Cytotoxic CD4 T cells in viral hepatitis.

abstract：:Treating chronic hepatitis C with pegylated interferon alpha may induce or exacerbate psychiatric illness including depression, mania and aggressive behaviour. There is limited data regarding treatment in the context of chronic schizophrenia. We sought to establish the safety and efficacy of treating patients with sch...

journal_title：Journal of viral hepatitis

authors： Mustafa MZ,Schofield J,Mills PR,Priest M,Fox R,Datta S,Morris J,Forrest EH,Gillespie R,Stanley AJ,Barclay ST

更新日期：2014-07-01 00:00:00

abstract：:In previous hepatitis C virus (HCV) treatment studies, Black patients not only had a lower sustained viral response (SVR) rate to interferon and ribavirin (RBV) than non-Black patients but also a higher frequency of HCV genotype 1 (GT-1) infection. The aim of this community-based study was to determine whether Black p...

journal_title：Journal of viral hepatitis

authors： Bräu N,Bini EJ,Currie S,Shen H,Schmidt WN,King PD,Ho SB,Cheung RC,Hu KQ,Anand BS,Simon FR,Aytaman A,Johnson DP,Awad JA,Ahmad J,Mendenhall CL,Pedrosa MC,Moseley RH,Hagedorn CH,Waters B,Chang KM,Morgan TR,Rossi

更新日期：2006-04-01 00:00:00

abstract：:Single nucleotide polymorphisms (SNPs) in the interleukin 28B gene (IL28B) are good pretreatment predictors of anti-hepatitis C virus (HCV) therapy with interferon. SNPs of the inosine triphosphatase (ITPA) gene are associated with reduced haemoglobin levels during treatment with ribavirin. The i-densy™ (Arkray, Inc.)...

journal_title：Journal of viral hepatitis

authors： Takahashi H,Mizuta T,Oeda S,Isoda H,Nakashita S,Kawaguchi Y,Izumi N,Hirai M,Kurose K,Iwane S,Eguchi Y,Kimura S,Anzai K,Ozaki I

更新日期：2013-04-01 00:00:00

abstract：:The Fas / Fas-ligand (FasL) system is an important death signal pathway in the liver. An enhanced local inflammatory response prompted by FasL expression, which contributes to neutrophil recruitment and interleukin-1 beta (IL-1beta) release, seems to be crucial to chronic liver damage, persistence of viral infections,...

journal_title：Journal of viral hepatitis

authors： Bortolami M,Kotsafti A,Cardin R,Farinati F

更新日期：2008-07-01 00:00:00

abstract：:Antiviral therapy has been shown to improve the prognosis of hepatitis B virus (HBV) DNA-positive hepatocellular carcinoma (HCC) after radical treatment, but antiviral treatments require further optimization. This study aimed to evaluate the efficacies of different antiviral strategies with HCC patients after hepatect...

journal_title：Journal of viral hepatitis

authors： Qi W,Zhang Q,Xu Y,Wang X,Yu F,Zhang Y,Zhao P,Guo H,Zhou C,Wang Z,Sun Y,Liu L,Xuan W,Wang J

更新日期：2020-04-01 00:00:00

abstract：:Treatment for chronic hepatitis C virus (HCV) infection has rapidly evolved into interferon-free directly acting antiviral regimens (DAA) that result in high sustained virologic response. DAAs primarily work by suppressing HCV replication and rely less on the immune system than interferon-based therapies. However, it ...

journal_title：Journal of viral hepatitis

authors： Shrivastava S,Wilson E,Poonia B,Tang L,Osinusi A,Kohli A,Kottilil S

更新日期：2017-09-01 00:00:00

abstract：:It is unclear whether the achievement of virologic response modifies the risk of hepatocellular carcinoma (HCC) differently in chronic hepatitis B (CHB) and chronic hepatitis C (CHC). Our aim was to compare the risk of HCC between patients with CHB and CHC who achieved virological response. We analysed data from patie...

