Clinical importance of serum hepatitis B surface antigen levels in chronic hepatitis B.

abstract：:To study the correlation between total Hepatitis C virus (HCV) Core antigen (Ag) and HCV-RNA, and to assess the proficiency of HCV Core Ag testing in monitoring and predicting virologic response during and after pegylated interferon (PEG-IFN) and ribavirin combination therapy. A total of 307 samples from treated and u...

journal_title：Journal of viral hepatitis

authors： Maynard M,Pradat P,Berthillon P,Picchio G,Voirin N,Martinot M,Marcellin P,Trepo C

更新日期：2003-07-01 00:00:00

abstract：:Anaemia during peginterferon (PEG-IFN) and ribavirin (RBV) therapy is common in human immunodeficiency virus/hepatitis C virus (HIV/HCV)-coinfected patients despite the use of lower doses of RBV than are recommended for HIV-seronegative persons. In addition, concurrent zidovudine (ZDV) may exacerbate the anaemia cause...

journal_title：Journal of viral hepatitis

authors： Alvarez D,Dieterich DT,Brau N,Moorehead L,Ball L,Sulkowski MS

更新日期：2006-10-01 00:00:00

abstract：:Patients with biopsy-proven chronic hepatitis C, who failed to respond to a previous course of either recombinant (rIFN-alpha) or lymphoblastoid (Ly IFN-alpha) interferon-alpha, were randomized to receive either leucocyte (Le) IFN-alpha (patients) or a second course of the same IFN-alpha (controls), to compare the eff...

journal_title：Journal of viral hepatitis

authors： Gaeta GB,Di Virgilio D,Russo G,Stornaiuolo G,Nicolella U,Colella F,Grimaldi M,Pasquale G,Giusti G

更新日期：1997-05-01 00:00:00

abstract：:The triglycerides × glucose (TyG) index is a recently proposed surrogate marker of insulin resistance (IR), calculated from fasting plasma triglyceride and glucose concentrations. We tested the host and viral factors associated with Tyg and homeostasis model assessment (HOMA) scores, comparing their associations with ...

journal_title：Journal of viral hepatitis

authors： Petta S,Di Marco V,Di Stefano R,Cabibi D,Cammà C,Marchesini G,Craxì A

更新日期：2011-07-01 00:00:00

abstract：:Despite the availability of effective direct-acting antiviral (DAA) treatments for Hepatitis C virus (HCV) infection, many people remain undiagnosed and untreated. We assessed the cost-effectiveness of a Médecins Sans Frontières (MSF) HCV screening and treatment programme within a primary health clinic in Karachi, Pak...

journal_title：Journal of viral hepatitis

authors： Mafirakureva N,Lim AG,Khalid GG,Aslam K,Campbell L,Zahid H,Van den Bergh R,Falq G,Fortas C,Wailly Y,Auat R,Donchuk D,Loarec A,Coast J,Vickerman P,Walker JG

更新日期：2021-02-01 00:00:00

abstract：:The study aimed to assess whether caesarean section and nonbreastfeeding can prevent mother-to-child transmission (MTCT) in HBsAg- and HBeAg-positive mothers via a cohort study and a meta-analysis. (1) Pregnant women who were positive for HBsAg and HBeAg and did not receive antiviral treatment during pregnancy were re...

journal_title：Journal of viral hepatitis

authors： Pan YC,Jia ZF,Wang YQ,Yang N,Liu JX,Zhai XJ,Song Y,Wang C,Li J,Jiang J

更新日期：2020-10-01 00:00:00

abstract：:Improved understanding of natural history of hepatitis C virus (HCV) RNA levels in chronic infection provides enhanced insights into immunopathogenesis of HCV and has implications for the clinical management of chronic HCV infection. This study assessed factors associated with HCV RNA levels during early chronic infec...

journal_title：Journal of viral hepatitis

authors： Hajarizadeh B,Grady B,Page K,Kim AY,McGovern BH,Cox AL,Rice TM,Sacks-Davis R,Bruneau J,Morris M,Amin J,Schinkel J,Applegate T,Maher L,Hellard M,Lloyd AR,Prins M,Geskus RB,Dore GJ,Grebely J,InC3 Study Group.

