当前位置： SCI文献检索 > JOURNAL OF VIRAL HEPATITIS期刊下所有文献 > Augmentation of hepatitis C virus-specific immunity and sustained virologic response.

Augmentation of hepatitis C virus-specific immunity and sustained virologic response.

Abstract：

:Treatment for chronic hepatitis C virus (HCV) infection has rapidly evolved into interferon-free directly acting antiviral regimens (DAA) that result in high sustained virologic response. DAAs primarily work by suppressing HCV replication and rely less on the immune system than interferon-based therapies. However, it is unclear whether the immune system recovers with suppression of HCV replication and contributes to HCV clearance with DAA therapy. We previously demonstrated HCV clearance is associated with increased HCV-specific immunity in CHCV-GT-1-infected patients during treatment with sofosbuvir (SOF)+ribavirin (RBV). Here, we aimed to analyse changes in HCV-specific immunological responses associated with viral clearance with combination DAA therapy of SOF+ledipasvir (LDV) for 12 weeks in CHCV-GT1 (N=14) patients who relapsed without augmentation of HCV-specific immunity during treatment with SOF+RBV. Phenotypic and functional changes within the T-cell compartment of PBMCs pre- and post-treatment were analysed. Retreatment of relapsers with LDV/SOF resulted in all patients attaining SVR12 . Suppression of HCV was associated with a decline in T-cell exhaustion markers (CD57; Tim3; PD1) along with augmented of HCV-specific T-cell IFN-gamma responses post-treatment. Addition of LDV to SOF was associated with augmentation of HCV-specific immunity and SVR in patients who previously failed SOF+RBV therapy without increased immunity. These findings demonstrate a novel effect of DAA in inducing host immune responses to aid HCV clearance and achieve SVR.

journal_name

J Viral Hepat

journal_title

Journal of viral hepatitis

authors

Shrivastava S,Wilson E,Poonia B,Tang L,Osinusi A,Kohli A,Kottilil S

doi

10.1111/jvh.12702

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

742-749

issue

9

eissn

1352-0504

issn

1365-2893

journal_volume

24

pub_type

杂志文章

相关文献

JOURNAL OF VIRAL HEPATITIS文献大全
  • Temporal evolution and global spread of hepatitis B virus genotype G.

    abstract：:Hepatitis B virus (HBV) infection is considered a major health problem in the world. HBV is classified into genotypes A to J disseminated worldwide. Genotypes A, D and F are the most frequent in the Western World, B and C are predominant in the East, and E, F, H and J are infrequent and restricted to specific regions....

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13431

    authors： Wolf JM,De Carli S,Pereira VRZB,Simon D,Lunge VR

    更新日期：2021-02-01 00:00:00

  • In vivo infectivity of liver extracts after resolution of hepadnaviral infection following therapy associating DNA vaccine and cytokine genes.

    abstract：:DNA-based vaccination appears of promise for chronic hepatitis B immunotherapy, although there is an urgent need to increase its efficacy. In this preclinical study, we evaluated the therapeutic benefit of cytokine (IL-2, IFN-γ) genes co-delivery with DNA vaccine targeting hepadnaviral proteins in the chronic duck hep...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12023

    authors： Saade F,Buronfosse T,Guerret S,Pradat P,Chevallier M,Zoulim F,Jamard C,Cova L

    更新日期：2013-04-01 00:00:00

  • Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity.

    abstract：:Phytochemicals exert antiviral activity and may play a potential therapeutic role in hepatitis C virus (HCV) infection. In this work, we aimed to isolate NS3 inhibitors from traditional Indian medicinal plants that were found, in our earlier study, to inhibit HCV NS3 protease activity and to evaluate their potential t...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01507.x

    authors： Bachmetov L,Gal-Tanamy M,Shapira A,Vorobeychik M,Giterman-Galam T,Sathiyamoorthy P,Golan-Goldhirsh A,Benhar I,Tur-Kaspa R,Zemel R

    更新日期：2012-02-01 00:00:00

  • Hepatitis C: What is the best treatment?