journal_title：Journal of viral hepatitis

authors： Kim GA,Han S,Kim HD,An J,Lim YS

更新日期：2017-11-01 00:00:00

abstract：:This study assessed the association of HIV RNA with indirect markers of liver injury including FIB-4 index, liver enzymes and platelet counts in a high-risk Hispanic population. The data were derived from a prospective study that included 138 HIV/hepatitis C (HCV)-coinfected and 68 HIV-infected participants without he...

journal_title：Journal of viral hepatitis

authors： Forrester JE,Rhee MS,McGovern BH,Sterling RK,Knox TA,Terrin N

更新日期：2012-02-01 00:00:00

abstract：SUMMARY:A simian hepatitis A virus (HAV) was identified retrospectively in a faecal sample from a rhesus monkey in India, inoculated in 1995 with a faecal suspension from a suspected patient of non-A to E hepatitis. The monkey was in captivity for 2 years in one of the experimental primate facilities in western India b...

journal_title：Journal of viral hepatitis

authors： Arankalle VA,Ramakrishnan J

更新日期：2009-03-01 00:00:00

abstract：:Triple therapy using boceprevir or telaprevir remains the reference treatment for genotype 1 chronic hepatitis C in countries where new interferon-free regimens have not yet become available. Antiviral treatment is highly required in cirrhotic patients, but they represent a difficult-to-treat population. We aimed to d...

journal_title：Journal of viral hepatitis

authors： Boursier J,Ducancelle A,Vergniol J,Veillon P,Moal V,Dufour C,Bronowicki JP,Larrey D,Hézode C,Zoulim F,Fontaine H,Canva V,Poynard T,Allam S,De Lédinghen V,ANRS CO20 CUPIC Study Group.

更新日期：2015-12-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is considered a major health problem in the world. HBV is classified into genotypes A to J disseminated worldwide. Genotypes A, D and F are the most frequent in the Western World, B and C are predominant in the East, and E, F, H and J are infrequent and restricted to specific regions....

journal_title：Journal of viral hepatitis

authors： Wolf JM,De Carli S,Pereira VRZB,Simon D,Lunge VR

更新日期：2021-02-01 00:00:00

abstract：:Increased infiltration of lymphocytes and induction of damage and destruction of hepatocytes by these lymphocytes are characteristic features of chronic viral hepatitis. As chemokines attract lymphocytes to inflamed tissues, we studied macrophage inflammatory protein (MIP)-3alpha, a CC chemokine, in chronic viral hepa...

journal_title：Journal of viral hepatitis

authors： Yamauchi K,Akbar SM,Horiike N,Michitaka K,Onji M

更新日期：2002-05-01 00:00:00

abstract：:DNA-based vaccination appears of promise for chronic hepatitis B immunotherapy, although there is an urgent need to increase its efficacy. In this preclinical study, we evaluated the therapeutic benefit of cytokine (IL-2, IFN-γ) genes co-delivery with DNA vaccine targeting hepadnaviral proteins in the chronic duck hep...

journal_title：Journal of viral hepatitis

authors： Saade F,Buronfosse T,Guerret S,Pradat P,Chevallier M,Zoulim F,Jamard C,Cova L

更新日期：2013-04-01 00:00:00

abstract：:Socio-demographic and behavioural characteristics are associated with delayed diagnosis and disease progression in HCV-infected persons. However, many analyses focused on single variables rather than groups defined by several variables. We used latent class analysis to study all 4488 persons enrolled in the Swiss Hepa...

journal_title：Journal of viral hepatitis

authors： Giudici F,Bertisch B,Negro F,Stirnimann G,Müllhaupt B,Moradpour D,Cerny A,Keiser O,Swiss Hepatitis C Cohort Study.

