Pharmacokinetics, efficacy and safety of daclatasvir plus asunaprevir in dialysis patients with chronic hepatitis C: pilot study.

abstract：SUMMARY:A simian hepatitis A virus (HAV) was identified retrospectively in a faecal sample from a rhesus monkey in India, inoculated in 1995 with a faecal suspension from a suspected patient of non-A to E hepatitis. The monkey was in captivity for 2 years in one of the experimental primate facilities in western India b...

journal_title：Journal of viral hepatitis

authors： Arankalle VA,Ramakrishnan J

更新日期：2009-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) is commonly transmitted by intravenous drug use (IDU) but drug users are under represented in many treatment cohorts, this is because of the assumption of lowered treatment success. We assessed HCV treatment outcomes in active intravenous drug users and patients on opiate substitution therapy. ...

journal_title：Journal of viral hepatitis

authors： Jafferbhoy H,Miller MH,Dunbar JK,Tait J,McLeod S,Dillon JF

更新日期：2012-02-01 00:00:00

abstract：:Dendritic cells (DCs) in chronic hepatitis C patients display impaired function, although the details remain unclear. To investigate the hepatitis C virus (HCV) protein that has the most impact on DC function, we compared five recombinant proteins and seven HCV protein genes in modulating DC phenotype and function. Im...

journal_title：Journal of viral hepatitis

authors： Takaki A,Tatsukawa M,Iwasaki Y,Koike K,Noguchi Y,Shiraha H,Sakaguchi K,Nakayama E,Yamamoto K

更新日期：2010-08-01 00:00:00

abstract：:Transient elastography (TE) is the reference method to obtain liver stiffness measurements (LSM), but no results are obtained in 3.1% and unreliable in 15.8%. We assessed the applicability and diagnostic accuracy of TE re-evaluation using M and XL probes. From March 2011 to April 2012 868 LSM were performed with the M...

journal_title：Journal of viral hepatitis

authors： Carrión JA,Puigvehí M,Coll S,Garcia-Retortillo M,Cañete N,Fernández R,Márquez C,Giménez MD,Garcia M,Bory F,Solà R

更新日期：2015-03-01 00:00:00

abstract：:A recombinant protein corresponding to part of the amino-terminal domain of hepatitis B virus (HBV) polymerase was expressed in Escherichia coli. Antisera raised against this protein stained hepatocytes, from human liver biopsies, predominantly in the nucleus but some cytoplasmic staining was also observed. No stainin...

journal_title：Journal of viral hepatitis

authors： McGarvey MJ,Goldin RD,Karayiannis P,Thomas HC

更新日期：1996-03-01 00:00:00

abstract：:The aims of the present study were to evaluate the efficacy and tolerability of ledipasvir/sofosbuvir (LDV/SOF) with or without ribavirin in the treatment of chronic hepatitis C (CHC) in patients with advanced liver disease and to analyse whether the use of LDV/SOF treatment is associated with a new occurrence of hepa...

journal_title：Journal of viral hepatitis

authors： Idilman R,Demir M,Aladag M,Erol C,Cavus B,Iliaz R,Koklu H,Cakaloglu Y,Sahin M,Ersoz G,Koksal İ,Karasu Z,Ozgenel M,Turan İ,Gunduz F,Ataseven H,Akdogan M,Kiyici M,Koksal AS,Akhan S,Gunsar F,Tabak F,Kaymakoglu S

更新日期：2019-06-01 00:00:00

abstract：:Previously, we have determined that human annexin V (hAV), a Ca2+-dependent phospholipid-binding protein, and not rat AV, binds specifically to small hepatitis B surface antigen (SHBsAg), and that transfection of a rat hepatoma cell line with a construct containing the hAV gene led to hAV expression and conferred susc...

journal_title：Journal of viral hepatitis

authors： De Meyer S,Gong ZJ,Hertogs K,Depla E,van Pelt JF,Roskams T,Maertens G,Yap SH