    abstract：:The treatment of hepatitis C is expensive, difficult and arduous from the patient's perspective. It is similarly difficult for the clinician to decide who and when to treat. If hepatitis C is viewed from the liver's perspective we need only treat those patients who will develop the complications of chronic liver disea...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2893.2004.00573.x

    authors： Dillon JF

    更新日期：2004-09-01 00:00:00

  • HBsAg plasma level kinetics: a new role for an old marker as a therapy response predictor in vertically infected children on combination therapy.

    abstract：:We aimed to investigate the ability of HBsAg plasma level kinetics to predict therapy response by studying 23 children with infancy-acquired chronic hepatitis B (CHB) during combination sequential therapy with lead-in lamivudine (LAM) and add-on interferon-α (IFN-α) [5 responders (R = anti-HBs seroconversion) and 18 n...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12316

    authors： Carey I,Bruce M,Horner M,Zen Y,D'Antiga L,Bansal S,Vergani D,Mieli-Vergani G

    更新日期：2015-04-01 00:00:00

  • Methamphetamine enhances Hepatitis C virus replication in human hepatocytes.

    abstract：:Very little is known about the interactions between hepatitis C virus (HCV) and methamphetamine, which is a highly abused psychostimulant and a known risk factor for human immunodeficiency virus (HIV)/HCV infection. This study examined whether methamphetamine has the ability to inhibit innate immunity in the host cell...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2007.00940.x

    authors： Ye L,Peng JS,Wang X,Wang YJ,Luo GX,Ho WZ

    更新日期：2008-04-01 00:00:00

  • Anti-envelope antibody responses in highly exposed seronegative individuals may be associated with protection from HCV infection.

    abstract：:In rare cases, individuals with a history of long-term injecting drug use remain seronegative and aviraemic, despite prolonged and likely repeated exposure to Hepatitis C virus (HCV) through high-risk behaviour. We describe anti-HCV Envelope (E) antibody responses in a prospective cohort of carefully defined highly ex...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13339

    authors： Mina M,Underwood A,Eltahla A,Wu BR,Walker MR,Bull RA,Lloyd AR

    更新日期：2020-10-01 00:00:00

  • Hepatocyte apoptotic bodies encasing nonstructural HCV proteins amplify hepatic stellate cell activation: implications for chronic hepatitis C.

    abstract：:Chronic hepatitis C infection leads to increased hepatocyte apoptosis. Because engulfment of apoptotic bodies (ABs) by hepatic stellate cells (HSC) is profibrogenic, we compared the effects of ABs derived from hepatitis C virus (HCV)-negative vs HCV-infected (Con1+) Huh7 hepatoblastoma cells on fibrogenic and activati...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2010.01362.x

    authors： Gieseler RK,Marquitan G,Schlattjan M,Sowa JP,Bechmann LP,Timm J,Roggendorf M,Gerken G,Friedman SL,Canbay A

    更新日期：2011-11-01 00:00:00

  • Comparison of liver disease state progression in patients with eradication of versus persistent infection with hepatitis C virus: Markov chain analysis.

    abstract：:To investigate the long-term prognosis of liver disease in patients with hepatitis C virus (HCV) eradication after antiviral therapy versus those with persistent HCV infection. Four hundred and eighty patients (5259 person-years [PYs]) who received interferon-based therapy and achieved sustained virologic response and...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13444

    authors： Tada T,Toyoda H,Kumada T,Kurisu A,Sugiyama A,Akita T,Ohisa M,Aikata H,Miki D,Chayama K,Tanaka J

    更新日期：2020-11-20 00:00:00

  • Semiquantitative assessment of IgM antibody to hepatitis B core antigen and prediction of the severity of chronic hepatitis B.

    abstract：:Controversial results have been reported concerning the correlation between serum levels of IgM antibodies to hepatitis B core antigen (IgM HBcAb) and the histological activity of chronic hepatitis B. In this study, paired serum samples and liver biopsies were collected from 200 consecutive chronic hepatitis B patient...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1046/j.1365-2893.1999.00171.x

    authors： Colloredo G,Bellati G,Sonzogni A,Zavaglia C,Fracassetti O,Leandro G,Ghislandi R,Minola E,Ideo G

    更新日期：1999-11-01 00:00:00

  • Changes in characteristics of hepatitis C patients seen in a liver centre in the United States during the last decade.