更新日期：2015-09-01 00:00:00

abstract：:For hepatitis B virus (HBV)-related chronic infection under treatment by nucleos(t)ide analogues (NUCs), HBsAg clearance is the ultimate therapeutic goal but very infrequent. We investigated how HBV envelope protein variability could lead to differential HBsAg clearance on NUCs. For 12 HBV genotype D patients receivin...

journal_title：Journal of viral hepatitis

authors： Velay A,Jeulin H,Eschlimann M,Malvé B,Goehringer F,Bensenane M,Frippiat JP,Abraham P,Ismail AM,Murray JM,Combet C,Zoulim F,Bronowicki JP,Schvoerer E

更新日期：2016-05-01 00:00:00

abstract：:CD4+ T cells are thought to contribute to antiviral immune responses by secretion of cytokines thereby providing help to CD8+ T and B cells. However, perforin-positive cytotoxic CD4+ T cells have been described in human immunodeficiency virus-positive patients suggesting a role not only of CD8+ but also of CD4+ T cell...

journal_title：Journal of viral hepatitis

authors： Aslan N,Yurdaydin C,Wiegand J,Greten T,Ciner A,Meyer MF,Heiken H,Kuhlmann B,Kaiser T,Bozkaya H,Tillmann HL,Bozdayi AM,Manns MP,Wedemeyer H

更新日期：2006-08-01 00:00:00

abstract：:GS-9857, an inhibitor of the hepatitis C virus (HCV) nonstructural protein (NS) 3/4A, demonstrates potent activity against HCV genotypes 1-6 and improved coverage against commonly encountered NS3 resistance-associated variants (RAVs). In this study, the safety, tolerability, antiviral activity and pharmacokinetics (PK...

journal_title：Journal of viral hepatitis

authors： Rodriguez-Torres M,Glass S,Hill J,Freilich B,Hassman D,Di Bisceglie AM,Taylor JG,Kirby BJ,Dvory-Sobol H,Yang JC,An D,Stamm LM,Brainard DM,Kim S,Krefetz D,Smith W,Marbury T,Lawitz E

更新日期：2016-08-01 00:00:00

abstract：AIM:Elevated body mass index (BMI) in chronic hepatitis C (CHC) has been associated with reduced rates of sustained virological response (SVR). The aims of this study were to determine whether early viral kinetics (and subsequently SVR) are influenced by weight or BMI by measuring HCV RNA at week 4 using two PCR assays...

journal_title：Journal of viral hepatitis

authors： Pattullo V,Ravindran NC,Mazzulli T,Wong DK,Heathcote EJ

更新日期：2010-12-01 00:00:00

abstract：:The Fas / Fas-ligand (FasL) system is an important death signal pathway in the liver. An enhanced local inflammatory response prompted by FasL expression, which contributes to neutrophil recruitment and interleukin-1 beta (IL-1beta) release, seems to be crucial to chronic liver damage, persistence of viral infections,...

journal_title：Journal of viral hepatitis

authors： Bortolami M,Kotsafti A,Cardin R,Farinati F

更新日期：2008-07-01 00:00:00

abstract：:Favourable efficacy and safety profiles for simeprevir in combination with pegylated interferon alpha (PEG-IFNα) and ribavirin (triple therapy) have been shown in clinical trials. This study was carried out to evaluate the effectiveness of simeprevir-based triple therapy for patients with prior telaprevir treatment fa...

journal_title：Journal of viral hepatitis

authors： Ogawa E,Furusyo N,Dohmen K,Kajiwara E,Kawano A,Nomura H,Takahashi K,Satoh T,Azuma K,Nakamuta M,Koyanagi T,Kotoh K,Shimoda S,Hayashi J,Kyushu University Liver Disease Study (KULDS) Group.

更新日期：2015-12-01 00:00:00

abstract：:Ultrasound-based elastography and serum indexes have been individually validated as noninvasive methods for staging liver fibrosis in chronic viral hepatitis. We aimed to compare the accuracy of transient elastography (TE), shear wave elastography (SWE), aspartate aminotransferase to platelet index (APRI) and Fibrosis...

journal_title：Journal of viral hepatitis

authors： Udompap P,Sukonrut K,Suvannarerg V,Pongpaibul A,Charatcharoenwitthaya P

更新日期：2020-04-01 00:00:00

abstract：:Treating chronic hepatitis C with pegylated interferon alpha may induce or exacerbate psychiatric illness including depression, mania and aggressive behaviour. There is limited data regarding treatment in the context of chronic schizophrenia. We sought to establish the safety and efficacy of treating patients with sch...

