期：2015-12-01 00:00:00

abstract：:Our study was conducted to further investigate the single-dose approach of hepatitis A vaccination, while providing supportive data on the flexibility of booster administration. Participants received at least one dose of Avaxim 80U Pediatric at 11-23 months of age, and they will be followed for 10 years. We report her...

journal_title：Journal of viral hepatitis

authors： Espul C,Benedetti L,Linares M,Cuello H,Rasuli A

更新日期：2015-04-01 00:00:00

abstract：:The short-term prognosis of patients with severe acute exacerbation of chronic hepatitis B (CHB) leading to acute liver failure is extremely poor. We have reported the efficacy of corticosteroid in combination with nucleoside analogue in the early stages, but virological efficacy has not been documented. Our aim was t...

journal_title：Journal of viral hepatitis

authors： Yasui S,Fujiwara K,Nakamura M,Miyamura T,Yonemitsu Y,Mikata R,Arai M,Kanda T,Imazeki F,Oda S,Yokosuka O

更新日期：2015-02-01 00:00:00

abstract：SUMMARY:Hepatitis C virus (HCV) genotypes 1 and 4 respond less well to pegylated interferon (pegIFN) plus ribavirin (RBV) therapy. For this reason most studies merge these two genotypes when assessing virological response. However, in most trials the HCV genotype 4 population is rather small, and conclusions are mainly...

journal_title：Journal of viral hepatitis

authors： Martín-Carbonero L,Puoti M,García-Samaniego J,De Luca A,Losada E,Quinzan G,Bruno R,Mariño A,González M,Núñez M,Soriano V

更新日期：2008-10-01 00:00:00

abstract：:Recently, attention has been focussed on adiponectin and its changes in different types of chronic liver disease. Its relation to hepatic fibrosis and insulin resistance in post-hepatitis liver disease is not clear. The aim of this study was to clarify the adiponectin changes in genotype 4 hepatitis C virus (HCV)-infe...

journal_title：Journal of viral hepatitis

authors： Derbala M,Rizk N,Al-Kaabi S,Amer A,Shebl F,Al Marri A,Aigha I,Alyaesi D,Mohamed H,Aman H,Basem N

更新日期：2009-10-01 00:00:00

abstract：:The aim of this study was to assess the validity of categorization of chronic hepatitis B viral infection into stages or phases based upon measures of disease activity and viral load, assuming these phenotypes will be useful for prognostication and determining the need for antiviral therapy. We assessed the phenotype ...

journal_title：Journal of viral hepatitis

authors： Di Bisceglie AM,Lombardero M,Teckman J,Roberts L,Janssen HL,Belle SH,Hoofnagle JH,Hepatitis B Research Network (HBRN).

更新日期：2017-04-01 00:00:00

abstract：:We evaluated the effect of sustained virologic response (SVR) from direct-acting antiviral (DAA)- and interferon-based treatments on hepatocellular carcinoma (HCC) risk in a large population-based cohort in Canada. We used data from the BC Hepatitis Testers Cohort, which includes ~1.3 million individuals tested for HC...

journal_title：Journal of viral hepatitis

authors： Janjua NZ,Wong S,Darvishian M,Butt ZA,Yu A,Binka M,Alvarez M,Woods R,Yoshida EM,Ramji A,Feld J,Krajden M

更新日期：2020-08-01 00:00:00

abstract：:The aim of this study was to assess the efficacy and safety of two protocols for retreatment of a cohort of Egyptian patients with chronic hepatitis C (CHC) who relapsed after NS5A inhibitor-based therapy. We conducted a prospective cohort study to assess the safety and efficacy of 12 weeks' retreatment with either co...

journal_title：Journal of viral hepatitis

authors： Yousif MM,Ahmed H,Elsadek HM,Shendi AM,Gouda TM,Elsayed IA,Gendia MA,Magdy MM,Lbrahim NF,Sadek AMEM,Zaki AM,Shafeik H,Zahran MH

更新日期：2020-11-01 00:00:00

abstract：:Bacteremia has rarely been reported in patients receiving treatment for hepatitis C virus (HCV) infection. We describe the features and investigation of four cases of Staphylococcus aureus bacteremia occurring between 3 November 2004 and 10 January 2005 in patients on therapy for chronic HCV infection. The unusual occ...

journal_title：Journal of viral hepatitis

authors： Webster D,Ahmed R,Tandon P,Chui L,McDonald RR,Obarianyk A,Antonishyn N,Doucette K