更新日期：2000-03-01 00:00:00

abstract：:Reports have described a decrease in glomerular filtration rate (eGFR) associated with tenofovir disoproxil fumarate (TDF) use in HIV positive individuals. However, no study has examined renal function over a prolonged period in HIV/hepatitis B virus (HBV) co-infected patients. We assessed the long-term durability and...

journal_title：Journal of viral hepatitis

authors： Tan LK,Gilleece Y,Mandalia S,Murungi A,Grover D,Fisher M,Atkins M,Nelson M

更新日期：2009-07-01 00:00:00

abstract：:Ultrasound-based elastography and serum indexes have been individually validated as noninvasive methods for staging liver fibrosis in chronic viral hepatitis. We aimed to compare the accuracy of transient elastography (TE), shear wave elastography (SWE), aspartate aminotransferase to platelet index (APRI) and Fibrosis...

journal_title：Journal of viral hepatitis

authors： Udompap P,Sukonrut K,Suvannarerg V,Pongpaibul A,Charatcharoenwitthaya P

更新日期：2020-04-01 00:00:00

abstract：:We evaluated the shift in the characteristics of people who received interferon-based hepatitis C virus (HCV) treatments and those who received recently introduced direct-acting antivirals (DAAs) in British Columbia (BC), Canada. The BC Hepatitis Testers Cohort includes 1.5 million individuals tested for HCV or HIV, o...

journal_title：Journal of viral hepatitis

authors： Janjua NZ,Islam N,Wong J,Yoshida EM,Ramji A,Samji H,Butt ZA,Chong M,Cook D,Alvarez M,Darvishian M,Tyndall M,Krajden M

更新日期：2017-08-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) from 45 treatment naïve, HIV-negative, chronically hepatitis C virus (HCV)-infected patients were analyzed for the presence of HCV RNA. Viral RNA was detected in 73% of the studied patients. Single-strand conformation polymorphism assays and sequence analysis of the HCV 5'unt...

journal_title：Journal of viral hepatitis

authors： Vera-Otarola J,Barría MI,León U,Marsac D,Carvallo P,Soza A,López-Lastra M

更新日期：2009-09-01 00:00:00

abstract：:Despite the availability of effective direct-acting antiviral (DAA) treatments for Hepatitis C virus (HCV) infection, many people remain undiagnosed and untreated. We assessed the cost-effectiveness of a Médecins Sans Frontières (MSF) HCV screening and treatment programme within a primary health clinic in Karachi, Pak...

journal_title：Journal of viral hepatitis

authors： Mafirakureva N,Lim AG,Khalid GG,Aslam K,Campbell L,Zahid H,Van den Bergh R,Falq G,Fortas C,Wailly Y,Auat R,Donchuk D,Loarec A,Coast J,Vickerman P,Walker JG

更新日期：2021-02-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection induces a wide range of chronic liver injury. The mechanism by which HBV evades the immune surveillance system remains obscure. Plasmacytoid dendritic cells (pDCs) seem to be the major endogenous interferon (IFN)-alpha producers and represent one of the most important cell types in th...

journal_title：Journal of viral hepatitis

authors： Wang K,Fan X,Fan Y,Wang B,Han L,Hou Y

更新日期：2007-04-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that regulates gene expression of inflammatory mediators in liver injury. Hepatitis B virus (HBV) suppresses the PPAR gamma-mediated transactivation in liver cancerous cell lines. However, the role of PPAR gamma in patients with chroni...

journal_title：Journal of viral hepatitis

authors： Zhao Q,Fan YC,Zhao J,Gao S,Zhao ZH,Wang K

更新日期：2013-06-01 00:00:00

abstract：:In rare cases, individuals with a history of long-term injecting drug use remain seronegative and aviraemic, despite prolonged and likely repeated exposure to Hepatitis C virus (HCV) through high-risk behaviour. We describe anti-HCV Envelope (E) antibody responses in a prospective cohort of carefully defined highly ex...

