Abstract:
:The potential interaction between chronic hepatitis B (CHB) and nonalcoholic fatty liver disease (NAFLD), two of the most prevalent liver diseases worldwide, has not been well defined. We performed liver stiffness (LS) and controlled attenuation parameter (CAP) measurements using transient elastography in 1202 CHB patients. Of these, 601 steatotic patients were matched with nonsteatotic controls in a 1:1 ratio by age, gender, nucleoside analogue treatment status, and treatment duration. Severe fibrosis was defined according to EASL-ALEH criteria, and steatosis was defined as CAP ≥222 dB m-1 . Anthropometric measurements and metabolic-related parameters were recorded. The mean age of the 1202 patients (51.4% male) was 51.8 years. 696 patients (57.9%) were on nucleoside analogues for a median duration of 76.2 months. Among treatment-naïve patients, median serum HBV DNA was lower in steatotic individuals than in controls (3.0 vs 3.4 log IU mL-1 , P < .05), with this inverse relationship remaining significant in multivariate analysis (odds ratio 0.859, 95% CI 0.743-0.994, P < .05). With increased steatosis severity, there was a stepwise decrease in median HBV DNA levels (3.1 and 2.6 log IU mL-1 in no steatosis and severe steatosis, respectively, P = .032). Steatosis was associated with a higher median LS (5.4 kPa vs 5.0 kPa, P < .001). Severe steatosis, when compared to mild/moderate steatosis, was associated with an increased percentage of severe fibrosis (23.2% and 12.6%, respectively, P = .005). We conclude that severe steatosis was associated with increased fibrosis in CHB patients. Increasing steatosis was independently associated with lower serum HBV DNA levels, suggesting its potential negative effects on viral replication.
journal_name
J Viral Hepatjournal_title
Journal of viral hepatitisauthors
Hui RWH,Seto WK,Cheung KS,Mak LY,Liu KSH,Fung J,Wong DK,Lai CL,Yuen MFdoi
10.1111/jvh.12766subject
Has Abstractpub_date
2018-01-01 00:00:00pages
97-104issue
1eissn
1352-0504issn
1365-2893journal_volume
25pub_type
杂志文章abstract::Mixed cryoglobulinaemia, when not secondary to other well-defined immunological disorders, is commonly associated with hepatitis C virus (HCV) infection. However, a minority of cases lack evidence of HCV infection and are, therefore, defined as 'true essential' mixed cryoglobulinaemias. We thoroughly investigated thre...
journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1046/j.1365-2893.2003.00462.x
更新日期:2003-11-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/jvh.12351
更新日期:2015-01-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/j.1365-2893.2011.01529.x
更新日期:2012-02-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2893.1996.tb00094.x
更新日期:1996-07-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/j.1365-2893.2011.01486.x
更新日期:2011-10-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/j.1365-2893.2012.01613.x
更新日期:2013-05-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/jvh.12996
更新日期:2019-01-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2893.1997.00146.x
更新日期:1997-05-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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更新日期:1998-11-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,多中心研究
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更新日期:2006-04-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1046/j.1365-2893.2001.00273.x
更新日期:2001-03-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1365-2893.2000.00230.x
更新日期:2000-07-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/jvh.12258
更新日期:2015-02-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2893.2011.01485.x
更新日期:2012-04-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
doi:10.1111/j.1365-2893.1997.tb00180.x
更新日期:1997-01-01 00:00:00