    abstract：:With the approval of 2 direct-acting antivirals (DAAs) in 2011 and anticipation of interferon (IFN)-free regimens, more hepatitis C virus (HCV) chronically infected patients are now seeking treatment. To describe the characteristics of newly referred HCV patients in 2011-2012 (Era-2) and compare them to those seen in ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12343

    authors： Talaat N,Yapali S,Fontana RJ,Conjeevaram HS,Lok AS

    更新日期：2015-05-01 00:00:00

  • Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein.

    abstract：:Hepatitis A virus (HAV) infection is still an important issue worldwide. A distinct set of viruses encode proteins that enhance viral cap-independent translation initiation driven by an internal ribosome entry site (IRES) and suppress cap-dependent host translation. Unlike cytolytic picornaviruses, replication of HAV ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2009.01221.x

    authors： Kanda T,Gauss-Müller V,Cordes S,Tamura R,Okitsu K,Shuang W,Nakamoto S,Fujiwara K,Imazeki F,Yokosuka O

    更新日期：2010-09-01 00:00:00

  • Hepatitis C: an epidemiological review.

    abstract：:The aim of the study was to analyse the current literature regarding the mode of transmission of HCV and its global prevalence in different groups of people. A systematic review of the literature on the epidemiology of hepatitis C from 1991 to 2000 using computerized bibliographic databases which include Medline, Curr...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2893.2002.00329.x

    authors： Memon MI,Memon MA

    更新日期：2002-03-01 00:00:00

  • Drug use and phylogenetic clustering of hepatitis C virus infection among people who use drugs in Vancouver, Canada: A latent class analysis approach.

    abstract：:This study estimated latent classes (ie, unobserved subgroups in a population) of people who use drugs in Vancouver, Canada, and examined how these classes relate to phylogenetic clustering of hepatitis C virus (HCV) infection. HCV antibody-positive people who use drugs from two cohorts in Vancouver, Canada (1996-2012...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12758

    authors： Jacka B,Bray BC,Applegate TL,Marshall BDL,Lima VD,Hayashi K,DeBeck K,Raghwani J,Harrigan PR,Krajden M,Montaner JSG,Grebely J Senior

    更新日期：2018-01-01 00:00:00

  • Exposure to hepatitis B and C of tattooists in Victoria in 1984.

    abstract：:Although tattooing is recognized as a risk factor for transmission of hepatitis C, the efficiency with which transmission occurs is unknown. Sera stored from a serosurvey of tattooists undertaken in 1984 to test for human immunodeficiency virus (HIV) provided the opportunity to determine the prevalence of serological ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.1997.tb00216.x

    authors： Thompson SC,Goudey RE,Breschkin AM,Carnie J,Catton M

    更新日期：1997-03-01 00:00:00

  • Factors associated with hepatitis C virus RNA levels in early chronic infection: the InC3 study.

    abstract：:Improved understanding of natural history of hepatitis C virus (HCV) RNA levels in chronic infection provides enhanced insights into immunopathogenesis of HCV and has implications for the clinical management of chronic HCV infection. This study assessed factors associated with HCV RNA levels during early chronic infec...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12384

    authors： Hajarizadeh B,Grady B,Page K,Kim AY,McGovern BH,Cox AL,Rice TM,Sacks-Davis R,Bruneau J,Morris M,Amin J,Schinkel J,Applegate T,Maher L,Hellard M,Lloyd AR,Prins M,Geskus RB,Dore GJ,Grebely J,InC3 Study Group.

    更新日期：2015-09-01 00:00:00

  • Serum miR-122 may serve as a biomarker for response to direct acting antivirals: effect of paritaprevir/R with dasabuvir or ombitasvir on miR-122 in HCV-infected subjects.

    abstract：:Circulating microRNAs (miRNA) have been intensely investigated as biomarkers in disease and therapy. Several studies have identified miR-122 as an important regulator of HCV replication. The effect of new therapies that directly target the HCV replication life cycle on circulating microRNA levels has not been elucidat...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,多中心研究

    doi：10.1111/jvh.12470

    authors： Waring JF,Dumas EO,Abel S,Coakley E,Cohen DE,Davis JW,Podsadecki T,Dutta S