更新日期：2016-09-01 00:00:00

abstract：:This open label study was initiated to assess the safety and efficacy of lymphoblastoid interferon-alpha (IFN-alpha) and thymosin alpha 1 (T alpha 1) in the treatment of 11 patients with chronic hepatitis B, who had failed to respond to standard IFN-alpha 2b therapy, and in four interferon naive patients. These fiftee...

journal_title：Journal of viral hepatitis

authors： Rasi G,Mutchnick MG,Di Virgilio D,Sinibaldi-Vallebona P,Pierimarchi P,Colella F,Favalli C,Garaci E

更新日期：1996-07-01 00:00:00

abstract：:There is little data on the long-term follow-up outcomes of chronic hepatitis C patients achieving sustained virological response (SVR) after treatment with peglylated interferon-α plus ribavirin. We prospectively investigated the overall clinical, biochemical, virological and histological outcomes in a ten-year cohor...

journal_title：Journal of viral hepatitis

authors： Wang X,Gao F,Yuan G,Shi K,Huang Y,Chen Y,Qiu R,Sun L,Liu J,Hu C,Zhou Y

更新日期：2016-12-01 00:00:00

abstract：:A simple, pangenotypic and effective treatment regimen for patients with a broad range of chronic hepatitis C virus (HCV) infections remains an unmet medical need. We conducted a phase 2, randomized, open study involving untreated patients with chronic HCV genotypes 1, 2, 3, or 6 infections. Patients without cirrhosis...

journal_title：Journal of viral hepatitis

authors： Rao H,Song G,Li G,Yang Y,Wu X,Guan Y,Mao Q,Jiang X,Wang C,Zhang Y,Jia J,Guo X,Li C,Ning J,Qin H,Pan H,Wei L

更新日期：2020-01-01 00:00:00

abstract：:The establishment of an in vitro system for hepatitis C virus (HCV) propagation is essential to characterize virus replication, virus persistence and viral pathogenicity. The aim was to establish HCV replication in HepG2 cells by gene transfer of infectious HCV cDNA. First, several gene transfer methods were evaluated...

journal_title：Journal of viral hepatitis

authors： Hiramatsu N,Dash S,Gerber MA

更新日期：1997-01-01 00:00:00

abstract：:Liver damage may result from multiple factors in HIV-infected patients. The availability of reliable noninvasive tools to measure liver fibrosis has permitted the screening of large patient populations. Cross-sectional study of all consecutive HIV outpatients who underwent examination by transient elastometry (FibroSc...

journal_title：Journal of viral hepatitis

authors： Blanco F,Barreiro P,Ryan P,Vispo E,Martín-Carbonero L,Tuma P,Labarga P,Medrano J,González-Lahoz J,Soriano V

更新日期：2011-01-01 00:00:00

abstract：:The triglycerides × glucose (TyG) index is a recently proposed surrogate marker of insulin resistance (IR), calculated from fasting plasma triglyceride and glucose concentrations. We tested the host and viral factors associated with Tyg and homeostasis model assessment (HOMA) scores, comparing their associations with ...

journal_title：Journal of viral hepatitis

authors： Petta S,Di Marco V,Di Stefano R,Cabibi D,Cammà C,Marchesini G,Craxì A

更新日期：2011-07-01 00:00:00

abstract：:The efficacy of lamivudine re-treatment in chronic hepatitis B (CHB) patients who relapse after HBeAg seroconversion with lamivudine has not been investigated. The aim of this study was to evaluate the efficacy of lamivudine re-treatment in relapsed patients. Among 192 patients who had achieved HBeAg seroconversion wi...

journal_title：Journal of viral hepatitis

authors： Shin JW,Park NH,Park JH,Park JH,Jeong ID,Bang SJ,Joo KR,Kim DH

更新日期：2005-07-01 00:00:00

abstract：:The impact of direct-acting antiviral (DAA) therapies on fibrosis regression remains uncertain. In the current study, we prospectively evaluated dynamics of liver stiffness by transient elastography (TE) in patients with chronic HCV infection receiving DAA-based treatment. Patients (260) were enrolled in the German He...

journal_title：Journal of viral hepatitis

authors： Knop V,Mauss S,Goeser T,Geier A,Zimmermann T,Herzer K,Postel N,Friedrich-Rust M,Hofmann WP,German Hepatitis C-Registry.

