Serum PAI-1 is a novel predictor for response to pegylated interferon-α-2b plus ribavirin therapy in chronic hepatitis C virus infection.

abstract：:Many Indigenous Australians in northern Australia living with chronic hepatitis B are unaware of their diagnosis due to low screening rates. A venous blood point of care test (POCT) or oral fluid laboratory test could improve testing uptake in this region. The purpose of this study was to assess the field performance ...

journal_title：Journal of viral hepatitis

authors： Sullivan RP,Davies J,Binks P,Dhurrkay RG,Gurruwiwi GG,Bukulatjpi SM,McKinnon M,Hosking K,Littlejohn M,Jackson K,Locarnini S,Davis JS,Tong SYC

更新日期：2020-04-01 00:00:00

abstract：:This study investigated the molecular and pharmacokinetic mechanisms of the enhanced antiviral efficacy associated with pegylated interferon (PEG-IFN) alpha-2b and ribavirin. The study involved comparing the expression of serial double-stranded RNA-activated protein kinase (PKR) before and during treatment in 26 PEG-I...

journal_title：Journal of viral hepatitis

authors： Asahina Y,Izumi N,Umeda N,Hosokawa T,Ueda K,Doi F,Tsuchiya K,Nakanishi H,Matsunaga K,Kitamura T,Kurosaki M,Uchihara M,Higaki M,Miyake S

更新日期：2007-06-01 00:00:00

abstract：:Hepatitis delta virus (HDV) RNA editing controls the formation of hepatitis-delta-antigen-S and -L and therefore indirectly regulates HDV replication. Editing is thought to be catalysed by the adenosine deaminase acting on RNA1 (ADAR1) of which two different forms exist, interferon (IFN)-alpha-inducible ADAR1-L and co...

journal_title：Journal of viral hepatitis

authors： Hartwig D,Schütte C,Warnecke J,Dorn I,Hennig H,Kirchner H,Schlenke P

更新日期：2006-03-01 00:00:00

abstract：:Controversial results have been reported concerning the correlation between serum levels of IgM antibodies to hepatitis B core antigen (IgM HBcAb) and the histological activity of chronic hepatitis B. In this study, paired serum samples and liver biopsies were collected from 200 consecutive chronic hepatitis B patient...

journal_title：Journal of viral hepatitis

authors： Colloredo G,Bellati G,Sonzogni A,Zavaglia C,Fracassetti O,Leandro G,Ghislandi R,Minola E,Ideo G

更新日期：1999-11-01 00:00:00

abstract：:A recombinant protein corresponding to part of the amino-terminal domain of hepatitis B virus (HBV) polymerase was expressed in Escherichia coli. Antisera raised against this protein stained hepatocytes, from human liver biopsies, predominantly in the nucleus but some cytoplasmic staining was also observed. No stainin...

journal_title：Journal of viral hepatitis

authors： McGarvey MJ,Goldin RD,Karayiannis P,Thomas HC

更新日期：1996-03-01 00:00:00

abstract：:Transient elastometry (TE) could provide a more accurate evaluation of the frequency and risk factors of liver fibrosis in hepatitis C virus (HCV) infection than that based on biopsy. The aim of this study was to assess the prevalence of and factors associated with significant liver fibrosis in a large population of H...

journal_title：Journal of viral hepatitis

authors： Pineda JA,González J,Ortega E,Tural C,Macías J,Griffa L,Burgos A,Grafihco Study Team.