更新日期：2007-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is associated with insulin resistance (IR), although mechanisms leading to IR in these patients are not completely understood. The aim of this study was to evaluate the association of interleukin 28B (IL28B) and interleukin 28 receptor alpha (IL28RA) polymorphisms with IR among human ...

journal_title：Journal of viral hepatitis

authors： Jiménez-Sousa MA,Berenguer J,Fernández-Rodríguez A,Micheloud D,Guzmán-Fulgencio M,Miralles P,Pineda-Tenor D,García-Álvarez M,López JC,Aldámiz-Echevarria T,Carrero A,Resino S

更新日期：2014-03-01 00:00:00

abstract：:The use of tenofovir disoproxil fumarate (TDF) is associated with a risk of renal dysfunction. We investigated whether TDF is associated with the deterioration of renal function in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) requiring frequent computed tomography (CT) evaluations and t...

journal_title：Journal of viral hepatitis

authors： Jeon MY,Lee JS,Lee HW,Kim BK,Park JY,Kim DY,Han KH,Ahn SH,Kim SU

更新日期：2020-09-01 00:00:00

abstract：:Even with pegylated (PEG) interferons (IFN), therapy of chronic hepatitis C (genotype 1) remains unsatisfactory. The initial viral response to IFN identifies patients infected with IFN resistant viruses not responding to standard IFN/ribavirin therapy. The impact of primary IFN unresponsiveness for PEG-IFN-alpha-2a/ri...

journal_title：Journal of viral hepatitis

authors： Jessner W,Stauber R,Hackl F,Datz C,Watkins-Riedel T,Hofer H,Gangl A,Kessler H,Ferenci P

更新日期：2003-01-01 00:00:00

abstract：:In southwestern China, small but substantial numbers of patients with acute hepatitis were found without known hepatropic viral infections (hepatitis A, B, C, D or E, cytomegalovirus, Epstein-Barr virus) and were receiving no hepatotoxic drugs. Prevalence of antibodies, both neutralizing and specific immunoglobulin (I...

journal_title：Journal of viral hepatitis

authors： Meng G,Lan Y,Nakagawa M,Maehara T,Mitani K,Tomiyama T,Che XG,Ohkubo A

更新日期：1997-07-01 00:00:00

abstract：:Cameroon is thought to have one of the highest prevalences of hepatitis C virus (HCV) infection in the world (4.9% among adults). A marked cohort effect exists in several communities where ≈50% of the elderly are infected. Better assessment of HCV distribution is needed for planning treatment programmes. We tested for...

journal_title：Journal of viral hepatitis

authors： Njouom R,Siffert I,Texier G,Lachenal G,Tejiokem MC,Pépin J,Fontanet A

更新日期：2018-08-01 00:00:00

abstract：:The aims of the present study were to evaluate the efficacy and tolerability of ledipasvir/sofosbuvir (LDV/SOF) with or without ribavirin in the treatment of chronic hepatitis C (CHC) in patients with advanced liver disease and to analyse whether the use of LDV/SOF treatment is associated with a new occurrence of hepa...

journal_title：Journal of viral hepatitis

authors： Idilman R,Demir M,Aladag M,Erol C,Cavus B,Iliaz R,Koklu H,Cakaloglu Y,Sahin M,Ersoz G,Koksal İ,Karasu Z,Ozgenel M,Turan İ,Gunduz F,Ataseven H,Akdogan M,Kiyici M,Koksal AS,Akhan S,Gunsar F,Tabak F,Kaymakoglu S

更新日期：2019-06-01 00:00:00

abstract：:The association between HBV infection and incident thrombocytopenia among subjects without cirrhosis or splenomegaly is unknown. Therefore, we sought to elucidate the association between HBV infection and the development of thrombocytopenia in a large cohort of apparently healthy men and women. A cohort study was perf...

journal_title：Journal of viral hepatitis

authors： Joo EJ,Chang Y,Yeom JS,Lee YG,Ryu S

更新日期：2017-03-01 00:00:00

abstract：:The efficacy of lamivudine re-treatment in chronic hepatitis B (CHB) patients who relapse after HBeAg seroconversion with lamivudine has not been investigated. The aim of this study was to evaluate the efficacy of lamivudine re-treatment in relapsed patients. Among 192 patients who had achieved HBeAg seroconversion wi...

journal_title：Journal of viral hepatitis

authors： Shin JW,Park NH,Park JH,Park JH,Jeong ID,Bang SJ,Joo KR,Kim DH

更新日期：2005-07-01 00:00:00

abstract：:Hepatitis Be antigen (HBeAg)-negative chronic hepatitis B (CHB) is associated with hepatitis B virus (HBV) variants harbouring changes in the precore region. Most commonly, a G to A point mutation at nucleotide 1896 (m1896) creates a novel translation stop codon that prevents HBeAg production. In the Mediterranean reg...