journal_title：Journal of viral hepatitis

authors： Mina M,Underwood A,Eltahla A,Wu BR,Walker MR,Bull RA,Lloyd AR

更新日期：2020-10-01 00:00:00

abstract：:Increased infiltration of lymphocytes and induction of damage and destruction of hepatocytes by these lymphocytes are characteristic features of chronic viral hepatitis. As chemokines attract lymphocytes to inflamed tissues, we studied macrophage inflammatory protein (MIP)-3alpha, a CC chemokine, in chronic viral hepa...

journal_title：Journal of viral hepatitis

authors： Yamauchi K,Akbar SM,Horiike N,Michitaka K,Onji M

更新日期：2002-05-01 00:00:00

abstract：:The Campania Region is a geographical area of southern Italy characterized by high incidence rates of hepatocellular carcinoma and of classic Kaposi's sarcoma. Epidemiological investigations carried out among different population groups in this region have found high prevalence rates of both hepatitis C virus (HCV) an...

journal_title：Journal of viral hepatitis

authors： Montella M,Serraino D,Crispo A,Romano N,Fusco M,Goedert JJ

更新日期：2004-05-01 00:00:00

abstract：:The incidence of, and risk factors for, acute hepatitis A (AHA) were assessed by using data collected from the Italian surveillance system of acute viral hepatitis (SEIEVA). To this end, a case-control study within a population-based surveillance for acute viral hepatitis was performed. AHA incidence has been estimate...

journal_title：Journal of viral hepatitis

authors： Tosti ME,Spada E,Romanò L,Zanetti A,Mele A,SEIEVA collaborating group.

更新日期：2008-10-01 00:00:00

abstract：:The focus of this study was to evaluate the safety and efficacy of sequential peginterferon α-2a (Pegasys) therapy for chronic hepatitis B with acute exacerbation [ALT > 10 × upper limit of normal (ULN), bilirubin <2.0 mg/dL]. Four groups of patients categorized by HBeAg status and treatment regimens were studied sinc...

journal_title：Journal of viral hepatitis

authors： Chen CC,Wang PC,Chang HW,Chen CF

更新日期：2012-03-01 00:00:00

abstract：:Socio-demographic and behavioural characteristics are associated with delayed diagnosis and disease progression in HCV-infected persons. However, many analyses focused on single variables rather than groups defined by several variables. We used latent class analysis to study all 4488 persons enrolled in the Swiss Hepa...

journal_title：Journal of viral hepatitis

authors： Giudici F,Bertisch B,Negro F,Stirnimann G,Müllhaupt B,Moradpour D,Cerny A,Keiser O,Swiss Hepatitis C Cohort Study.

更新日期：2016-09-01 00:00:00

abstract：SUMMARY:Treatment of hepatitis C virus (HCV) infection with interferon (IFN)-alpha, as monotherapy or in combination with ribavirin, is associated with significant side-effects including weight loss. The aim of our study was to describe the evolution of body weight during combination antiviral treatment and to examine ...

journal_title：Journal of viral hepatitis

authors： Seyam MS,Freshwater DA,O'Donnell K,Mutimer DJ

更新日期：2005-09-01 00:00:00

abstract：:Both hepatitis B and hepatitis C viruses (HBV and HCV) cause chronic infections worldwide that are associated with development of liver diseases ranging from mild liver inflammation to hepatocellular carcinomas. While efficient preventive vaccines are available for HBV, efforts are ongoing to develop one in case of HC...

journal_title：Journal of viral hepatitis

authors： Inchauspé G,Michel ML

更新日期：2007-11-01 00:00:00

abstract：:In previous hepatitis C virus (HCV) treatment studies, Black patients not only had a lower sustained viral response (SVR) rate to interferon and ribavirin (RBV) than non-Black patients but also a higher frequency of HCV genotype 1 (GT-1) infection. The aim of this community-based study was to determine whether Black p...

journal_title：Journal of viral hepatitis

authors： Bräu N,Bini EJ,Currie S,Shen H,Schmidt WN,King PD,Ho SB,Cheung RC,Hu KQ,Anand BS,Simon FR,Aytaman A,Johnson DP,Awad JA,Ahmad J,Mendenhall CL,Pedrosa MC,Moseley RH,Hagedorn CH,Waters B,Chang KM,Morgan TR,Rossi