    更新日期：2016-02-01 00:00:00

  • Inpatient resource utilization, disease severity, mortality and insurance coverage for patients hospitalized for hepatitis C virus in the United States.

    abstract：:Although the incidence of new hepatitis C virus (HCV) infection has fallen, HCV-related complications are on the rise. Our aim was to assess and describe the 2005-2009 national inpatient mortality and resource utilization trends for patients with HCV. Data from the National Inpatient Sample (NIS) and the National Hosp...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12262

    authors： Younossi ZM,Otgonsuren M,Henry L,Arsalla Z,Stepnaova M,Mishra A,Venkatesan C,Hunt S

    更新日期：2015-02-01 00:00:00

  • Combination low-dose lymphoblastoid interferon and thymosin alpha 1 therapy in the treatment of chronic hepatitis B.

    abstract：:This open label study was initiated to assess the safety and efficacy of lymphoblastoid interferon-alpha (IFN-alpha) and thymosin alpha 1 (T alpha 1) in the treatment of 11 patients with chronic hepatitis B, who had failed to respond to standard IFN-alpha 2b therapy, and in four interferon naive patients. These fiftee...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2893.1996.tb00094.x

    authors： Rasi G,Mutchnick MG,Di Virgilio D,Sinibaldi-Vallebona P,Pierimarchi P,Colella F,Favalli C,Garaci E

    更新日期：1996-07-01 00:00:00

  • Retreatment for 24 vs 48 weeks with interferon-alpha2b plus ribavirin of chronic hepatitis C patients who relapsed or did not respond to interferon alone.

    abstract：:We assessed the efficacy of interferon (IFN) plus ribavirin over 24 or 48 weeks for the retreatment of patients with chronic hepatitis C who had relapsed or did not respond to a previous course of IFN. One-hundred and twenty patients (69 non-responders and 51 relapsers) were randomly assigned to receive IFN-alpha2b (3...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2893.2000.00243.x

    authors： Enríquez J,Gallego A,Torras X,Pérez-Olmeda T,Diago M,Soriano V,Luján MS,García-Samaniego J

    更新日期：2000-11-01 00:00:00

  • Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infection.

    abstract：:Long-term safety of treatment with hepatitis B virus (HBV) polymerase inhibitors is a concern. Adefovir dipivoxil (ADV) therapy has previously been associated with impairment of renal function. Limited data are available on the safety of combination therapy with nucleos(t)ide analogues and interferon alfa (IFNα). The ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1365-2893.2011.01560.x

    authors： Mederacke I,Yurdaydin C,Großhennig A,Erhardt A,Cakaloglu Y,Yalcin K,Gurel S,Zeuzem S,Zachou K,Chatzikyrkou C,Bozkaya H,Dalekos GN,Manns MP,Wedemeyer H,Hep-Net\/International Delta Hepatitis Study Group.

    更新日期：2012-06-01 00:00:00

  • Low recurrence rate of hepatocellular carcinoma following ledipasvir and sofosbuvir treatment in a real-world chronic hepatitis C patients cohort.

    abstract：:The aims of the present study were to evaluate the efficacy and tolerability of ledipasvir/sofosbuvir (LDV/SOF) with or without ribavirin in the treatment of chronic hepatitis C (CHC) in patients with advanced liver disease and to analyse whether the use of LDV/SOF treatment is associated with a new occurrence of hepa...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.13075

    authors： Idilman R,Demir M,Aladag M,Erol C,Cavus B,Iliaz R,Koklu H,Cakaloglu Y,Sahin M,Ersoz G,Koksal İ,Karasu Z,Ozgenel M,Turan İ,Gunduz F,Ataseven H,Akdogan M,Kiyici M,Koksal AS,Akhan S,Gunsar F,Tabak F,Kaymakoglu S

    更新日期：2019-06-01 00:00:00

  • Potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China.

    abstract：:The aim of this study was to further investigate the prevalence of infection and genotype of hepatitis E virus (HEV) among different species of animals, people whose works are related to pigs and the general population in the suburb of Beijing, China. Serum and faecal samples were collected from 10 animal species and ...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01472.x

    authors： Geng J,Wang L,Wang X,Fu H,Bu Q,Liu P,Zhu Y,Wang M,Sui Y,Zhuang H

    更新日期：2011-10-01 00:00:00

  • Flaviviridae polymerase and RNA replication.

