Abstract:
:Peripheral blood mononuclear cells (PBMCs) from 45 treatment naïve, HIV-negative, chronically hepatitis C virus (HCV)-infected patients were analyzed for the presence of HCV RNA. Viral RNA was detected in 73% of the studied patients. Single-strand conformation polymorphism assays and sequence analysis of the HCV 5'untranslated regions amplified from RNA recovered from both Plasma and PBMCs suggested virus compartmentalization in 57.6% of patients studied. In summary, our study presents evidence that HCV RNA can be found in PBMCs of treatment naïve chronically infected patients that are not immunocompromised or co-infected with the human immunodeficiency virus.
journal_name
J Viral Hepatjournal_title
Journal of viral hepatitisauthors
Vera-Otarola J,Barría MI,León U,Marsac D,Carvallo P,Soza A,López-Lastra Mdoi
10.1111/j.1365-2893.2009.01112.xsubject
Has Abstractpub_date
2009-09-01 00:00:00pages
633-43issue
9eissn
1352-0504issn
1365-2893pii
JVH1112journal_volume
16pub_type
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