journal_title：Journal of viral hepatitis

authors： Mustafa MZ,Schofield J,Mills PR,Priest M,Fox R,Datta S,Morris J,Forrest EH,Gillespie R,Stanley AJ,Barclay ST

更新日期：2014-07-01 00:00:00

abstract：:Through molecular virological testing it is now clear that HCV reinfection of the allograft is virtually universal in liver transplant recipients. Although histopathological recurrence of hepatitis C occurs in the majority of patients, it is absent in a substantial minority. To date, no prognostic factors, other than ...

journal_title：Journal of viral hepatitis

authors： Vierling JM,Villamil FG,Rojter SE,Camacho KB,Goldman DE

更新日期：1997-01-01 00:00:00

abstract：:This study estimated latent classes (ie, unobserved subgroups in a population) of people who use drugs in Vancouver, Canada, and examined how these classes relate to phylogenetic clustering of hepatitis C virus (HCV) infection. HCV antibody-positive people who use drugs from two cohorts in Vancouver, Canada (1996-2012...

journal_title：Journal of viral hepatitis

authors： Jacka B,Bray BC,Applegate TL,Marshall BDL,Lima VD,Hayashi K,DeBeck K,Raghwani J,Harrigan PR,Krajden M,Montaner JSG,Grebely J Senior

更新日期：2018-01-01 00:00:00

abstract：:Transcription of p21 was activated in hepatitis C virus (HCV) Core-expressing HepG2 cells where its upstream p53 was stabilized. However, this effect was not absolutely required for the activation of p21 by Core, as demonstrated in Hep3B cells. In addition, an opposite effect on the transcription of p21 was observed i...

journal_title：Journal of viral hepatitis

authors： Kwun HJ,Jang KL

更新日期：2003-07-01 00:00:00

abstract：:Due to the severe shortage of the donor pool in China, a large number of patients are waiting for a suitable liver, or even worse lose the opportunity of transplantation. Reasonable use of hepatitis B surface antigen-positive (HBsAg-positive) donors is one possible strategy to increase the donor pool but the long-term...

journal_title：Journal of viral hepatitis

authors： Wei L,Chen D,Zhang B,Zhao Y,Liu B,Shi H,Zeng F,Ming C,Jiang J,Du D,Chen Z

更新日期：2018-12-01 00:00:00

abstract：:Acute kidney injury (AKI) is a common complication in patients with decompensated cirrhosis and is also an important cause for poor outcome. This study aimed at investigating the clinical characteristics and long-term prognosis of AKI in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACL...

journal_title：Journal of viral hepatitis

authors： Shi X,Zhu P,Yan G,Liu C,Zhang C,Huang G,Zhang Y,Yan Z,Wang Y

更新日期：2016-11-01 00:00:00

abstract：:Long-term safety of treatment with hepatitis B virus (HBV) polymerase inhibitors is a concern. Adefovir dipivoxil (ADV) therapy has previously been associated with impairment of renal function. Limited data are available on the safety of combination therapy with nucleos(t)ide analogues and interferon alfa (IFNα). The ...

journal_title：Journal of viral hepatitis

authors： Mederacke I,Yurdaydin C,Großhennig A,Erhardt A,Cakaloglu Y,Yalcin K,Gurel S,Zeuzem S,Zachou K,Chatzikyrkou C,Bozkaya H,Dalekos GN,Manns MP,Wedemeyer H,Hep-Net\/International Delta Hepatitis Study Group.

更新日期：2012-06-01 00:00:00

abstract：:We aimed to compare the evolution of estimated glomerular filtration rate (eGFR) in HIV-, HIV-HBV- and HBV-infected patients treated with tenofovir disoproxil fumarate (TDF). Three groups of patients receiving TDF > 12 months were recruited: 194 HIV-infected patients, 85 HIV-HBV-coinfected patients and 50 HBV-infected...

journal_title：Journal of viral hepatitis

authors： Pradat P,Le Pogam MA,Okon JB,Trolliet P,Miailhes P,Brochier C,Maynard M,Bailly F,Zoulim F,Cotte L