更新日期：2010-10-01 00:00:00

abstract：:Hepatitis C virus (HCV) is commonly transmitted by intravenous drug use (IDU) but drug users are under represented in many treatment cohorts, this is because of the assumption of lowered treatment success. We assessed HCV treatment outcomes in active intravenous drug users and patients on opiate substitution therapy. ...

journal_title：Journal of viral hepatitis

authors： Jafferbhoy H,Miller MH,Dunbar JK,Tait J,McLeod S,Dillon JF

更新日期：2012-02-01 00:00:00

abstract：:The human La (hLa) protein functions in RNA metabolism and is activated by casein kinase 2 (CK2) phosphorylation. Hepatitis B virus (HBV) can exploit hLa to stabilize its RNA and promote its pathogenesis. To enhance our knowledge of host molecular pathways involved in HBV pathogenesis, a bioinformatic approach was use...

journal_title：Journal of viral hepatitis

authors： Tang J,Zhang ZH,Liu GL

更新日期：2013-01-01 00:00:00

abstract：:Better understanding of hepatitis B virus (HBV) replication, natural history and the immunopathogenesis of chronic hepatitis B, together with the introduction of effective agents with different mechanisms of action are the basis for better therapeutic strategies against chronic hepatitis B. Among currently available d...

journal_title：Journal of viral hepatitis

authors： Liaw YF

更新日期：2002-11-01 00:00:00

abstract：:Very little is known about the interactions between hepatitis C virus (HCV) and methamphetamine, which is a highly abused psychostimulant and a known risk factor for human immunodeficiency virus (HIV)/HCV infection. This study examined whether methamphetamine has the ability to inhibit innate immunity in the host cell...

journal_title：Journal of viral hepatitis

authors： Ye L,Peng JS,Wang X,Wang YJ,Luo GX,Ho WZ

更新日期：2008-04-01 00:00:00

abstract：:Even with pegylated (PEG) interferons (IFN), therapy of chronic hepatitis C (genotype 1) remains unsatisfactory. The initial viral response to IFN identifies patients infected with IFN resistant viruses not responding to standard IFN/ribavirin therapy. The impact of primary IFN unresponsiveness for PEG-IFN-alpha-2a/ri...

journal_title：Journal of viral hepatitis

authors： Jessner W,Stauber R,Hackl F,Datz C,Watkins-Riedel T,Hofer H,Gangl A,Kessler H,Ferenci P

更新日期：2003-01-01 00:00:00

abstract：:In this pilot study, we evaluated the efficacy of interferon-alpha (IFN) plus Thymosin-alpha 1 (TA1) to that of IFN alone in naive patients with chronic hepatitis C. Twenty-two patients were randomized to receive interferon-alpha 2b (3 million units three times a week) plus thymosin-alpha l (900 microg/m2 body surface...

journal_title：Journal of viral hepatitis

authors： Andreone P,Gramenzi A,Cursaro C,Felline F,Loggi E,D'Errico A,Spinosa M,Lorenzini S,Biselli M,Bernardi M

更新日期：2004-01-01 00:00:00

abstract：:A significant proportion of chronic hepatitis C patients fails to achieve sustained virologic response even after treatment with the current, more potent, combination of pegylated interferon-alpha (IFNa) plus ribavirin. Such patients represent a rather heterogeneous group and may be divided initially into relapsers an...

journal_title：Journal of viral hepatitis

authors： Papatheodoridis GV,Cholongitas E

更新日期：2004-07-01 00:00:00

abstract：:We determined whether triple therapy comprising amantadine (AMA), ribavirin (RBV) and either peginterferon (PEG-IFN) alpha-2a or conventional IFN alpha-2a would improve sustained virological response (SVR) rates over dual therapy with IFN alpha-2a and RBV in patients with chronic HCV infection. A total of 362 treatmen...

journal_title：Journal of viral hepatitis

authors： Mangia A,Ricci GL,Persico M,Minerva N,Carretta V,Bacca D,Cela M,Piattelli M,Annese M,Maio G,Conte D,Guadagnino V,Pazienza V,Festi D,Spirito F,Andriulli A

更新日期：2005-05-01 00:00:00

abstract：:Hepatitis delta virus (HDV) infection is a usually severe type of viral hepatitis associated with increased mortality and rapid evolution to cirrhosis. Currently, treatment is limited to extended interferon administration and measurement of HDV RNA blood levels is essential to judge the response. The aim of this study...