    abstract：:Sequence motifs within the non-structural protein NS5 or NS5B of the members of the family Flaviviridae suggest that this protein is the RNA-dependent RNA polymerase. This protein has now been expressed in various in vitro systems and used in polymerase assays. To understand the role of the RNA polymerase in RNA repli...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2893.1999.00173.x

    authors： Bartholomeusz A,Thompson P

    更新日期：1999-07-01 00:00:00

  • Efficacy of interferon plus ribavirin in the treatment of hepatitis C virus genotype 5.

    abstract：:Hepatitis C virus (HCV) genotype 5 has only been reported in a few countries and treatment response has not been well characterized. Our aim is to present the treatment outcome for HCV genotype 5 patients evaluated at three medical centres in Syria between January 2004 and June 2007. Medical records were reviewed retr...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1111/j.1365-2893.2007.00946.x

    authors： Antaki N,Hermes A,Hadad M,Ftayeh M,Antaki F,Abdo N,Kebbewar K

    更新日期：2008-05-01 00:00:00

  • Reliability and validity of a self-efficacy instrument for hepatitis C antiviral treatment regimens.

    abstract：:Self-efficacy or confidence in one's ability to successfully engage in goal-directed behaviour has been shown to influence medication adherence across many chronic illnesses. In the present study, we investigated the psychometric properties of a self-efficacy instrument used during treatment for chronic hepatitis C vi...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2011.01550.x

    authors： Bonner JE,Esserman D,Evon DM

    更新日期：2012-05-01 00:00:00

  • Noninvasive assessment of liver fibrosis via spleen stiffness measurement using acoustic radiation force impulse sonoelastography in patients with chronic hepatitis B or C.

    abstract：:Portal hypertension and splenomegaly are common in patients with cirrhosis. However, there is limited previous in vivo research on the correlation between spleen stiffness and stages of liver fibrosis. This study aimed to evaluate the diagnostic value of spleen stiffness measurement (SSM), using acoustic radiation for...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/j.1365-2893.2012.01588.x

    authors： Chen SH,Li YF,Lai HC,Kao JT,Peng CY,Chuang PH,Su WP,Chiang IP

    更新日期：2012-09-01 00:00:00

  • Therapy of chronic hepatitis B: current challenges and opportunities.

    abstract：:Better understanding of hepatitis B virus (HBV) replication, natural history and the immunopathogenesis of chronic hepatitis B, together with the introduction of effective agents with different mechanisms of action are the basis for better therapeutic strategies against chronic hepatitis B. Among currently available d...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章,评审

    doi：10.1046/j.1365-2893.2002.00388.x

    authors： Liaw YF

    更新日期：2002-11-01 00:00:00

  • Efficacy and tolerance of a 6-month treatment course of daily interferon-alpha 2a for chronic hepatitis C with cirrhosis. The Australian Hepatitis C Study Group.

    abstract：:Response to interferon-alpha (IFN-alpha) treatment in hepatitis C is poorer when cirrhosis is present. In the third Australian multicentre hepatitis C trial, Aushep-3, we examined the efficacy and tolerability of an intensive 24-week course of interferon-alpha 2a in Child-Pugh grade A patients with chronic hepatitis C...

    journal_title：Journal of viral hepatitis

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1046/j.1365-2893.1997.00062.x

    authors： Farrell G,Cooksley WG,Dudley FJ,Watson K

    更新日期：1997-09-01 00:00:00

  • Clinical characteristics and long-term outcome of acute kidney injury in patients with HBV-related acute-on-chronic liver failure.

    abstract：:Acute kidney injury (AKI) is a common complication in patients with decompensated cirrhosis and is also an important cause for poor outcome. This study aimed at investigating the clinical characteristics and long-term prognosis of AKI in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACL...

    journal_title：Journal of viral hepatitis

    pub_type： 杂志文章

    doi：10.1111/jvh.12566

    authors： Shi X,Zhu P,Yan G,Liu C,Zhang C,Huang G,Zhang Y,Yan Z,Wang Y

    更新日期：2016-11-01 00:00:00