更新日期：2013-09-01 00:00:00

abstract：:Understanding local viral hepatitis and HIV epidemiology is essential if WHO elimination targets are to be achieved. We demonstrate a consistently high prevalence of undiagnosed active infection in urban emergency department attendees in England, with variations in local risk groups crucial to informing targeted testi...

journal_title：Journal of viral hepatitis

authors： Hopkins MJ,Todd S,Beadsworth M,Anderson C,Mohamed Z,Muir D,Vivancos R,Brown AS,Ruf M,Chawla A

更新日期：2020-01-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV)-infected patients with liver failure have a poor prognosis, and no satisfactory biomarkers are available for diagnosis before the end-stage. We explored serum peptide profiling for diagnosis and prediction of progression to liver failure in HBV-infected patients. Serum samples (164) fro...

journal_title：Journal of viral hepatitis

authors： Han T,Liu H,Yu ZL,Li J,Wang L,Xiao SX,Li Y,Yu ML

更新日期：2010-03-01 00:00:00

abstract：:The establishment of an in vitro system for hepatitis C virus (HCV) propagation is essential to characterize virus replication, virus persistence and viral pathogenicity. The aim was to establish HCV replication in HepG2 cells by gene transfer of infectious HCV cDNA. First, several gene transfer methods were evaluated...

journal_title：Journal of viral hepatitis

authors： Hiramatsu N,Dash S,Gerber MA

更新日期：1997-01-01 00:00:00

abstract：:Travel to endemic areas is one of the most frequently reported risk factors for infection with the hepatitis A virus (HAV). We evaluated the association between HAV infection and travel, by area of destination. We conducted a case-control study on all cases of HAV infection reported to the Italian National Surveillanc...

journal_title：Journal of viral hepatitis

authors： Ciccozzi M,Tosti ME,Gallo G,Ragni P,Zotti C,Lopalco P,Ara G,Sangalli M,Balocchini E,Szklo AS,Mele A,SEIEVA collaborating group.

更新日期：2002-11-01 00:00:00

abstract：:A recombinant protein corresponding to part of the amino-terminal domain of hepatitis B virus (HBV) polymerase was expressed in Escherichia coli. Antisera raised against this protein stained hepatocytes, from human liver biopsies, predominantly in the nucleus but some cytoplasmic staining was also observed. No stainin...

journal_title：Journal of viral hepatitis

authors： McGarvey MJ,Goldin RD,Karayiannis P,Thomas HC

更新日期：1996-03-01 00:00:00

abstract：:Italy is one of the countries on track with the WHO's agenda to eliminate hepatitis C virus (HCV) by 2030. Healthcare facilities play a crucial role in seeking patients who are infected but have not yet been treated. We assessed the effectiveness of a recall strategy, named 'Telepass' project, for patients exposed to ...

journal_title：Journal of viral hepatitis

authors： Ponziani FR,Santopaolo F,Siciliano M,De Belvis AG,Tortora A,Mora V,Fanali C,Morsella A,Balducci F,Vetrugno G,D'Alfonso ME,Cambieri A,Cauda R,Bellantone R,Sanguinetti M,Pompili M,Gasbarrini A

更新日期：2021-01-09 00:00:00

abstract：:Virus-like particles encapsulating HBV-RNA represent a serum biomarker for assessing viral replication activity in clinical practice. However, baseline levels of serum HBV-RNA and their associations with viral replicative intermediates and liver disease in phases of chronic hepatitis B remain unknown. In this cross-se...

journal_title：Journal of viral hepatitis

authors： Wang J,Yu Y,Li G,Shen C,Li J,Chen S,Zhang X,Zhu M,Zheng J,Song Z,Wu J,Shao L,Meng Z,Wang X,Huang Y,Zhang J,Qiu C,Zhang W

更新日期：2018-09-01 00:00:00

abstract：:IL28B and inosine triphosphatase (ITPA) polymorphisms are able to predict treatment response and degree of ribavirin-related anaemia, respectively, in the treatment of chronic hepatitis C virus (HCV) infection. However, their roles in the treatment of chronic HCV genotype 6 remain undetermined. Sixty patients who were...

journal_title：Journal of viral hepatitis

authors： Seto WK,Tsang OT,Liu K,Chan JM,Wong DK,Fung J,Lai CL,Yuen MF

更新日期：2013-07-01 00:00:00