journal_title：Journal of viral hepatitis

authors： Katsoulidou A,Manesis E,Rokka C,Issaris C,Pagoni A,Sypsa V,Hatzakis A

更新日期：2013-04-01 00:00:00

abstract：:With the approval of 2 direct-acting antivirals (DAAs) in 2011 and anticipation of interferon (IFN)-free regimens, more hepatitis C virus (HCV) chronically infected patients are now seeking treatment. To describe the characteristics of newly referred HCV patients in 2011-2012 (Era-2) and compare them to those seen in ...

journal_title：Journal of viral hepatitis

authors： Talaat N,Yapali S,Fontana RJ,Conjeevaram HS,Lok AS

更新日期：2015-05-01 00:00:00

abstract：:Hepatitis C virus (HCV) genotype 5 has only been reported in a few countries and treatment response has not been well characterized. Our aim is to present the treatment outcome for HCV genotype 5 patients evaluated at three medical centres in Syria between January 2004 and June 2007. Medical records were reviewed retr...

journal_title：Journal of viral hepatitis

authors： Antaki N,Hermes A,Hadad M,Ftayeh M,Antaki F,Abdo N,Kebbewar K

更新日期：2008-05-01 00:00:00

abstract：:Egypt is the country with the largest hepatitis C virus (HCV) epidemic in the world. In 2008, a Demographic Health Survey (DHS) was carried out in Egypt, providing for the first time a unique opportunity for HCV antibody testing on a nationwide representative sample of individuals. Consenting individuals answered a qu...

journal_title：Journal of viral hepatitis

authors： Guerra J,Garenne M,Mohamed MK,Fontanet A

更新日期：2012-08-01 00:00:00

abstract：:Hepatitis B virus (HBV) infection is associated with many extrahepatic malignancies, but its association with and impact on ovarian cancer has not been examined. We therefore examined the prevalence of HBV infection among women with primary ovarian carcinoma in an endemic area, and whether this impacts the presentatio...

journal_title：Journal of viral hepatitis

authors： Wong L,Cheung TH,Yim SF,Lao TT

更新日期：2020-05-01 00:00:00

abstract：:Triple therapy with telaprevir, pegylated interferon and ribavirin has been reported to improve antiviral efficacy but have potentially severe adverse effects in patients with chronic hepatitis C. To avoid the severe effects of telaprevir, lowering the dose has been suggested. However, impact of dosage changes on anti...

journal_title：Journal of viral hepatitis

authors： Oze T,Hiramatsu N,Yakushijin T,Yamada R,Harada N,Morishita N,Oshita M,Mita E,Ito T,Inui Y,Inada M,Tamura S,Yoshihara H,Imai Y,Kato M,Miyagi T,Yoshida Y,Tatsumi T,Kasahara A,Hayashi N,Takehara T

更新日期：2015-03-01 00:00:00

abstract：:An estimated incidence of hepatocellular carcinoma (HCC) in Mongolia is currently one of the highest in the world. According to previous reports, the sero-prevalence of hepatitis B (HBV) and hepatitis C (HCV) viruses in general population of the country is very high (HBV, 10% and HCV, 15%, respectively). Moreover, the...

journal_title：Journal of viral hepatitis

authors： Kurbanov F,Tanaka Y,Elkady A,Oyunsuren T,Mizokami M

更新日期：2007-09-01 00:00:00

abstract：:Serological and biochemical studies indicate that acute HBV infection is resolved in the context of an efficient cell-mediated immune (CMI) response, whereas, chronic infection is characterized by weak to undetectable CMI responses and relatively efficient humoral immunity. Because humoral immunity and CMI are regulat...

journal_title：Journal of viral hepatitis

authors： Milich DR

更新日期：1997-01-01 00:00:00

abstract：:Self-efficacy or confidence in one's ability to successfully engage in goal-directed behaviour has been shown to influence medication adherence across many chronic illnesses. In the present study, we investigated the psychometric properties of a self-efficacy instrument used during treatment for chronic hepatitis C vi...

