Abstract:
:A recombinant protein corresponding to part of the amino-terminal domain of hepatitis B virus (HBV) polymerase was expressed in Escherichia coli. Antisera raised against this protein stained hepatocytes, from human liver biopsies, predominantly in the nucleus but some cytoplasmic staining was also observed. No staining was observed in hepatocytes from uninfected patients. Liver biopsies, taken from patients who were infected with human immunodeficiency virus (HIV) as well as HBV showed more intense staining with these antisera than that seen in patients who were infected with HBV alone. The staining pattern suggests that either the whole HBV polymerase protein, or a portion encoding the amino-terminal domain, is translocated to the nucleus. This event may be an important early step in replication of the HBV genome.
journal_name
J Viral Hepatjournal_title
Journal of viral hepatitisauthors
McGarvey MJ,Goldin RD,Karayiannis P,Thomas HCdoi
10.1111/j.1365-2893.1996.tb00083.xsubject
Has Abstractpub_date
1996-03-01 00:00:00pages
67-73issue
2eissn
1352-0504issn
1365-2893journal_volume
3pub_type
杂志文章abstract::Egypt is the country with the largest hepatitis C virus (HCV) epidemic in the world. In 2008, a Demographic Health Survey (DHS) was carried out in Egypt, providing for the first time a unique opportunity for HCV antibody testing on a nationwide representative sample of individuals. Consenting individuals answered a qu...
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,评审
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,评审
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,多中心研究
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journal_title:Journal of viral hepatitis
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abstract::Peripheral blood mononuclear cells (PBMCs) from 45 treatment naïve, HIV-negative, chronically hepatitis C virus (HCV)-infected patients were analyzed for the presence of HCV RNA. Viral RNA was detected in 73% of the studied patients. Single-strand conformation polymorphism assays and sequence analysis of the HCV 5'unt...
journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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abstract::Peginterferon alpha-2a (40 kDa) plus ribavirin is effective at achieving sustained viral response compared with no treatment in patients with chronic hepatitis C (CHC) and persistently normal aminotransferase levels (PNALT). The cost-effectiveness of treating CHC in the setting of PNALT has not been assessed. Disease ...
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pub_type: 杂志文章,随机对照试验
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