journal_title：Journal of viral hepatitis

authors： Laras A,Koskinas J,Avgidis K,Hadziyannis SJ

更新日期：1998-07-01 00:00:00

abstract：:The human La (hLa) protein functions in RNA metabolism and is activated by casein kinase 2 (CK2) phosphorylation. Hepatitis B virus (HBV) can exploit hLa to stabilize its RNA and promote its pathogenesis. To enhance our knowledge of host molecular pathways involved in HBV pathogenesis, a bioinformatic approach was use...

journal_title：Journal of viral hepatitis

authors： Tang J,Zhang ZH,Liu GL

更新日期：2013-01-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMC) from chronic hepatitis C virus-infected persons can harbour viral variants that are not detected in plasma samples. We explored the presence and persistence of HCV genotypes in plasma and PBMC cultures from 25 HCV-monoinfected and 25 HIV/HCV-coinfected patients with haemophili...

journal_title：Journal of viral hepatitis

authors： Parodi C,García G,Monzani MC,Culasso A,Aloisi N,Corti M,Campos R,de E de Bracco MM,Baré P

更新日期：2015-07-01 00:00:00

abstract：:Improved understanding of natural history of hepatitis C virus (HCV) RNA levels in chronic infection provides enhanced insights into immunopathogenesis of HCV and has implications for the clinical management of chronic HCV infection. This study assessed factors associated with HCV RNA levels during early chronic infec...

journal_title：Journal of viral hepatitis

authors： Hajarizadeh B,Grady B,Page K,Kim AY,McGovern BH,Cox AL,Rice TM,Sacks-Davis R,Bruneau J,Morris M,Amin J,Schinkel J,Applegate T,Maher L,Hellard M,Lloyd AR,Prins M,Geskus RB,Dore GJ,Grebely J,InC3 Study Group.

更新日期：2015-09-01 00:00:00

abstract：:Seroconversion from hepatitis B surface antigen (HBsAg) to antibodies against HBsAg (anti-HBs) usually indicates resolution of hepatitis B virus (HBV) infection. Here, two HBV-infected patients with seroconversion to anti-HBs were found to be persistently positive for HBeAg and HBV DNA. Immunohistology of liver biopsi...

journal_title：Journal of viral hepatitis

authors： Zhang ZH,Li L,Zhao XP,Glebe D,Bremer CM,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Gerlich W,Roggendorf M,Li X,Lu M,Yang DL

更新日期：2011-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that regulates gene expression of inflammatory mediators in liver injury. Hepatitis B virus (HBV) suppresses the PPAR gamma-mediated transactivation in liver cancerous cell lines. However, the role of PPAR gamma in patients with chroni...

journal_title：Journal of viral hepatitis

authors： Zhao Q,Fan YC,Zhao J,Gao S,Zhao ZH,Wang K

更新日期：2013-06-01 00:00:00

abstract：:To determine if chemiluminescence can be used in an enzyme immunoassay (EIA) format to test for hepatitis C virus (HCV) antibody and to compare sensitivity and specificity of chemiluminescence to a licensed anti-HCV EIA method, random volunteer donor samples were evaluated. One thousand and seventy-four random volunte...

journal_title：Journal of viral hepatitis

authors： Ornopia GL,Kuramoto K

更新日期：1995-01-01 00:00:00

abstract：:Socio-demographic and behavioural characteristics are associated with delayed diagnosis and disease progression in HCV-infected persons. However, many analyses focused on single variables rather than groups defined by several variables. We used latent class analysis to study all 4488 persons enrolled in the Swiss Hepa...

journal_title：Journal of viral hepatitis

authors： Giudici F,Bertisch B,Negro F,Stirnimann G,Müllhaupt B,Moradpour D,Cerny A,Keiser O,Swiss Hepatitis C Cohort Study.

更新日期：2016-09-01 00:00:00

abstract：:Transcription of p21 was activated in hepatitis C virus (HCV) Core-expressing HepG2 cells where its upstream p53 was stabilized. However, this effect was not absolutely required for the activation of p21 by Core, as demonstrated in Hep3B cells. In addition, an opposite effect on the transcription of p21 was observed i...

journal_title：Journal of viral hepatitis

authors： Kwun HJ,Jang KL

更新日期：2003-07-01 00:00:00