更新日期：2006-04-01 00:00:00

abstract：:Improved understanding of natural history of hepatitis C virus (HCV) RNA levels in chronic infection provides enhanced insights into immunopathogenesis of HCV and has implications for the clinical management of chronic HCV infection. This study assessed factors associated with HCV RNA levels during early chronic infec...

journal_title：Journal of viral hepatitis

authors： Hajarizadeh B,Grady B,Page K,Kim AY,McGovern BH,Cox AL,Rice TM,Sacks-Davis R,Bruneau J,Morris M,Amin J,Schinkel J,Applegate T,Maher L,Hellard M,Lloyd AR,Prins M,Geskus RB,Dore GJ,Grebely J,InC3 Study Group.

更新日期：2015-09-01 00:00:00

abstract：:The global scale-up of hepatitis C virus (HCV) diagnosis requires simplified and affordable HCV diagnostic pathways. This study evaluated the sensitivity and specificity of the HCV Architect core antigen (HCVcAg) assay for detection of active HCV infection in plasma and capillary whole blood dried blood spots (DBS) co...

journal_title：Journal of viral hepatitis

authors： Catlett B,Lamoury FMJ,Bajis S,Hajarizadeh B,Martinez D,Mowat Y,Cunningham PH,Jacka BP,Cloherty GA,Marks P,Dore GJ,Grebely J,Applegate TL

更新日期：2019-12-01 00:00:00

abstract：:The study included 309 HIV-infected pregnant women receiving a lamivudine-containing antiretroviral regimen from week 25 of gestational age until 6 months postpartum, during breastfeeding. Twenty-seven of them (8.7%) were hepatitis B virus surface antigen (HBsAg) positive; at baseline, hepatitis B virus (HBV) DNA leve...

journal_title：Journal of viral hepatitis

authors： Pirillo MF,Scarcella P,Andreotti M,Jere H,Buonomo E,Sagno JB,Amici R,Mancini MG,Leone P,Ceffa S,Mancinelli S,Marazzi MC,Vella S,Palombi L,Giuliano M

更新日期：2015-03-01 00:00:00

abstract：:The potential interaction between chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD), two of the most prevalent liver diseases worldwide, has not been well defined. We performed liver stiffness (LS) and controlled attenuation parameter (CAP) measurements using transient elastography in 1202 CHB pat...

journal_title：Journal of viral hepatitis

authors： Hui RWH,Seto WK,Cheung KS,Mak LY,Liu KSH,Fung J,Wong DK,Lai CL,Yuen MF

更新日期：2018-01-01 00:00:00

abstract：:The aim of the study was to analyse the current literature regarding the mode of transmission of HCV and its global prevalence in different groups of people. A systematic review of the literature on the epidemiology of hepatitis C from 1991 to 2000 using computerized bibliographic databases which include Medline, Curr...

journal_title：Journal of viral hepatitis

authors： Memon MI,Memon MA

更新日期：2002-03-01 00:00:00

abstract：:Only in a minority of patients with chronic hepatitis B (CHB) will treatment with interferon (IFN)-alpha or nucleoside analogues lead to sustained virological response. In vivo immunization (IVI) following virus suppression aims to optimize conditions for an effective immune response: following rapid and profound viru...

journal_title：Journal of viral hepatitis

authors： Sprengers D,van der Molen RG,Binda R,Kusters JG,de Man RA,Niesters HG,Schalm SW,Janssen HL

更新日期：2007-10-01 00:00:00

abstract：:Primary or secondary failure of adefovir dipivoxil (ADV) therapy of chronic hepatitis B is not infrequent. The reasons for suboptimal responses are not well defined. In HIV and hepatitis C virus infection, failure of antiviral drug therapy has been linked with low blood drug levels. We have studied 20 well-defined pat...

journal_title：Journal of viral hepatitis

authors： Deterding K,Naesens L,Buti M,Janssen H,Kirschner J,Guerrero A,Reijnders J,Neyts J,Zoulim F,Wedemeyer H

更新日期：2011-07-01 00:00:00