更新日期：2020-07-01 00:00:00

abstract：:Autoantibodies are commonly detected in chronic hepatitis C (HCV) but their significance remains uncertain. We assessed the prevalence of anti-nuclear (ANA) and anti-smooth muscle (ASM) antibodies within a cohort of 963 treatment-naïve HCV patients. We also assessed for differences between autoantibody-positive and au...

journal_title：Journal of viral hepatitis

authors： Williams MJ,Lawson A,Neal KR,Ryder SD,Irving WL,Trent HCV Group.

更新日期：2009-05-01 00:00:00

abstract：:The aim of this work was to estimate the future disease burden of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections in the United States until the year 2030. Two back-calculation models of the HIV and the HCV epidemic were developed. They were based on US epidemiological data regarding prevalen...

journal_title：Journal of viral hepatitis

authors： Deuffic-Burban S,Poynard T,Sulkowski MS,Wong JB

更新日期：2007-02-01 00:00:00

abstract：:The association between HBV infection and incident thrombocytopenia among subjects without cirrhosis or splenomegaly is unknown. Therefore, we sought to elucidate the association between HBV infection and the development of thrombocytopenia in a large cohort of apparently healthy men and women. A cohort study was perf...

journal_title：Journal of viral hepatitis

authors： Joo EJ,Chang Y,Yeom JS,Lee YG,Ryu S

更新日期：2017-03-01 00:00:00

abstract：:Oral therapy for chronic hepatitis B remains suboptimal. Mathematical modelling of viral decay kinetics to rapidly assess potential antiviral regimens has proved valuable for human immunodeficiency virus and cytomegalovirus. We defined the kinetics of viral replication in 10 chronic hepatitis B patients randomized to ...

journal_title：Journal of viral hepatitis

authors： Wang CC,Holte S,Huang ML,Sacks SL,Engelberg R,Ferrenberg J,Shuhart M,Corey L

更新日期：2004-09-01 00:00:00

abstract：:Hepatitis E virus (HEV) represents one of the foremost causes of acute hepatitis globally. Although there is no proven medication for hepatitis E, pegylated interferon-α (IFN-α) has been used as off-label drug for treating HEV. However, the efficacy and molecular mechanisms of how IFN signalling interacts with HEV rem...

journal_title：Journal of viral hepatitis

authors： Zhou X,Xu L,Wang W,Watashi K,Wang Y,Sprengers D,de Ruiter PE,van der Laan LJ,Metselaar HJ,Kamar N,Peppelenbosch MP,Pan Q

更新日期：2016-04-01 00:00:00

abstract：:Seroconversion from hepatitis B surface antigen (HBsAg) to antibodies against HBsAg (anti-HBs) usually indicates resolution of hepatitis B virus (HBV) infection. Here, two HBV-infected patients with seroconversion to anti-HBs were found to be persistently positive for HBeAg and HBV DNA. Immunohistology of liver biopsi...

journal_title：Journal of viral hepatitis

authors： Zhang ZH,Li L,Zhao XP,Glebe D,Bremer CM,Zhang ZM,Tian YJ,Wang BJ,Yang Y,Gerlich W,Roggendorf M,Li X,Lu M,Yang DL

更新日期：2011-06-01 00:00:00

abstract：:Although there are no dietary restrictions recommended in acute viral hepatitis (AVH), there is an altered food intake, probably because of perceptions and traditional nutritional practices, leading to sub-optimal intake and poorer clinical outcome. Therefore, we aimed to determine nutritional intake of AVH patients b...

journal_title：Journal of viral hepatitis

authors： Sathiaraj E,Chutke M,Mahurkar S,Nagaraja Rao P,Nageshwar Reddy D

更新日期：2010-05-01 00:00:00

abstract：:The limitations of liver biopsy have led to the development of indirect noninvasive models for liver fibrosis assessment. We aimed to evaluate and compare the performance of 30 noninvasive models to predict fibrosis stage in treatment-naïve and treated chronic hepatitis B (CHB) patients. A total of 576 Chinese treatme...

journal_title：Journal of viral hepatitis

authors： Dong XQ,Wu Z,Zhao H,Wang GQ,China HepB-Related Fibrosis Assessment Research Group.

更新日期：2019-02-01 00:00:00