journal_title：Journal of viral hepatitis

authors： Bonner JE,Esserman D,Evon DM

更新日期：2012-05-01 00:00:00

abstract：SUMMARY:Hepatitis C virus (HCV) genotypes 1 and 4 respond less well to pegylated interferon (pegIFN) plus ribavirin (RBV) therapy. For this reason most studies merge these two genotypes when assessing virological response. However, in most trials the HCV genotype 4 population is rather small, and conclusions are mainly...

journal_title：Journal of viral hepatitis

authors： Martín-Carbonero L,Puoti M,García-Samaniego J,De Luca A,Losada E,Quinzan G,Bruno R,Mariño A,González M,Núñez M,Soriano V

更新日期：2008-10-01 00:00:00

abstract：:We compared sustained virological response (SVR) in chronic hepatitis C patients with severe fibrosis treated with pegylated interferon (Peg-IFN) alpha-2b 1.5 microg/kg/week or 0.75 microg/kg/week in combination with ribavirin 800 mg/day for 48 weeks. This was a multicentre randomized controlled study. SVR was observe...

journal_title：Journal of viral hepatitis

authors： Abergel A,Hezode C,Leroy V,Barange K,Bronowicki JP,Tran A,Alric L,Castera L,Bernard PH,Henquell C,Lafeuille H,Ughetto S,Darcha C,Chevallier M,Martineau N,Dubost S,Randl K,Dhumeaux D,Bommelaer G,Bonny C,French mult

更新日期：2006-12-01 00:00:00

abstract：:We used a PCR method to develop a diagnostic assay for the detection of cytomegalovirus (CMV) DNA in infantile hepatitis, which has been suggested to be associated with CMV infection. CMV DNA was detected in 25 (58.1%) of 43 patients with elevated serum alanine aminotransferase (ALT) levels but no jaundice, and no hep...

journal_title：Journal of viral hepatitis

authors： Funato T,Satou N,Abukawa D,Satou J,Abe Y,Ishii KK,Iinuma K,Kaku M,Sasaski T

更新日期：2001-05-01 00:00:00

abstract：:The efficacy and tolerability of 12-month treatment with titrated doses of recombinant interferon-alpha 2a (IFN-alpha 2a) in chronic hepatitis C were studied in 67 consecutively recruited patients randomly assigned either to a starting dose of IFN-alpha 2a 6 MU, subsequently adjusted to the serum alanine aminotransfer...

journal_title：Journal of viral hepatitis

authors： Rumi MG,del Ninno E,Parravicini ML,Romeo R,Soffredini R,Donato MF,Zahm F,Colombo M

更新日期：1995-01-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a variable RNA virus that can readily establish persistent infection. Cellular immune responses are important in the early control of the virus. Evidence from animal models suggests that mutation in epitopes recognized by CD8+ T lymphocytes may play an important role in the establishment of ...

journal_title：Journal of viral hepatitis

authors： Komatsu H,Lauer G,Pybus OG,Ouchi K,Wong D,Ward S,Walker B,Klenerman P

更新日期：2006-02-01 00:00:00

abstract：SUMMARY:Treatment of hepatitis C virus (HCV) infection with interferon (IFN)-alpha, as monotherapy or in combination with ribavirin, is associated with significant side-effects including weight loss. The aim of our study was to describe the evolution of body weight during combination antiviral treatment and to examine ...

journal_title：Journal of viral hepatitis

authors： Seyam MS,Freshwater DA,O'Donnell K,Mutimer DJ

更新日期：2005-09-01 00:00:00

abstract：:To evaluate, among 70 hepatitis C virus (HCV)-monoinfected and 36 human immunodeficiency virus (HIV)-coinfected naïve patients with genotypes 1/4 receiving weight-adjusted pegylated interferon-alpha-2b/ribavirin, viral kinetics and the feasibility to predict treatment failure measuring early HCV-RNA decreases. HCV-RNA...

journal_title：Journal of viral hepatitis

authors： Moreno A,Bárcena R,García-Garzón S,Moreno L,Quereda C,Muriel A,Zamora J,Mateos ML,Pérez-Elías MJ,Antela A,Diz S,Moreno A,Moreno S

更新日期：2006-07-01 00:00:00