Abstract:
:Oral therapy for chronic hepatitis B remains suboptimal. Mathematical modelling of viral decay kinetics to rapidly assess potential antiviral regimens has proved valuable for human immunodeficiency virus and cytomegalovirus. We defined the kinetics of viral replication in 10 chronic hepatitis B patients randomized to lamivudine 100 mg vs 600 mg for 48 weeks. Viral decay kinetics conformed to a biphasic pattern in nine of 10 subjects. Persons receiving 600 mg daily of lamivudine exhibited a 1.6-fold faster decay rate in the infected cell compartment (0.028/day vs 0.017/day, P = 0.06) and a greater overall change in serum viral load when compared with those receiving 100 mg (4.06 vs 1.52 log(10) copies/mL, P = 0.08). More potent therapy appeared to result in more rapid decrease in the infected cell population. Studies using mathematical modelling of viral decay may be a useful method to evaluate single or combination therapy for HBV infection in vivo.
journal_name
J Viral Hepatjournal_title
Journal of viral hepatitisauthors
Wang CC,Holte S,Huang ML,Sacks SL,Engelberg R,Ferrenberg J,Shuhart M,Corey Ldoi
10.1111/j.1365-2893.2004.00523.xsubject
Has Abstractpub_date
2004-09-01 00:00:00pages
443-7issue
5eissn
1352-0504issn
1365-2893pii
JVH523journal_volume
11pub_type
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章,随机对照试验
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